J:Biol. Pharm. Bull.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 2 0.54 5.93 32.4
2 INT69823 Binding of GHR and RYBP 1 3 0.01 0 3.23
3 INT153728 RYBP Positive_regulation of Gpt 3 1 0.03 2.01 2.36
4 INT146930 CAP1 Regulation of ABCB1 1 2 0.29 0.3 2.19
5 INT129212 RYBP Positive_regulation of Tnf 2 1 0.03 1.9 1.95
6 INT62065 Binding of YY1 and Penk 3 1 0.14 0 1.69
7 INT69824 Negative_regulation of Binding of GHR and RYBP 1 1 0.01 0 1.14
8 INT81583 Cyp3a23/3a1 Positive_regulation of st 1 1 0.04 0 1.08
9 INT81580 Cyp3a23/3a1 Positive_regulation of Nudt14 1 1 0.01 0 1.08
10 INT81582 Plec Positive_regulation of st 1 1 0.02 0 1.07
11 INT81581 Plec Positive_regulation of Nudt14 1 1 0.01 0 1.07
12 INT153727 Sds Negative_regulation of RYBP Positive_regulation of Slc17a5 1 1 0.02 0.68 1.01
13 INT53103 Igh-Dex Negative_regulation of Cia1 1 1 0.10 1.23 0.98
14 INT153729 RYBP Positive_regulation of Slc17a5 1 1 0.02 0.65 0.97
15 INT150995 Sfpq Positive_regulation of Gene_expression of Il4 1 1 0.06 0.71 0.74
16 INT150997 Sfpq Positive_regulation of Gene_expression of Il10 1 1 0.09 0.71 0.74
17 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 1 0.03 0.69 0.72
18 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 1 0.04 0.7 0.72
19 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 1 0.04 0.7 0.72
20 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 1 0.05 0.69 0.69
21 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 1 0.03 0.69 0.66
22 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 1 0.00 0.87 0.54
23 INT129911 Skiv2l Negative_regulation of Localization of IL1A 1 1 0.01 0.74 0.48
24 INT51341 Binding of Pomc and Clu 1 4 0.14 0 0.38
25 INT158355 Cacna1a Regulation of Alox5 1 1 0.01 0.7 0.37
26 INT93694 Binding of Hspa8 and Ptgs1 1 2 0.30 0.79 0.36
27 INT130678 CYP2C9 Regulation of Cyp1a2 1 1 0.06 0 0.26
28 INT130677 CYP2C9 Regulation of Binding of Ugt2b7 1 1 0.18 0 0.26
29 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 1 0.12 0 0.25
30 INT51345 Binding of Vtn and Pomc 1 2 0.03 0 0.2
31 INT51343 Binding of Pomc and Diablo 1 2 0.25 0 0.19
32 INT148835 asa Negative_regulation of Tyr 1 1 0.33 0.58 0.18
33 INT93693 Positive_regulation of Binding of Hspa8 and Ptgs1 1 1 0.31 0.38 0.17
34 INT148836 asa Negative_regulation of Gene_expression of Tyr 1 1 0.43 0.52 0.16
35 INT87110 Apom Negative_regulation of Pde1a 1 1 0.00 0 0.15
36 INT96955 Glul Positive_regulation of Positive_regulation of Ugcg 1 1 0.07 0.14 0.14
37 INT89763 Positive_regulation of APEX1 Positive_regulation of Positive_regulation of NR4A1 1 1 0.10 0.87 0.14
38 INT51346 Binding of Vtn and Diablo 1 1 0.02 0 0.1
39 INT51342 Binding of Pomc and Vtn 1 1 0.23 0 0.1
40 INT51344 Binding of Clu and Vtn 1 1 0.06 0 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 1 3083 0.78 894.43 1639.02
2 INT796 Gene_expression of Penk 2 1902 0.78 275.47 1057.59
3 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
5 INT50058 Negative_regulation of Cpox 2 907 0.58 426.28 428.29
6 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
7 INT76660 Gene_expression of Trpv1 2 691 0.78 329.46 386.42
