J:BMC Syst Biol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT179872 Binding of HGF and MET 7 3 0.09 4.69 0.07
2 INT317416 Binding of FN1 and ITGB1 1 1 0.47 0.69 0.05
3 INT212442 HGF Positive_regulation of MET 2 2 0.21 1.25 0.04
4 INT306527 Binding of Htt and Aifm1 1 1 0.20 0.82 0.04
5 INT317417 Binding of CFH and MMP9 1 1 0.10 1.27 0.04
6 INT225898 Positive_regulation of RAC1 Positive_regulation of PAK1 1 1 0.01 0.08 0
7 INT225909 Binding of GRB2 and SOS1 1 2 0.01 0.11 0
8 INT205985 Ptn Positive_regulation of Trib3 1 3 0.00 0.73 0
9 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 1 0.22 0.58 0
10 INT225892 Binding of GAB1 and RASA1 1 1 0.01 0.06 0
11 INT225889 Binding of MET and SHC1 1 1 0.01 0 0
12 INT225887 HGF Positive_regulation of ATF2 1 1 0.01 0 0
13 INT225905 Binding of GRB2 and SHC1 1 1 0.00 0 0
14 INT205975 Binding of PTCH1 and Smo 1 1 0.02 0.72 0
15 INT225870 Binding of CRKL and Cbl 1 1 0.00 0 0
16 INT225906 Binding of GAB1 and GRB2 1 2 0.01 0.27 0
17 INT225908 Binding of RAC1 and IQGAP1 1 1 0.00 0.09 0
18 INT225890 Binding of RAC1 and STAT3 1 1 0.01 0 0
19 INT205974 Smo Positive_regulation of GLI1 1 1 0.04 0.66 0
20 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 1 0.35 0.57 0
21 INT205960 Binding of PTCH1 and SHH 1 1 0.21 0.71 0
22 INT225873 Ilk Positive_regulation of AKT1 1 1 0.00 0.07 0
23 INT225903 Binding of GAB1 and PIK3CG 1 1 0.01 0.13 0
24 INT225896 HGF Positive_regulation of STAT3 1 1 0.01 0 0
25 INT258614 Positive_regulation of Binding of Foxn1 and Tph2 1 1 0.46 0.06 0
26 INT225876 PIK3CG Positive_regulation of Ilk 1 1 0.00 0 0
27 INT205984 Mapk8 Positive_regulation of Map3k12 1 1 0.15 0.24 0
28 INT258615 Binding of Foxn1 and Tph2 1 1 0.44 0.06 0
29 INT205964 SMOX Positive_regulation of GLI1 1 1 0.20 0.66 0
30 INT225902 Binding of CRKL and GAB1 1 2 0.01 0.1 0
31 INT225874 Positive_regulation of ras Positive_regulation of RAF1 1 1 0.00 0 0
32 INT205959 Binding of SHH and SMOX 1 1 0.12 0.72 0
33 INT205987 Ptn Positive_regulation of Map3k12 1 1 0.03 0.24 0
34 INT225871 RAF1 Positive_regulation of Mdk 1 1 0.00 0 0
35 INT225895 Binding of CRK and GAB1 1 2 0.01 0.1 0
36 INT225897 PDPK1 Positive_regulation of AKT1 1 1 0.01 0.07 0
37 INT205965 Binding of Ptch1 and Smo 1 1 0.03 0.72 0
38 INT205986 Mapk8 Positive_regulation of Trib3 1 3 0.02 0.73 0
39 INT225891 DOCK1 Positive_regulation of RAC1 1 1 0.01 0 0
40 INT225872 Binding of CRK and Cbl 1 1 0.00 0 0
41 INT225875 ras Positive_regulation of RAF1 1 1 0.00 0 0
42 INT205976 Binding of Ptch1 and SMOX 1 1 0.21 0.72 0
43 INT205962 Binding of PTCH1 and SMOX 1 1 0.14 0.72 0
44 INT225894 Binding of MET and PIK3CG 1 1 0.00 0.13 0
45 INT225893 Binding of CRKL and DOCK1 1 1 0.01 0 0
46 INT225900 Binding of GAB1 and MET 1 2 0.00 0.26 0
