J:Can. J. Physiol. Pharmacol.

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT103330	Ngf Positive_regulation of Gdnf	2	1	0.28	1.27	2.45
2	INT103332	Ngf Regulation of Gene_expression of TRPV1	3	1	0.09	2.6	2.4
3	INT76508	Pnoc Regulation of Oprl1	1	1	0.47	0.25	1.32
4	INT40900	PDYN Regulation of Localization of POMC	2	1	0.07	0.56	1.22
5	INT22726	Positive_regulation of Ahr Positive_regulation of Hrtrt1	1	1	0.22	0.18	0.95
6	INT22725	Ahr Positive_regulation of Hrtrt1	1	1	0.22	0.18	0.95
7	INT31950	PIF1 Positive_regulation of Localization of Prl	1	1	0.06	0	0.87
8	INT103331	Ngf Positive_regulation of Gdnf	1	1	0.01	0.57	0.8
9	INT103334	Gdnf Regulation of Gene_expression of TRPV1	1	1	0.02	0.53	0.77
10	INT103333	Gdnf Regulation of TRPV1	1	1	0.02	0.53	0.77
11	INT103335	Ngf Regulation of TRPV1	1	1	0.05	0.53	0.77
12	INT31951	Negative_regulation of PIF1 Positive_regulation of Prl	1	1	0.07	0	0.68
13	INT47461	PDYN Regulation of POMC	1	1	0.01	0	0.6
14	INT31948	Spic Regulation of Localization of Prl	1	1	0.02	0	0.55
15	INT11651	Nlrp1a Negative_regulation of Gpt	1	1	0.12	0.24	0.47
16	INT58663	Binding of KNG1 and Ugt1a2	1	1	0.02	0.4	0.47
17	INT31952	Localization of PIF1 Regulation of Localization of Prl	1	1	0.04	0	0.46
18	INT31953	PIF1 Regulation of Localization of Prl	1	1	0.06	0	0.46
19	INT36340	Binding of NRP2 and Penk	1	1	0.04	0.07	0.39
20	INT43331	Binding of Oxt and Ptgfr	1	1	0.01	0.37	0.37
21	INT43332	Positive_regulation of Binding of Oxt and Ptgfr	1	1	0.02	0.37	0.37
22	INT148342	Hsd17b6 Negative_regulation of Oxt	1	1	0.21	0.37	0.31
23	INT151424	Tfrc Negative_regulation of Positive_regulation of Tnni3	1	2	0.21	0.98	0.2
24	INT3326	PRSS1 Positive_regulation of ATP6AP2	1	1	0.01	0	0.11
25	INT151423	Tfrc Positive_regulation of Gene_expression of Nos2	1	1	0.24	0.49	0.1
26	INT42532	Binding of Pomc and Klk1c2	1	1	0.21	0	0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT2542	Localization of Calca	21	2008	0.81	518.3	1408.65
2	INT796	Gene_expression of Penk	4	1902	0.78	275.47	1057.59
3	INT158	Localization of Prl	17	2431	0.81	378.96	952.2
4	INT1912	Gene_expression of Calca	14	1152	0.78	453.25	739.84
5	INT292	Localization of Penk	1	876	0.81	88.44	669.14
6	INT728	Positive_regulation of Penk	2	1068	0.70	186.9	636.87
7	INT2543	Positive_regulation of Calca	6	787	0.70	331.13	592.08
8	INT797	Regulation of Penk	1	812	0.62	111.13	542.24
9	INT5228	Positive_regulation of Fos	7	934	0.70	209.8	503.87
10	INT155	Positive_regulation of Prl	5	1233	0.70	317.93	457.82
11	INT443	Localization of POMC	2	1020	0.81	284.52	443.17
12	INT50058	Negative_regulation of Cpox	2	907	0.58	426.28	428.29
13	INT4758	Positive_regulation of Localization of Calca	5	557	0.70	138.55	411.04
14	INT5895	Gene_expression of Oprm1	2	525	0.78	120.67	407.29
15	INT64202	Positive_regulation of Trpv1	1	643	0.70	249.66	397.42
