J:Biomark Insights

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT255260 Binding of Cd47 and Tsp1 1 3 0.20 1.42 0.67
2 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 1 0.02 2.42 0.51
3 INT277063 CRP Positive_regulation of Gene_expression of MMP10 1 2 0.39 1.53 0.48
4 INT277065 CRP Positive_regulation of Gene_expression of MMP1 1 2 0.41 1.52 0.47
5 INT22674 Binding of SERPINE1 and PLAT 7 1 0.04 0.65 0.45
6 INT277064 CRP Positive_regulation of Gene_expression of TIMP1 1 2 0.15 1.47 0.45
7 INT277011 CRP Positive_regulation of Gene_expression of F3 1 1 0.06 1.03 0.32
8 INT271350 MPO Positive_regulation of TIMP1 1 1 0.05 1.66 0.29
9 INT245091 CCL1 Negative_regulation of Localization of VIM 1 1 0.02 1.08 0.25
10 INT245092 TNF Negative_regulation of Localization of VIM 1 1 0.03 1.1 0.25
11 INT277066 MMP1 Positive_regulation of Gene_expression of TIMP1 1 1 0.16 0.76 0.24
12 INT255261 Tsp1 Positive_regulation of Binding of Cd47 1 1 0.27 0.5 0.23
13 INT89612 Binding of FABP3 and MB 3 1 0.34 1.49 0.22
14 INT277072 Binding of PLA2G7 and Lipg 1 1 0.00 1.32 0.21
15 INT255257 Binding of Serpine1 and Tsp1 1 2 0.07 0.85 0.2
16 INT255259 Binding of Plg and Tsp1 1 2 0.05 0.84 0.2
17 INT252330 Binding of Cd36 and Cd47 2 1 0.10 0.72 0.19
18 INT277112 Binding of AMD1 and CFH 1 3 0.16 2.45 0.18
19 INT277013 PLAT Positive_regulation of Gene_expression of F13A1 1 1 0.02 0.31 0.17
20 INT232005 Binding of Cd36 and Tsp1 2 2 0.25 1.81 0.16
21 INT255258 Binding of Rb1 and Tsp1 1 2 0.38 0.95 0.15
22 INT277012 Binding of PAPPA and ACE2 1 1 0.02 1.26 0.15
23 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 1 0.02 1.17 0.13
24 INT271343 Binding of CRP and PAPPA 1 1 0.20 0.86 0.1
25 INT271349 ACCS Positive_regulation of PAPPA 1 1 0.06 0.87 0.09
26 INT271347 Negative_regulation of Binding of TNNT2 and ACCS 1 1 0.01 0.67 0.08
27 INT255255 Binding of Nsg1 and Tsp1 1 1 0.08 0.48 0.08
28 INT271354 MPO Regulation of Gene_expression of CRP 1 1 0.16 1.74 0.08
29 INT255256 Positive_regulation of Binding of Rb1 and Tsp1 1 1 0.50 0.48 0.08
30 INT271346 Binding of TNNT2 and ACCS 1 1 0.01 0.67 0.08
31 INT271351 MPO Positive_regulation of CRP 1 1 0.07 1.69 0.08
32 INT277010 Binding of PAPPA and TNNT1 1 1 0.24 0.99 0.07
33 INT277053 Protein_catabolism of TIMP1 Positive_regulation of COL5A2 1 1 0.01 0.14 0.07
34 INT277016 Binding of MB and PAPPA 1 1 0.10 1 0.07
35 INT271355 PGF Positive_regulation of PIGF 1 1 0.01 0.99 0.06
36 INT106823 Binding of MBP and PAPPA 2 5 0.17 3.89 0.05
37 INT247439 Binding of APOA1 and HSD11B1 3 1 0.32 5.01 0.03
38 INT271328 FABP3 Positive_regulation of Binding of FABP3 and MB 1 1 0.00 0.81 0.03
39 INT217776 TP53 Regulation of MITF 1 1 0.00 1.28 0
40 INT217779 POLR2B Regulation of Gene_expression of RASGRP1 1 1 0.01 0.2 0
41 INT217788 MIR181A1 Regulation of EIF5A 1 1 0.23 0.69 0
42 INT217782 MIR181A1 Regulation of TNS3 1 1 0.14 0.7 0
43 INT217785 POLR2B Regulation of Gene_expression of MAP3K3 1 1 0.06 0.2 0
44 INT217778 MAP3K3 Regulation of Gene_expression of RASGRP1 1 1 0.09 0.19 0
45 INT271348 Binding of CHKB and MB 1 2 0.01 1.01 0
46 INT217786 TSC1 Regulation of MITF 1 1 0.00 1.27 0
47 INT217781 Binding of MITF and TP53 1 1 0.00 1.2 0
48 INT217780 MIR181A1 Regulation of GATA6 1 1 0.17 0.7 0
49 INT217773 MIR208A Regulation of Gene_expression of RASGRP1 1 1 0.06 0.2 0
