J:Can. J. Physiol. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT103330 Ngf Positive_regulation of Gdnf 2 1 0.28 1.27 2.45
2 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 1 0.09 2.6 2.4
3 INT76508 Pnoc Regulation of Oprl1 1 1 0.47 0.25 1.32
4 INT40900 PDYN Regulation of Localization of POMC 2 1 0.07 0.56 1.22
5 INT22726 Positive_regulation of Ahr Positive_regulation of Hrtrt1 1 1 0.22 0.18 0.95
6 INT22725 Ahr Positive_regulation of Hrtrt1 1 1 0.22 0.18 0.95
7 INT31950 PIF1 Positive_regulation of Localization of Prl 1 1 0.06 0 0.87
8 INT103331 Ngf Positive_regulation of Gdnf 1 1 0.01 0.57 0.8
9 INT103334 Gdnf Regulation of Gene_expression of TRPV1 1 1 0.02 0.53 0.77
10 INT103333 Gdnf Regulation of TRPV1 1 1 0.02 0.53 0.77
11 INT103335 Ngf Regulation of TRPV1 1 1 0.05 0.53 0.77
12 INT31951 Negative_regulation of PIF1 Positive_regulation of Prl 1 1 0.07 0 0.68
13 INT47461 PDYN Regulation of POMC 1 1 0.01 0 0.6
14 INT31948 Spic Regulation of Localization of Prl 1 1 0.02 0 0.55
15 INT11651 Nlrp1a Negative_regulation of Gpt 1 1 0.12 0.24 0.47
16 INT58663 Binding of KNG1 and Ugt1a2 1 1 0.02 0.4 0.47
17 INT31952 Localization of PIF1 Regulation of Localization of Prl 1 1 0.04 0 0.46
18 INT31953 PIF1 Regulation of Localization of Prl 1 1 0.06 0 0.46
19 INT36340 Binding of NRP2 and Penk 1 1 0.04 0.07 0.39
20 INT43331 Binding of Oxt and Ptgfr 1 1 0.01 0.37 0.37
21 INT43332 Positive_regulation of Binding of Oxt and Ptgfr 1 1 0.02 0.37 0.37
22 INT148342 Hsd17b6 Negative_regulation of Oxt 1 1 0.21 0.37 0.31
23 INT151424 Tfrc Negative_regulation of Positive_regulation of Tnni3 1 2 0.21 0.98 0.2
24 INT3326 PRSS1 Positive_regulation of ATP6AP2 1 1 0.01 0 0.11
25 INT151423 Tfrc Positive_regulation of Gene_expression of Nos2 1 1 0.24 0.49 0.1
26 INT42532 Binding of Pomc and Klk1c2 1 1 0.21 0 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 21 2008 0.81 518.3 1408.65
2 INT796 Gene_expression of Penk 4 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 17 2431 0.81 378.96 952.2
4 INT1912 Gene_expression of Calca 14 1152 0.78 453.25 739.84
5 INT292 Localization of Penk 1 876 0.81 88.44 669.14
6 INT728 Positive_regulation of Penk 2 1068 0.70 186.9 636.87
7 INT2543 Positive_regulation of Calca 6 787 0.70 331.13 592.08
8 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
9 INT5228 Positive_regulation of Fos 7 934 0.70 209.8 503.87
10 INT155 Positive_regulation of Prl 5 1233 0.70 317.93 457.82
11 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
12 INT50058 Negative_regulation of Cpox 2 907 0.58 426.28 428.29
13 INT4758 Positive_regulation of Localization of Calca 5 557 0.70 138.55 411.04
14 INT5895 Gene_expression of Oprm1 2 525 0.78 120.67 407.29
15 INT64202 Positive_regulation of Trpv1 1 643 0.70 249.66 397.42
16 INT467 Gene_expression of POMC 3 1048 0.78 332.8 394.16
17 INT1395 Negative_regulation of Penk 2 537 0.59 87.33 389.81
18 INT2540 Negative_regulation of Calca 10 538 0.59 172.11 384.38
19 INT18357 Gene_expression of TRPV1 4 825 0.78 307.11 382.81
20 INT6580 Negative_regulation of Ptgs1 5 929 0.59 381.53 376.26
21 INT157 Positive_regulation of Localization of Prl 11 790 0.70 104.54 374.78
22 INT287 Localization of Cck 1 518 0.81 86.84 364.04
23 INT439 Localization of Gnrh1 7 976 0.81 100.96 363.25
24 INT5660 Binding of Oprd1 2 477 0.48 71.86 342.06
25 INT2649 Regulation of Calca 8 433 0.62 146.05 330.95
26 INT162 Regulation of Prl 2 794 0.62 165.01 322.24
27 INT5979 Gene_expression of Oprd1 2 428 0.78 75.64 320.32
28 INT5540 Positive_regulation of Oprm1 4 344 0.70 76.77 319.71
