J:Biochemical Journal

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT182194 Binding of IL8 and CXCR2 10 2 0.56 7.14 4.16
2 INT208572 Binding of IL8 and CXCR1 6 1 0.33 5.2 3.08
3 INT239539 Binding of CXCR2 and CALCRL 1 3 0.00 0.38 0.98
4 INT239533 Binding of MTNR1A and NCOR2 1 3 0.01 0.53 0.87
5 INT201945 Binding of CXCR1 and CXCR2 3 1 0.14 0.84 0.8
6 INT239538 Binding of CXCR4 and CALCRL 1 1 0.00 0.35 0.71
7 INT149221 Binding of Ryr1 and Trpc3 5 4 0.40 0 0.37
8 INT239540 Binding of CXCR2 and MYC 1 2 0.15 0.09 0.33
9 INT239558 Binding of CXCR2 and Hopx 1 6 0.06 0.44 0.31
10 INT239537 CXCR2 Regulation of MYC 1 1 0.15 0.05 0.29
11 INT239536 Binding of CXCR2 and NCOR2 1 1 0.00 0 0.2
12 INT149220 Binding of Trpc1 and Trpc3 1 3 0.35 0 0.18
13 INT239557 Binding of MYC and Hopx 1 1 0.14 0 0.14
14 INT149219 Binding of Ryr1 and Trpc1 1 2 0.35 0 0.11
15 INT338789 HFE2 Regulation of HAMP 1 4 0.11 1 0.09
16 INT260728 Binding of Samsn1 and NAFLD2 1 1 0.00 1.15 0.05
17 INT338827 Binding of Slc40a1 and HAMP 1 1 0.00 0.27 0.05
18 INT338787 SYCP3 Regulation of HAMP 1 1 0.11 0.27 0.04
19 INT338788 TMPRSS6 Regulation of HAMP 1 1 0.10 0.27 0.04
20 INT338783 Binding of SEA and TMPRSS6 1 1 0.06 0 0
21 INT338781 Gene_expression of TMPRSS6 Negative_regulation of HAMP 1 1 0.11 0 0
22 INT338828 Binding of Trf and TMPRSS6 1 1 0.05 0.1 0
23 INT338791 TMPRSS6 Regulation of Gene_expression of HAMP 1 1 0.18 0 0
24 INT338784 Binding of TMPRSS6 and Regulation of Gene_expression of HAMP 1 1 0.08 0 0
25 INT338786 Binding of HFE2 and TMPRSS6 1 4 0.23 0.06 0
26 INT338771 HFE2 Regulation of HFE2 Regulation of HAMP 1 1 0.01 0.23 0
27 INT323590 Binding of Aldh2 and Napa 1 1 0.01 0.16 0
28 INT338785 Gene_expression of TMPRSS6 Positive_regulation of Positive_regulation of HAMP 1 1 0.10 0.24 0
29 INT323591 Negative_regulation of Binding of Aldh2 and Napa 1 1 0.02 0.17 0
30 INT260727 Binding of Gfm1 and NAFLD2 1 1 0.00 1.05 0
31 INT260726 Positive_regulation of Binding of Gfm1 and NAFLD2 1 1 0.00 1.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
2 INT6354 Localization of Gabrg1 2 321 0.74 41.41 186.74
3 INT49441 Negative_regulation of Cpox 4 494 0.59 303.22 177.46
4 INT66280 Gene_expression of Nos2 5 534 0.78 330.78 157.07
5 INT6323 Positive_regulation of Gabrg1 1 213 0.70 45.08 124.34
6 INT77435 Positive_regulation of Nos2 4 343 0.70 208.49 91.43
7 INT9516 Negative_regulation of Gabrg1 2 149 0.53 27.83 91.02
8 INT56291 Gene_expression of Ros1 3 503 0.63 274.12 81.5
9 INT2289 Gene_expression of PENK 1 203 0.78 55.62 79.49
10 INT6894 Gene_expression of CNR1 1 168 0.78 74.07 62.84
