J:Behav Brain Funct

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT189999 Binding of Vta1 and Cfp 2 1 0.08 1.25 1.97
2 INT227493 Binding of TCEA1 and SIRT2 1 3 0.01 1.55 1.93
3 INT172206 Binding of Slc6a3 and ADHD1 2 3 0.03 2.76 1.61
4 INT192080 Foxm1 Positive_regulation of Cnr1 2 1 0.14 0.72 1.3
5 INT209132 Binding of Drd2 and Riok3 1 3 0.01 1.57 1.16
6 INT307047 Foxm1 Positive_regulation of Casp3 1 3 0.11 0.06 1.03
7 INT215650 Binding of Adora1 and Drd1a 2 1 0.39 0.54 0.92
8 INT197470 Binding of Sostdc1 and Hbtq 1 3 0.00 0.87 0.87
9 INT202254 Binding of COMT and DRD2 1 4 0.41 0.23 0.86
10 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 1 0.01 0.29 0.85
11 INT164364 Binding of DRD2 and SUGT1 2 1 0.06 0.33 0.77
12 INT307044 Tmie Regulation of Casp3 1 1 0.01 0 0.75
13 INT307046 Tmie Positive_regulation of Cnr1 1 1 0.05 0.31 0.69
14 INT227498 Binding of KDELR1 and TMED4 1 1 0.00 0.37 0.67
15 INT209131 Binding of Bcl2a1a and Drd2 1 1 0.22 0.45 0.62
16 INT227499 Binding of PTPN4 and ECA1 1 1 0.01 0.33 0.59
17 INT184878 Binding of Lmo1 and ADHD1 2 1 0.04 2.33 0.53
18 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 1 0.13 0.97 0.51
19 INT307048 Cnr1 Positive_regulation of Casp3 1 1 0.08 0 0.47
20 INT352387 Binding of CFP and HPSE 1 2 0.01 1.25 0.46
21 INT184877 Negative_regulation of Binding of Slc6a3 and ADHD1 1 1 0.01 0.69 0.45
22 INT227495 Regulation of Binding of TCEA1 and SIRT2 1 1 0.01 0.45 0.45
23 INT331675 Binding of Drd1a and Sptan1 1 1 0.03 0.33 0.4
24 INT209130 Binding of Riok3 and Sugt1 1 1 0.00 0.44 0.4
25 INT229105 Binding of GRIN1 and LMOD1 1 1 0.07 0.15 0.4
26 INT209133 Binding of Bcl2a1a and Riok3 1 1 0.00 0.44 0.4
27 INT190003 Binding of MVD and Slc6a3 1 2 0.13 0.19 0.37
28 INT227496 PTPN4 Regulation of PMEL 1 1 0.00 0.45 0.33
29 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 1 0.34 0.61 0.23
30 INT202252 COMT Regulation of DRD2 1 1 0.31 0 0.21
31 INT184868 Binding of Slc6a3 and Lmo1 1 1 0.02 0.72 0.19
32 INT190000 Binding of MVD and Slc6a3 Positive_regulation of Ubqln1 1 1 0.01 0.09 0.19
33 INT249707 Binding of Cd4 and GRDX 1 1 0.01 0.46 0.16
34 INT249685 Binding of CD8A and GRDX 1 1 0.02 0.46 0.16
35 INT202253 Binding of COMT and TCN1 1 1 0.16 0 0.12
36 INT202255 Binding of DRD2 and TCN1 1 1 0.16 0 0.12
37 INT356238 Binding of HLA-E and PI3 1 1 0.02 0 0.05
38 INT202573 Binding of DIO2 and DRD4 1 1 0.07 0.09 0.03
39 INT197466 Dpcd Positive_regulation of Sostdc1 1 1 0.00 0 0
40 INT202572 NOVA2 Regulation of DDT 1 1 0.03 0.14 0
41 INT356237 Binding of CLTC and GPSM2 1 1 0.00 0 0
42 INT245589 Binding of Glb1 and B3galt6 1 2 0.01 0.94 0
43 INT204927 Binding of LGMN and IL33 1 1 0.00 0.52 0
44 INT356252 Binding of CLTC and Dlg3 1 1 0.00 0 0
45 INT202571 Binding of DRD2 and DRD4 1 2 0.41 0.76 0
46 INT197467 Binding of Dpcd and Memor1 1 2 0.00 0.12 0
47 INT237728 CDR1 Regulation of ADHD1 1 1 0.03 0.98 0
48 INT318922 XIAP Regulation of COMMD1 1 1 0.09 0.37 0
49 INT197469 Binding of Dpcd and Hbtq 1 1 0.00 0 0
50 INT197468 Dpcd Positive_regulation of Hbtq 1 1 0.00 0 0
51 INT356253 Binding of CLTC and Gphn 1 1 0.00 0 0