16	INT467	Gene_expression of POMC	3	1048	0.78	332.8	394.16
17	INT1395	Negative_regulation of Penk	2	537	0.59	87.33	389.81
18	INT2540	Negative_regulation of Calca	10	538	0.59	172.11	384.38
19	INT18357	Gene_expression of TRPV1	4	825	0.78	307.11	382.81
20	INT6580	Negative_regulation of Ptgs1	5	929	0.59	381.53	376.26
21	INT157	Positive_regulation of Localization of Prl	11	790	0.70	104.54	374.78
22	INT287	Localization of Cck	1	518	0.81	86.84	364.04
23	INT439	Localization of Gnrh1	7	976	0.81	100.96	363.25
24	INT5660	Binding of Oprd1	2	477	0.48	71.86	342.06
25	INT2649	Regulation of Calca	8	433	0.62	146.05	330.95
26	INT162	Regulation of Prl	2	794	0.62	165.01	322.24
27	INT5979	Gene_expression of Oprd1	2	428	0.78	75.64	320.32
28	INT5540	Positive_regulation of Oprm1	4	344	0.70	76.77	319.71
29	INT5680	Gene_expression of Ngf	1	530	0.78	264.29	310.56
30	INT4941	Positive_regulation of Oprd1	3	345	0.70	74.26	304.41
31	INT477	Localization of Avp	3	813	0.81	131.58	300.4
32	INT161	Regulation of Localization of Prl	2	615	0.62	65.37	298.66
33	INT1352	Localization of Acot1	10	728	0.80	73.01	296.01
34	INT886	Gene_expression of Pomc	8	676	0.78	129.87	295.98
35	INT3579	Localization of Oxt	3	555	0.81	43.35	292.44
36	INT2365	Positive_regulation of Cck	2	354	0.70	87.8	277.41
37	INT49750	Negative_regulation of CPOX	2	735	0.58	360.06	274.19
38	INT1396	Binding of Penk	3	355	0.48	22.79	269.65
39	INT3948	Regulation of Cck	4	291	0.62	58.07	255.88
40	INT1005	Localization of Sst	4	385	0.81	26.31	244.56
41	INT738	Regulation of POMC	1	459	0.62	111.19	243.74
42	INT1562	Localization of Crh	1	499	0.81	126.74	236.68
43	INT5597	Gene_expression of Pdyn	3	433	0.78	62.97	235.47
44	INT4759	Negative_regulation of Localization of Calca	1	294	0.59	82.62	226.45
45	INT1212	Binding of Oprl1	2	312	0.48	28.6	225.15
46	INT1308	Localization of Pomc	5	457	0.81	66.83	217.5
47	INT767	Localization of Gnrhr	4	565	0.80	106.68	214.57
48	INT22548	Positive_regulation of Casp3	3	483	0.70	258.78	213.07
49	INT48955	Gene_expression of Nos2	2	753	0.78	403.87	208.08
50	INT50670	Gene_expression of CPOX	2	763	0.76	442.13	195.02
51	INT156	Negative_regulation of Prl	1	542	0.59	131.97	192.24
52	INT1652	Regulation of Pomc	7	387	0.62	61.01	186.51
53	INT10194	Positive_regulation of IL6	2	702	0.70	600.62	183.38
54	INT943	Negative_regulation of Cck	1	205	0.59	38.42	174.78
55	INT26472	Regulation of Oprm1	1	191	0.62	35.84	173.1
56	INT5930	Positive_regulation of Oprm1	2	221	0.70	31.19	172.93
57	INT159	Negative_regulation of Localization of Prl	1	416	0.59	55.34	171.8
58	INT1114	Localization of Ins1	1	748	0.80	192.95	165.48
59	INT5513	Negative_regulation of Pomc	5	295	0.59	60.9	158.63
60	INT768	Positive_regulation of Oprl1	1	179	0.70	40.05	156.93
61	INT1303	Negative_regulation of Npr1	1	278	0.55	35.1	156.78
62	INT5050	Regulation of Localization of Calca	2	149	0.62	41.25	148.57
