J:Brain Behav. Immun.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 1 0.26 1.99 2.36
2 INT20888 POMC Positive_regulation of Localization of PDYN 1 1 0.40 0 0.92
3 INT120147 Tlr4 Positive_regulation of Tnf 3 1 0.39 2.14 0.89
4 INT140922 Btnl2 Negative_regulation of EDA 1 1 0.00 0.88 0.8
5 INT140921 Btnl2 Negative_regulation of Cd4 1 1 0.01 0.88 0.8
6 INT140920 Btnl2 Negative_regulation of Itgam 1 1 0.02 0.88 0.79
7 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 1 0.18 0.91 0.66
8 INT120146 seb Positive_regulation of Gene_expression of Tnf 1 1 0.40 0.86 0.66
9 INT120145 seb Positive_regulation of Tnf 1 1 0.40 0.85 0.65
10 INT11558 POMC Positive_regulation of CASP3 1 1 0.05 0 0.62
11 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 1 0.18 0.76 0.55
12 INT32597 Pomc Regulation of Gene_expression of Il2 1 1 0.29 0 0.49
13 INT141016 Il18 Positive_regulation of Gene_expression of Ifng 1 1 0.39 0.27 0.39
14 INT20890 SLTM Regulation of Localization of IGKV1D-39 1 1 0.06 0 0.37
15 INT20889 PDYN Regulation of Localization of IGKV1D-39 1 1 0.15 0 0.37
16 INT26193 OPRD1 Positive_regulation of MET 1 1 0.47 0 0.33
17 INT94355 NOVA2 Positive_regulation of Dbi 1 2 0.00 0.15 0.18
18 INT94353 Crh Negative_regulation of Positive_regulation of Dbi 1 1 0.03 0.14 0.08
19 INT94354 Crh Negative_regulation of Dbi 1 1 0.03 0.14 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
2 INT292 Localization of Penk 4 876 0.81 88.44 669.14
3 INT2543 Positive_regulation of Calca 1 787 0.70 331.13 592.08
4 INT9238 Gene_expression of IL6 3 1575 0.78 1135.66 424.22
5 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
6 INT5660 Binding of Oprd1 3 477 0.48 71.86 342.06
7 INT5680 Gene_expression of Ngf 4 530 0.78 264.29 310.56
8 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
9 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
10 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
11 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
12 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
13 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
14 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
15 INT94952 Positive_regulation of Mapk14 1 305 0.70 197.83 186.61
16 INT1652 Regulation of Pomc 2 387 0.62 61.01 186.51
17 INT24326 Gene_expression of Ngf 6 346 0.78 218.67 184.71
18 INT10194 Positive_regulation of IL6 2 702 0.70 600.62 183.38
19 INT49441 Negative_regulation of Cpox 1 494 0.59 303.22 177.46
20 INT15516 Gene_expression of Crp 2 711 0.77 615.33 173.09
21 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
22 INT739 Negative_regulation of POMC 2 358 0.59 102.28 166.77
23 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
24 INT60694 Gene_expression of Il10 3 567 0.78 369.48 143.69
25 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
26 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
27 INT48953 Positive_regulation of Nos2 1 486 0.70 239.85 131.87
28 INT49439 Gene_expression of Cpox 4 508 0.73 326.97 130.17
29 INT695 Binding of POMC 1 304 0.48 56.66 126.85
30 INT2555 Positive_regulation of Localization of Penk 1 116 0.70 24.35 119.73
31 INT12501 Positive_regulation of Adarb1 1 166 0.58 36.94 118.92
32 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
33 INT20374 Gene_expression of Il4 2 515 0.76 306.15 114.12
34 INT114 Binding of Oprl1 1 139 0.48 23 103.35
35 INT10272 Gene_expression of Il1b 6 194 0.78 121.02 103.03
36 INT1898 Regulation of Crh 1 220 0.62 61.33 102.64
