J:Biol. Pharm. Bull.

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT66535	Binding of Pnoc and Oprl1	43	2	0.54	5.93	32.4
2	INT69823	Binding of GHR and RYBP	1	3	0.01	0	3.23
3	INT153728	RYBP Positive_regulation of Gpt	3	1	0.03	2.01	2.36
4	INT146930	CAP1 Regulation of ABCB1	1	2	0.29	0.3	2.19
5	INT129212	RYBP Positive_regulation of Tnf	2	1	0.03	1.9	1.95
6	INT62065	Binding of YY1 and Penk	3	1	0.14	0	1.69
7	INT69824	Negative_regulation of Binding of GHR and RYBP	1	1	0.01	0	1.14
8	INT81583	Cyp3a23/3a1 Positive_regulation of st	1	1	0.04	0	1.08
9	INT81580	Cyp3a23/3a1 Positive_regulation of Nudt14	1	1	0.01	0	1.08
10	INT81582	Plec Positive_regulation of st	1	1	0.02	0	1.07
11	INT81581	Plec Positive_regulation of Nudt14	1	1	0.01	0	1.07
12	INT153727	Sds Negative_regulation of RYBP Positive_regulation of Slc17a5	1	1	0.02	0.68	1.01
13	INT53103	Igh-Dex Negative_regulation of Cia1	1	1	0.10	1.23	0.98
14	INT153729	RYBP Positive_regulation of Slc17a5	1	1	0.02	0.65	0.97
15	INT150995	Sfpq Positive_regulation of Gene_expression of Il4	1	1	0.06	0.71	0.74
16	INT150997	Sfpq Positive_regulation of Gene_expression of Il10	1	1	0.09	0.71	0.74
17	INT150992	Sfpq Negative_regulation of Gene_expression of Tnf	1	1	0.03	0.69	0.72
18	INT150993	Sfpq Positive_regulation of Gene_expression of Il1b	1	1	0.04	0.7	0.72
19	INT150996	Sfpq Positive_regulation of Gene_expression of Il6	1	1	0.04	0.7	0.72
20	INT150998	Sfpq Negative_regulation of Gene_expression of Il6	1	1	0.05	0.69	0.69
21	INT150994	Sfpq Negative_regulation of Gene_expression of Il1b	1	1	0.03	0.69	0.66
22	INT129912	Skiv2l Negative_regulation of Gene_expression of PTGS2	1	1	0.00	0.87	0.54
23	INT129911	Skiv2l Negative_regulation of Localization of IL1A	1	1	0.01	0.74	0.48
24	INT51341	Binding of Pomc and Clu	1	4	0.14	0	0.38
25	INT158355	Cacna1a Regulation of Alox5	1	1	0.01	0.7	0.37
26	INT93694	Binding of Hspa8 and Ptgs1	1	2	0.30	0.79	0.36
27	INT130678	CYP2C9 Regulation of Cyp1a2	1	1	0.06	0	0.26
28	INT130677	CYP2C9 Regulation of Binding of Ugt2b7	1	1	0.18	0	0.26
29	INT130663	Cyp1a2 Regulation of Binding of Ugt2b7	1	1	0.12	0	0.25
30	INT51345	Binding of Vtn and Pomc	1	2	0.03	0	0.2
31	INT51343	Binding of Pomc and Diablo	1	2	0.25	0	0.19
32	INT148835	asa Negative_regulation of Tyr	1	1	0.33	0.58	0.18
33	INT93693	Positive_regulation of Binding of Hspa8 and Ptgs1	1	1	0.31	0.38	0.17
34	INT148836	asa Negative_regulation of Gene_expression of Tyr	1	1	0.43	0.52	0.16
35	INT87110	Apom Negative_regulation of Pde1a	1	1	0.00	0	0.15
36	INT96955	Glul Positive_regulation of Positive_regulation of Ugcg	1	1	0.07	0.14	0.14
37	INT89763	Positive_regulation of APEX1 Positive_regulation of Positive_regulation of NR4A1	1	1	0.10	0.87	0.14
38	INT51346	Binding of Vtn and Diablo	1	1	0.02	0	0.1
39	INT51342	Binding of Pomc and Vtn	1	1	0.23	0	0.1
40	INT51344	Binding of Clu and Vtn	1	1	0.06	0	0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT5200	Gene_expression of Fos	1	3083	0.78	894.43	1639.02
2	INT796	Gene_expression of Penk	2	1902	0.78	275.47	1057.59
3	INT728	Positive_regulation of Penk	1	1068	0.70	186.9	636.87
4	INT797	Regulation of Penk	2	812	0.62	111.13	542.24