50 INT277047 Binding of APOB and LDLR 1 1 0.25 0.82 0
51 INT217777 EIF4E Regulation of Gene_expression of MAP3K3 1 1 0.05 0.19 0
52 INT277136 Ebp Positive_regulation of Gene_expression of Mlh1 1 1 0.01 1.45 0
53 INT217771 MIR181A1 Regulation of E2F5 1 1 0.19 0.7 0
54 INT217784 Binding of MITF and TSC1 1 1 0.00 1.21 0
55 INT217787 Binding of TP53 and MIR208A 1 1 0.21 0.5 0
56 INT277045 APOB Positive_regulation of Binding of APOB and LDLR 1 1 0.38 0.82 0
57 INT217790 EIF4E Regulation of Gene_expression of RASGRP1 1 1 0.01 0.19 0
58 INT217770 MIR181A1 Regulation of PPP3CB 1 1 0.00 0.7 0
59 INT217774 TP53 Regulation of TSC1 1 1 0.02 1.28 0
60 INT217783 MIR208A Regulation of Gene_expression of MAP3K3 1 1 0.26 0.2 0
61 INT217791 TP53 Positive_regulation of TSC1 1 1 0.04 0.61 0
62 INT217775 CCNL1 Regulation of Gene_expression of RASGRP1 1 1 0.04 0.25 0
63 INT217789 CCNL1 Regulation of Gene_expression of MAP3K3 1 1 0.19 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT50058 Negative_regulation of Cpox 2 907 0.58 426.28 428.29
2 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
3 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
4 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
5 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
6 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
7 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
8 INT68684 Gene_expression of VEGFA 4 2371 0.78 1742.52 259.2
9 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
10 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
11 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
12 INT51921 Gene_expression of Cpox 3 501 0.73 229.81 157.81
13 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
14 INT17612 Gene_expression of CRP 5 676 0.78 580.61 119.03
15 INT17612 Gene_expression of CRP 16 676 0.78 580.61 119.03
16 INT170025 Gene_expression of Fig4 1 588 0.67 183.27 113.32
17 INT11051 Positive_regulation of Gene_expression of IL6 2 415 0.69 319.21 109.3
18 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
19 INT69440 Gene_expression of ROS1 1 752 0.78 477.64 103.83
20 INT18009 Positive_regulation of CRP 7 518 0.70 553.03 103.74
21 INT18009 Positive_regulation of CRP 12 518 0.70 553.03 103.74
22 INT1760 Gene_expression of PTGER2 2 524 0.57 226.94 96.4
23 INT11587 Gene_expression of CSF2 3 645 0.78 544.38 93.89
24 INT48408 Gene_expression of ICAM1 2 494 0.78 340.08 88.6
25 INT5617 Localization of Nppa 1 266 0.81 83.51 83.89
26 INT68682 Positive_regulation of VEGFA 3 640 0.70 454.14 81.65
27 INT62374 Gene_expression of NGF 3 158 0.78 77.87 76.45
28 INT60691 Gene_expression of Il12a 1 331 0.78 208.03 75.96
29 INT5374 Gene_expression of Esr1 1 412 0.77 263.89 67.34
30 INT6486 Positive_regulation of Tnf 1 168 0.70 123.47 66.05
31 INT4960 Positive_regulation of CSF2 1 285 0.70 256.73 65.73
32 INT15514 Negative_regulation of Crp 1 275 0.59 194.6 64.86
33 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
34 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
35 INT546 Binding of ALB 1 311 0.48 85.98 60.14
36 INT1759 Gene_expression of TIMP1 2 267 0.77 133.87 59.29
37 INT1759 Gene_expression of TIMP1 3 267 0.77 133.87 59.29
38 INT169926 Positive_regulation of Gopc 1 416 0.46 157.8 58.67