52 INT318919 Binding of ATP7B and COMMD1 1 2 0.37 0.76 0
53 INT318920 Binding of XIAP and COMMD1 1 1 0.12 0.78 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 11 3083 0.78 894.43 1639.02
2 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
3 INT7114 Positive_regulation of Ltp 1 1192 0.62 290.76 755.77
4 INT443 Localization of POMC 3 1020 0.81 284.52 443.17
5 INT467 Gene_expression of POMC 3 1048 0.78 332.8 394.16
6 INT6056 Negative_regulation of Gene_expression of Fos 4 601 0.59 193.05 386.84
7 INT720 Positive_regulation of POMC 8 807 0.70 237.37 353.83
8 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
9 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
10 INT5379 Gene_expression of Fos 3 656 0.78 255.5 292.54
11 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
12 INT1893 Localization of Gh 2 1041 0.79 340.23 256.58
13 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
14 INT6406 Binding of Oprm1 2 280 0.48 40.54 226.26
15 INT1212 Binding of Oprl1 1 312 0.48 28.6 225.15
16 INT11009 Phosphorylation of Creb1 4 458 0.82 111.34 221.97
17 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
18 INT22548 Positive_regulation of Casp3 1 483 0.70 258.78 213.07
19 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
20 INT7506 Negative_regulation of Ltp 1 267 0.46 91.01 176.8
21 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
22 INT768 Positive_regulation of Oprl1 1 179 0.70 40.05 156.93
23 INT4658 Binding of OPRM1 3 188 0.48 25.96 136.24
24 INT65600 Positive_regulation of Casp3 24 376 0.70 198.44 128.03
25 INT1614 Gene_expression of Oprl1 1 164 0.78 31.43 127.74
26 INT5842 Gene_expression of Gfap 9 372 0.78 153.71 127.71
27 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
28 INT14151 Gene_expression of Casp3 12 311 0.78 140.26 120.68
29 INT48593 Positive_regulation of NOS1 3 420 0.68 226.15 114.71
30 INT170025 Gene_expression of Fig4 3 588 0.67 183.27 113.32
31 INT1530 Regulation of Gh 1 382 0.61 115.96 112.47
32 INT11011 Positive_regulation of Phosphorylation of Creb1 2 190 0.70 49.25 112.01
33 INT49651 Gene_expression of Creb1 1 276 0.78 114.77 111.96
34 INT5906 Negative_regulation of Oprm1 1 125 0.59 19.58 101.57
35 INT7944 Positive_regulation of Fos 3 193 0.70 60.69 98.31
36 INT17459 Positive_regulation of Gene_expression of FOS 1 182 0.67 53.45 96.38
37 INT5865 Positive_regulation of Localization of Gh 2 282 0.69 84.86 93.5
38 INT6585 Positive_regulation of Insrr 1 110 0.52 40.67 89.9
39 INT75999 Gene_expression of BDNF 1 344 0.78 114.19 83.12
40 INT7528 Regulation of OPRM1 2 100 0.62 20.63 80.57
41 INT16654 Gene_expression of Insrr 1 138 0.46 58.96 75.68
42 INT79506 Gene_expression of Grin2b 1 122 0.78 43.71 73.42
43 INT31774 Positive_regulation of Vta1 1 67 0.44 14.52 71.79
44 INT5861 Gene_expression of Egr1 4 203 0.78 49.35 68.13
45 INT24989 Positive_regulation of Cfp 1 125 0.61 29.55 64.9
46 INT31116 Gene_expression of Casp3 3 192 0.78 78.21 57.43
47 INT17458 Negative_regulation of Gene_expression of FOS 1 98 0.57 36.77 55.69
48 INT82650 Gene_expression of Bcl2 4 312 0.78 211.71 55.03
49 INT7898 Gene_expression of Homer1 1 123 0.78 31.52 53.67
