J:Cancer Metastasis Rev

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT339532	FGF2 Positive_regulation of YWHAZ	1	2	0.00	1.26	0.54
2	INT339570	'Gene_expression of ' Positive_regulation of Gene_expression of CYP4A11	1	1	0.00	0.5	0.23
3	INT339535	FGF2 Positive_regulation of Gene_expression of CYP4A11	1	1	0.00	0.55	0.22
4	INT339533	VEGFA Positive_regulation of Gene_expression of CYP2C8	1	1	0.09	0.57	0.09
5	INT339534	VEGFA Positive_regulation of CYP2C18	1	1	0.04	0.57	0.08
6	INT339569	VEGFA Positive_regulation of Litaf	1	1	0.18	0.6	0.04
7	INT192164	Binding of BAK1 and BCL2	3	1	0.04	2.8	0.03
8	INT192914	Binding of ESR1 and GOPC	2	1	0.02	0.61	0
9	INT329746	ENG Positive_regulation of SMAD1	1	1	0.15	0.44	0
10	INT329745	AKT1 Negative_regulation of BAD	1	1	0.03	1.43	0
11	INT329747	AKT1 Negative_regulation of GSK	1	1	0.09	1.55	0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT10832	Gene_expression of IL8	1	1050	0.78	698.72	270
2	INT68684	Gene_expression of VEGFA	3	2371	0.78	1742.52	259.2
3	INT65600	Positive_regulation of Casp3	1	376	0.70	198.44	128.03
4	INT27096	Positive_regulation of Nfkb1	1	325	0.70	195.11	109.06
5	INT68682	Positive_regulation of VEGFA	2	640	0.70	454.14	81.65
6	INT56298	Gene_expression of IL4	1	306	0.78	182.18	72.92
7	INT10837	Positive_regulation of Gene_expression of IL8	1	294	0.70	190.08	70.34
8	INT79494	Positive_regulation of Gene_expression of VEGFA	1	577	0.70	442.94	69.73
9	INT17401	Gene_expression of IGF1	1	475	0.78	232.18	62.07
10	INT103924	Positive_regulation of Akt1	1	359	0.69	158.94	60.34
11	INT73048	Gene_expression of MMP9	3	268	0.77	159.75	57.81
12	INT69876	Negative_regulation of Nfkb1	1	147	0.58	89.81	55.5
13	INT7093	Negative_regulation of CYP2B6	3	146	0.58	37.3	48.39
14	INT26500	Gene_expression of MMP2	6	201	0.78	110.57	46.9
15	INT157666	Positive_regulation of GOPC	1	335	0.60	120.19	42.75
16	INT9082	Positive_regulation of ESR1	1	238	0.69	148.51	36.69
17	INT10796	Gene_expression of CYP2B6	3	131	0.77	30.14	35.27
18	INT7675	Gene_expression of ENG	1	146	0.77	45.35	34.6
19	INT11764	Positive_regulation of ENG	2	78	0.61	27.65	33.69
20	INT73498	Gene_expression of IL13	1	117	0.44	83.85	32.26
21	INT48693	Regulation of VEGFA	1	268	0.62	191.88	31.52
22	INT65960	Gene_expression of BCL2	2	352	0.78	312.03	30.73
23	INT20462	Binding of ESR1	7	210	0.44	102.7	26.34
24	INT34488	Negative_regulation of MMP2	2	85	0.59	41.98	21.72
25	INT62042	Positive_regulation of Gene_expression of IL4	1	67	0.56	42.05	20.39
26	INT86187	Positive_regulation of AKT1	2	199	0.69	122.13	19.44
27	INT10214	Gene_expression of VIM	1	153	0.78	115.88	16.29
28	INT142464	Gene_expression of Socs3	1	58	0.77	52.04	15.34
29	INT5333	Gene_expression of NPEPPS	1	45	0.65	26.34	15.25
30	INT26501	Positive_regulation of Gene_expression of MMP2	1	51	0.67	39	15.16
31	INT24670	Gene_expression of FGF2	2	121	0.78	85.64	15.12