8 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
9 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
10 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
11 INT63932 Positive_regulation of Ephb1 3 537 0.70 259.67 296.14
12 INT1352 Localization of Acot1 8 728 0.80 73.01 296.01
13 INT9158 Gene_expression of Tnf 7 722 0.78 522.01 277.68
14 INT2365 Positive_regulation of Cck 1 354 0.70 87.8 277.41
15 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
16 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
17 INT16868 Gene_expression of Il6 3 807 0.78 499.48 256.57
18 INT3948 Regulation of Cck 1 291 0.62 58.07 255.88
19 INT1902 Gene_expression of Cck 2 348 0.78 70.33 241.92
20 INT1212 Binding of Oprl1 2 312 0.48 28.6 225.15
21 INT4893 Gene_expression of Tacr1 1 366 0.78 129.67 213.92
22 INT22548 Positive_regulation of Casp3 1 483 0.70 258.78 213.07
23 INT48955 Gene_expression of Nos2 12 753 0.78 403.87 208.08
24 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
25 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
26 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
27 INT6488 Gene_expression of Tnf 6 484 0.78 339.61 191.58
28 INT63934 Phosphorylation of Ephb1 1 377 0.82 150.52 188.66
29 INT49441 Negative_regulation of Cpox 2 494 0.59 303.22 177.46
30 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
31 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
32 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
33 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
34 INT66280 Gene_expression of Nos2 1 534 0.78 330.78 157.07
35 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
36 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
37 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
38 INT60694 Gene_expression of Il10 1 567 0.78 369.48 143.69
39 INT48895 Gene_expression of Il10 1 333 0.78 221.2 138.52
40 INT60126 Regulation of Trpv1 1 186 0.62 85.53 133.4
41 INT48953 Positive_regulation of Nos2 10 486 0.70 239.85 131.87
42 INT49439 Gene_expression of Cpox 1 508 0.73 326.97 130.17
43 INT64161 Positive_regulation of Prkca 4 213 0.70 85.06 129.91
44 INT8243 Positive_regulation of Il6 1 451 0.70 358.24 119.28
45 INT50674 Gene_expression of PTGS2 3 459 0.78 253.33 118.51
46 INT4207 Regulation of Avp 1 267 0.62 63.72 115.33
47 INT27096 Positive_regulation of Nfkb1 3 325 0.70 195.11 109.06
48 INT10272 Gene_expression of Il1b 2 194 0.78 121.02 103.03
49 INT1898 Regulation of Crh 1 220 0.62 61.33 102.64
50 INT293 Protein_catabolism of Penk 5 161 1.00 11.71 98.45
51 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
52 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
53 INT9516 Negative_regulation of Gabrg1 1 149 0.53 27.83 91.02
54 INT10166 Localization of Tnf 1 237 0.81 153.95 88.64
55 INT1472 Positive_regulation of Ins1 2 349 0.69 146.2 86.36
56 INT22967 Positive_regulation of RYBP 14 94 0.56 37.04 85.92
57 INT3766 Positive_regulation of Localization of Acot1 7 192 0.69 21.8 85.35
58 INT56291 Gene_expression of Ros1 1 503 0.63 274.12 81.5
