J:Cancer Cell Int

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT180961 Binding of MOCS1 and PLAU 1 2 0.00 0.61 0.67
2 INT337323 KNG1 Positive_regulation of PRKCA 1 1 0.15 0.17 0.62
3 INT180958 Binding of F13A1 and PLAT 2 1 0.03 2.16 0.47
4 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 1 0.02 0 0.43
5 INT337325 PIK3CD Positive_regulation of Phosphorylation of IL2RG 1 1 0.00 0 0.43
6 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 1 0.02 0 0.43
7 INT337327 KNG1 Positive_regulation of BDKRB2 1 1 0.21 0.4 0.32
8 INT180964 PLG Positive_regulation of MMP13 1 1 0.24 0.45 0.25
9 INT320883 Agtr2 Positive_regulation of Localization of VEGFA 1 2 0.08 2.8 0.17
10 INT320884 Agtrap Positive_regulation of Localization of VEGFA 1 2 0.10 2.81 0.17
11 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 1 0.02 1.07 0.14
12 INT177911 PRKG1 Positive_regulation of MAPK8 1 1 0.02 1.07 0.14
13 INT180960 Protein_catabolism of COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 1 0.00 0.59 0.14
14 INT180963 COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 1 0.00 0.59 0.14
15 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 1 0.05 1.07 0.14
16 INT156829 EGF Positive_regulation of MAPK3 2 1 0.08 0.87 0.1
17 INT310743 TP53 Regulation of BAX 1 1 0.09 1.11 0.1
18 INT239559 MSC Regulation of Gene_expression of BDNF 1 1 0.05 1 0.09
19 INT320881 Ang Positive_regulation of Agtrap 1 1 0.12 1.35 0.08
20 INT320880 Chi3l1 Positive_regulation of Agtr2 1 1 0.01 1.22 0.08
21 INT351422 Mfng Negative_regulation of Jag1 1 1 0.06 1.29 0.07
22 INT351423 Sparc Positive_regulation of Mmp2 1 1 0.02 1.31 0.04
23 INT180955 PLG Regulation of Positive_regulation of TIMP1 1 1 0.21 0.38 0.04
24 INT239560 MSC Regulation of Gene_expression of IFN1@ 1 1 0.11 0.87 0.04
25 INT187897 Pgp Positive_regulation of Mod2 1 1 0.11 0.51 0.04
26 INT320882 Agtr2 Positive_regulation of Gene_expression of VEGFA 1 1 0.08 0.9 0.04
27 INT180956 PLG Regulation of Positive_regulation of MMP13 1 1 0.32 0.38 0.04
28 INT180957 Binding of PLG and Regulation of Positive_regulation of MMP13 1 1 0.14 0.38 0.04
29 INT180954 PASK Regulation of COL5A2 1 1 0.00 0.7 0.03
30 INT176543 Binding of Cd44 and Spp1 2 1 0.31 0.57 0
31 INT320877 Agtr2 Positive_regulation of Pla2g2a 1 1 0.10 0.67 0
32 INT177945 EGF Regulation of ras 1 1 0.02 0.84 0
33 INT320878 Positive_regulation of Agtr2 Positive_regulation of Pla2g2a 1 1 0.10 0.67 0
34 INT177915 EGF Positive_regulation of Phosphorylation of AKT1 1 1 0.03 0.51 0
35 INT187899 Binding of Pgp and Mir486 1 1 0.00 0.25 0
36 INT177917 Positive_regulation of EGF Positive_regulation of Phosphorylation of MAPK3 1 1 0.04 0.4 0
37 INT177912 EGF Regulation of MAPK3 1 1 0.02 0.84 0
38 INT177913 EGF Positive_regulation of Phosphorylation of MAPK3 1 1 0.04 0.4 0
39 INT187898 Negative_regulation of Binding of Pgp and Mir486 1 1 0.01 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT10832 Gene_expression of IL8 17 1050 0.78 698.72 270
2 INT68684 Gene_expression of VEGFA 4 2371 0.78 1742.52 259.2
3 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