32	INT7674	Regulation of ENG	1	42	0.30	11.41	14.44
33	INT72127	Protein_catabolism of MMRN1	3	68	0.52	56	14.13
34	INT89395	Negative_regulation of AKT1	1	127	0.58	70.27	12.54
35	INT28952	Negative_regulation of Gene_expression of IGF1	1	75	0.58	41.11	12.32
36	INT93715	Negative_regulation of MMP9	2	69	0.55	36.05	11.73
37	INT70877	Gene_expression of PPIG	13	72	0.75	22.39	10.93
38	INT110178	Phosphorylation of MAPK14	1	40	0.68	19.38	10.37
39	INT89282	Regulation of MMP9	1	39	0.60	25.45	10.34
40	INT126031	Negative_regulation of Gene_expression of MMP9	2	40	0.57	22.71	9.79
41	INT68372	Regulation of CYP2C9	1	28	0.62	5.64	9.53
42	INT26502	Negative_regulation of Gene_expression of MMP2	5	39	0.58	21.45	9.42
43	INT7673	Negative_regulation of ENG	1	31	0.42	7.9	8.61
44	INT108202	Positive_regulation of PIK3CG	1	47	0.67	25.83	8.25
45	INT73595	Positive_regulation of BAX	1	61	0.61	56.97	7.82
46	INT111607	Gene_expression of CDH1	1	103	0.75	90.45	7.77
47	INT57922	Gene_expression of CYP2C9	5	65	0.78	22.24	7.53
48	INT23375	Binding of ENG	1	17	0.47	6.02	6.46
49	INT2039	Regulation of CYP2B6	1	30	0.60	7.75	6.43
50	INT43415	Gene_expression of CYP4A11	6	11	0.56	7.65	5.94
51	INT111545	Phosphorylation of VEGFA	1	50	0.76	22.19	5.88
52	INT113112	Negative_regulation of CXCR4	1	39	0.58	28.28	5.36
53	INT95120	Positive_regulation of CASP9	3	76	0.67	67.55	5.33
54	INT87420	Gene_expression of BCL2L1	1	56	0.75	48.84	5.32
55	INT39256	Localization of PTGS1	1	17	0.74	6.62	5.1
56	INT124136	Positive_regulation of YWHAZ	1	7	0.67	1.85	4.51
57	INT94863	Gene_expression of Litaf	1	27	0.65	10.21	4.35
58	INT50581	Regulation of PPIG	1	26	0.55	8.96	4.32
59	INT5332	Negative_regulation of Gene_expression of NPEPPS	1	11	0.04	7.79	4.29
60	INT87345	Phosphorylation of PTK2	2	110	0.82	59.39	4.28
61	INT73503	Positive_regulation of Gene_expression of IL13	1	16	0.37	14.6	4.23
62	INT101857	Negative_regulation of BCL2L1	1	22	0.57	23.56	3.95
63	INT124579	Localization of BAX	1	35	0.78	30.31	3.43
64	INT89392	Negative_regulation of Positive_regulation of AKT1	1	23	0.50	15.69	3.02
65	INT102233	Gene_expression of MMP7	1	40	0.76	15.78	2.93
66	INT90875	Negative_regulation of CCND1	1	31	0.42	26.22	2.66
67	INT169987	Transcription of GOPC	1	45	0.60	21.88	2.61
68	INT138437	Gene_expression of Sphk1	2	23	0.65	10.01	2.61
69	INT110179	Negative_regulation of Phosphorylation of MAPK14	1	11	0.36	5.25	2.38
70	INT29402	Gene_expression of Src	1	16	0.74	4.57	2.29
71	INT55736	Transcription of MMP2	1	11	0.68	5.78	2.28
72	INT179101	Gene_expression of CYP4F3	1	14	0.65	6.89	1.98
73	INT100046	Gene_expression of BTG2	1	16	0.20	10.81	1.95
74	INT65880	Gene_expression of CYP2C8	3	25	0.77	9.49	1.92
75	INT197166	Gene_expression of Cyp4a10	1	27	0.75	15.63	1.81
76	INT122487	Positive_regulation of Positive_regulation of CASP9	1	16	0.67	17.88	1.79