29 INT5680 Gene_expression of Ngf 1 530 0.78 264.29 310.56
30 INT4941 Positive_regulation of Oprd1 3 345 0.70 74.26 304.41
31 INT477 Localization of Avp 3 813 0.81 131.58 300.4
32 INT161 Regulation of Localization of Prl 2 615 0.62 65.37 298.66
33 INT1352 Localization of Acot1 10 728 0.80 73.01 296.01
34 INT886 Gene_expression of Pomc 8 676 0.78 129.87 295.98
35 INT3579 Localization of Oxt 3 555 0.81 43.35 292.44
36 INT2365 Positive_regulation of Cck 2 354 0.70 87.8 277.41
37 INT49750 Negative_regulation of CPOX 2 735 0.58 360.06 274.19
38 INT1396 Binding of Penk 3 355 0.48 22.79 269.65
39 INT3948 Regulation of Cck 4 291 0.62 58.07 255.88
40 INT1005 Localization of Sst 4 385 0.81 26.31 244.56
41 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
42 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
43 INT5597 Gene_expression of Pdyn 3 433 0.78 62.97 235.47
44 INT4759 Negative_regulation of Localization of Calca 1 294 0.59 82.62 226.45
45 INT1212 Binding of Oprl1 2 312 0.48 28.6 225.15
46 INT1308 Localization of Pomc 5 457 0.81 66.83 217.5
47 INT767 Localization of Gnrhr 4 565 0.80 106.68 214.57
48 INT22548 Positive_regulation of Casp3 3 483 0.70 258.78 213.07
49 INT48955 Gene_expression of Nos2 2 753 0.78 403.87 208.08
50 INT50670 Gene_expression of CPOX 2 763 0.76 442.13 195.02
51 INT156 Negative_regulation of Prl 1 542 0.59 131.97 192.24
52 INT1652 Regulation of Pomc 7 387 0.62 61.01 186.51
53 INT10194 Positive_regulation of IL6 2 702 0.70 600.62 183.38
54 INT943 Negative_regulation of Cck 1 205 0.59 38.42 174.78
55 INT26472 Regulation of Oprm1 1 191 0.62 35.84 173.1
56 INT5930 Positive_regulation of Oprm1 2 221 0.70 31.19 172.93
57 INT159 Negative_regulation of Localization of Prl 1 416 0.59 55.34 171.8
58 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
59 INT5513 Negative_regulation of Pomc 5 295 0.59 60.9 158.63
60 INT768 Positive_regulation of Oprl1 1 179 0.70 40.05 156.93
61 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
62 INT5050 Regulation of Localization of Calca 2 149 0.62 41.25 148.57
63 INT2451 Positive_regulation of Avp 3 355 0.70 102.66 147.69
64 INT1033 Positive_regulation of Ca2 4 507 0.68 131.76 147.64
65 INT9852 Positive_regulation of Gpt 2 563 0.70 364.64 146.82
66 INT1414 Regulation of Oprl1 1 169 0.62 32.05 139.99
67 INT2541 Binding of Calca 4 200 0.48 67.14 134.62
68 INT48953 Positive_regulation of Nos2 2 486 0.70 239.85 131.87
69 INT1614 Gene_expression of Oprl1 2 164 0.78 31.43 127.74
70 INT695 Binding of POMC 1 304 0.48 56.66 126.85
71 INT5931 Regulation of Oprm1 1 149 0.62 18.15 125.93
72 INT6822 Gene_expression of Pdyn 2 215 0.78 35.99 125.76
73 INT4259 Positive_regulation of Npr1 2 262 0.70 49.37 123.11
74 INT1438 Localization of Pomc 1 360 0.81 101.26 116.47
75 INT4207 Regulation of Avp 3 267 0.62 63.72 115.33
76 INT1793 Localization of CGA 1 379 0.81 67.38 114.69
77 INT7362 Gene_expression of Sst 1 185 0.78 41.73 111.37
78 INT5283 Positive_regulation of Npy 1 191 0.70 66.77 109.2
79 INT8413 Gene_expression of Ptgs1 2 248 0.78 110.17 108.58
80 INT9012 Localization of Vip 3 283 0.81 31.71 106.16
81 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
82 INT4742 Gene_expression of Tac1 1 177 0.78 69.99 102.66
83 INT1898 Regulation of Crh 4 220 0.62 61.33 102.64
84 INT82878 Gene_expression of Ccl2 1 201 0.78 164.95 101.35
85 INT5940 Negative_regulation of Avp 2 236 0.59 67.86 101.2
86 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
87 INT1004 Regulation of Sst 2 140 0.62 18.52 94.84