5	INT50058	Negative_regulation of Cpox	2	907	0.58	426.28	428.29
6	INT1395	Negative_regulation of Penk	1	537	0.59	87.33	389.81
7	INT76660	Gene_expression of Trpv1	2	691	0.78	329.46	386.42
8	INT720	Positive_regulation of POMC	2	807	0.70	237.37	353.83
9	INT5660	Binding of Oprd1	1	477	0.48	71.86	342.06
10	INT4941	Positive_regulation of Oprd1	1	345	0.70	74.26	304.41
11	INT63932	Positive_regulation of Ephb1	3	537	0.70	259.67	296.14
12	INT1352	Localization of Acot1	8	728	0.80	73.01	296.01
13	INT9158	Gene_expression of Tnf	7	722	0.78	522.01	277.68
14	INT2365	Positive_regulation of Cck	1	354	0.70	87.8	277.41
15	INT1396	Binding of Penk	1	355	0.48	22.79	269.65
16	INT9659	Gene_expression of Il6	1	991	0.78	715.11	265.57
17	INT16868	Gene_expression of Il6	3	807	0.78	499.48	256.57
18	INT3948	Regulation of Cck	1	291	0.62	58.07	255.88
19	INT1902	Gene_expression of Cck	2	348	0.78	70.33	241.92
20	INT1212	Binding of Oprl1	2	312	0.48	28.6	225.15
21	INT4893	Gene_expression of Tacr1	1	366	0.78	129.67	213.92
22	INT22548	Positive_regulation of Casp3	1	483	0.70	258.78	213.07
23	INT48955	Gene_expression of Nos2	12	753	0.78	403.87	208.08
24	INT2651	Positive_regulation of Pomc	1	403	0.70	95.72	206.24
25	INT2391	Negative_regulation of PTGS1	2	501	0.59	207.62	205.6
26	INT11313	Positive_regulation of Il6	1	526	0.70	331.27	201.59
27	INT6488	Gene_expression of Tnf	6	484	0.78	339.61	191.58
28	INT63934	Phosphorylation of Ephb1	1	377	0.82	150.52	188.66
29	INT49441	Negative_regulation of Cpox	2	494	0.59	303.22	177.46
30	INT19472	Gene_expression of Il1	1	554	0.76	419.75	175.35
31	INT438	Gene_expression of Crh	1	376	0.78	159.11	169.17
32	INT739	Negative_regulation of POMC	1	358	0.59	102.28	166.77
33	INT1114	Localization of Ins1	1	748	0.80	192.95	165.48
34	INT66280	Gene_expression of Nos2	1	534	0.78	330.78	157.07
35	INT2640	Gene_expression of Pomc	1	424	0.78	120.72	155.37
36	INT13353	Positive_regulation of Tnf	1	332	0.70	248.75	148.1
37	INT1033	Positive_regulation of Ca2	1	507	0.68	131.76	147.64
38	INT60694	Gene_expression of Il10	1	567	0.78	369.48	143.69
39	INT48895	Gene_expression of Il10	1	333	0.78	221.2	138.52
40	INT60126	Regulation of Trpv1	1	186	0.62	85.53	133.4
41	INT48953	Positive_regulation of Nos2	10	486	0.70	239.85	131.87
42	INT49439	Gene_expression of Cpox	1	508	0.73	326.97	130.17
43	INT64161	Positive_regulation of Prkca	4	213	0.70	85.06	129.91
44	INT8243	Positive_regulation of Il6	1	451	0.70	358.24	119.28
45	INT50674	Gene_expression of PTGS2	3	459	0.78	253.33	118.51
46	INT4207	Regulation of Avp	1	267	0.62	63.72	115.33
47	INT27096	Positive_regulation of Nfkb1	3	325	0.70	195.11	109.06
48	INT10272	Gene_expression of Il1b	2	194	0.78	121.02	103.03
49	INT1898	Regulation of Crh	1	220	0.62	61.33	102.64
50	INT293	Protein_catabolism of Penk	5	161	1.00	11.71	98.45
51	INT940	Negative_regulation of Ptgs1	1	219	0.59	104.34	95.97
52	INT77435	Positive_regulation of Nos2	1	343	0.70	208.49	91.43
53	INT9516	Negative_regulation of Gabrg1	1	149	0.53	27.83	91.02
54	INT10166	Localization of Tnf	1	237	0.81	153.95	88.64
55	INT1472	Positive_regulation of Ins1	2	349	0.69	146.2	86.36
56	INT22967	Positive_regulation of RYBP	14	94	0.56	37.04	85.92