63	INT2451	Positive_regulation of Avp	3	355	0.70	102.66	147.69
64	INT1033	Positive_regulation of Ca2	4	507	0.68	131.76	147.64
65	INT9852	Positive_regulation of Gpt	2	563	0.70	364.64	146.82
66	INT1414	Regulation of Oprl1	1	169	0.62	32.05	139.99
67	INT2541	Binding of Calca	4	200	0.48	67.14	134.62
68	INT48953	Positive_regulation of Nos2	2	486	0.70	239.85	131.87
69	INT1614	Gene_expression of Oprl1	2	164	0.78	31.43	127.74
70	INT695	Binding of POMC	1	304	0.48	56.66	126.85
71	INT5931	Regulation of Oprm1	1	149	0.62	18.15	125.93
72	INT6822	Gene_expression of Pdyn	2	215	0.78	35.99	125.76
73	INT4259	Positive_regulation of Npr1	2	262	0.70	49.37	123.11
74	INT1438	Localization of Pomc	1	360	0.81	101.26	116.47
75	INT4207	Regulation of Avp	3	267	0.62	63.72	115.33
76	INT1793	Localization of CGA	1	379	0.81	67.38	114.69
77	INT7362	Gene_expression of Sst	1	185	0.78	41.73	111.37
78	INT5283	Positive_regulation of Npy	1	191	0.70	66.77	109.2
79	INT8413	Gene_expression of Ptgs1	2	248	0.78	110.17	108.58
80	INT9012	Localization of Vip	3	283	0.81	31.71	106.16
81	INT12082	Localization of IL6	1	365	0.81	241.78	105.78
82	INT4742	Gene_expression of Tac1	1	177	0.78	69.99	102.66
83	INT1898	Regulation of Crh	4	220	0.62	61.33	102.64
84	INT82878	Gene_expression of Ccl2	1	201	0.78	164.95	101.35
85	INT5940	Negative_regulation of Avp	2	236	0.59	67.86	101.2
86	INT940	Negative_regulation of Ptgs1	1	219	0.59	104.34	95.97
87	INT1004	Regulation of Sst	2	140	0.62	18.52	94.84
88	INT3537	Positive_regulation of Car2	4	413	0.56	103.51	94.35
89	INT203	Positive_regulation of Pomc	1	257	0.70	90.56	92.84
90	INT2122	Negative_regulation of Localization of Gnrh1	3	226	0.59	26.92	92.04
91	INT74376	Gene_expression of Cnr1	1	173	0.78	73.43	89.7
92	INT10166	Localization of Tnf	1	237	0.81	153.95	88.64
93	INT1635	Gene_expression of Vip	2	245	0.78	53.36	88.13
94	INT1472	Positive_regulation of Ins1	6	349	0.69	146.2	86.36
95	INT4798	Gene_expression of Nts	2	169	0.77	29.56	86.04
96	INT3766	Positive_regulation of Localization of Acot1	1	192	0.69	21.8	85.35
97	INT5780	Regulation of Gene_expression of Calca	4	90	0.62	59.52	85.03
98	INT2520	Negative_regulation of Ca2	4	271	0.57	72.13	83.71
99	INT6107	Localization of Npy	4	180	0.81	26.76	81.67
100	INT1309	Positive_regulation of Localization of Gnrhr	2	152	0.69	24.25	81.56
101	INT148	Positive_regulation of Gnrhr	2	182	0.70	47.44	79.64
102	INT2431	Positive_regulation of Mpo	1	275	0.70	211.99	78.47
103	INT12476	Negative_regulation of TRPV1	1	124	0.59	47.95	77.98
104	INT4358	Positive_regulation of Localization of Avp	1	195	0.70	30.79	77.58
105	INT9382	Regulation of TRPV1	1	149	0.62	53.99	77.46
106	INT3657	Gene_expression of Ins1	7	514	0.78	321.69	75.76
107	INT16654	Gene_expression of Insrr	1	138	0.46	58.96	75.68
108	INT1353	Negative_regulation of Localization of Acot1	1	153	0.53	15.05	75.17
109	INT7028	Localization of Pdyn	1	90	0.81	8.89	73.54