88 INT3537 Positive_regulation of Car2 4 413 0.56 103.51 94.35
89 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
90 INT2122 Negative_regulation of Localization of Gnrh1 3 226 0.59 26.92 92.04
91 INT74376 Gene_expression of Cnr1 1 173 0.78 73.43 89.7
92 INT10166 Localization of Tnf 1 237 0.81 153.95 88.64
93 INT1635 Gene_expression of Vip 2 245 0.78 53.36 88.13
94 INT1472 Positive_regulation of Ins1 6 349 0.69 146.2 86.36
95 INT4798 Gene_expression of Nts 2 169 0.77 29.56 86.04
96 INT3766 Positive_regulation of Localization of Acot1 1 192 0.69 21.8 85.35
97 INT5780 Regulation of Gene_expression of Calca 4 90 0.62 59.52 85.03
98 INT2520 Negative_regulation of Ca2 4 271 0.57 72.13 83.71
99 INT6107 Localization of Npy 4 180 0.81 26.76 81.67
100 INT1309 Positive_regulation of Localization of Gnrhr 2 152 0.69 24.25 81.56
101 INT148 Positive_regulation of Gnrhr 2 182 0.70 47.44 79.64
102 INT2431 Positive_regulation of Mpo 1 275 0.70 211.99 78.47
103 INT12476 Negative_regulation of TRPV1 1 124 0.59 47.95 77.98
104 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
105 INT9382 Regulation of TRPV1 1 149 0.62 53.99 77.46
106 INT3657 Gene_expression of Ins1 7 514 0.78 321.69 75.76
107 INT16654 Gene_expression of Insrr 1 138 0.46 58.96 75.68
108 INT1353 Negative_regulation of Localization of Acot1 1 153 0.53 15.05 75.17
109 INT7028 Localization of Pdyn 1 90 0.81 8.89 73.54
110 INT7886 Regulation of Localization of Avp 1 146 0.62 14.53 72.99
111 INT442 Localization of PDYN 1 99 0.81 11.87 72.75
112 INT2055 Regulation of Gnrh1 1 185 0.62 23.65 71.26
113 INT5993 Positive_regulation of Nts 3 122 0.70 26.82 70.45
114 INT2123 Positive_regulation of Gnrh1 1 209 0.70 24.2 68.97
115 INT7344 Gene_expression of TAC1 2 132 0.75 35.48 68.26
116 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
117 INT19511 Localization of Il6 1 212 0.81 118.17 67.67
118 INT7468 Negative_regulation of Localization of Oxt 1 109 0.59 9.46 66.79
119 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
120 INT1425 Gene_expression of Rbm39 1 143 0.58 51.32 65.44
121 INT217 Negative_regulation of Th 1 134 0.59 26.83 62.63
122 INT46 Localization of Ren 5 233 0.81 46.15 62.44
123 INT10706 Regulation of Il6 1 150 0.62 93.23 62.34
124 INT8363 Localization of Nts 1 135 0.81 14.29 61.71
125 INT7884 Regulation of Localization of Oxt 1 102 0.62 7.95 61.71
126 INT18981 Gene_expression of ABAT 2 78 0.68 38.35 61.36
127 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
128 INT1437 Negative_regulation of Pomc 1 132 0.59 35.22 60.97
129 INT66779 Binding of Pnoc 1 79 0.48 6.43 60.46
130 INT1536 Negative_regulation of NA 4 244 0.55 52.67 59.79
131 INT6623 Gene_expression of NA 1 231 0.78 45.78 59.36
132 INT1794 Regulation of Localization of CGA 2 136 0.57 13.39 59.07
133 INT7032 Positive_regulation of Pdyn 1 94 0.66 26.51 58.83
134 INT8732 Positive_regulation of Gene_expression of Oprm1 1 76 0.70 22.59 58.83
135 INT1307 Positive_regulation of Localization of Pomc 2 120 0.70 24.58 58.48
136 INT770 Regulation of Localization of Gnrhr 2 127 0.61 17.91 58.23
137 INT20964 Gene_expression of OPRK1 1 96 0.78 23.54 58.18
138 INT74389 Gene_expression of Gdnf 1 131 0.78 58.52 57.06
139 INT20266 Positive_regulation of Bdkrb1 1 60 0.69 63.64 56.59
140 INT1510 Binding of PDYN 1 94 0.48 4.68 56.44
141 INT83602 Positive_regulation of Gene_expression of TRPV1 1 114 0.70 51.19 56.35
142 INT1463 Binding of Pomc 2 129 0.48 15.89 56.27
143 INT1200 Negative_regulation of Ins1 4 274 0.58 155.17 56.14
144 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