47 INT225899 Binding of DOCK1 and RAC1 1 1 0.01 0 0
48 INT205977 Binding of SHH and Ptch1 1 1 0.31 0.71 0
49 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 1 0.25 0.58 0
50 INT225907 Binding of CRK and DOCK1 1 1 0.01 0 0
51 INT225888 AKT1 Positive_regulation of PAK1 1 1 0.01 0.08 0
52 INT225904 Binding of GAB1 and PIK3CA 1 1 0.07 0.06 0
53 INT225901 Binding of GRB2 and MET 1 3 0.00 0.33 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1 1026 0.81 515.6 145.31
2 INT71789 Positive_regulation of MAPK1 2 396 0.70 234.44 89.27
3 INT14740 Gene_expression of TGFB1 1 272 0.78 168.48 60.18
4 INT251 Regulation of INS 1 398 0.62 232.47 55.04
5 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
6 INT1322 Positive_regulation of Localization of INS 1 293 0.70 120.86 45.98
7 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
8 INT81037 Negative_regulation of Slc6a3 2 70 0.59 15.31 37.01
9 INT70437 Negative_regulation of Mdk 1 115 0.57 41.03 35.72
10 INT32165 Binding of CALM1 1 92 0.48 24.19 29.57
11 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
12 INT83708 Negative_regulation of MAPK1 1 156 0.57 84.93 27.85
13 INT21687 Positive_regulation of ras 3 143 0.58 97.34 27.31
14 INT93360 Gene_expression of Slc6a3 2 63 0.78 19.54 26.55
15 INT89396 Phosphorylation of AKT1 1 225 0.82 111.66 19.61
16 INT14737 Gene_expression of FN1 6 117 0.78 78.74 18.99
17 INT29555 Positive_regulation of CALM1 2 58 0.69 14.09 17.37
18 INT76406 Gene_expression of Hmox1 2 140 0.78 85.86 17.15
19 INT98647 Positive_regulation of Mdk 2 65 0.59 32.93 15.67
20 INT12464 Binding of MET 1 38 0.47 10.3 13.15
21 INT12156 Positive_regulation of MET 6 43 0.67 17.75 12.64
22 INT13240 Gene_expression of TF 3 94 0.76 57.81 10.99
23 INT91774 Gene_expression of Nr3c1 2 27 0.78 16.14 10.7
24 INT100379 Positive_regulation of HIF1A 1 69 0.69 57.31 10.4
25 INT149015 Gene_expression of Tph2 3 20 0.78 9.45 10.4
26 INT27551 Gene_expression of SERPINH1 1 45 0.62 42.87 9.04
27 INT119831 Gene_expression of PTEN 1 55 0.75 40.37 8.57
28 INT191765 Regulation of CALM1 1 15 0.52 9.52 8.56
29 INT91370 Phosphorylation of STAT3 2 123 0.82 49.25 8.42
30 INT87650 Positive_regulation of EPHB2 2 49 0.67 22.77 8.25
31 INT14732 Positive_regulation of FN1 1 46 0.69 31.17 7.33
32 INT9397 Regulation of MET 2 17 0.60 8.36 7.04
33 INT17618 Gene_expression of B2M 1 36 0.66 16.39 6.68
34 INT86805 Localization of HGF 1 49 0.71 28.48 6.35
35 INT26919 Gene_expression of ITPR3 1 47 0.42 5.86 5.79
36 INT94453 Gene_expression of ITGB1 3 50 0.75 18.41 4.72
37 INT98453 Positive_regulation of Src 1 19 0.47 7.84 4.62
38 INT89103 Regulation of Gene_expression of TGFB1 1 15 0.56 8.11 4.37
39 INT64170 Gene_expression of GLI2 1 31 0.46 14.96 3.99
40 INT43931 Binding of CFH 2 49 0.48 31.85 3.96
