J:Biol. Psychiatry

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT31439 Penk Positive_regulation of Localization of Prl 8 1 0.55 0.23 6.24
2 INT10844 Ghrh Regulation of Gh 13 1 0.13 4.77 4.71
3 INT1390 Trh Positive_regulation of Prl 14 1 0.67 4.42 4.39
4 INT59203 ecs Positive_regulation of Negative_regulation of Ube2d3 1 2 0.00 1.93 1.15
5 INT30575 SST Negative_regulation of Localization of Pomc 1 1 0.00 0.71 1.06
6 INT17528 Prl Regulation of Gh 2 1 0.28 1.28 0.73
7 INT59201 ecs Positive_regulation of Ncam1 1 1 0.01 0.98 0.59
8 INT59202 ecs Positive_regulation of Ube2d3 1 1 0.00 0.98 0.59
9 INT36571 MDK Positive_regulation of Localization of PRL 1 1 0.04 0.19 0.29
10 INT25375 Trh Regulation of Gh 1 1 0.04 1.01 0.28
11 INT136605 Binding of OPRD1 and RAN 1 2 0.37 0.54 0.15
12 INT136606 Binding of RAN and DLL1 1 1 0.33 0.45 0.15
13 INT129864 Ddc Positive_regulation of Gene_expression of Fosb 1 1 0.02 0.13 0
14 INT145555 Ddc Positive_regulation of Phosphorylation of Mapk1 1 1 0.03 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 1 3083 0.78 894.43 1639.02
2 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 8 2431 0.81 378.96 952.2
4 INT292 Localization of Penk 1 876 0.81 88.44 669.14
5 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
6 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
7 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
8 INT6056 Negative_regulation of Gene_expression of Fos 1 601 0.59 193.05 386.84
9 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
10 INT439 Localization of Gnrh1 1 976 0.81 100.96 363.25
11 INT720 Positive_regulation of POMC 4 807 0.70 237.37 353.83
12 INT162 Regulation of Prl 5 794 0.62 165.01 322.24
13 INT161 Regulation of Localization of Prl 2 615 0.62 65.37 298.66
14 INT1893 Localization of Gh 4 1041 0.79 340.23 256.58
15 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
16 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
17 INT11009 Phosphorylation of Creb1 1 458 0.82 111.34 221.97
18 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
19 INT156 Negative_regulation of Prl 3 542 0.59 131.97 192.24
20 INT528 Gene_expression of Prl 3 693 0.78 217.18 192.2
21 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
22 INT4803 Transcription of Penk 1 435 0.72 59.09 182.4
23 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
24 INT739 Negative_regulation of POMC 2 358 0.59 102.28 166.77
25 INT3448 Positive_regulation of Gh 17 521 0.69 180.03 161.18
26 INT768 Positive_regulation of Oprl1 2 179 0.70 40.05 156.93
27 INT6042 Binding of Oprm1 1 248 0.48 31.77 154.34
28 INT2451 Positive_regulation of Avp 1 355 0.70 102.66 147.69
29 INT425 Localization of PRL 2 455 0.81 189.64 144.8
30 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
31 INT4658 Binding of OPRM1 1 188 0.48 25.96 136.24
32 INT11012 Positive_regulation of Creb1 1 258 0.70 84.4 132
33 INT695 Binding of POMC 1 304 0.48 56.66 126.85
34 INT252 Localization of GH1 1 529 0.80 227.4 122.05
35 INT92669 Gene_expression of Bdnf 2 309 0.78 178.26 116.68
36 INT1530 Regulation of Gh 14 382 0.61 115.96 112.47
37 INT49651 Gene_expression of Creb1 1 276 0.78 114.77 111.96
38 INT915 Positive_regulation of PRL 3 342 0.70 141.96 104.31
39 INT5906 Negative_regulation of Oprm1 1 125 0.59 19.58 101.57
40 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