39 INT6477 Gene_expression of IL1RN 1 213 0.77 114.69 58.62
40 INT73048 Gene_expression of MMP9 6 268 0.77 159.75 57.81
41 INT73048 Gene_expression of MMP9 1 268 0.77 159.75 57.81
42 INT48232 Gene_expression of MMP1 1 245 0.78 96.31 57.72
43 INT48232 Gene_expression of MMP1 3 245 0.78 96.31 57.72
44 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
45 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
46 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
47 INT375 Positive_regulation of REN 3 293 0.70 152.46 47.55
48 INT26500 Gene_expression of MMP2 7 201 0.78 110.57 46.9
49 INT26500 Gene_expression of MMP2 1 201 0.78 110.57 46.9
50 INT71786 Phosphorylation of MAPK1 1 256 0.82 110.09 46.17
51 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
52 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
53 INT4216 Gene_expression of CD40LG 3 328 0.78 256.02 44.23
54 INT52732 Negative_regulation of CRP 6 169 0.59 138.47 40.33
55 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
56 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
57 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
58 INT9094 Gene_expression of COL7A1 1 277 0.77 143.42 38.73
59 INT12892 Negative_regulation of TIMP1 2 136 0.58 83.13 36.54
60 INT5620 Positive_regulation of Localization of Nppa 1 105 0.70 30.23 36.45
61 INT62827 Positive_regulation of ICAM1 3 184 0.70 180.95 36.28
62 INT101992 Localization of VEGFA 1 413 0.81 258.23 36.15
63 INT8905 Gene_expression of EDN1 1 215 0.78 157.1 34.19
64 INT666 Gene_expression of Jun 1 124 0.78 54.61 33.67
65 INT99610 Localization of MMP9 1 126 0.79 48.46 32.67
66 INT65960 Gene_expression of BCL2 3 352 0.78 312.03 30.73
67 INT23435 Positive_regulation of NGF 2 54 0.70 32.41 30.11
68 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
69 INT9650 Gene_expression of LPA 1 141 0.75 104.57 29
70 INT28361 Gene_expression of TP53 6 443 0.78 384.86 28.8
71 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
72 INT55737 Positive_regulation of MMP2 1 101 0.68 59.11 27.71
73 INT55737 Positive_regulation of MMP2 2 101 0.68 59.11 27.71
74 INT12129 Gene_expression of CYP3A4 5 107 0.78 23.11 27.6
75 INT129956 Gene_expression of MMP13 1 145 0.72 60.48 26.98
76 INT2609 Localization of ELANE 1 111 0.81 50.22 26.63
77 INT100861 Binding of CRP 5 179 0.48 175.2 26.45
78 INT100861 Binding of CRP 1 179 0.48 175.2 26.45
79 INT73047 Positive_regulation of MMP9 5 133 0.68 73.22 26.42
80 INT73047 Positive_regulation of MMP9 3 133 0.68 73.22 26.42
81 INT69036 Gene_expression of IL18 2 99 0.77 77.92 25.95
82 INT130176 Positive_regulation of Gene_expression of CRP 4 125 0.66 137.06 25.9
83 INT130176 Positive_regulation of Gene_expression of CRP 2 125 0.66 137.06 25.9
84 INT11159 Gene_expression of EGFR 7 698 0.78 548.93 25.69
85 INT12124 Gene_expression of MAPK1 1 141 0.75 82.4 25.58
86 INT5622 Gene_expression of Nppa 4 101 0.78 49.46 25.31
87 INT49196 Gene_expression of SELE 1 105 0.78 107.29 22.92
88 INT3330 Gene_expression of AGT 3 149 0.76 98.65 22.73
89 INT91891 Gene_expression of Kit 1 268 0.78 158.89 22.67
90 INT11659 Gene_expression of COL2A1 1 164 0.78 78.49 22.58
91 INT48312 Gene_expression of NTRK1 4 72 0.78 38.21 22.24
92 INT3299 Positive_regulation of AGT 2 126 0.68 79.45 21.91
93 INT23257 Regulation of CRP 5 127 0.62 100.05 21.87