41 INT2397 Gene_expression of Maoa 1 12 0.77 11.85 3.88
42 INT78619 Positive_regulation of RAC1 2 27 0.65 10.43 3.75
43 INT121818 Binding of STAT3 1 25 0.47 11.16 3.67
44 INT12083 Regulation of TGFB1 1 22 0.53 15.4 3.6
45 INT205196 Gene_expression of Lpar2 2 18 0.74 12.19 3.49
46 INT16236 Negative_regulation of CFH 1 31 0.57 19.59 3.36
47 INT137350 Phosphorylation of Src 2 13 0.45 4.14 3.32
48 INT106318 Gene_expression of S100A4 2 21 0.75 12.13 3.23
49 INT64 Regulation of Ptpn6 1 12 0.14 2.45 3.17
50 INT104708 Gene_expression of Msh3 7 6 0.72 0.07 3.17
51 INT61500 Binding of FN1 1 39 0.48 27.33 3.13
52 INT87314 Gene_expression of Htt 3 112 0.78 55.82 3.03
53 INT120201 Gene_expression of Aco1 1 54 0.35 26.29 2.95
54 INT9130 Negative_regulation of TGFB1 1 16 0.41 12.21 2.92
55 INT156148 Gene_expression of CTGF 1 16 0.78 9.98 2.87
56 INT96338 Gene_expression of HPSE 1 17 0.75 18.71 2.73
57 INT100360 Negative_regulation of TF 3 19 0.42 10.43 2.68
58 INT248419 Negative_regulation of Tph2 1 11 0.59 6.32 2.59
59 INT23998 Positive_regulation of Sp1 1 4 0.40 0.51 2.56
60 INT1829 Gene_expression of CFH 8 71 0.75 64.24 2.49
61 INT114327 Positive_regulation of RAF1 1 26 0.51 20.87 2.32
62 INT163545 Gene_expression of PDGFRB 2 39 0.78 25.5 2.2
63 INT179885 Regulation of PTEN 1 8 0.26 11.88 2.18
64 INT100381 Positive_regulation of Positive_regulation of HIF1A 1 12 0.49 12.05 2.17
65 INT70987 Binding of RAC1 2 14 0.37 12.14 2.13
66 INT62711 Binding of HGF 1 27 0.31 15.23 2.08
67 INT173851 Localization of FN1 1 20 0.76 13.95 1.97
68 INT57272 Negative_regulation of Gene_expression of FN1 1 16 0.43 11.42 1.93
69 INT244600 Negative_regulation of POSTN 1 5 0.18 3.12 1.64
70 INT140058 Regulation of Cish 1 17 0.37 8.69 1.58
71 INT248418 Localization of Tph2 2 5 0.75 2.45 1.45
72 INT35636 Gene_expression of Sord 1 6 0.78 2.31 1.35
73 INT225375 Negative_regulation of Cytip 1 3 0.30 1.63 1.27
74 INT130207 Phosphorylation of ATF2 1 5 0.60 1.34 1.25
75 INT132453 Binding of TF 3 31 0.36 12.98 1.22
76 INT147909 Gene_expression of Lpl 2 21 0.58 9.35 1.14
77 INT70209 Negative_regulation of FYN 1 3 0.08 1.07 1.06
78 INT113712 Positive_regulation of Gene_expression of Msh3 1 2 0.43 0 1.04
79 INT164079 Regulation of Gene_expression of CTGF 1 4 0.44 2 0.9
80 INT64173 Regulation of Gene_expression of GLI2 1 4 0.37 2.89 0.88
81 INT143912 Localization of Src 1 4 0.48 2.51 0.78
82 INT306520 Negative_regulation of Msh3 1 2 0.40 0.22 0.76
83 INT102439 Negative_regulation of SMOX 1 2 0.41 0.76 0.76
84 INT272511 Positive_regulation of DMPK 1 8 0.54 6.85 0.72
85 INT225373 Gene_expression of Cytip 4 7 0.54 0.68 0.67
86 INT24735 Regulation of TF 2 10 0.44 5.55 0.65
87 INT205957 Negative_regulation of Smo 1 4 0.08 2.57 0.6