41 INT5865 Positive_regulation of Localization of Gh 1 282 0.69 84.86 93.5
42 INT2122 Negative_regulation of Localization of Gnrh1 1 226 0.59 26.92 92.04
43 INT1281 Negative_regulation of Maoa 3 203 0.59 22.47 91.66
44 INT1639 Negative_regulation of OPRM1 1 107 0.59 13.86 90.37
45 INT5594 Regulation of Pdyn 1 137 0.62 27.04 86.63
46 INT92434 Phosphorylation of Mapk1 2 287 0.82 91.65 83.46
47 INT1498 Gene_expression of Gh 5 521 0.75 220.84 81.16
48 INT62374 Gene_expression of NGF 2 158 0.78 77.87 76.45
49 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
50 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
51 INT5852 Gene_expression of Penk 1 167 0.78 44.44 71.13
52 INT5843 Positive_regulation of Gfap 3 184 0.70 108.2 70.21
53 INT1377 Positive_regulation of Trh 3 172 0.70 40.55 69.83
54 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
55 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
56 INT6486 Positive_regulation of Tnf 1 168 0.70 123.47 66.05
57 INT253 Regulation of PRL 2 184 0.62 47.27 65.79
58 INT5095 Localization of Ghrh 1 185 0.81 28.09 62.08
59 INT48934 Positive_regulation of Mapk1 6 157 0.70 60.61 61.72
60 INT3161 Regulation of Localization of Gh 2 163 0.61 35.43 59.45
61 INT7340 Regulation of Grin1 1 87 0.62 30.37 57.93
62 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
63 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
64 INT117713 Phosphorylation of Akt1 1 275 0.82 95.82 54.34
65 INT5118 Regulation of SST 6 97 0.62 34.35 51.74
66 INT7287 Positive_regulation of Transcription of Penk 1 103 0.70 19.81 50.37
67 INT1232 Positive_regulation of Pdpk1 1 78 0.42 24.33 50.17
68 INT2323 Gene_expression of Trh 1 146 0.78 29.92 49.5
69 INT40777 Positive_regulation of Akt1 1 163 0.69 59.41 49.43
70 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
71 INT683 Positive_regulation of AVP 1 173 0.70 74.55 46.41
72 INT63383 Binding of Cnr1 1 77 0.48 22.28 44.61
73 INT98498 Binding of Trpv1 1 75 0.48 33.67 44.4
74 INT1894 Negative_regulation of Localization of Gh 1 168 0.58 64.12 43.56
75 INT9039 Negative_regulation of Htr1a 2 69 0.57 9.56 41.84
76 INT918 Positive_regulation of Localization of PRL 1 90 0.70 23.97 40.3
77 INT114751 Gene_expression of Mapk1 1 137 0.76 60.14 39.98
78 INT16455 Gene_expression of Drd2 1 116 0.78 22.71 38.47
79 INT1596 Negative_regulation of Oprl1 1 61 0.57 13.5 38.41
80 INT1976 Regulation of Gene_expression of Prl 2 80 0.62 20.19 36
81 INT2296 Positive_regulation of Gene_expression of Prl 1 137 0.70 36.96 35.39
82 INT692 Negative_regulation of SST 2 72 0.59 28.68 34.52
83 INT21527 Gene_expression of FosB 2 47 0.78 11.2 34.39
84 INT109434 Phosphorylation of Mapk1 5 110 0.82 61.64 34.05
85 INT7286 Regulation of Transcription of Penk 1 81 0.62 9.25 33.45
86 INT5868 Positive_regulation of GNRH1 2 122 0.69 20.96 32.8
87 INT89055 Phosphorylation of Prkaca 1 60 0.61 13.41 32.49
88 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
89 INT985 Negative_regulation of GH1 1 213 0.57 89.53 32.39
90 INT7787 Positive_regulation of Akr1d1 1 52 0.66 3.55 31.71
91 INT15347 Positive_regulation of Localization of Pomc 1 81 0.70 28.1 31.01
92 INT8531 Transcription of PDYN 1 56 0.72 19.51 30.99
93 INT7845 Regulation of OPRK1 1 44 0.62 4.54 30.49
94 INT11279 Positive_regulation of Penk 2 65 0.70 18.72 30.29