50 INT48642 Positive_regulation of TCEA1 1 92 0.70 24.59 53.64
51 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
52 INT22546 Positive_regulation of Gene_expression of Casp3 1 97 0.70 47.89 51.92
53 INT50334 Negative_regulation of Cnr1 3 84 0.58 30.86 51.75
54 INT51627 Gene_expression of Grin2a 1 82 0.76 25.09 47.6
55 INT374 Positive_regulation of Ldha 1 212 0.70 107.08 47.43
56 INT6864 Positive_regulation of Gene_expression of Gfap 3 110 0.70 59.01 47.07
57 INT170646 Negative_regulation of Fig4 1 213 0.37 81.29 46.92
58 INT30170 Gene_expression of Car2 1 330 0.66 77.26 46.76
59 INT683 Positive_regulation of AVP 1 173 0.70 74.55 46.41
60 INT8152 Gene_expression of Vta1 1 40 0.58 19.9 46.28
61 INT1564 Localization of OPRM1 2 41 0.80 8.03 44.67
62 INT63383 Binding of Cnr1 2 77 0.48 22.28 44.61
63 INT122953 Gene_expression of COMT 7 65 0.77 25.84 40.49
64 INT92517 Gene_expression of Grin1 3 105 0.78 29.53 39.43
65 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
66 INT1931 Positive_regulation of Gene_expression of POMC 2 116 0.70 37.26 38.67
67 INT16455 Gene_expression of Drd2 2 116 0.78 22.71 38.47
68 INT30817 Gene_expression of Th 2 142 0.76 33.56 38.12
69 INT81037 Negative_regulation of Slc6a3 1 70 0.59 15.31 37.01
70 INT17736 Gene_expression of Cfp 1 111 0.65 40.68 36.61
71 INT13501 Binding of Drd2 4 65 0.48 23.76 35.6
72 INT14031 Gene_expression of Npy 3 107 0.78 36.48 35.4
73 INT72651 Gene_expression of TH1L 1 114 0.75 80.15 35.15
74 INT52194 Positive_regulation of Grin1 1 83 0.69 25.09 34.76
75 INT66005 Regulation of Cnr1 2 47 0.61 19.21 34.52
76 INT14559 Gene_expression of Igf1 4 254 0.78 112 34.17
77 INT5862 Positive_regulation of Egr1 1 82 0.70 30.4 33.96
78 INT11325 Gene_expression of HLA-E 23 209 0.76 98.05 33.72
79 INT11087 Positive_regulation of Drd2 8 54 0.69 12.4 31.43
80 INT65597 Negative_regulation of Casp3 2 69 0.59 39.19 29.32
81 INT169180 Binding of SNRNP70 1 204 0.47 119.1 29.3
82 INT3841 Gene_expression of FCGR3B 2 117 0.75 58.99 28.87
83 INT65598 Negative_regulation of Positive_regulation of Casp3 1 45 0.59 18.36 28.59
84 INT1196 Positive_regulation of Positive_regulation of POMC 1 51 0.70 15.99 28.58
85 INT66200 Gene_expression of Gfap 3 215 0.78 88.04 28.25
86 INT5653 Positive_regulation of ELANE 4 136 0.70 72.78 27.94
87 INT90313 Negative_regulation of Gene_expression of Casp3 2 57 0.57 22.23 26.77
88 INT2609 Localization of ELANE 1 111 0.81 50.22 26.63
89 INT93360 Gene_expression of Slc6a3 1 63 0.78 19.54 26.55
90 INT19856 Gene_expression of CD8A 3 240 0.75 147.86 26.39
91 INT7899 Positive_regulation of Gene_expression of Homer1 1 41 0.70 7.29 25.98
92 INT6054 Positive_regulation of Gene_expression of Egr1 1 67 0.70 18.45 25.93
93 INT61664 Regulation of GRIN1 1 38 0.60 16.45 25.35
94 INT48766 Regulation of NOS1 1 73 0.61 37.01 24.59
95 INT100423 Gene_expression of Bax 4 141 0.75 98.43 24.48
96 INT56686 Regulation of Vta1 1 26 0.44 3.43 24.48
97 INT13838 Positive_regulation of Drd1a 16 48 0.70 9.83 23.42
98 INT29704 Regulation of Casp3 1 51 0.56 22.13 22.79
99 INT17962 Regulation of Car2 1 124 0.41 33.98 22.71