88 INT147734 Phosphorylation of RAC1 1 3 0.64 1.33 0.58
89 INT287206 Regulation of Gene_expression of Htt 1 6 0.50 3.27 0.57
90 INT93386 Gene_expression of Sord 1 2 0.55 0.58 0.56
91 INT139780 Binding of AQP1 1 7 0.32 4.62 0.54
92 INT102563 Phosphorylation of ELK1 1 2 0.20 0.54 0.47
93 INT98456 Negative_regulation of Src 1 17 0.42 8.3 0.42
94 INT114740 Binding of GRB2 1 8 0.36 2.24 0.37
95 INT232743 Positive_regulation of LAMB2 1 5 0.06 1.94 0.37
96 INT248415 Binding of Tph2 6 9 0.44 3.88 0.34
97 INT40753 Gene_expression of GLI1 3 9 0.75 5.98 0.33
98 INT201520 Gene_expression of IFITM1 1 3 0.38 1.33 0.33
99 INT116867 Positive_regulation of Gene_expression of CFH 1 11 0.67 11.42 0.3
100 INT244618 Regulation of TRERF1 1 2 0.07 1.43 0.28
101 INT183055 Gene_expression of PTCH1 1 10 0.77 15.54 0.26
102 INT28524 Gene_expression of SMOX 2 3 0.58 1.99 0.26
103 INT183062 Gene_expression of SHH 3 12 0.65 5.28 0.21
104 INT134477 Negative_regulation of SHH 1 2 0.37 1.13 0.2
105 INT112171 Regulation of MB 1 2 0.22 0.23 0.19
106 INT94668 Negative_regulation of Binding of FN1 1 5 0.58 4.44 0.18
107 INT181807 Positive_regulation of Atxn1 1 12 0.34 3.96 0.15
108 INT198600 Negative_regulation of Gene_expression of CFH 1 4 0.41 3.25 0.12
109 INT185024 Negative_regulation of FHL2 1 3 0.29 0.71 0.11
110 INT225845 Binding of CRKL 1 2 0.23 0.42 0.11
111 INT235505 Protein_catabolism of Lpl 1 2 0.76 1.4 0.1
112 INT28525 Localization of SMOX 1 2 0.68 1.29 0.09
113 INT225029 Gene_expression of TRERF1 1 3 0.53 1.62 0.08
114 INT244250 Gene_expression of Bin1 1 2 0.65 0 0.08
115 INT287203 Negative_regulation of Gene_expression of Htt 1 7 0.37 5.08 0.07
116 INT212445 Phosphorylation of MET 1 3 0.35 3.11 0.07
117 INT205973 Binding of SHH 1 3 0.35 1.03 0.07
118 INT342842 Negative_regulation of Protein_catabolism of Lpl 1 1 0.37 0.73 0.07
119 INT306521 Transcription of Htt 4 1 0.69 4.13 0.05
120 INT198606 Localization of CFH 1 8 0.65 4.37 0.04
121 INT205969 Regulation of GLI1 1 4 0.41 3.09 0.04
122 INT181793 Positive_regulation of SHH 2 3 0.67 2.59 0.04
123 INT317422 Binding of INPP5E 1 1 0.01 0.8 0.04
124 INT317421 Gene_expression of LINC00273 1 1 0.02 0.49 0.03
125 INT244610 Negative_regulation of LOXL1 1 1 0.24 0.12 0.03
126 INT244619 Negative_regulation of TMSB4X 1 1 0.21 0.13 0.03
127 INT244603 Negative_regulation of SPARC 1 1 0.18 0.12 0.03
128 INT324499 Gene_expression of Fut9 1 5 0.27 1.27 0
129 INT340362 Gene_expression of Ocrl 1 3 0.67 2.27 0
130 INT202434 Gene_expression of IGFBP6 1 3 0.53 1.52 0
131 INT205968 Negative_regulation of PTCH1 1 2 0.58 2.35 0
132 INT244605 Gene_expression of BASP1 1 2 0.56 0.92 0
133 INT244611 Gene_expression of CCPG1 1 2 0.34 1.29 0
134 INT190020 Gene_expression of Msh2 3 2 0.69 0.69 0
135 INT244607 Gene_expression of CAMK2B 1 2 0.23 0.23 0