11 INT16850 Negative_regulation of Localization of Gabrg1 1 73 0.51 8.28 47.89
12 INT88322 Gene_expression of CCR5 1 111 0.78 77.36 39.84
13 INT6357 Positive_regulation of Localization of Gabrg1 1 53 0.41 7.03 39.21
14 INT77434 Positive_regulation of Gene_expression of Nos2 1 151 0.69 96.76 38.94
15 INT92837 Negative_regulation of Gene_expression of Nos2 1 116 0.59 59.67 31.82
16 INT6855 Binding of NCOR2 3 71 0.41 15.64 28.96
17 INT133876 Positive_regulation of Gene_expression of Ros1 3 141 0.32 75.55 27.45
18 INT145426 Positive_regulation of Ros1 1 185 0.56 106.76 27.21
19 INT19856 Gene_expression of CD8A 2 240 0.75 147.86 26.39
20 INT10836 Negative_regulation of IL8 1 95 0.59 52.59 24.71
21 INT27933 Gene_expression of NCOR2 5 65 0.72 31.35 24.23
22 INT28642 Gene_expression of CXCR2 17 60 0.78 38.69 18.11
23 INT22068 Binding of CALCRL 2 53 0.41 6.14 17.32
24 INT1721 Negative_regulation of HP 2 148 0.42 86.82 16.89
25 INT10834 Binding of IL8 1 65 0.48 41.66 16.53
26 INT42810 Gene_expression of CALCRL 7 53 0.77 10.87 15.42
27 INT107585 Gene_expression of CCR2 3 35 0.71 26.44 14.75
28 INT40478 Negative_regulation of NCOR2 2 23 0.48 12.77 14.56
29 INT20420 Gene_expression of MYC 14 99 0.75 49.32 14.36
30 INT53747 Positive_regulation of Cyp2e1 6 34 0.70 29.03 13.39
31 INT8548 Gene_expression of HP 1 86 0.77 47.62 11.94
32 INT66606 Gene_expression of CXCR1 1 34 0.75 27.79 11.36
33 INT73959 Positive_regulation of NOSTRIN 1 49 0.61 31.1 11.27
34 INT5464 Regulation of CALCRL 3 24 0.16 4.2 11.19
35 INT62580 Gene_expression of Cyp2e1 2 31 0.78 15.4 11.08
36 INT82854 Gene_expression of MRGPRX1 6 61 0.75 10.14 10.65
37 INT67048 Gene_expression of ITGA4 1 58 0.75 28.93 10.16
38 INT53746 Regulation of Cyp2e1 2 11 0.62 3.82 9.52
39 INT141185 Regulation of Ros1 1 30 0.24 20.73 8.88
40 INT116605 Binding of Nos2 1 28 0.37 16.88 8.18
41 INT50290 Binding of Cpox 1 29 0.27 17.19 8.01
42 INT92755 Regulation of MRGPRX1 2 26 0.27 3.63 7.37
43 INT77756 Positive_regulation of GTPBP4 1 16 0.11 2.6 7.29
44 INT120895 Binding of CCL2 2 22 0.37 15.86 6.55
45 INT143357 Binding of Ros1 3 48 0.36 27.76 6
46 INT63177 Regulation of HP 1 71 0.44 39.48 5.86
47 INT117189 Binding of CXCR4 1 34 0.37 24.27 5.81
48 INT190298 Binding of MRGPRX1 3 61 0.46 2.66 5.75
49 INT4613 Positive_regulation of Sirt1 1 32 0.67 18.19 5.53
50 INT149217 Gene_expression of Kcnip3 1 2 0.63 6.31 5.26
51 INT80038 Positive_regulation of Gene_expression of MYC 2 24 0.67 13.93 5.17
52 INT59723 Binding of Slc40a1 1 5 0.35 1.31 5.17
53 INT62958 Positive_regulation of CXCR2 4 14 0.59 8.61 4.92
54 INT92572 Gene_expression of Mapk7 1 17 0.78 3.71 4.76
55 INT18011 Positive_regulation of HP 1 60 0.50 31.88 4.75