59 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
60 INT64636 Positive_regulation of Gene_expression of Nos2 4 242 0.70 147.52 79.53
61 INT2431 Positive_regulation of Mpo 1 275 0.70 211.99 78.47
62 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
63 INT1353 Negative_regulation of Localization of Acot1 1 153 0.53 15.05 75.17
64 INT48244 Gene_expression of Il4 1 172 0.76 132.38 73.42
65 INT63936 Positive_regulation of Phosphorylation of Ephb1 1 131 0.70 49.38 73.16
66 INT39565 Gene_expression of Ptger2 2 424 0.75 229.28 72.68
67 INT58400 Negative_regulation of Tnf 2 182 0.59 129.97 71
68 INT15913 Negative_regulation of CYP2D6 2 174 0.59 22.45 70.91
69 INT49995 Positive_regulation of Gene_expression of Tnf 2 187 0.70 125.07 70.54
70 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
71 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
72 INT19511 Localization of Il6 2 212 0.81 118.17 67.67
73 INT15613 Negative_regulation of Ptgs2 1 160 0.59 71.08 65.08
74 INT3950 Gene_expression of Ptger2 2 293 0.77 122.28 62.42
75 INT48934 Positive_regulation of Mapk1 3 157 0.70 60.61 61.72
76 INT39153 Positive_regulation of PTGS2 2 182 0.70 96.16 60.6
77 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
78 INT66779 Binding of Pnoc 18 79 0.48 6.43 60.46
79 INT17564 Gene_expression of Gpt 2 322 0.75 208.51 60.36
80 INT55344 Gene_expression of Ros1 1 396 0.54 217.64 59.98
81 INT65078 Negative_regulation of Pnoc 2 64 0.59 15.48 59.81
82 INT13938 Positive_regulation of Nkx1-1 1 64 0.68 30.83 58.75
83 INT18883 Negative_regulation of RYBP 2 53 0.56 21.14 57.52
84 INT48891 Positive_regulation of Il10 1 143 0.70 101.42 56.72
85 INT1463 Binding of Pomc 4 129 0.48 15.89 56.27
86 INT1200 Negative_regulation of Ins1 2 274 0.58 155.17 56.14
87 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
88 INT69876 Negative_regulation of Nfkb1 1 147 0.58 89.81 55.5
89 INT52800 Negative_regulation of Gene_expression of Tnf 3 142 0.59 92.27 55.47
90 INT84495 Positive_regulation of Positive_regulation of Ephb1 1 85 0.70 46.12 54.11
91 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
92 INT49993 Positive_regulation of Gene_expression of Il6 1 149 0.70 88.07 53.78
93 INT48952 Negative_regulation of Nos2 4 204 0.59 101.73 53.15
94 INT52611 Negative_regulation of Ptgs2 4 142 0.59 66.31 52.71
95 INT49017 Negative_regulation of Gene_expression of Nos2 5 169 0.59 80.64 52.67
96 INT53083 Gene_expression of Ptgs2 6 153 0.78 90.04 50.39
97 INT12471 Regulation of Insrr 1 52 0.35 17.8 48.31
98 INT66029 Negative_regulation of Tnf 1 100 0.59 84.28 48.16
99 INT26500 Gene_expression of MMP2 2 201 0.78 110.57 46.9
100 INT55670 Negative_regulation of Gene_expression of Tnf 6 83 0.59 57.16 46.33
101 INT4656 Localization of RYBP 1 49 0.77 5.28 46.21
102 INT2275 Negative_regulation of Localization of Ins1 1 183 0.59 51.02 44.94
103 INT5307 Regulation of Tnf 1 87 0.62 78.71 43.4
104 INT60695 Positive_regulation of Gene_expression of Il10 1 154 0.70 120.28 43.07
105 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
106 INT11180 Binding of RYBP 1 52 0.46 13.86 42.53