94 INT73593 Gene_expression of BAX 5 173 0.76 147.81 20.94
95 INT171820 Localization of Fig4 1 144 0.65 27.38 20.88
96 INT63340 Positive_regulation of Gene_expression of ICAM1 1 109 0.70 90.82 20.61
97 INT51055 Positive_regulation of TIMP1 2 103 0.69 50.07 19.86
98 INT93663 Positive_regulation of MMP1 4 72 0.67 33.38 19.86
99 INT8662 Positive_regulation of EDN1 1 144 0.70 125.34 19.59
100 INT86187 Positive_regulation of AKT1 1 199 0.69 122.13 19.44
101 INT9552 Positive_regulation of TNNI3 5 209 0.70 128.67 19.15
102 INT18010 Positive_regulation of CD40LG 1 122 0.70 100.8 18.46
103 INT18010 Positive_regulation of CD40LG 3 122 0.70 100.8 18.46
104 INT55335 Binding of Cpox 1 49 0.34 15.48 18.46
105 INT56749 Gene_expression of PCNA 2 219 0.77 111.25 18.42
106 INT28215 Gene_expression of CDKN1A 1 196 0.76 113.9 18.3
107 INT61519 Gene_expression of Mpo 2 112 0.78 89.29 18.22
108 INT20631 Positive_regulation of CHKB 6 166 0.69 109.86 17.92
109 INT4067 Negative_regulation of Esr1 1 97 0.50 43.45 17.52
110 INT17237 Regulation of Esr1 1 74 0.43 49.09 17.25
111 INT1721 Negative_regulation of HP 2 148 0.42 86.82 16.89
112 INT93948 Negative_regulation of Gene_expression of Il12a 1 48 0.55 27.77 16.87
113 INT13510 Gene_expression of ERBB2 1 530 0.78 405.68 16.79
114 INT65856 Positive_regulation of TP53 1 138 0.67 112.65 16.71
115 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
116 INT10834 Binding of IL8 1 65 0.48 41.66 16.53
117 INT99898 Gene_expression of Mmp14 1 37 0.56 28.54 16.39
118 INT10214 Gene_expression of VIM 18 153 0.78 115.88 16.29
119 INT899 Gene_expression of F13A1 1 122 0.70 78.02 16.26
120 INT14152 Gene_expression of Slc17a5 1 46 0.61 20.01 15.9
121 INT102680 Protein_catabolism of COL7A1 3 49 0.69 34.68 15.78
122 INT103245 Positive_regulation of Gene_expression of MMP9 1 64 0.68 36.86 15.7
123 INT171666 Regulation of GOPC 1 117 0.39 40.41 15.47
124 INT116465 Gene_expression of Birc5 8 241 0.78 192.31 15.32
125 INT111488 Gene_expression of HAS1 1 56 0.77 32.6 15.29
126 INT106745 Localization of CRP 4 65 0.81 66.44 15.21
127 INT26501 Positive_regulation of Gene_expression of MMP2 1 51 0.67 39 15.16
128 INT74587 Gene_expression of MMP8 1 31 0.78 24.4 14.91
129 INT74587 Gene_expression of MMP8 3 31 0.78 24.4 14.91
130 INT11636 Positive_regulation of SERPINE1 1 85 0.69 68.73 14.8
131 INT5904 Localization of MPO 1 62 0.81 36.37 14.64
132 INT5904 Localization of MPO 1 62 0.81 36.37 14.64
133 INT92823 Positive_regulation of Gene_expression of MMP1 1 65 0.68 25.69 14.31
134 INT37722 Gene_expression of NCAM1 4 103 0.75 81.57 14.18
135 INT59870 Gene_expression of F3 1 51 0.65 51.83 14.01
136 INT59870 Gene_expression of F3 1 51 0.65 51.83 14.01
137 INT1758 Positive_regulation of Gene_expression of TIMP1 1 62 0.69 31.72 13.98
138 INT9649 Positive_regulation of LPA 3 105 0.69 74.75 13.89
139 INT18773 Localization of ALB 1 117 0.80 69.18 13.8
140 INT78472 Gene_expression of CDKN2A 2 223 0.78 173.76 13.61
141 INT24684 Localization of PLAT 4 30 0.78 26.21 13.56
142 INT19399 Gene_expression of Rf 2 43 0.36 33.39 13.53
143 INT86383 Negative_regulation of EGFR 1 258 0.59 173.94 13.32
144 INT2129 Positive_regulation of F2 2 83 0.70 58.95 12.63
145 INT158124 Gene_expression of COL5A2 8 136 0.69 72.3 12.44
146 INT9083 Gene_expression of Nppb 31 74 0.78 70.96 12.19