110	INT7886	Regulation of Localization of Avp	1	146	0.62	14.53	72.99
111	INT442	Localization of PDYN	1	99	0.81	11.87	72.75
112	INT2055	Regulation of Gnrh1	1	185	0.62	23.65	71.26
113	INT5993	Positive_regulation of Nts	3	122	0.70	26.82	70.45
114	INT2123	Positive_regulation of Gnrh1	1	209	0.70	24.2	68.97
115	INT7344	Gene_expression of TAC1	2	132	0.75	35.48	68.26
116	INT7134	Localization of KNG1	1	127	0.79	65.73	67.97
117	INT19511	Localization of Il6	1	212	0.81	118.17	67.67
118	INT7468	Negative_regulation of Localization of Oxt	1	109	0.59	9.46	66.79
119	INT8347	Gene_expression of SST	1	181	0.78	104.59	65.45
120	INT1425	Gene_expression of Rbm39	1	143	0.58	51.32	65.44
121	INT217	Negative_regulation of Th	1	134	0.59	26.83	62.63
122	INT46	Localization of Ren	5	233	0.81	46.15	62.44
123	INT10706	Regulation of Il6	1	150	0.62	93.23	62.34
124	INT8363	Localization of Nts	1	135	0.81	14.29	61.71
125	INT7884	Regulation of Localization of Oxt	1	102	0.62	7.95	61.71
126	INT18981	Gene_expression of ABAT	2	78	0.68	38.35	61.36
127	INT1169	Negative_regulation of Bche	1	322	0.59	149.22	61.27
128	INT1437	Negative_regulation of Pomc	1	132	0.59	35.22	60.97
129	INT66779	Binding of Pnoc	1	79	0.48	6.43	60.46
130	INT1536	Negative_regulation of NA	4	244	0.55	52.67	59.79
131	INT6623	Gene_expression of NA	1	231	0.78	45.78	59.36
132	INT1794	Regulation of Localization of CGA	2	136	0.57	13.39	59.07
133	INT7032	Positive_regulation of Pdyn	1	94	0.66	26.51	58.83
134	INT8732	Positive_regulation of Gene_expression of Oprm1	1	76	0.70	22.59	58.83
135	INT1307	Positive_regulation of Localization of Pomc	2	120	0.70	24.58	58.48
136	INT770	Regulation of Localization of Gnrhr	2	127	0.61	17.91	58.23
137	INT20964	Gene_expression of OPRK1	1	96	0.78	23.54	58.18
138	INT74389	Gene_expression of Gdnf	1	131	0.78	58.52	57.06
139	INT20266	Positive_regulation of Bdkrb1	1	60	0.69	63.64	56.59
140	INT1510	Binding of PDYN	1	94	0.48	4.68	56.44
141	INT83602	Positive_regulation of Gene_expression of TRPV1	1	114	0.70	51.19	56.35
142	INT1463	Binding of Pomc	2	129	0.48	15.89	56.27
143	INT1200	Negative_regulation of Ins1	4	274	0.58	155.17	56.14
144	INT19	Regulation of Gnrhr	1	131	0.62	36.4	55.66
145	INT5770	Binding of Rbm39	1	88	0.41	13.23	55.5
146	INT82650	Gene_expression of Bcl2	1	312	0.78	211.71	55.03
147	INT5506	Positive_regulation of Gene_expression of Pomc	1	132	0.70	26.78	54.3
148	INT2276	Regulation of Ins1	6	234	0.61	103.78	54.05
149	INT49747	Transcription of Oprm1	1	68	0.72	9.01	53.78
150	INT4891	Transcription of Calca	4	81	0.72	35.27	53.75
151	INT771	Regulation of Nts	2	93	0.61	13.13	53.57
152	INT1032	Regulation of Ca2	2	202	0.52	54.91	53.03
153	INT49017	Negative_regulation of Gene_expression of Nos2	1	169	0.59	80.64	52.67
154	INT5858	Positive_regulation of Drd1a	1	66	0.69	4.51	51.73
155	INT5338	Regulation of Npy	1	92	0.62	25.54	51.24