56 INT45813 Negative_regulation of Negative_regulation of Gabrg1 1 10 0.46 0.66 4.51
57 INT7437 Gene_expression of CFP 1 21 0.65 4.93 3.89
58 INT144522 Gene_expression of Trpc3 1 27 0.76 3.31 3.37
59 INT14281 Gene_expression of Hspa5 2 44 0.63 34.19 3.31
60 INT139010 Regulation of Gfm1 2 16 0.32 5.02 3.27
61 INT18394 Regulation of Ryr1 1 6 0.60 0.28 3.26
62 INT19393 Gene_expression of Gfm1 2 31 0.51 18.9 3.2
63 INT120201 Gene_expression of Aco1 1 54 0.35 26.29 2.95
64 INT28640 Positive_regulation of Gene_expression of CXCR2 3 8 0.69 5.51 2.91
65 INT52084 Localization of Cyp2e1 2 6 0.71 1.99 2.79
66 INT208588 Binding of CXCR2 4 11 0.48 6.43 2.68
67 INT122656 Gene_expression of MTNR1A 1 21 0.75 6.37 2.46
68 INT82798 Regulation of MYC 1 19 0.60 12.06 2.31
69 INT110038 Negative_regulation of Aco1 2 26 0.23 17.41 2.2
70 INT82722 Negative_regulation of Positive_regulation of Cyp2e1 2 6 0.59 3.74 2.02
71 INT281878 Positive_regulation of Gene_expression of Aco1 1 35 0.31 17.15 1.98
72 INT182243 Regulation of CXCR2 2 4 0.39 2.59 1.94
73 INT20421 Positive_regulation of MYC 2 19 0.67 10.43 1.9
74 INT105162 Gene_expression of Ad 1 47 0.12 46.53 1.83
75 INT173324 Positive_regulation of Gene_expression of MRGPRX1 1 13 0.48 1.49 1.75
76 INT15990 Binding of Gfm1 1 10 0.31 8.53 1.37
77 INT148883 Gene_expression of HCRTR1 1 8 0.36 24.82 1.35
78 INT149216 Binding of Trpc3 9 15 0.48 0 1.33
79 INT115374 Positive_regulation of Gene_expression of Cyp2e1 2 6 0.67 4.36 1.27
80 INT25451 Negative_regulation of Gfm1 1 13 0.27 8.22 1.06
81 INT239527 Gene_expression of Hopx 17 1 0.26 0.5 1.06
82 INT168065 Binding of Sirt1 1 13 0.47 4.55 1.02
83 INT51994 Positive_regulation of Gene_expression of CALCRL 1 4 0.03 0.13 1.02
84 INT204156 Gene_expression of HAMP 13 7 0.75 8.1 0.94
85 INT182220 Regulation of Positive_regulation of CXCR2 1 2 0.39 1.29 0.91
86 INT116831 Binding of Ryr1 6 11 0.47 0.12 0.9
87 INT227337 Gene_expression of NAFLD2 1 7 0.05 10.98 0.83
88 INT144908 Gene_expression of SEA 1 15 0.52 3.81 0.79
89 INT117031 Binding of Samsn1 1 6 0.21 6.82 0.76
90 INT149215 Regulation of Gene_expression of Kcnip3 1 2 0.36 0.18 0.66
91 INT173078 Phosphorylation of NCOR2 1 2 0.04 0.44 0.57
92 INT239556 Positive_regulation of Phosphorylation of CXCR2 1 1 0.18 0.11 0.53
93 INT239543 Phosphorylation of CXCR1 1 1 0.59 0.1 0.53
94 INT239553 Positive_regulation of Phosphorylation of CXCR1 1 1 0.50 0.11 0.53
95 INT239544 Phosphorylation of CXCR2 1 1 0.29 0.1 0.53
96 INT239551 Binding of CCR2 1 2 0.39 0 0.52
97 INT297528 Transcription of HAMP 2 3 0.69 3.64 0.5
98 INT239549 Gene_expression of GPR50 2 3 0.44 0.06 0.5