57	INT3766	Positive_regulation of Localization of Acot1	7	192	0.69	21.8	85.35
58	INT56291	Gene_expression of Ros1	1	503	0.63	274.12	81.5
59	INT55944	Positive_regulation of Cpox	1	214	0.57	105.14	81.4
60	INT64636	Positive_regulation of Gene_expression of Nos2	4	242	0.70	147.52	79.53
61	INT2431	Positive_regulation of Mpo	1	275	0.70	211.99	78.47
62	INT3657	Gene_expression of Ins1	1	514	0.78	321.69	75.76
63	INT1353	Negative_regulation of Localization of Acot1	1	153	0.53	15.05	75.17
64	INT48244	Gene_expression of Il4	1	172	0.76	132.38	73.42
65	INT63936	Positive_regulation of Phosphorylation of Ephb1	1	131	0.70	49.38	73.16
66	INT39565	Gene_expression of Ptger2	2	424	0.75	229.28	72.68
67	INT58400	Negative_regulation of Tnf	2	182	0.59	129.97	71
68	INT15913	Negative_regulation of CYP2D6	2	174	0.59	22.45	70.91
69	INT49995	Positive_regulation of Gene_expression of Tnf	2	187	0.70	125.07	70.54
70	INT1988	Positive_regulation of Localization of Ins1	1	254	0.69	59.25	68.37
71	INT6489	Positive_regulation of Gene_expression of Tnf	1	140	0.70	92.31	67.85
72	INT19511	Localization of Il6	2	212	0.81	118.17	67.67
73	INT15613	Negative_regulation of Ptgs2	1	160	0.59	71.08	65.08
74	INT3950	Gene_expression of Ptger2	2	293	0.77	122.28	62.42
75	INT48934	Positive_regulation of Mapk1	3	157	0.70	60.61	61.72
76	INT39153	Positive_regulation of PTGS2	2	182	0.70	96.16	60.6
77	INT9196	Gene_expression of PTGS1	1	215	0.77	96.99	60.5
78	INT66779	Binding of Pnoc	18	79	0.48	6.43	60.46
79	INT17564	Gene_expression of Gpt	2	322	0.75	208.51	60.36
80	INT55344	Gene_expression of Ros1	1	396	0.54	217.64	59.98
81	INT65078	Negative_regulation of Pnoc	2	64	0.59	15.48	59.81
82	INT13938	Positive_regulation of Nkx1-1	1	64	0.68	30.83	58.75
83	INT18883	Negative_regulation of RYBP	2	53	0.56	21.14	57.52
84	INT48891	Positive_regulation of Il10	1	143	0.70	101.42	56.72
85	INT1463	Binding of Pomc	4	129	0.48	15.89	56.27
86	INT1200	Negative_regulation of Ins1	2	274	0.58	155.17	56.14
87	INT52692	Gene_expression of Ptgs2	1	160	0.78	85.06	55.73
88	INT69876	Negative_regulation of Nfkb1	1	147	0.58	89.81	55.5
89	INT52800	Negative_regulation of Gene_expression of Tnf	3	142	0.59	92.27	55.47
90	INT84495	Positive_regulation of Positive_regulation of Ephb1	1	85	0.70	46.12	54.11
91	INT2276	Regulation of Ins1	1	234	0.61	103.78	54.05
92	INT49993	Positive_regulation of Gene_expression of Il6	1	149	0.70	88.07	53.78
93	INT48952	Negative_regulation of Nos2	4	204	0.59	101.73	53.15
94	INT52611	Negative_regulation of Ptgs2	4	142	0.59	66.31	52.71
95	INT49017	Negative_regulation of Gene_expression of Nos2	5	169	0.59	80.64	52.67
96	INT53083	Gene_expression of Ptgs2	6	153	0.78	90.04	50.39
97	INT12471	Regulation of Insrr	1	52	0.35	17.8	48.31
98	INT66029	Negative_regulation of Tnf	1	100	0.59	84.28	48.16
99	INT26500	Gene_expression of MMP2	2	201	0.78	110.57	46.9
100	INT55670	Negative_regulation of Gene_expression of Tnf	6	83	0.59	57.16	46.33
101	INT4656	Localization of RYBP	1	49	0.77	5.28	46.21
102	INT2275	Negative_regulation of Localization of Ins1	1	183	0.59	51.02	44.94
103	INT5307	Regulation of Tnf	1	87	0.62	78.71	43.4
104	INT60695	Positive_regulation of Gene_expression of Il10	1	154	0.70	120.28	43.07