77	INT111603	Positive_regulation of Gene_expression of CDH1	1	14	0.49	11.17	1.72
78	INT104220	Positive_regulation of Gene_expression of PPIG	7	14	0.49	7.38	1.7
79	INT67704	Negative_regulation of Negative_regulation of CYP2B6	1	3	0.41	1.69	1.66
80	INT116110	Positive_regulation of PTK2	4	20	0.66	10.53	1.64
81	INT113110	Negative_regulation of CXCL12	1	8	0.43	6.01	1.63
82	INT197173	Positive_regulation of Cyp4a10	1	29	0.62	15.68	1.61
83	INT197174	Positive_regulation of Gene_expression of Cyp4a10	1	17	0.67	8.65	1.4
84	INT123754	Gene_expression of Bcl2l2	1	4	0.65	4.36	1.38
85	INT110550	Regulation of CYP2C8	1	3	0.45	1.59	1.34
86	INT71281	Positive_regulation of Gene_expression of CYP2C9	1	13	0.62	5.11	1.3
87	INT87343	Negative_regulation of Phosphorylation of PTK2	2	34	0.59	18.38	1.19
88	INT87346	Binding of PTK2	2	6	0.37	4.03	1.18
89	INT135556	Localization of AKT1	1	38	0.69	12.78	1.17
90	INT28083	Negative_regulation of Gene_expression of VIM	1	9	0.41	7.23	1.17
91	INT111605	Positive_regulation of CDH1	1	12	0.50	7.95	1.15
92	INT149035	Positive_regulation of Cyp2c11	1	5	0.62	3.35	1.08
93	INT87344	Gene_expression of PTK2	3	90	0.78	59.03	0.87
94	INT306854	Positive_regulation of CDC25A	1	3	0.37	1.57	0.82
95	INT70019	Binding of BCL2	1	25	0.47	17.55	0.79
96	INT148984	Positive_regulation of Localization of BAX	1	6	0.48	5.29	0.77
97	INT258791	Positive_regulation of CDK1	2	14	0.45	5.73	0.74
98	INT53386	Negative_regulation of Cyp4a10	1	7	0.32	4.13	0.7
99	INT199793	Gene_expression of CYP2J2	15	18	0.68	19.6	0.67
100	INT203749	Binding of FOXM1	4	10	0.31	6.1	0.64
101	INT174239	Gene_expression of CYP2C18	1	5	0.65	2.25	0.63
102	INT263233	Positive_regulation of CYP2J2	2	2	0.40	3.1	0.63
103	INT162444	Positive_regulation of CYP4A11	2	4	0.43	4.11	0.61
104	INT323284	Negative_regulation of EPHX2	5	4	0.14	8.25	0.54
105	INT117998	Positive_regulation of Gene_expression of Src	1	4	0.36	1.45	0.51
106	INT57462	Gene_expression of Cyp4a	1	5	0.65	2.4	0.48
107	INT62272	Negative_regulation of CDK1	1	9	0.57	6.46	0.46
108	INT185835	Negative_regulation of Gene_expression of MMP7	1	4	0.35	2.35	0.46
109	INT57460	Positive_regulation of Gene_expression of cyp4a	1	3	0.45	1.05	0.42
110	INT158641	Positive_regulation of CHEK2	1	5	0.35	4.15	0.37
111	INT233007	Negative_regulation of VIM	1	6	0.41	3.46	0.36
112	INT83287	Regulation of Gene_expression of PPIG	1	4	0.46	1.74	0.36
113	INT181918	Positive_regulation of SMAD3	1	6	0.35	2.62	0.31
114	INT148796	Regulation of Phosphorylation of VEGFA	1	3	0.35	1.66	0.26
115	INT339567	Positive_regulation of Negative_regulation of EPHX2	1	1	0.10	0.55	0.26
116	INT339556	Negative_regulation of Negative_regulation of EPHX2	1	1	0.09	0.55	0.26
117	INT179920	Regulation of Litaf	1	2	0.44	1.13	0.23
118	INT87338	Regulation of PTK2	1	10	0.62	4.75	0.21
119	INT292483	Negative_regulation of Positive_regulation of PTK2	4	2	0.41	3.51	0.18