99 INT199174 Positive_regulation of Binding of Ros1 2 6 0.10 2.82 0.41
100 INT260722 Positive_regulation of Lipo2 5 10 0.02 7.9 0.37
101 INT133819 Localization of CXCR2 1 3 0.61 1.64 0.37
102 INT258168 Gene_expression of Ino80b 1 2 0.03 0.05 0.37
103 INT306940 Positive_regulation of HAMP 10 3 0.49 5.06 0.36
104 INT239554 Positive_regulation of C1orf148 2 1 0.01 0.07 0.36
105 INT157416 Positive_regulation of Samsn1 4 6 0.53 4.28 0.33
106 INT3321 Positive_regulation of ALAS2 1 10 0.51 3.08 0.32
107 INT310530 Positive_regulation of Gene_expression of HAMP 8 3 0.49 4.16 0.28
108 INT239542 Negative_regulation of GPR50 1 1 0.43 0.07 0.26
109 INT252721 Binding of NAFLD2 1 3 0.03 5.36 0.23
110 INT55191 Negative_regulation of Lipo2 1 2 0.08 1.64 0.23
111 INT281876 Regulation of Aco1 1 4 0.11 4 0.22
112 INT160670 Negative_regulation of Pdia3 1 3 0.42 0.7 0.22
113 INT193399 Localization of SEA 1 4 0.54 0.6 0.2
114 INT107338 Positive_regulation of DMRT1 1 2 0.41 0.08 0.2
115 INT239531 Localization of Hopx 1 1 0.24 0.06 0.16
116 INT168064 Negative_regulation of Nqo2 1 1 0.37 0.21 0.16
117 INT252705 Positive_regulation of NAFLD2 1 2 0.04 2.56 0.14
118 INT192920 Localization of HAMP 2 2 0.28 1.35 0.14
119 INT239529 Binding of Hopx 3 1 0.14 0.28 0.13
120 INT239550 Negative_regulation of Binding of CCL2 1 1 0.18 0 0.13
121 INT260717 Binding of Lipo2 2 1 0.01 1.19 0.11
122 INT149211 Regulation of Gene_expression of Trpc3 1 2 0.60 0 0.1
123 INT239532 Phosphorylation of Hopx 1 1 0.27 0.17 0.1
124 INT192918 Negative_regulation of HAMP 1 3 0.57 2.29 0.09
125 INT209705 Positive_regulation of Dner 1 3 0.04 0 0.09
126 INT310526 Gene_expression of HFE2 5 2 0.32 1.14 0.09
127 INT239552 Regulation of Positive_regulation of MYC 1 1 0.44 0.09 0.09
128 INT192840 Transcription of Hspa5 1 4 0.47 1.93 0.08
129 INT296382 Positive_regulation of SLC11A2 1 3 0.31 1.49 0.08
130 INT338798 Protein_catabolism of HFE2 3 1 0.37 0.52 0.08
131 INT241866 Binding of HAMP 1 2 0.47 1.65 0.07
132 INT338793 Transcription of TMPRSS6 2 1 0.69 0.46 0.07
133 INT149213 Regulation of Trpc1 1 1 0.17 0 0.07
134 INT149214 Regulation of Jph2 1 1 0.39 0 0.07
135 INT338804 Negative_regulation of Localization of TMPRSS6 1 1 0.37 0.26 0.05
136 INT338820 Negative_regulation of Localization of HAMP 1 1 0.09 0.26 0.05
137 INT338821 Localization of TMPRSS6 13 1 0.80 1.01 0.05
138 INT197172 Negative_regulation of Gene_expression of Gfm1 1 2 0.02 1.68 0.04
139 INT204165 Regulation of Cs 2 2 0.09 1.35 0.04
140 INT338801 Binding of HFE2 5 1 0.36 0.55 0.04
141 INT338826 Negative_regulation of Protein_catabolism of HFE2 1 1 0.18 0.25 0.04