105	INT85943	Negative_regulation of Nos2	1	161	0.59	108.56	42.65
106	INT11180	Binding of RYBP	1	52	0.46	13.86	42.53
107	INT48929	Regulation of Ephb1	1	71	0.62	24.42	42.11
108	INT48075	Positive_regulation of Il1b	1	71	0.67	48.63	40.48
109	INT2429	Negative_regulation of Mpo	1	128	0.59	93.76	39.57
110	INT11560	Positive_regulation of CASP3	5	236	0.70	184.33	39.38
111	INT2531	Positive_regulation of Cebpz	1	166	0.00	43.08	38.86
112	INT3188	Regulation of Localization of Acot1	1	84	0.59	8.94	38.56
113	INT55135	Positive_regulation of Gene_expression of PTGS2	2	137	0.70	80.32	38.46
114	INT18774	Gene_expression of RYBP	4	67	0.65	47.66	37.59
115	INT56870	Gene_expression of CYP2D6	2	87	0.78	8.83	37.53
116	INT60710	Gene_expression of Col7a1	1	217	0.78	113.2	35.2
117	INT12161	Positive_regulation of P2rx2	1	70	0.69	34.22	34.4
118	INT8905	Gene_expression of EDN1	6	215	0.78	157.1	34.19
119	INT109434	Phosphorylation of Mapk1	1	110	0.82	61.64	34.05
120	INT7133	Negative_regulation of MME	1	85	0.59	29.22	33.1
121	INT9658	Negative_regulation of Gene_expression of Il6	1	110	0.59	66.29	32.58
122	INT9655	Regulation of Il6	2	98	0.62	70.92	31.95
123	INT92837	Negative_regulation of Gene_expression of Nos2	1	116	0.59	59.67	31.82
124	INT86780	Positive_regulation of Hmox1	1	145	0.70	117.09	31.18
125	INT10797	Binding of CYP2D6	1	86	0.48	15.09	31.16
126	INT56290	Negative_regulation of Gene_expression of Il6	1	79	0.59	47.98	31.07
127	INT65960	Gene_expression of BCL2	7	352	0.78	312.03	30.73
128	INT1158	Regulation of Agt	1	106	0.61	29.4	30.29
129	INT52690	Positive_regulation of Ptgs2	1	65	0.68	39.51	30.02
130	INT724	Negative_regulation of Alb	1	151	0.59	93.57	29.65
131	INT651	Positive_regulation of PTGS1	2	93	0.69	37.27	29.18
132	INT87212	Negative_regulation of Positive_regulation of Nfkb1	1	74	0.57	38.21	28.31
133	INT133876	Positive_regulation of Gene_expression of Ros1	1	141	0.32	75.55	27.45
134	INT8881	Regulation of Gene_expression of Tacr1	1	38	0.61	17.49	27.19
135	INT12681	Regulation of Trib3	1	76	0.53	23.92	26.58
136	INT5650	Gene_expression of Mpo	1	117	0.77	80.27	26.42
137	INT50490	Regulation of PTGS2	1	80	0.48	39.51	25.85
138	INT61953	Transcription of Nos2	3	101	0.72	46.64	25.49
139	INT47075	Positive_regulation of Ptger2	1	142	0.70	78.55	25.47
140	INT9886	Gene_expression of Ptgs1	1	92	0.77	40.66	25.31
141	INT2140	Regulation of REN	1	104	0.62	28.24	24.49
142	INT6726	Positive_regulation of Edn1	2	118	0.70	65.96	24.07
143	INT70503	Regulation of Gene_expression of Nos2	4	71	0.62	44	24.01
144	INT9155	Gene_expression of Glul	1	60	0.77	17.97	23.95
145	INT66758	Binding of Nfkb1	5	97	0.48	50.65	23.65
146	INT50039	Positive_regulation of Il4	1	48	0.55	34.8	23.34
147	INT18884	Regulation of RYBP	1	25	0.38	11.43	23.2
148	INT71875	Localization of Nfkb1	1	92	0.78	48.13	22.94
149	INT49196	Gene_expression of SELE	1	105	0.78	107.29	22.92
150	INT7678	Localization of Alb	1	142	0.81	80.93	22.49
151	INT66753	Negative_regulation of Positive_regulation of Tnf	1	45	0.59	35.28	22.33
152	INT35711	Positive_regulation of Sdcbp	1	110	0.60	50.45	22.11
153	INT5905	Negative_regulation of ELANE	3	113	0.59	47.43	22.09