37 INT293 Protein_catabolism of Penk 5 161 1.00 11.71 98.45
38 INT10166 Localization of Tnf 2 237 0.81 153.95 88.64
39 INT54571 Positive_regulation of NFKB1 1 263 0.70 138.99 87.32
40 INT4798 Gene_expression of Nts 1 169 0.77 29.56 86.04
41 INT21793 Positive_regulation of Ngf 3 154 0.70 94.78 85.27
42 INT16254 Positive_regulation of Gene_expression of Ngf 2 144 0.70 80.61 82.08
43 INT64636 Positive_regulation of Gene_expression of Nos2 1 242 0.70 147.52 79.53
44 INT2431 Positive_regulation of Mpo 2 275 0.70 211.99 78.47
45 INT442 Localization of PDYN 1 99 0.81 11.87 72.75
46 INT39565 Gene_expression of Ptger2 1 424 0.75 229.28 72.68
47 INT6656 Gene_expression of YY1 1 135 0.75 24.73 72.16
48 INT10359 Gene_expression of Ifng 11 159 0.78 79.6 72.14
49 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
50 INT5843 Positive_regulation of Gfap 2 184 0.70 108.2 70.21
51 INT7534 Gene_expression of Ifng 5 193 0.78 111.02 68.6
52 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
53 INT11807 Gene_expression of Il2 2 266 0.78 112 64.97
54 INT8733 Localization of Oprm1 1 61 0.75 7.55 64.61
55 INT11937 Localization of Il6 2 228 0.81 139.83 64.39
56 INT67981 Positive_regulation of CCL2 1 165 0.70 136.84 61.85
57 INT1430 Regulation of PDYN 1 88 0.60 16.99 60.32
58 INT5819 Regulation of Localization of Penk 1 64 0.62 6.69 57.68
59 INT48891 Positive_regulation of Il10 2 143 0.70 101.42 56.72
60 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
61 INT63975 Positive_regulation of Il10 1 175 0.68 134.13 54.69
62 INT6073 Negative_regulation of Localization of Penk 1 63 0.59 8.67 53.95
63 INT27954 Positive_regulation of Gene_expression of Ngf 1 87 0.70 57.91 51.96
64 INT12345 Gene_expression of Il2 11 142 0.78 59.17 51.21
65 INT9210 Regulation of IL6 4 166 0.62 125.61 49.95
66 INT20345 Gene_expression of Dbi 1 136 0.78 56.41 46.2
67 INT2774 Binding of Crp 5 241 0.48 195.89 44.39
68 INT13354 Transcription of TNF 2 108 0.72 85.81 42.32
69 INT48075 Positive_regulation of Il1b 5 71 0.67 48.63 40.48
70 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
71 INT89661 Gene_expression of Hrec 2 102 0.21 69.91 39.57
72 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
73 INT107576 Gene_expression of Atf3 1 114 0.78 72.42 38.64
74 INT104551 Gene_expression of Il18 1 156 0.76 115.51 36.95
75 INT9239 Regulation of Gene_expression of IL6 2 106 0.61 75.24 36.53
76 INT20380 Gene_expression of Il5 1 172 0.78 104.75 34.78
77 INT67039 Positive_regulation of Cpox 8 144 0.65 98.4 33.77
78 INT11325 Gene_expression of HLA-E 1 209 0.76 98.05 33.72
79 INT77310 Gene_expression of Aif1 1 89 0.78 50.49 33.68
80 INT666 Gene_expression of Jun 1 124 0.78 54.61 33.67
81 INT5989 Positive_regulation of Dbi 3 79 0.49 24.38 32.56
82 INT22939 Gene_expression of Csf2 1 164 0.78 85.1 32.22
83 INT35406 Localization of Tnf 2 94 0.81 64.63 31.65
84 INT1079 Positive_regulation of Ache 2 104 0.70 23.52 30.28
85 INT90792 Localization of Il10 2 144 0.80 87.88 30.03
86 INT6660 Positive_regulation of Jun 1 148 0.69 67.58 29.73
87 INT10684 Negative_regulation of Protein_catabolism of Penk 1 41 0.59 2.33 28.63
88 INT6364 Gene_expression of Edn1 4 123 0.78 73.76 28.43
89 INT57692 Positive_regulation of Gene_expression of Il1b 1 50 0.67 43.54 28.29
90 INT5650 Gene_expression of Mpo 1 117 0.77 80.27 26.42
91 INT10273 Positive_regulation of Gene_expression of Il1b 2 47 0.68 31.15 26.21
92 INT20044 Negative_regulation of Gpi1 2 50 0.59 29.96 26