145 INT5770 Binding of Rbm39 1 88 0.41 13.23 55.5
146 INT82650 Gene_expression of Bcl2 1 312 0.78 211.71 55.03
147 INT5506 Positive_regulation of Gene_expression of Pomc 1 132 0.70 26.78 54.3
148 INT2276 Regulation of Ins1 6 234 0.61 103.78 54.05
149 INT49747 Transcription of Oprm1 1 68 0.72 9.01 53.78
150 INT4891 Transcription of Calca 4 81 0.72 35.27 53.75
151 INT771 Regulation of Nts 2 93 0.61 13.13 53.57
152 INT1032 Regulation of Ca2 2 202 0.52 54.91 53.03
153 INT49017 Negative_regulation of Gene_expression of Nos2 1 169 0.59 80.64 52.67
154 INT5858 Positive_regulation of Drd1a 1 66 0.69 4.51 51.73
155 INT5338 Regulation of Npy 1 92 0.62 25.54 51.24
156 INT76620 Gene_expression of Cnr2 1 93 0.78 34.7 50.14
157 INT10304 Binding of OPRK1 1 89 0.48 9.28 49.42
158 INT937 Positive_regulation of Oxt 1 195 0.70 37.82 49.3
159 INT7059 Regulation of Adra2a 1 89 0.62 18.24 48.43
160 INT7093 Negative_regulation of CYP2B6 3 146 0.58 37.3 48.39
161 INT32718 Gene_expression of OPRD1 1 82 0.76 9.43 48.38
162 INT654 Localization of REN 1 250 0.81 75.12 47.86
163 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
164 INT374 Positive_regulation of Ldha 2 212 0.70 107.08 47.43
165 INT2783 Gene_expression of Slc3a1 1 86 0.65 8.84 45.4
166 INT619 Positive_regulation of Positive_regulation of Prl 1 116 0.70 22.69 45.06
167 INT14853 Negative_regulation of Tac1 1 80 0.59 30.87 45.06
168 INT49552 Negative_regulation of Positive_regulation of Casp3 1 76 0.55 36.04 44.78
169 INT29105 Positive_regulation of OPRK1 2 68 0.70 7.06 44.69
170 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
171 INT82883 Positive_regulation of Ccl2 1 105 0.69 84.96 42.27
172 INT2364 Localization of Sct 1 134 0.80 26.21 41.47
173 INT49643 Gene_expression of Bdkrb1 1 39 0.78 46.49 40.21
174 INT3188 Regulation of Localization of Acot1 2 84 0.59 8.94 38.56
175 INT65125 Gene_expression of Tacr1 2 81 0.77 23.9 38.35
176 INT1354 Negative_regulation of Acot1 1 87 0.43 15.01 36.44
177 INT8837 Positive_regulation of TAC1 2 59 0.67 21.94 35.97
178 INT927 Gene_expression of Oxt 1 184 0.78 44.71 35.79
179 INT49 Negative_regulation of Ren 1 129 0.59 37.48 35.62
180 INT1361 Negative_regulation of Gnrhr 1 118 0.58 57.77 35.54
181 INT10796 Gene_expression of CYP2B6 1 131 0.77 30.14 35.27
182 INT7282 Regulation of Localization of Sst 2 58 0.62 1.92 34.83
183 INT946 Negative_regulation of Nts 3 60 0.57 4.61 34.44
184 INT4403 Binding of CYP2B6 1 113 0.48 21.17 33.83
185 INT3913 Positive_regulation of ABAT 2 47 0.69 22.73 33.4
186 INT64171 Regulation of CPOX 2 109 0.36 55.36 32.96
187 INT1159 Negative_regulation of Agt 1 133 0.59 40.14 31.67
188 INT22239 Negative_regulation of TAC1 1 52 0.57 12.96 31.41
189 INT608 Negative_regulation of KNG1 2 98 0.43 72.36 31.23
190 INT5418 Negative_regulation of Alox5 2 108 0.57 42.09 31.17
191 INT49110 Regulation of Grip2 1 46 0.61 13.57 30.87
192 INT65960 Gene_expression of BCL2 2 352 0.78 312.03 30.73
193 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
194 INT50 Negative_regulation of Localization of Ren 3 87 0.59 14.94 30.22
195 INT19396 Regulation of Rac1 1 66 0.53 37.41 30.01
196 INT16769 Positive_regulation of Positive_regulation of Oprm1 2 31 0.57 8.29 29.66
197 INT894 Binding of Avp 1 84 0.48 29.16 29.63
198 INT50230 Positive_regulation of Localization of IL6 1 105 0.70 69.21 29.52
199 INT5514 Negative_regulation of Localization of Crh 1 64 0.58 8.12 29.29
200 INT11796 Positive_regulation of Helt 1 52 0.31 11.7 29.22
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