154	INT73593	Gene_expression of BAX	2	173	0.76	147.81	20.94
155	INT52529	Regulation of Nfkb1	1	48	0.61	26.2	20.89
156	INT51474	Binding of Il6	1	55	0.48	44.99	20.52
157	INT8662	Positive_regulation of EDN1	3	144	0.70	125.34	19.59
158	INT66751	Negative_regulation of Localization of Tnf	1	48	0.59	26	19.36
159	INT9230	Gene_expression of Htr3a	1	43	0.78	10.54	18.81
160	INT105197	Negative_regulation of GTS	1	14	0.37	3.88	17.14
161	INT3206	Positive_regulation of Got1	2	39	0.69	19.36	17.02
162	INT65211	Binding of Prkcg	4	38	0.48	14.75	16.92
163	INT108780	Positive_regulation of Gene_expression of Ptger2	1	94	0.49	59.71	16.22
164	INT108588	Gene_expression of CASP3	1	126	0.78	84.49	16.2
165	INT14152	Gene_expression of Slc17a5	2	46	0.61	20.01	15.9
166	INT10323	Gene_expression of Fam166a	1	48	0.00	11.76	15.68
167	INT83682	Positive_regulation of Abcb1a	1	22	0.68	3.3	15.6
168	INT128401	Positive_regulation of Positive_regulation of Mapk1	2	39	0.70	10.88	15.38
169	INT615	Regulation of Alb	1	66	0.62	33.43	15.33
170	INT6278	Negative_regulation of Gene_expression of Pomc	1	35	0.59	11.07	14.8
171	INT9191	Localization of EDN1	9	94	0.81	57.01	14.78
172	INT52696	Positive_regulation of Ptgs2	3	48	0.70	27.65	14.44
173	INT8904	Positive_regulation of Gene_expression of EDN1	3	66	0.70	65.4	14.42
174	INT17035	Positive_regulation of TFPI	1	55	0.61	34.88	14.18
175	INT35120	Gene_expression of Sdcbp	1	68	0.67	21.33	13.96
176	INT25076	Negative_regulation of Gene_expression of Il1	1	41	0.52	30.58	13.85
177	INT67855	Negative_regulation of PPIG	1	64	0.57	17.83	13.54
178	INT60764	Positive_regulation of PPIG	4	39	0.67	17.08	13.48
179	INT71879	Negative_regulation of Localization of Nfkb1	1	30	0.57	21.8	13.48
180	INT3174	Negative_regulation of Ptger2	1	43	0.38	20.95	13.43
181	INT53747	Positive_regulation of Cyp2e1	1	34	0.70	29.03	13.39
182	INT12369	Negative_regulation of Htr3a	1	28	0.59	8.78	12.62
183	INT21979	Negative_regulation of EDN1	1	52	0.58	24.65	12.55
184	INT30101	Regulation of Cacna1a	2	25	0.45	14.38	12.43
185	INT59080	Negative_regulation of Gene_expression of PTGS2	2	55	0.58	22.92	12.39
186	INT50580	Binding of PPIG	1	39	0.36	11.17	12.34
187	INT3969	Positive_regulation of Sds	1	27	0.69	7.52	12.31
188	INT4460	Regulation of Mpo	2	44	0.62	31.16	12.11
189	INT48335	Negative_regulation of NOSTRIN	1	38	0.56	16.22	12.05
190	INT49509	Negative_regulation of Ptger2	1	53	0.42	24.87	11.66
191	INT97381	Negative_regulation of Positive_regulation of Nos2	1	34	0.59	16.66	11.6
192	INT11894	Negative_regulation of Gene_expression of Ptger2	1	47	0.55	16.95	11.59
193	INT83611	Negative_regulation of Gene_expression of Cpox	1	55	0.29	31.09	11.5
194	INT53082	Positive_regulation of Gene_expression of Ptgs2	6	47	0.64	25.39	11.39
195	INT49396	Negative_regulation of Positive_regulation of Il6	1	29	0.59	16.39	11.31
196	INT9945	Negative_regulation of Csf2	1	35	0.51	17.85	11.22
197	INT48956	Negative_regulation of Positive_regulation of Nos2	2	34	0.46	13.15	11.15
198	INT1934	Positive_regulation of Cys1	5	68	0.68	60.56	10.47
199	INT94004	Negative_regulation of Lox	3	31	0.59	13.76	10.45
200	INT25613	Gene_expression of Il1f5	1	32	0.77	13.29	10.44