107 INT48929 Regulation of Ephb1 1 71 0.62 24.42 42.11
108 INT48075 Positive_regulation of Il1b 1 71 0.67 48.63 40.48
109 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
110 INT11560 Positive_regulation of CASP3 5 236 0.70 184.33 39.38
111 INT2531 Positive_regulation of Cebpz 1 166 0.00 43.08 38.86
112 INT3188 Regulation of Localization of Acot1 1 84 0.59 8.94 38.56
113 INT55135 Positive_regulation of Gene_expression of PTGS2 2 137 0.70 80.32 38.46
114 INT18774 Gene_expression of RYBP 4 67 0.65 47.66 37.59
115 INT56870 Gene_expression of CYP2D6 2 87 0.78 8.83 37.53
116 INT60710 Gene_expression of Col7a1 1 217 0.78 113.2 35.2
117 INT12161 Positive_regulation of P2rx2 1 70 0.69 34.22 34.4
118 INT8905 Gene_expression of EDN1 6 215 0.78 157.1 34.19
119 INT109434 Phosphorylation of Mapk1 1 110 0.82 61.64 34.05
120 INT7133 Negative_regulation of MME 1 85 0.59 29.22 33.1
121 INT9658 Negative_regulation of Gene_expression of Il6 1 110 0.59 66.29 32.58
122 INT9655 Regulation of Il6 2 98 0.62 70.92 31.95
123 INT92837 Negative_regulation of Gene_expression of Nos2 1 116 0.59 59.67 31.82
124 INT86780 Positive_regulation of Hmox1 1 145 0.70 117.09 31.18
125 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
126 INT56290 Negative_regulation of Gene_expression of Il6 1 79 0.59 47.98 31.07
127 INT65960 Gene_expression of BCL2 7 352 0.78 312.03 30.73
128 INT1158 Regulation of Agt 1 106 0.61 29.4 30.29
129 INT52690 Positive_regulation of Ptgs2 1 65 0.68 39.51 30.02
130 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
131 INT651 Positive_regulation of PTGS1 2 93 0.69 37.27 29.18
132 INT87212 Negative_regulation of Positive_regulation of Nfkb1 1 74 0.57 38.21 28.31
133 INT133876 Positive_regulation of Gene_expression of Ros1 1 141 0.32 75.55 27.45
134 INT8881 Regulation of Gene_expression of Tacr1 1 38 0.61 17.49 27.19
135 INT12681 Regulation of Trib3 1 76 0.53 23.92 26.58
136 INT5650 Gene_expression of Mpo 1 117 0.77 80.27 26.42
137 INT50490 Regulation of PTGS2 1 80 0.48 39.51 25.85
138 INT61953 Transcription of Nos2 3 101 0.72 46.64 25.49
139 INT47075 Positive_regulation of Ptger2 1 142 0.70 78.55 25.47
140 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
141 INT2140 Regulation of REN 1 104 0.62 28.24 24.49
142 INT6726 Positive_regulation of Edn1 2 118 0.70 65.96 24.07
143 INT70503 Regulation of Gene_expression of Nos2 4 71 0.62 44 24.01
144 INT9155 Gene_expression of Glul 1 60 0.77 17.97 23.95
145 INT66758 Binding of Nfkb1 5 97 0.48 50.65 23.65
146 INT50039 Positive_regulation of Il4 1 48 0.55 34.8 23.34
147 INT18884 Regulation of RYBP 1 25 0.38 11.43 23.2
148 INT71875 Localization of Nfkb1 1 92 0.78 48.13 22.94
149 INT49196 Gene_expression of SELE 1 105 0.78 107.29 22.92
150 INT7678 Localization of Alb 1 142 0.81 80.93 22.49
151 INT66753 Negative_regulation of Positive_regulation of Tnf 1 45 0.59 35.28 22.33
152 INT35711 Positive_regulation of Sdcbp 1 110 0.60 50.45 22.11
153 INT5905 Negative_regulation of ELANE 3 113 0.59 47.43 22.09
154 INT73593 Gene_expression of BAX 2 173 0.76 147.81 20.94
155 INT52529 Regulation of Nfkb1 1 48 0.61 26.2 20.89