100 INT4369 Gene_expression of Ldha 1 157 0.76 88.12 22.45
101 INT7715 Regulation of Drd2 4 35 0.62 10.79 22.3
102 INT5905 Negative_regulation of ELANE 1 113 0.59 47.43 22.09
103 INT23564 Negative_regulation of Car2 1 103 0.50 27.28 21.86
104 INT8580 Gene_expression of ELANE 1 132 0.75 62.98 21.79
105 INT28728 Regulation of Cfp 1 49 0.46 13.15 21.43
106 INT61825 Negative_regulation of Slc6a3 2 47 0.59 6.52 21.27
107 INT49774 Binding of DRD2 12 48 0.48 17.42 20.73
108 INT5096 Positive_regulation of Gtf3a 1 79 0.60 42.26 20.62
109 INT24240 Positive_regulation of Th 1 60 0.70 9.92 20.18
110 INT48663 Negative_regulation of Gene_expression of Gfap 1 45 0.59 18.34 19.84
111 INT7581 Binding of ADHD1 8 132 0.46 135.1 19.73
112 INT135629 Binding of COMT 7 33 0.48 16.68 19.37
113 INT1278 Negative_regulation of Ldha 1 93 0.59 37.66 19.36
114 INT93734 Positive_regulation of Gene_expression of Bcl2 1 76 0.70 61.95 18.46
115 INT12575 Regulation of Hpse 3 33 0.59 17.7 18.45
116 INT30197 Positive_regulation of Ubqln1 6 26 0.08 2.07 18.28
117 INT11275 Regulation of Fos 1 37 0.60 5.79 18.18
118 INT7439 Positive_regulation of CFP 9 52 0.67 19.97 17.87
119 INT51779 Gene_expression of Drd1a 3 46 0.66 11.18 17.51
120 INT10056 Positive_regulation of Fabp6 6 77 0.59 36.99 16.8
121 INT65214 Binding of Slc6a3 1 54 0.48 4.77 16.79
122 INT22547 Regulation of Gene_expression of Casp3 1 23 0.62 8.04 16.78
123 INT197375 Gene_expression of Car1 2 84 0.65 16.46 16.45
124 INT68913 Gene_expression of Cd14 4 55 0.76 38.99 15.67
125 INT26729 Negative_regulation of Drd2 2 28 0.55 9.32 15.17
126 INT29086 Negative_regulation of Sert1 1 37 0.58 7.49 14.98
127 INT3002 Binding of SUGT1 4 62 0.24 55.9 14.91
128 INT65263 Positive_regulation of Gene_expression of Igf1 1 61 0.69 25.69 14.49
129 INT109264 Positive_regulation of Transcription of Th 1 17 0.50 4.73 14.33
130 INT79149 Gene_expression of CSE 4 26 0.58 11.76 14.16
131 INT92513 Regulation of Grin1 1 26 0.59 9.12 13.94
132 INT108063 Gene_expression of Adora2a 1 29 0.78 13.11 13.78
133 INT21646 Positive_regulation of Npy 10 40 0.70 31.31 13.57
134 INT11699 Binding of HLA-E 2 85 0.47 52.51 13.41
135 INT86646 Positive_regulation of SCN10A 1 71 0.69 50.61 13.24
136 INT31341 Positive_regulation of CSE 1 15 0.60 11.57 12.29
137 INT47743 Negative_regulation of Slc6a4 1 22 0.59 6.23 12.23
138 INT184844 Gene_expression of Snap25 5 130 0.78 14.32 12.13
139 INT145425 Positive_regulation of NLRP1 1 19 0.47 6.93 12.09
140 INT184853 Gene_expression of ADHD1 11 87 0.65 89.2 11.8
141 INT69029 Gene_expression of PTPRC 4 127 0.75 74.26 11.57
142 INT373 Regulation of Ldha 1 37 0.61 17.86 11.41
143 INT10009 Positive_regulation of TRH 1 31 0.67 8.94 11.03
144 INT63773 Gene_expression of DRD2 5 25 0.78 10.41 10.8
145 INT78567 Positive_regulation of Gene_expression of Th 1 25 0.68 5.32 10.75
146 INT93967 Binding of Slc6a3 1 22 0.48 6.81 10.74
147 INT71633 Negative_regulation of SLC6A3 1 25 0.59 10.5 10.69
148 INT121796 Gene_expression of NeuN 2 92 0.78 23.18 10.53
149 INT78695 Regulation of Casp3 2 24 0.44 9.43 10.48
150 INT90639 Positive_regulation of Slc6a3 6 25 0.61 10.95 10.41