142 INT338794 Binding of TMPRSS6 6 1 0.36 0.33 0.04
143 INT197014 Localization of LDLR 1 8 0.63 3.29 0.03
144 INT338816 Gene_expression of TMPRSS6 29 1 0.77 2.4 0.03
145 INT260720 Positive_regulation of Binding of Lipo2 1 1 0.01 0.34 0.03
146 INT186639 Gene_expression of SLC11A2 1 4 0.65 1.91 0
147 INT196389 Gene_expression of Cisd1 2 3 0.01 0.44 0
148 INT199185 Regulation of Binding of Ros1 1 3 0.12 0.56 0
149 INT289783 Negative_regulation of Hspa5 1 2 0.22 0.7 0
150 INT260715 Regulation of Lipo2 1 2 0.01 2.12 0
151 INT260719 Regulation of Gene_expression of Ino80b 1 1 0.02 0.05 0
152 INT338795 Positive_regulation of HFE2 1 1 0.19 0.23 0
153 INT323583 Negative_regulation of Cisd1 1 1 0.01 0 0
154 INT338810 Positive_regulation of SLC25A28 2 1 0.33 0.15 0
155 INT338817 Positive_regulation of Positive_regulation of TMPRSS6 1 1 0.47 0.07 0
156 INT260718 Negative_regulation of Nucks1 1 1 0.04 0.06 0
157 INT338808 Positive_regulation of TMPRSS6 6 1 0.69 0.59 0
158 INT338800 Regulation of Gene_expression of HAMP 1 1 0.07 0.17 0
159 INT338792 Protein_catabolism of TMPRSS6 2 1 0.87 0 0
160 INT338824 Gene_expression of KLK11 1 1 0.01 0.23 0
161 INT338811 Positive_regulation of Gene_expression of HFE2 1 1 0.21 0 0
162 INT338818 Negative_regulation of TMPRSS6 2 1 0.38 0.08 0
163 INT338812 Regulation of TMPRSS6 3 1 0.61 0.2 0
164 INT338796 Negative_regulation of HFE2 1 1 0.18 0.28 0
165 INT338805 Negative_regulation of Positive_regulation of HFE2 1 1 0.18 0.23 0
166 INT338797 Negative_regulation of Positive_regulation of TMPRSS6 1 1 0.58 0.07 0
167 INT323586 Negative_regulation of Skil 1 1 0.01 0 0
168 INT338806 Positive_regulation of Protein_catabolism of TMPRSS6 1 1 0.60 0 0
169 INT338814 Negative_regulation of Negative_regulation of HFE2 1 1 0.18 0.28 0
170 INT323587 Transcription of Aco1 1 1 0.03 0.1 0
171 INT323574 Negative_regulation of Immt 1 1 0.06 0.09 0
172 INT338813 Gene_expression of TMPRSS15 1 1 0.11 0.22 0
173 INT323584 Protein_catabolism of Cisd1 1 1 0.01 0 0
174 INT338819 Phosphorylation of TMPRSS6 1 1 0.55 0 0
175 INT260716 Positive_regulation of Regulation of Lipo2 1 1 0.01 0.74 0
176 INT323573 Gene_expression of Immt 1 1 0.09 0.09 0
177 INT338809 Positive_regulation of Gene_expression of TMPRSS6 11 1 0.69 0.53 0
178 INT338799 Positive_regulation of Localization of HAMP 1 1 0.10 0.21 0
179 INT323585 Regulation of Transcription of Aco1 1 1 0.02 0.1 0
180 INT338825 Positive_regulation of Transcription of HAMP 1 1 0.10 0 0
181 INT338807 Positive_regulation of Positive_regulation of HAMP 1 1 0.10 0.07 0
182 INT239530 Gene_expression of Dner 1 1 0.05 0.06 0
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