4 INT66280 Gene_expression of Nos2 2 534 0.78 330.78 157.07
5 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
6 INT65600 Positive_regulation of Casp3 4 376 0.70 198.44 128.03
7 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
8 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
9 INT77435 Positive_regulation of Nos2 7 343 0.70 208.49 91.43
10 INT75999 Gene_expression of BDNF 1 344 0.78 114.19 83.12
11 INT68682 Positive_regulation of VEGFA 5 640 0.70 454.14 81.65
12 INT10837 Positive_regulation of Gene_expression of IL8 1 294 0.70 190.08 70.34
13 INT170332 Gene_expression of IFN1@ 3 477 0.75 275.21 69.65
14 INT8357 Gene_expression of KNG1 2 153 0.75 77.26 68.66
15 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
16 INT1759 Gene_expression of TIMP1 4 267 0.77 133.87 59.29
17 INT11491 Positive_regulation of KNG1 5 128 0.67 60.41 58.74
18 INT73048 Gene_expression of MMP9 1 268 0.77 159.75 57.81
19 INT48232 Gene_expression of MMP1 2 245 0.78 96.31 57.72
20 INT31116 Gene_expression of Casp3 4 192 0.78 78.21 57.43
21 INT26500 Gene_expression of MMP2 1 201 0.78 110.57 46.9
22 INT48718 Positive_regulation of PRKCA 4 109 0.69 36.16 46.49
23 INT71786 Phosphorylation of MAPK1 2 256 0.82 110.09 46.17
24 INT6979 Positive_regulation of CA2 2 206 0.67 50.79 44.97
25 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
26 INT77434 Positive_regulation of Gene_expression of Nos2 4 151 0.69 96.76 38.94
27 INT80690 Positive_regulation of MAPK8 6 223 0.68 125.63 36.75
28 INT12892 Negative_regulation of TIMP1 1 136 0.58 83.13 36.54
29 INT101992 Localization of VEGFA 8 413 0.81 258.23 36.15
30 INT104392 Gene_expression of Cxcl10 17 113 0.75 106.86 34.12
31 INT73498 Gene_expression of IL13 1 117 0.44 83.85 32.26
32 INT88318 Gene_expression of CXCR4 6 208 0.77 189.67 31.72
33 INT48693 Regulation of VEGFA 2 268 0.62 191.88 31.52
34 INT608 Negative_regulation of KNG1 1 98 0.43 72.36 31.23
35 INT129207 Gene_expression of Cxcl1 1 114 0.75 68.54 30.82
36 INT65960 Gene_expression of BCL2 10 352 0.78 312.03 30.73
37 INT28361 Gene_expression of TP53 1 443 0.78 384.86 28.8
38 INT55737 Positive_regulation of MMP2 1 101 0.68 59.11 27.71
39 INT21687 Positive_regulation of ras 7 143 0.58 97.34 27.31
40 INT3167 Binding of KNG1 4 48 0.48 23.26 26.77
41 INT20462 Binding of ESR1 1 210 0.44 102.7 26.34
42 INT11159 Gene_expression of EGFR 1 698 0.78 548.93 25.69
43 INT140193 Gene_expression of Mmp3 3 58 0.71 49.65 25.4
44 INT48235 Negative_regulation of NPEPPS 1 72 0.46 44.54 25.03
45 INT72370 Gene_expression of Timp1 6 82 0.65 57.52 24.16
46 INT89854 Regulation of Nos2 1 49 0.61 42.58 24.1
47 INT71781 Phosphorylation of MAPK3 6 62 0.80 27.73 23.73
48 INT86534 Positive_regulation of MAPK14 1 81 0.62 57.81 23.62
49 INT110427 Gene_expression of Spp1 10 199 0.78 176.11 23.31
50 INT16996 Gene_expression of PRTN3 1 113 0.75 85.61 22.57
51 INT7573 Positive_regulation of Nr3c2 2 38 0.67 20 21.84
52 INT171924 Gene_expression of MAPK14 1 60 0.65 54.38 21.68
53 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
54 INT73593 Gene_expression of BAX 13 173 0.76 147.81 20.94
55 INT170444 Binding of Gopc 2 172 0.39 45.05 20.71