147 INT8548 Gene_expression of HP 1 86 0.77 47.62 11.94
148 INT16772 Gene_expression of MPO 3 81 0.78 90.98 11.9
149 INT16772 Gene_expression of MPO 8 81 0.78 90.98 11.9
150 INT9084 Positive_regulation of Nppb 23 74 0.70 69.77 11.85
151 INT4047 Binding of F13A1 2 105 0.43 66.54 11.81
152 INT93715 Negative_regulation of MMP9 2 69 0.55 36.05 11.73
153 INT24816 Binding of CD40LG 1 68 0.47 45.48 11.56
154 INT19795 Positive_regulation of EGFR 1 161 0.70 103.69 11.55
155 INT65713 Localization of ICAM1 1 42 0.81 39.55 11.49
156 INT661 Gene_expression of REN 4 100 0.78 48.21 11.36
157 INT94438 Gene_expression of OLR1 1 86 0.78 80.38 11.03
158 INT94438 Gene_expression of OLR1 5 86 0.78 80.38 11.03
159 INT4498 Gene_expression of F2 1 83 0.65 57.4 10.8
160 INT9550 Gene_expression of TNNI3 5 113 0.78 86.79 10.56
161 INT89282 Regulation of MMP9 1 39 0.60 25.45 10.34
162 INT94784 Binding of ROS1 1 113 0.40 71.57 10.26
163 INT110110 Gene_expression of ACCS 2 85 0.58 75.88 10.2
164 INT110110 Gene_expression of ACCS 1 85 0.58 75.88 10.2
165 INT2378 Negative_regulation of SERPINE1 1 47 0.59 34.55 9.9
166 INT57424 Positive_regulation of TNNT1 2 42 0.67 31.84 9.7
167 INT87863 Positive_regulation of IL18 2 40 0.69 34.08 9.53
168 INT285 Positive_regulation of Salpa1 1 73 0.68 61.47 9.19
169 INT62829 Positive_regulation of VCAM1 1 39 0.70 38.42 9.15
170 INT80037 Gene_expression of BAK1 3 58 0.75 39.49 9.08
171 INT102698 Binding of ACCS 1 54 0.42 66.73 9.06
172 INT9548 Gene_expression of CHKB 3 99 0.65 50.86 9.03
173 INT173587 Protein_catabolism of COL5A2 1 59 0.32 32.73 8.96
174 INT173587 Protein_catabolism of COL5A2 11 59 0.32 32.73 8.96
175 INT69264 Gene_expression of KIT 1 207 0.78 179.41 8.95
176 INT22965 Positive_regulation of Pah 2 42 0.61 41.41 8.84
177 INT131788 Positive_regulation of NPPB 14 87 0.67 86.1 8.81
178 INT131788 Positive_regulation of NPPB 4 87 0.67 86.1 8.81
179 INT144430 Gene_expression of Erbb2 1 137 0.77 103.87 8.66
180 INT129962 Positive_regulation of Gene_expression of MMP13 1 41 0.65 20.74 8.54
181 INT66041 Positive_regulation of NTRK1 1 24 0.70 16.12 8.42
182 INT36798 Gene_expression of Mki67 3 178 0.77 132 8.24
183 INT56223 Positive_regulation of MPO 3 35 0.70 43 8.2
184 INT56223 Positive_regulation of MPO 3 35 0.70 43 8.2
185 INT92680 Gene_expression of Fgf2 3 59 0.77 28.11 8.12
186 INT22056 Positive_regulation of CYBB 1 88 0.68 32.13 7.95
187 INT53487 Gene_expression of TSC1 2 81 0.58 77.71 7.94
188 INT1925 Gene_expression of PLAT 2 47 0.75 34.76 7.88
189 INT173808 Positive_regulation of CYP27A1 1 35 0.68 23.7 7.87
190 INT111607 Gene_expression of CDH1 2 103 0.75 90.45 7.77
191 INT39406 Positive_regulation of OLR1 2 45 0.70 37.8 7.72
192 INT39406 Positive_regulation of OLR1 4 45 0.70 37.8 7.72
193 INT95133 Gene_expression of FASLG 1 38 0.75 44.09 7.51
194 INT57748 Positive_regulation of Gene_expression of TP53 1 85 0.69 79.55 7.49
195 INT103154 Gene_expression of FLT1 1 138 0.76 58.5 7.41
196 INT1124 Negative_regulation of CD40LG 1 53 0.57 36.26 7
197 INT16722 Negative_regulation of MPO 1 25 0.59 18.55 6.99
198 INT16722 Negative_regulation of MPO 2 25 0.59 18.55 6.99
199 INT63057 Regulation of CYP3A4 2 31 0.61 5.75 6.92
200 INT104979 Gene_expression of MITF 11 51 0.62 54.83 6.91
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