156 INT51474 Binding of Il6 1 55 0.48 44.99 20.52
157 INT8662 Positive_regulation of EDN1 3 144 0.70 125.34 19.59
158 INT66751 Negative_regulation of Localization of Tnf 1 48 0.59 26 19.36
159 INT9230 Gene_expression of Htr3a 1 43 0.78 10.54 18.81
160 INT105197 Negative_regulation of GTS 1 14 0.37 3.88 17.14
161 INT3206 Positive_regulation of Got1 2 39 0.69 19.36 17.02
162 INT65211 Binding of Prkcg 4 38 0.48 14.75 16.92
163 INT108780 Positive_regulation of Gene_expression of Ptger2 1 94 0.49 59.71 16.22
164 INT108588 Gene_expression of CASP3 1 126 0.78 84.49 16.2
165 INT14152 Gene_expression of Slc17a5 2 46 0.61 20.01 15.9
166 INT10323 Gene_expression of Fam166a 1 48 0.00 11.76 15.68
167 INT83682 Positive_regulation of Abcb1a 1 22 0.68 3.3 15.6
168 INT128401 Positive_regulation of Positive_regulation of Mapk1 2 39 0.70 10.88 15.38
169 INT615 Regulation of Alb 1 66 0.62 33.43 15.33
170 INT6278 Negative_regulation of Gene_expression of Pomc 1 35 0.59 11.07 14.8
171 INT9191 Localization of EDN1 9 94 0.81 57.01 14.78
172 INT52696 Positive_regulation of Ptgs2 3 48 0.70 27.65 14.44
173 INT8904 Positive_regulation of Gene_expression of EDN1 3 66 0.70 65.4 14.42
174 INT17035 Positive_regulation of TFPI 1 55 0.61 34.88 14.18
175 INT35120 Gene_expression of Sdcbp 1 68 0.67 21.33 13.96
176 INT25076 Negative_regulation of Gene_expression of Il1 1 41 0.52 30.58 13.85
177 INT67855 Negative_regulation of PPIG 1 64 0.57 17.83 13.54
178 INT60764 Positive_regulation of PPIG 4 39 0.67 17.08 13.48
179 INT71879 Negative_regulation of Localization of Nfkb1 1 30 0.57 21.8 13.48
180 INT3174 Negative_regulation of Ptger2 1 43 0.38 20.95 13.43
181 INT53747 Positive_regulation of Cyp2e1 1 34 0.70 29.03 13.39
182 INT12369 Negative_regulation of Htr3a 1 28 0.59 8.78 12.62
183 INT21979 Negative_regulation of EDN1 1 52 0.58 24.65 12.55
184 INT30101 Regulation of Cacna1a 2 25 0.45 14.38 12.43
185 INT59080 Negative_regulation of Gene_expression of PTGS2 2 55 0.58 22.92 12.39
186 INT50580 Binding of PPIG 1 39 0.36 11.17 12.34
187 INT3969 Positive_regulation of Sds 1 27 0.69 7.52 12.31
188 INT4460 Regulation of Mpo 2 44 0.62 31.16 12.11
189 INT48335 Negative_regulation of NOSTRIN 1 38 0.56 16.22 12.05
190 INT49509 Negative_regulation of Ptger2 1 53 0.42 24.87 11.66
191 INT97381 Negative_regulation of Positive_regulation of Nos2 1 34 0.59 16.66 11.6
192 INT11894 Negative_regulation of Gene_expression of Ptger2 1 47 0.55 16.95 11.59
193 INT83611 Negative_regulation of Gene_expression of Cpox 1 55 0.29 31.09 11.5
194 INT53082 Positive_regulation of Gene_expression of Ptgs2 6 47 0.64 25.39 11.39
195 INT49396 Negative_regulation of Positive_regulation of Il6 1 29 0.59 16.39 11.31
196 INT9945 Negative_regulation of Csf2 1 35 0.51 17.85 11.22
197 INT48956 Negative_regulation of Positive_regulation of Nos2 2 34 0.46 13.15 11.15
198 INT1934 Positive_regulation of Cys1 5 68 0.68 60.56 10.47
199 INT94004 Negative_regulation of Lox 3 31 0.59 13.76 10.45
200 INT25613 Gene_expression of Il1f5 1 32 0.77 13.29 10.44
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