56 INT68683 Regulation of Gene_expression of VEGFA 1 143 0.62 104.19 20.14
57 INT6848 Gene_expression of BDKRB2 1 40 0.75 17.19 20.04
58 INT81210 Positive_regulation of PRKG1 2 71 0.70 26.83 19.89
59 INT51055 Positive_regulation of TIMP1 2 103 0.69 50.07 19.86
60 INT104395 Gene_expression of Cxcl9 19 83 0.76 73.1 19.79
61 INT89396 Phosphorylation of AKT1 2 225 0.82 111.66 19.61
62 INT14737 Gene_expression of FN1 1 117 0.78 78.74 18.99
63 INT192409 Positive_regulation of Gene_expression of IFN1@ 1 102 0.67 64.66 18.8
64 INT56749 Gene_expression of PCNA 2 219 0.77 111.25 18.42
65 INT27670 Negative_regulation of Ace 1 122 0.57 79.21 18.08
66 INT71787 Positive_regulation of MAPK3 3 37 0.67 17.5 17.88
67 INT116950 Negative_regulation of MAPK8 2 103 0.57 44.48 17.53
68 INT65856 Positive_regulation of TP53 3 138 0.67 112.65 16.71
69 INT17313 Positive_regulation of HSPG2 1 57 0.67 55.78 16.65
70 INT109929 Phosphorylation of MAPK8 2 102 0.81 39.98 16.54
71 INT77433 Regulation of Gene_expression of Nos2 1 49 0.62 35.07 16.33
72 INT103245 Positive_regulation of Gene_expression of MMP9 1 64 0.68 36.86 15.7
73 INT171666 Regulation of GOPC 1 117 0.39 40.41 15.47
74 INT5333 Gene_expression of NPEPPS 1 45 0.65 26.34 15.25
75 INT34590 Gene_expression of ALPP 2 199 0.75 89.85 15.1
76 INT88544 Gene_expression of MMRN1 1 102 0.75 68.8 14.55
77 INT1556 Regulation of Dnahc8 1 20 0.61 3.23 14.44
78 INT72127 Protein_catabolism of MMRN1 2 68 0.52 56 14.13
79 INT27739 Positive_regulation of EGF 1 49 0.70 28.31 13.68
80 INT80685 Gene_expression of MAPK8 2 90 0.72 51.91 13.36
81 INT20376 Gene_expression of Ccl3 12 39 0.75 45.42 13.15
82 INT6322 Gene_expression of Ceacam1 1 46 0.75 32.13 12.46
83 INT123779 Positive_regulation of MMP13 3 42 0.65 24.3 12.45
84 INT158124 Gene_expression of COL5A2 4 136 0.69 72.3 12.44
85 INT11359 Gene_expression of PLAU 8 84 0.76 49.54 12.31
86 INT55687 Localization of TIMP1 1 47 0.74 30.24 12.31
87 INT12315 Gene_expression of Nr3c2 1 37 0.75 19.28 11.97
88 INT66718 Positive_regulation of BDKRB2 4 21 0.64 9.89 11.6
89 INT39188 Gene_expression of IGKV5-2 2 22 0.38 10.95 9.91
90 INT181405 Gene_expression of Ccl20 10 26 0.65 23.02 9.46
91 INT73596 Positive_regulation of Gene_expression of BAX 5 43 0.67 40.97 9.22
92 INT33220 Negative_regulation of ras 4 110 0.58 70.21 9.19
93 INT155808 Gene_expression of Ccl4 6 24 0.65 21.36 9.18
94 INT94196 Negative_regulation of Phosphorylation of MAPK1 1 60 0.59 31.64 9.16
95 INT173587 Protein_catabolism of COL5A2 13 59 0.32 32.73 8.96
96 INT70017 Positive_regulation of BCL2 1 87 0.67 66.62 8.68
97 INT71763 Gene_expression of Mri1 5 33 0.58 12.56 8.6
98 INT17024 Gene_expression of COL1A2 1 69 0.77 36.38 8.29
99 INT65959 Positive_regulation of Gene_expression of BCL2 1 75 0.70 77.3 8.27
100 INT71785 Gene_expression of MAPK3 1 22 0.75 11.35 8.21
101 INT96068 Positive_regulation of Timp1 3 30 0.58 23.94 8.17
102 INT36678 Binding of TIMP1 1 33 0.36 14.99 7.87
103 INT73595 Positive_regulation of BAX 2 61 0.61 56.97 7.82
104 INT21685 Gene_expression of ras 6 115 0.66 85.6 7.76