93 INT63769 Regulation of Ngf 1 44 0.62 21.82 25.84
94 INT13415 Positive_regulation of Hpse 2 58 0.70 24.9 25.53
95 INT56224 Negative_regulation of Gene_expression of Ifng 1 40 0.58 23.34 25.08
96 INT43486 Positive_regulation of Ifng 1 52 0.69 32.71 24.77
97 INT55583 Localization of IFNA1 1 135 0.78 85.07 24.13
98 INT6441 Positive_regulation of CRH 3 98 0.69 57.22 24.12
99 INT15390 Positive_regulation of Edn1 1 64 0.70 47.36 23.8
100 INT51029 Negative_regulation of Il1b 2 34 0.57 29.34 23.62
101 INT6866 Regulation of Gfap 2 51 0.61 19.6 23.56
102 INT66208 Positive_regulation of Positive_regulation of NFKB1 1 45 0.68 20.17 22.62
103 INT69993 Positive_regulation of Gene_expression of Cpox 3 93 0.55 69.4 22.05
104 INT8483 Positive_regulation of Positive_regulation of TNF 1 73 0.67 60.35 22.03
105 INT28728 Regulation of Cfp 1 49 0.46 13.15 21.43
106 INT30887 Negative_regulation of Ngf 2 56 0.59 32.96 20.86
107 INT20379 Localization of Il4 1 85 0.73 51.22 20.55
108 INT25222 Positive_regulation of Gene_expression of Ifng 1 32 0.50 24.18 19.58
109 INT74286 Regulation of Il10 2 42 0.44 28.06 19.44
110 INT3359 Regulation of YY1 1 32 0.60 8.19 19.2
111 INT70614 Gene_expression of FAS 1 118 0.75 112.33 19.01
112 INT19509 Localization of Ifng 1 55 0.78 28.25 18.67
113 INT12575 Regulation of Hpse 1 33 0.59 17.7 18.45
114 INT35086 Positive_regulation of Gene_expression of Ifng 1 40 0.69 22.55 18.35
115 INT66857 Regulation of CCL2 2 39 0.53 28.55 18.35
116 INT28642 Gene_expression of CXCR2 1 60 0.78 38.69 18.11
117 INT24209 Negative_regulation of Ifng 1 37 0.57 16.52 17.15
118 INT10169 Positive_regulation of Localization of Tnf 2 44 0.70 27.71 16.75
119 INT6480 Positive_regulation of IL1RN 1 59 0.69 33.7 16.66
120 INT19929 Negative_regulation of Positive_regulation of TNF 2 52 0.59 38.16 16.51
121 INT49986 Transcription of Tnf 1 25 0.72 18.3 16.22
122 INT20892 Localization of IGKV1D-39 5 21 0.48 2.54 15.82
123 INT10709 Negative_regulation of CD4 2 106 0.59 95.6 14.89
124 INT53080 Positive_regulation of Ptgs1 1 42 0.42 23.58 14.37
125 INT22098 Positive_regulation of Il2 1 27 0.69 14.77 14.1
126 INT15011 Positive_regulation of Gpi1 1 29 0.47 12.47 13.48
127 INT141014 Positive_regulation of Gene_expression of Il18 1 46 0.68 47.63 13.3
128 INT10016 Negative_regulation of CD8A 2 81 0.42 56.68 13.15
129 INT7532 Negative_regulation of Gene_expression of Ifng 2 33 0.59 18.56 13.14
130 INT20381 Localization of Il2 1 71 0.77 34.23 13.03
131 INT55255 Positive_regulation of Localization of Il6 1 48 0.69 24.88 12.76
132 INT52905 Gene_expression of Cd4 1 84 0.78 45.68 12.75
133 INT58226 Negative_regulation of Gene_expression of Il1b 2 24 0.57 18.09 12.68
134 INT32595 Positive_regulation of Gene_expression of Il2 3 30 0.70 6.55 12.56
135 INT51028 Regulation of Il1b 1 28 0.60 21.15 12.47
136 INT9160 Negative_regulation of Ifng 1 31 0.58 16.37 11.84
137 INT52625 Regulation of IL1RN 1 30 0.61 19.12 11.31
138 INT14334 Negative_regulation of Il2 2 31 0.58 18.63 11.08
139 INT11794 Gene_expression of Cd2 1 27 0.76 17.31 10.99
140 INT71766 Transcription of Il10 2 31 0.69 24.66 10.78
141 INT49129 Positive_regulation of GFAP 1 35 0.69 28.78 10.38
142 INT12344 Negative_regulation of Gene_expression of Il2 1 28 0.59 15.53 10.23
143 INT27955 Negative_regulation of Gene_expression of Ngf 1 16 0.59 10.43 10.17
144 INT10019 Binding of CD8A 1 57 0.36 31.49 10.08
145 INT10546 Positive_regulation of Prss12 1 12 0.44 4.57 10.05
146 INT75768 Transcription of Cpox 3 37 0.27 19.41 9.79