151 INT64193 Regulation of Grin2a 1 19 0.54 2.98 10.31
152 INT4297 Negative_regulation of CFP 5 21 0.42 12.7 10.29
153 INT5788 Gene_expression of IL2RA 1 60 0.75 40.67 9.98
154 INT14881 Gene_expression of Car3 2 49 0.73 14.89 9.94
155 INT69306 Negative_regulation of TH1L 1 28 0.57 24.81 9.74
156 INT15722 Positive_regulation of PPAP2A 1 25 0.43 4.83 9.65
157 INT83674 Negative_regulation of SCN10A 1 14 0.59 7.28 9.65
158 INT12563 Localization of Mpo 2 33 0.81 20.99 9.58
159 INT102110 Positive_regulation of Gene_expression of Bax 2 42 0.67 35.77 9.51
160 INT57039 Positive_regulation of Gene_expression of Drd2 1 16 0.50 1.98 9.48
161 INT12398 Regulation of Flvcr2 1 11 0.39 1.8 9.47
162 INT47744 Binding of Slc6a4 1 21 0.48 5.52 9.45
163 INT21794 Positive_regulation of Gene_expression of Npy 1 20 0.70 8.44 9.3
164 INT3954 Regulation of Fabp6 2 33 0.52 15.64 9.27
165 INT105103 Regulation of Gene_expression of Casp3 1 11 0.39 3.15 9.22
166 INT1224 Gene_expression of Fabp6 5 34 0.64 23.69 9.08
167 INT220 Negative_regulation of Ddc 1 16 0.59 2.94 8.66
168 INT15805 Gene_expression of TFRC 1 35 0.75 17.44 8.52
169 INT184864 Gene_expression of Lmo1 14 16 0.26 8.09 8.48
170 INT29121 Positive_regulation of DIO2 1 23 0.67 6.13 8.46
171 INT28671 Positive_regulation of Gene_expression of HLA-E 1 43 0.67 22.85 8.39
172 INT5194 Positive_regulation of Lpo 1 63 0.70 26.44 8.37
173 INT15189 Localization of Npy 5 26 0.79 9.09 8.28
174 INT102512 Gene_expression of B3galt6 2 10 0.52 3.01 8.25
175 INT53798 Gene_expression of Oprk1 1 14 0.73 1.82 8.24
176 INT109265 Transcription of Th 1 18 0.68 4.5 8.21
177 INT78696 Regulation of Positive_regulation of Casp3 1 9 0.39 2.93 8.2
178 INT36135 Negative_regulation of CSE 1 19 0.50 1.77 7.81
179 INT184845 Negative_regulation of Gene_expression of Slc6a3 1 13 0.59 3.25 7.79
180 INT135113 Localization of Grin1 1 18 0.73 3.73 7.69
181 INT6055 Transcription of Egr1 1 47 0.69 3.61 7.68
182 INT18190 Regulation of DRD2 1 11 0.60 9.01 7.63
183 INT72523 Regulation of TCEA1 1 18 0.45 3.19 7.6
184 INT91445 Regulation of Bcl2 1 50 0.56 38.8 7.41
185 INT75063 Regulation of Gene_expression of Drd2 1 10 0.62 2.82 7.38
186 INT102107 Negative_regulation of Gene_expression of Bax 1 30 0.57 29.48 7.33
187 INT5195 Negative_regulation of Lpo 1 32 0.59 14.45 7.3
188 INT60931 Negative_regulation of Fst 2 15 0.57 5.44 7.21
189 INT32903 Negative_regulation of PPAP2A 1 14 0.48 5.02 7.2
190 INT73760 Transcription of Drd2 1 14 0.72 2.11 7.19
191 INT18340 Gene_expression of CRX 3 16 0.22 13.85 7.13
192 INT2605 Regulation of ELANE 1 39 0.61 18.22 7.11
193 INT133237 Gene_expression of Homer1 1 19 0.78 6.39 7.05
194 INT184858 Positive_regulation of Gene_expression of Lmo1 11 12 0.23 5.46 7.04
195 INT22369 Negative_regulation of Drd1a 6 15 0.47 6.13 6.87
196 INT90461 Negative_regulation of DRD2 1 21 0.53 8.35 6.55
197 INT50337 Negative_regulation of Foxm1 3 24 0.43 11.12 6.48
198 INT86060 Positive_regulation of Fst 1 13 0.64 3.04 6.33
199 INT14560 Regulation of Igf1 1 41 0.59 19.59 6.3
200 INT42132 Negative_regulation of TCEA1 3 13 0.51 4.12 6.28
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