105 INT91618 Positive_regulation of Phosphorylation of MAPK3 3 21 0.67 7.99 7.65
106 INT89046 Positive_regulation of P2RX2 1 15 0.67 7.25 7.52
107 INT122901 Positive_regulation of Spp1 10 67 0.67 58.03 7.49
108 INT75526 Positive_regulation of Positive_regulation of PRKCA 2 16 0.50 4.34 7.46
109 INT120401 Positive_regulation of PIK3CD 2 33 0.45 14.89 7.37
110 INT77756 Positive_regulation of GTPBP4 1 16 0.11 2.6 7.29
111 INT153794 Gene_expression of Ctsk 10 51 0.77 24.99 7.28
112 INT134967 Gene_expression of Ecm1 1 66 0.29 38.4 7.16
113 INT78199 Gene_expression of Neu1 1 65 0.75 62.88 7.16
114 INT29583 Positive_regulation of Agtr2 11 30 0.45 21.47 7.04
115 INT21579 Negative_regulation of Gene_expression of TIMP1 1 25 0.57 12.41 6.94
116 INT2037 Negative_regulation of EGF 2 30 0.59 15.05 6.81
117 INT84685 Regulation of BCL2 2 67 0.60 72.96 6.65
118 INT28122 Gene_expression of MSC 6 111 0.58 26.83 6.57
119 INT122902 Positive_regulation of Gene_expression of Spp1 3 54 0.70 56.3 6.33
120 INT44163 Gene_expression of Ren1 1 69 0.78 97.75 6.27
121 INT4561 Gene_expression of PLG 8 32 0.75 17.59 6.21
122 INT94197 Negative_regulation of Phosphorylation of MAPK3 2 13 0.57 5.51 6.18
123 INT27628 Gene_expression of IL2RG 1 28 0.75 20.95 6.16
124 INT26919 Gene_expression of ITPR3 2 47 0.42 5.86 5.79
125 INT86111 Positive_regulation of Positive_regulation of VEGFA 1 38 0.69 33.81 5.78
126 INT179810 Protein_catabolism of Ecm1 1 30 0.11 18.28 5.75
127 INT21647 Negative_regulation of Positive_regulation of KNG1 4 11 0.43 5.54 5.73
128 INT71764 Positive_regulation of Mri1 1 24 0.44 12.31 5.67
129 INT183689 Positive_regulation of Gene_expression of Cxcl1 1 21 0.58 9.13 5.5
130 INT174851 Positive_regulation of COL5A2 1 46 0.54 12.73 5.48
131 INT89794 Positive_regulation of CDKN2A 1 58 0.67 50.18 5.38
132 INT87420 Gene_expression of BCL2L1 1 56 0.75 48.84 5.32
133 INT18681 Gene_expression of Thy1 1 80 0.71 38.8 5.23
134 INT70613 Negative_regulation of Gene_expression of BCL2 1 48 0.59 38.91 5.22
135 INT60585 Regulation of TP53 1 59 0.59 54.55 5.21
136 INT37227 Regulation of EGF 1 19 0.45 11.16 5.17
137 INT70800 Negative_regulation of Positive_regulation of PRKCA 2 9 0.34 2.18 5.17
138 INT73262 Negative_regulation of BCL2 1 67 0.57 61.01 5.07
139 INT26334 Localization of ITPR3 1 39 0.49 2.53 5.07
140 INT91225 Positive_regulation of Pla2g2a 4 22 0.57 14.77 5.01
141 INT109848 Gene_expression of P2RY1 1 26 0.62 6.71 4.98
142 INT105393 Positive_regulation of Localization of VEGFA 4 66 0.70 45.45 4.9
143 INT105336 Regulation of AKT1 1 52 0.56 32.53 4.89
144 INT60066 Positive_regulation of NPEPPS 1 17 0.22 11.99 4.83
145 INT12104 Positive_regulation of PLG 4 45 0.68 28.94 4.81
146 INT22557 Gene_expression of BMP1 1 3 0.59 20.18 4.73
147 INT15474 Gene_expression of PLAUR 2 36 0.75 22.32 4.63
148 INT62684 Negative_regulation of TP53 1 66 0.58 66.09 4.62
149 INT47451 Positive_regulation of Positive_regulation of ras 2 18 0.35 10.07 4.6
150 INT104389 Positive_regulation of Gene_expression of Cxcl9 2 15 0.49 17.42 4.59
151 INT351414 Gene_expression of Mipep 42 1 0.75 41.22 4.59