147 INT80110 Regulation of Positive_regulation of TNF 1 34 0.44 25.79 9.78
148 INT12563 Localization of Mpo 2 33 0.81 20.99 9.58
149 INT52924 Negative_regulation of GSR 1 49 0.58 28.08 9.28
150 INT5512 Negative_regulation of Dbi 3 32 0.36 7.33 9.1
151 INT17101 Positive_regulation of Gene_expression of Edn1 2 24 0.69 24.9 8.86
152 INT12095 Negative_regulation of Edn1 1 26 0.59 12.01 8.79
153 INT2225 Binding of Gfap 2 31 0.47 11.78 8.53
154 INT80034 Positive_regulation of Gene_expression of FAS 1 32 0.67 30.34 8.51
155 INT8160 Gene_expression of Prss12 2 20 0.67 4.83 8.17
156 INT61363 Positive_regulation of TFAM 1 43 0.69 26.43 8.14
157 INT32596 Regulation of Gene_expression of Il2 5 13 0.61 6.85 7.83
158 INT66926 Transcription of Il1b 2 15 0.69 13.16 7.81
159 INT52937 Gene_expression of Cd68 1 37 0.67 31.33 7.54
160 INT48626 Positive_regulation of Csf3 2 33 0.66 29.79 7.34
161 INT15012 Regulation of Gpi1 3 18 0.60 11.64 6.91
162 INT94356 Regulation of Slc12a2 1 11 0.58 12.8 6.59
163 INT6052 Gene_expression of Ptn 1 12 0.78 8.4 6.5
164 INT84716 Negative_regulation of Positive_regulation of Il1b 1 9 0.57 5.34 6.27
165 INT128587 Localization of Mapk14 1 15 0.81 8.41 6.1
166 INT104547 Negative_regulation of Il18 1 24 0.59 17.89 6.01
167 INT52819 Negative_regulation of NR3C1 1 14 0.50 7.22 5.84
168 INT55578 Regulation of Gene_expression of Il1b 2 7 0.62 4.74 5.55
169 INT111520 Regulation of Tnfrsf1a 1 10 0.61 7.25 5.41
170 INT85653 Regulation of Gene_expression of Cpox 1 24 0.24 20.55 5.22
171 INT65554 Positive_regulation of Hpse 1 13 0.69 8.16 5.17
172 INT103230 Gene_expression of Btnl2 2 17 0.75 8.55 4.77
173 INT62132 Regulation of Gene_expression of Ifng 6 12 0.62 1.28 4.77
174 INT53784 Positive_regulation of Regulation of Gfap 2 7 0.50 3.31 4.68
175 INT24820 Positive_regulation of Binding of POMC 1 9 0.67 2.98 4.6
176 INT19777 Binding of Crh 2 16 0.40 6.65 4.36
177 INT20372 Localization of Il5 1 26 0.41 18.33 4.27
178 INT56404 Gene_expression of EDA 1 16 0.75 7.09 4.24
179 INT91327 Positive_regulation of CCL4 1 12 0.67 8.55 4.1
180 INT141015 Regulation of Il18 2 14 0.59 6.3 3.73
181 INT47201 Gene_expression of RT1-EC2 1 7 0.38 3.15 3.49
182 INT63534 Binding of CRH 1 23 0.47 6.84 3.43
183 INT97438 Transcription of Il4 1 17 0.67 9.17 3.4
184 INT20893 Positive_regulation of Localization of IGKV1D-39 2 4 0.23 0.25 3.4
185 INT13321 Negative_regulation of Hpse 2 11 0.56 4.64 3.39
186 INT117476 Negative_regulation of Gene_expression of Mpo 1 10 0.43 8.25 3.33
187 INT66922 Positive_regulation of Transcription of Il1b 1 7 0.49 6.58 3.14
188 INT24926 Regulation of Csf3 2 17 0.52 10.41 3.04
189 INT47443 Gene_expression of seb 1 9 0.61 2.65 2.68
190 INT111145 Negative_regulation of Positive_regulation of Ifng 1 7 0.41 2.21 2.61
191 INT8654 Protein_catabolism of Nts 1 10 0.61 0.77 2.41
192 INT10558 Regulation of Regulation of IL6 1 6 0.45 4.94 2.33
193 INT105761 Binding of GFAP 2 13 0.36 14.94 2.32
194 INT45202 Regulation of Cys1 1 8 0.08 5.62 2.23
195 INT121036 Positive_regulation of Transcription of Cpox 3 12 0.21 6.34 2.04
196 INT76834 Negative_regulation of Gene_expression of Edn1 2 4 0.43 1.76 1.88
197 INT95650 Negative_regulation of Positive_regulation of Ngf 1 6 0.43 4.41 1.84
198 INT91326 Regulation of CCL4 1 4 0.44 2.86 1.69
199 INT69298 Negative_regulation of seb 1 4 0.36 2.78 1.69
200 INT70954 Negative_regulation of Cd3e 1 11 0.41 4.22 1.31
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