95 INT5100 Positive_regulation of Ghrh 1 100 0.64 24.2 30.21
96 INT28 Regulation of Gast 1 106 0.62 26.37 29.85
97 INT53384 Positive_regulation of fosB 2 41 0.69 8.43 28.91
98 INT9296 Negative_regulation of PLEK 1 100 0.57 36.65 27.52
99 INT14690 Localization of CSF2 1 124 0.80 85.17 27.26
100 INT6934 Binding of OPRD1 3 51 0.48 7.72 25.73
101 INT9781 Binding of INSRR 1 64 0.31 19.1 25.2
102 INT5851 Positive_regulation of Gene_expression of Penk 1 52 0.70 14.57 25.05
103 INT250 Regulation of GHRH 1 65 0.61 17.46 23.19
104 INT61160 Negative_regulation of Gene_expression of Creb1 1 37 0.59 17.95 23.17
105 INT6270 Binding of HTR1D 2 55 0.47 9.54 22.86
106 INT7715 Regulation of Drd2 1 35 0.62 10.79 22.3
107 INT48312 Gene_expression of NTRK1 1 72 0.78 38.21 22.24
108 INT16303 Negative_regulation of Localization of GH1 1 89 0.59 37.31 22.15
109 INT89805 Gene_expression of Prkaca 1 45 0.77 11.03 20.77
110 INT955 Gene_expression of GHRH 1 126 0.78 59.91 20.74
111 INT48144 Gene_expression of Fgf2 5 117 0.78 43 20.48
112 INT160 Regulation of Positive_regulation of Prl 1 37 0.62 7.56 20.09
113 INT9782 Binding of HTR1B 4 43 0.47 12.08 19.83
114 INT53574 Regulation of Tnf 2 45 0.62 40.68 19.71
115 INT7364 Regulation of Ghrh 1 49 0.58 8.05 19.05
116 INT13454 Positive_regulation of Positive_regulation of Gh 3 49 0.68 14.53 18.49
117 INT97984 Negative_regulation of SLC6A4 1 45 0.59 15.43 18.09
118 INT27670 Negative_regulation of Ace 1 122 0.57 79.21 18.08
119 INT871 Negative_regulation of Gene_expression of Prl 1 53 0.58 18.89 17.79
120 INT7644 Positive_regulation of Gene_expression of PDYN 1 27 0.69 10.19 17.47
121 INT10841 Positive_regulation of Gene_expression of Gh 1 101 0.59 45.39 16.96
122 INT7290 Negative_regulation of Transcription of Penk 1 33 0.59 7.28 16.5
123 INT84924 Positive_regulation of Gene_expression of NGF 2 29 0.68 17.91 16.46
124 INT49986 Transcription of Tnf 1 25 0.72 18.3 16.22
125 INT4616 Regulation of Maoa 1 40 0.62 6.09 15.94
126 INT128401 Positive_regulation of Positive_regulation of Mapk1 2 39 0.70 10.88 15.38
127 INT61548 Positive_regulation of Fgf2 2 72 0.70 32.18 14.49
128 INT22301 Positive_regulation of Gene_expression of CSF2 1 66 0.63 59.49 14.24
129 INT22272 Negative_regulation of HTR2A 1 28 0.57 7.62 13.87
130 INT1491 Regulation of Rtcd1 1 33 0.53 5.17 13.4
131 INT30961 Binding of HTR2A 1 33 0.47 11.44 12.86
132 INT27507 Positive_regulation of Dio1 1 23 0.44 3.43 12.11
133 INT66606 Gene_expression of CXCR1 1 34 0.75 27.79 11.36
134 INT73959 Positive_regulation of NOSTRIN 1 49 0.61 31.1 11.27
135 INT11673 Positive_regulation of ECT 2 43 0.59 13.93 11.25
136 INT6748 Regulation of Dio1 1 15 0.45 2.63 11.18
137 INT14132 Negative_regulation of HTR1A 1 25 0.57 4.93 10.91
138 INT53201 Negative_regulation of gr 1 35 0.50 17.76 10.62
139 INT59357 Gene_expression of Fosb 7 36 0.78 7.81 9.68
140 INT18121 Binding of Maoa 1 20 0.48 2.4 9.3
141 INT109432 Negative_regulation of Phosphorylation of Mapk1 1 19 0.54 7.01 8.98
142 INT860 Regulation of ALB 1 48 0.60 25.11 8.95
143 INT18258 Negative_regulation of Thop1 1 20 0.56 1.6 8.61
144 INT10969 Positive_regulation of PLEK 2 33 0.67 16.96 8.35
145 INT126848 Positive_regulation of Phosphorylation of Mapk1 1 30 0.50 15.94 8.34
146 INT12975 Regulation of PLEK 1 21 0.60 13.62 8.28
147 INT1150 Gene_expression of ecs 1 42 0.59 29.38 7.73