136 INT225851 Phosphorylation of RASA1 1 2 0.05 0.14 0
137 INT205972 Regulation of Gene_expression of GLI1 2 1 0.41 1.17 0
138 INT225842 Positive_regulation of Negative_regulation of FYN 1 1 0.04 0.14 0
139 INT258603 Localization of Leo1 1 1 0.04 0 0
140 INT225844 Regulation of Localization of HGF 1 1 0.08 0 0
141 INT244609 Binding of KCNJ13 1 1 0.09 0 0
142 INT306522 Negative_regulation of Gene_expression of Msh3 1 1 0.40 0 0
143 INT244608 Gene_expression of IKZF5 1 1 0.32 0.33 0
144 INT306526 Negative_regulation of Gene_expression of Cytip 1 1 0.30 0 0
145 INT244613 Regulation of MAPKBP1 1 1 0.15 0.27 0
146 INT225856 Protein_catabolism of MYC 1 1 0.64 0.06 0
147 INT258606 Gene_expression of Foxn1 1 1 0.68 0.65 0
148 INT225858 Binding of DOCK1 1 1 0.05 0 0
149 INT244602 Regulation of CCPG1 1 1 0.07 0.27 0
150 INT225857 Positive_regulation of CRKL 1 1 0.05 0 0
151 INT244617 Regulation of Gene_expression of COL12A1 1 1 0.36 0.25 0
152 INT258607 Positive_regulation of Positive_regulation of Foxn1 1 1 0.44 0.06 0
153 INT244614 Regulation of FHL2 1 1 0.07 0.27 0
154 INT342844 Gene_expression of Rhbg 1 1 0.16 0.11 0
155 INT306523 Negative_regulation of Gene_expression of Ogg1 1 1 0.38 0 0
156 INT244601 Gene_expression of MAPKBP1 1 1 0.17 0.27 0
157 INT205970 Regulation of Gene_expression of SMOX 1 1 0.27 0.59 0
158 INT342845 Positive_regulation of Fut9 1 1 0.42 0.52 0
159 INT244604 Gene_expression of KCNJ13 1 1 0.15 0 0
160 INT244615 Gene_expression of FBXL2 1 1 0.15 0.27 0
161 INT306525 Gene_expression of Ogg1 3 1 0.68 0 0
162 INT205971 Negative_regulation of Gene_expression of SMOX 1 1 0.25 0.57 0
163 INT244606 Gene_expression of COL12A1 1 1 0.46 0.25 0
164 INT225821 Phosphorylation of Cbl 1 1 0.03 0 0
165 INT244620 Regulation of IFITM1 1 1 0.06 0.27 0
166 INT258609 Transcription of Leo1 1 1 0.03 0 0
167 INT306524 Negative_regulation of Ogg1 1 1 0.38 0 0
168 INT343611 Binding of Tmem158 1 1 0.36 0.14 0
169 INT205956 Localization of Smo 1 1 0.06 0.71 0
170 INT205967 Localization of GLI1 1 1 0.50 0.57 0
171 INT342843 Gene_expression of Pafah1b3 1 1 0.17 0.11 0
172 INT258608 Positive_regulation of Localization of Leo1 2 1 0.02 0 0
173 INT244616 Gene_expression of FHL2 1 1 0.18 0.27 0
174 INT258605 Negative_regulation of Transcription of Leo1 2 1 0.02 0 0
175 INT225843 Positive_regulation of CRK 1 1 0.04 0 0
176 INT225822 Positive_regulation of Mapk1ip1 1 1 0.01 0.44 0
177 INT244612 Regulation of FBXL2 1 1 0.06 0.27 0
178 INT306519 Regulation of Gene_expression of Msh3 1 1 0.42 0 0
179 INT225846 Phosphorylation of GAB1 1 1 0.10 0.06 0
180 INT225855 Binding of IQGAP1 1 1 0.02 0.09 0
181 INT258604 Positive_regulation of Foxn1 1 1 0.44 0.06 0
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