152 INT78995 Negative_regulation of Agtr2 1 26 0.42 13.05 4.56
153 INT22080 Regulation of ras 3 40 0.53 36.24 4.44
154 INT17818 Gene_expression of Agtr2 4 24 0.56 12.96 4.41
155 INT16349 Positive_regulation of alp 2 25 0.60 16.74 4.34
156 INT80983 Regulation of Abcb1b 1 16 0.60 1.95 4.32
157 INT3327 Protein_catabolism of PRSS1 1 22 1.00 6.96 4.29
158 INT21686 Positive_regulation of Gene_expression of ras 2 19 0.42 13.79 4.28
159 INT109450 Positive_regulation of Phosphorylation of AKT1 1 62 0.64 25.18 4.21
160 INT110343 Negative_regulation of PIK3CD 1 22 0.40 5.84 4.2
161 INT84686 Regulation of BAX 2 26 0.49 28.54 4.13
162 INT156137 Gene_expression of Col1a2 1 28 0.73 13.3 3.99
163 INT132103 Positive_regulation of Gene_expression of MAPK8 1 26 0.46 16.54 3.94
164 INT118835 Positive_regulation of Vegfa 1 18 0.59 11.2 3.91
165 INT17819 Regulation of Agtr2 5 10 0.51 9.33 3.9
166 INT26191 Positive_regulation of ITPR3 1 24 0.44 1.9 3.74
167 INT9144 Localization of MSC 1 18 0.56 10.17 3.69
168 INT137702 Binding of TTN 3 7 0.35 4.48 3.62
169 INT39986 Regulation of Agtr2 1 13 0.45 10.39 3.55
170 INT49238 Protein_catabolism of COL1A2 8 30 0.97 15.64 3.45
171 INT130295 Gene_expression of Abcg2 1 21 0.75 9.75 3.42
172 INT109403 Regulation of Gene_expression of BCL2 1 31 0.60 31.22 3.4
173 INT17511 Negative_regulation of PRTN3 1 19 0.41 12 3.3
174 INT109914 Positive_regulation of MAPK9 5 16 0.56 7.64 3.27
175 INT59433 Gene_expression of PASK 4 24 0.68 25.13 3.21
176 INT91173 Gene_expression of Pdgfrb 5 33 0.65 32.55 3.09
177 INT103674 Positive_regulation of Gene_expression of CXCR4 2 32 0.69 37.1 3.08
178 INT93936 Gene_expression of Pgp 5 10 0.59 3.43 3.04
179 INT87288 Positive_regulation of Positive_regulation of MAPK3 1 5 0.67 1.62 3.04
180 INT137609 Localization of Vegfa 1 22 0.78 14.67 3.01
181 INT180971 Protein_catabolism of GOPC 3 21 0.77 6.15 2.98
182 INT136388 Gene_expression of Cxcl5 13 13 0.75 21.45 2.98
183 INT91432 Binding of MMRN1 1 23 0.36 9.79 2.95
184 INT91520 Negative_regulation of Positive_regulation of CA2 1 7 0.30 0.99 2.92
185 INT37734 Positive_regulation of Ang 1 18 0.46 9.17 2.87
186 INT134795 Positive_regulation of Scrib 1 30 0.22 36.91 2.81
187 INT56150 Localization of IL2RG 1 7 0.45 2.74 2.68
188 INT86815 Gene_expression of Pla2g2a 2 18 0.55 5.72 2.59
189 INT175685 Positive_regulation of Gene_expression of Timp1 1 11 0.57 8.18 2.58
190 INT179788 Gene_expression of Sparc 1 42 0.77 19.96 2.57
191 INT61465 Gene_expression of Acp5 1 22 0.75 7.06 2.55
192 INT40315 Gene_expression of Abcc1 1 10 0.76 5.66 2.53
193 INT92141 Negative_regulation of CDKN2A 1 53 0.57 44.23 2.48
194 INT148071 Gene_expression of Agt 1 42 0.74 44.9 2.43
195 INT26918 Positive_regulation of Gene_expression of ITPR3 2 14 0.27 2.31 2.41
196 INT60765 Gene_expression of LAMB2 1 28 0.49 13.93 2.38
197 INT87284 Negative_regulation of Positive_regulation of MAPK3 1 7 0.41 2.65 2.38
198 INT186094 Binding of Mri1 2 14 0.20 7.8 2.35
199 INT4560 Protein_catabolism of PLG 3 18 0.96 11.64 2.32
200 INT131456 Negative_regulation of MMRN1 1 14 0.19 9.49 2.29
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