156	INT76620	Gene_expression of Cnr2	1	93	0.78	34.7	50.14
157	INT10304	Binding of OPRK1	1	89	0.48	9.28	49.42
158	INT937	Positive_regulation of Oxt	1	195	0.70	37.82	49.3
159	INT7059	Regulation of Adra2a	1	89	0.62	18.24	48.43
160	INT7093	Negative_regulation of CYP2B6	3	146	0.58	37.3	48.39
161	INT32718	Gene_expression of OPRD1	1	82	0.76	9.43	48.38
162	INT654	Localization of REN	1	250	0.81	75.12	47.86
163	INT375	Positive_regulation of REN	2	293	0.70	152.46	47.55
164	INT374	Positive_regulation of Ldha	2	212	0.70	107.08	47.43
165	INT2783	Gene_expression of Slc3a1	1	86	0.65	8.84	45.4
166	INT619	Positive_regulation of Positive_regulation of Prl	1	116	0.70	22.69	45.06
167	INT14853	Negative_regulation of Tac1	1	80	0.59	30.87	45.06
168	INT49552	Negative_regulation of Positive_regulation of Casp3	1	76	0.55	36.04	44.78
169	INT29105	Positive_regulation of OPRK1	2	68	0.70	7.06	44.69
170	INT8465	Regulation of Ptgs1	1	100	0.57	36.03	44.41
171	INT82883	Positive_regulation of Ccl2	1	105	0.69	84.96	42.27
172	INT2364	Localization of Sct	1	134	0.80	26.21	41.47
173	INT49643	Gene_expression of Bdkrb1	1	39	0.78	46.49	40.21
174	INT3188	Regulation of Localization of Acot1	2	84	0.59	8.94	38.56
175	INT65125	Gene_expression of Tacr1	2	81	0.77	23.9	38.35
176	INT1354	Negative_regulation of Acot1	1	87	0.43	15.01	36.44
177	INT8837	Positive_regulation of TAC1	2	59	0.67	21.94	35.97
178	INT927	Gene_expression of Oxt	1	184	0.78	44.71	35.79
179	INT49	Negative_regulation of Ren	1	129	0.59	37.48	35.62
180	INT1361	Negative_regulation of Gnrhr	1	118	0.58	57.77	35.54
181	INT10796	Gene_expression of CYP2B6	1	131	0.77	30.14	35.27
182	INT7282	Regulation of Localization of Sst	2	58	0.62	1.92	34.83
183	INT946	Negative_regulation of Nts	3	60	0.57	4.61	34.44
184	INT4403	Binding of CYP2B6	1	113	0.48	21.17	33.83
185	INT3913	Positive_regulation of ABAT	2	47	0.69	22.73	33.4
186	INT64171	Regulation of CPOX	2	109	0.36	55.36	32.96
187	INT1159	Negative_regulation of Agt	1	133	0.59	40.14	31.67
188	INT22239	Negative_regulation of TAC1	1	52	0.57	12.96	31.41
189	INT608	Negative_regulation of KNG1	2	98	0.43	72.36	31.23
190	INT5418	Negative_regulation of Alox5	2	108	0.57	42.09	31.17
191	INT49110	Regulation of Grip2	1	46	0.61	13.57	30.87
192	INT65960	Gene_expression of BCL2	2	352	0.78	312.03	30.73
193	INT11650	Negative_regulation of Gpt	1	122	0.59	69.15	30.36
194	INT50	Negative_regulation of Localization of Ren	3	87	0.59	14.94	30.22
195	INT19396	Regulation of Rac1	1	66	0.53	37.41	30.01
196	INT16769	Positive_regulation of Positive_regulation of Oprm1	2	31	0.57	8.29	29.66
197	INT894	Binding of Avp	1	84	0.48	29.16	29.63
198	INT50230	Positive_regulation of Localization of IL6	1	105	0.70	69.21	29.52
199	INT5514	Negative_regulation of Localization of Crh	1	64	0.58	8.12	29.29
200	INT11796	Positive_regulation of Helt	1	52	0.31	11.7	29.22