J:Cephalalgia

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT1392 Trh Regulation of Prl 15 3 0.29 2.47 4.29
2 INT24934 Calca Regulation of Nka1 3 1 0.05 0.43 1.73
3 INT70226 Binding of TAC1 and B3GAT1 4 1 0.24 4.5 1.26
4 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 2 0.08 0.75 1.2
5 INT58745 CPP Positive_regulation of Localization of Prl 1 1 0.01 0.92 1.06
6 INT54972 Binding of EDNRA and EDNRB 7 1 0.52 3.31 0.97
7 INT103833 Sp5 Positive_regulation of Fos 1 2 0.51 0 0.96
8 INT117404 Binding of Pnoc and OR4F4 1 1 0.00 0.46 0.86
9 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 1 0.09 0.16 0.85
10 INT124877 Gnat3 Negative_regulation of FOS 1 1 0.09 0.15 0.82
11 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 1 0.09 0.15 0.82
12 INT130948 Amt Regulation of Gene_expression of LEP 1 1 0.00 1.04 0.78
13 INT110130 NR3C1 Regulation of ADORA1 1 1 0.04 0.73 0.77
14 INT130949 Amt Regulation of LEP 1 1 0.00 1.04 0.77
15 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 1 0.23 0.07 0.76
16 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 1 0.03 0.24 0.65
17 INT104162 HTR1D Regulation of Localization of CALCA 1 1 0.31 0.28 0.58
18 INT27730 Binding of ALB and Shbg 2 1 0.01 0.44 0.5
19 INT19906 Positive_regulation of Trh Regulation of Prl 2 1 0.04 0.47 0.43
20 INT70227 Binding of Calca and B3GAT1 1 1 0.36 0.35 0.42
21 INT35201 Trh Regulation of Tshb 1 1 0.01 0.28 0.39
22 INT19905 Trh Regulation of Gnrhr 1 1 0.00 0.25 0.22

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 21 2431 0.81 378.96 952.2
2 INT5228 Positive_regulation of Fos 3 934 0.70 209.8 503.87
3 INT155 Positive_regulation of Prl 13 1233 0.70 317.93 457.82
4 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
5 INT467 Gene_expression of POMC 6 1048 0.78 332.8 394.16
6 INT6580 Negative_regulation of Ptgs1 2 929 0.59 381.53 376.26
7 INT157 Positive_regulation of Localization of Prl 6 790 0.70 104.54 374.78
8 INT720 Positive_regulation of POMC 3 807 0.70 237.37 353.83
9 INT16260 Gene_expression of Bdnf 3 671 0.78 283.44 339.1
10 INT162 Regulation of Prl 11 794 0.62 165.01 322.24
11 INT5979 Gene_expression of Oprd1 1 428 0.78 75.64 320.32
12 INT5680 Gene_expression of Ngf 3 530 0.78 264.29 310.56
13 INT161 Regulation of Localization of Prl 7 615 0.62 65.37 298.66
14 INT5379 Gene_expression of Fos 2 656 0.78 255.5 292.54
15 INT1893 Localization of Gh 10 1041 0.79 340.23 256.58
16 INT738 Regulation of POMC 2 459 0.62 111.19 243.74
17 INT11377 Positive_regulation of Ngf 1 331 0.70 206.5 238
18 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
19 INT626 Localization of CALCA 11 289 0.81 125.39 221.15
20 INT6665 Gene_expression of FOS 6 520 0.77 165.31 217.66
21 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
22 INT48955 Gene_expression of Nos2 3 753 0.78 403.87 208.08
23 INT156 Negative_regulation of Prl 5 542 0.59 131.97 192.24
24 INT528 Gene_expression of Prl 6 693 0.78 217.18 192.2
25 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
26 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
27 INT159 Negative_regulation of Localization of Prl 4 416 0.59 55.34 171.8
28 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
29 INT5127 Localization of Lhb 1 488 0.80 50.48 162.66
30 INT3448 Positive_regulation of Gh 6 521 0.69 180.03 161.18
31 INT768 Positive_regulation of Oprl1 1 179 0.70 40.05 156.93
32 INT5050 Regulation of Localization of Calca 8 149 0.62 41.25 148.57
33 INT2541 Binding of Calca 7 200 0.48 67.14 134.62
34 INT62124 Gene_expression of NOS1 6 444 0.78 218.08 114.85
35 INT1793 Localization of CGA 1 379 0.81 67.38 114.69
36 INT1530 Regulation of Gh 5 382 0.61 115.96 112.47
37 INT48923 Gene_expression of Ephb1 1 211 0.77 106.23 109.9
38 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
39 INT4936 Localization of Tacr1 1 125 0.80 35.7 107.7
40 INT915 Positive_regulation of PRL 1 342 0.70 141.96 104.31
41 INT4742 Gene_expression of Tac1 2 177 0.78 69.99 102.66
42 INT7944 Positive_regulation of Fos 2 193 0.70 60.69 98.31
43 INT4860 Positive_regulation of CALCA 10 148 0.00 73.35 97.61