148 INT25 Positive_regulation of LAMC2 1 19 0.67 8.64 7.06
149 INT71824 Phosphorylation of Pdpk1 1 14 0.38 4.9 6.86
150 INT21138 Binding of ADRA2A 3 16 0.48 5.57 6.8
151 INT59351 Positive_regulation of Gene_expression of Fosb 3 20 0.70 3.53 6.74
152 INT29368 Binding of ECT 1 25 0.41 11.65 5.81
153 INT131944 Gene_expression of Mki67 1 30 0.53 6.58 5.63
154 INT52814 Negative_regulation of Nr3c1 1 9 0.57 5.69 5.41
155 INT92054 Positive_regulation of Transcription of Tnf 1 8 0.50 4.93 5.05
156 INT67182 Gene_expression of Tms 1 10 0.53 5.14 4.29
157 INT5015 Regulation of Gene_expression of Trh 1 9 0.62 6.47 4.25
158 INT56027 Positive_regulation of Ncam1 1 12 0.69 4.96 4.1
159 INT68099 Positive_regulation of Agtr2 1 21 0.48 16.63 4.07
160 INT40036 Binding of DLL1 1 10 0.36 2.88 3.95
161 INT120742 Negative_regulation of Gene_expression of Prkaca 1 6 0.24 3.76 3.86
162 INT32124 Negative_regulation of ecs 1 10 0.37 6.53 3.81
163 INT95556 Negative_regulation of Binding of Cnr1 1 5 0.58 3.1 3.67
164 INT41428 Binding of Vom2r2 1 4 0.32 1.26 3.35
165 INT22949 Gene_expression of CCBE1 1 8 0.19 4.27 3.25
166 INT1360 Negative_regulation of Regulation of Gnrhr 1 5 0.43 0.77 2.86
167 INT83073 Negative_regulation of Tyrp1 5 10 0.23 4.4 2.65
168 INT64688 Negative_regulation of Gene_expression of Fgf2 1 5 0.59 5.07 2.56
169 INT79880 Gene_expression of Aanat 4 5 0.77 7.72 2.33
170 INT125674 Negative_regulation of Positive_regulation of FosB 2 3 0.57 0.84 2.21
171 INT64687 Regulation of Gene_expression of Fgf2 1 7 0.62 2.29 1.89
172 INT56028 Regulation of Ncam1 2 6 0.38 3.6 1.78
173 INT30573 Regulation of Regulation of SST 1 2 0.18 1.55 1.69
174 INT32858 Localization of ECT 1 9 0.66 2.86 1.6
175 INT6438 Positive_regulation of RAN 1 6 0.42 2.09 1.59
176 INT70963 Binding of Adra1d 1 4 0.07 0 1.46
177 INT118927 Positive_regulation of Phosphorylation of Pdpk1 1 2 0.04 0.76 1.38
178 INT29416 Positive_regulation of Binding of OPRD1 1 2 0.47 0.52 1.31
179 INT3013 Binding of trm 1 3 0.47 1.32 1.27
180 INT59866 Regulation of Aanat 2 4 0.37 0.97 1.26
181 INT59200 Negative_regulation of Ube2d3 2 3 0.13 2.37 1.23
182 INT56230 Regulation of RT1-EC2 1 3 0.13 0.7 1.16
183 INT79881 Positive_regulation of Aanat 2 4 0.69 2.32 1.01
184 INT29788 Gene_expression of DNASE1L1 1 3 0.03 0.61 0.99
185 INT120741 Phosphorylation of Pik3r2 1 4 0.20 0.9 0.9
186 INT44757 Gene_expression of PRCP 1 3 0.53 1.39 0.82
187 INT70065 Regulation of MAFD1 2 1 0.00 1.23 0.79
188 INT88204 Positive_regulation of Gene_expression of PRCP 2 1 0.07 0.36 0.62
189 INT79878 Localization of Asmt 1 2 0.06 0.09 0.61
190 INT60752 Gene_expression of ZFP91 1 6 0.58 2.55 0.53
191 INT79879 Regulation of Gene_expression of Aanat 2 1 0.27 0 0.47
192 INT102999 Binding of DCAF7 1 1 0.05 0.69 0.41
193 INT21932 Negative_regulation of NMS 1 2 0.37 1.96 0.4
194 INT69708 Negative_regulation of PMMoV 1 2 0.41 0.24 0.39
195 INT130584 Positive_regulation of Binding of Trpv1 1 2 0.64 0.18 0.36
196 INT88203 Negative_regulation of Gene_expression of PRCP 1 1 0.07 0.18 0.31
197 INT130583 Regulation of Binding of Cnr1 1 2 0.41 0.17 0.26
198 INT129863 Phosphorylation of Fosb 2 3 0.81 0.54 0.25
199 INT27669 Negative_regulation of Ace2 1 2 0.42 0.68 0.22
200 INT3012 Positive_regulation of trm 1 2 0.49 0.98 0.2
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