120	INT173184	Regulation of CDK1	1	4	0.30	2.97	0.15
121	INT339538	Gene_expression of Cyp2c44	2	1	0.58	1.95	0.14
122	INT185872	Localization of BAK1	1	6	0.74	11.28	0.12
123	INT265485	Positive_regulation of Localization of BAK1	1	4	0.50	5.17	0.12
124	INT339555	Binding of EPHX2	2	1	0.09	0	0.12
125	INT339564	Regulation of Localization of CYP2J2	1	1	0.30	0.47	0.12
126	INT339554	Localization of CYP2J2	1	1	0.49	0.47	0.12
127	INT144198	Positive_regulation of HSPB2	1	7	0.48	5.66	0.11
128	INT203751	Negative_regulation of FOXM1	1	2	0.20	0.94	0.11
129	INT333011	Positive_regulation of Eltd1	1	2	0.03	0.56	0.09
130	INT252551	Phosphorylation of CHEK2	1	4	0.48	4.73	0.08
131	INT183123	Phosphorylation of FGF2	1	3	0.30	1.2	0.08
132	INT339566	Positive_regulation of Gene_expression of CYP2J2	2	3	0.61	2.22	0.08
133	INT194789	Phosphorylation of HSPB2	3	2	0.30	2.61	0.08
134	INT144400	Positive_regulation of Gene_expression of PTK2	2	33	0.70	21.24	0.06
135	INT339557	Phosphorylation of CYP2J2	1	1	0.54	0	0.05
136	INT329775	Regulation of Regulation of PTK2	1	1	0.11	0.49	0.05
137	INT339560	Gene_expression of CYP4X1	1	1	0.20	0	0.04
138	INT339559	Gene_expression of CYP2U1	1	1	0.18	0	0.04
139	INT339568	Localization of CYP4A11	1	1	0.01	0.05	0.03
140	INT329787	Regulation of CCNB1	1	1	0.08	1.21	0.03
141	INT339551	Gene_expression of EPHX2	5	1	0.18	8.11	0.03
142	INT116842	Negative_regulation of CYP2J2	2	4	0.39	3.31	0
143	INT262779	Localization of PTK2	1	3	0.71	2.75	0
144	INT339558	Transcription of CYP2J2	2	3	0.63	3.49	0
145	INT329776	Gene_expression of TRAM1	1	2	0.18	0.86	0
146	INT280155	Gene_expression of MAP2K4	1	2	0.30	1.56	0
147	INT339539	Positive_regulation of Gene_expression of Ephb4	1	1	0.17	0.06	0
148	INT329771	Positive_regulation of SMAD1	5	1	0.36	2.3	0
149	INT329784	Gene_expression of SMAD3	1	1	0.31	0.41	0
150	INT329780	Negative_regulation of Positive_regulation of SMAD1	1	1	0.22	0.51	0
151	INT329769	Positive_regulation of Localization of PTK2	1	1	0.17	1.42	0
152	INT339537	Gene_expression of Ephb4	1	1	0.19	0.06	0
153	INT329765	Negative_regulation of Gene_expression of MAP2K4	1	1	0.19	0.54	0
154	INT339561	Regulation of Gene_expression of CYP2J2	1	1	0.26	1.42	0
155	INT329779	Positive_regulation of CHEK1	1	1	0.22	0.76	0
156	INT329761	Negative_regulation of MAP2K4	4	1	0.26	2.36	0
157	INT339552	Positive_regulation of Gene_expression of EPHX2	3	1	0.16	5.37	0
158	INT329762	Positive_regulation of CDC25C	1	1	0.22	0.82	0
159	INT329767	Regulation of MAP2K4	1	1	0.28	0.55	0
160	INT329763	Phosphorylation of CDC25A	1	1	0.23	0.81	0
161	INT329772	Phosphorylation of CDC25C	1	1	0.28	0.81	0
162	INT329783	Phosphorylation of CHEK1	1	1	0.26	0.82	0
163	INT329766	Positive_regulation of Positive_regulation of PTK2	1	1	0.11	0.51	0
164	INT329786	Negative_regulation of Phosphorylation of HSPB2	1	1	0.21	1.04	0
165	INT339565	Protein_catabolism of CYP4A11	1	1	0.01	0	0