44 INT17459 Positive_regulation of Gene_expression of FOS 4 182 0.67 53.45 96.38
45 INT5865 Positive_regulation of Localization of Gh 1 282 0.69 84.86 93.5
46 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
47 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
48 INT67682 Localization of Bdnf 1 204 0.81 72.36 88.92
49 INT1635 Gene_expression of Vip 1 245 0.78 53.36 88.13
50 INT339 Regulation of Trh 3 156 0.62 39.27 83.55
51 INT1309 Positive_regulation of Localization of Gnrhr 1 152 0.69 24.25 81.56
52 INT403 Localization of Trh 2 241 0.81 28.55 81.45
53 INT1498 Gene_expression of Gh 2 521 0.75 220.84 81.16
54 INT148 Positive_regulation of Gnrhr 2 182 0.70 47.44 79.64
55 INT17546 Negative_regulation of Ngf 1 135 0.59 60.28 77.19
56 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
57 INT10274 Positive_regulation of Il1b 4 123 0.70 79.76 73.56
58 INT5128 Positive_regulation of Lhb 1 232 0.69 44.23 71.26
59 INT6490 Negative_regulation of ADCY1 1 145 0.58 26.25 70.96
60 INT1377 Positive_regulation of Trh 5 172 0.70 40.55 69.83
61 INT66416 Regulation of Pnoc 3 66 0.61 17.32 68.91
62 INT7344 Gene_expression of TAC1 4 132 0.75 35.48 68.26
63 INT462 Regulation of Pomc 1 157 0.62 41.67 67.27
64 INT253 Regulation of PRL 1 184 0.62 47.27 65.79
65 INT8347 Gene_expression of SST 3 181 0.78 104.59 65.45
66 INT66531 Gene_expression of Pnoc 3 88 0.78 22.9 65.11
67 INT1599 Positive_regulation of ADCY1 3 146 0.67 30.05 64.9
68 INT47690 Regulation of Bdnf 1 118 0.62 53.02 64.5
69 INT546 Binding of ALB 1 311 0.48 85.98 60.14
70 INT65078 Negative_regulation of Pnoc 4 64 0.59 15.48 59.81
71 INT3161 Regulation of Localization of Gh 3 163 0.61 35.43 59.45
72 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
73 INT74389 Gene_expression of Gdnf 3 131 0.78 58.52 57.06
74 INT5356 Positive_regulation of FOS 3 153 0.69 54.21 56.74
75 INT48891 Positive_regulation of Il10 1 143 0.70 101.42 56.72
76 INT17458 Negative_regulation of Gene_expression of FOS 1 98 0.57 36.77 55.69
77 INT19 Regulation of Gnrhr 4 131 0.62 36.4 55.66
78 INT8528 Negative_regulation of Gene_expression of Fos 1 100 0.59 41.15 55.6
79 INT1579 Gene_expression of PRL 3 279 0.78 119.2 55.41
80 INT4241 Regulation of CALCA 5 87 0.62 28.19 55.29
81 INT8700 Positive_regulation of Positive_regulation of Calca 2 56 0.67 21.69 53.66
82 INT5118 Regulation of SST 1 97 0.62 34.35 51.74
83 INT83199 Gene_expression of Nos3 4 193 0.78 100.72 51.57
84 INT8690 Localization of Tac1 1 71 0.80 22.98 50.75
85 INT2197 Gene_expression of Gnrh1 1 184 0.78 40.04 50.57
86 INT7093 Negative_regulation of CYP2B6 1 146 0.58 37.3 48.39
87 INT17881 Gene_expression of LEP 3 278 0.78 221.61 48.31
88 INT1197 Negative_regulation of Localization of POMC 2 109 0.59 28.29 48.02
89 INT1977 Negative_regulation of Positive_regulation of Prl 1 98 0.59 17.06 47.88
90 INT8713 Regulation of Tac1 1 56 0.60 25.29 45.94
91 INT619 Positive_regulation of Positive_regulation of Prl 1 116 0.70 22.69 45.06
92 INT14853 Negative_regulation of Tac1 1 80 0.59 30.87 45.06
93 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
94 INT19078 Binding of Ngf 1 78 0.48 31.03 44.33
95 INT47683 Negative_regulation of Bdnf 1 92 0.59 47.53 43.55
96 INT52531 Gene_expression of Nfkb1 1 153 0.75 82.84 42.9
97 INT11406 Positive_regulation of Localization of CALCA 2 49 0.70 20.64 42.8
98 INT5539 Negative_regulation of Mme 1 75 0.59 28.91 41.84
99 INT3987 Positive_regulation of IGHE 2 316 0.70 283.2 40.16
100 INT47939 Gene_expression of Selp 1 171 0.76 87.54 39.03
101 INT2531 Positive_regulation of Cebpz 1 166 0.00 43.08 38.86
102 INT8835 Localization of SFTPA1 1 65 0.68 32.81 38.65
103 INT5711 Positive_regulation of Localization of Lhb 1 90 0.70 10.92 36.76
104 INT2416 Negative_regulation of MAOA 1 92 0.59 42.24 36.5
105 INT64436 Gene_expression of P2rx1 1 93 0.78 32.69 36.12
106 INT1976 Regulation of Gene_expression of Prl 1 80 0.62 20.19 36
107 INT59466 Gene_expression of ISYNA1 3 204 0.77 112.57 35.48
108 INT316 Regulation of Cebpz 7 105 0.00 27.21 35.41
109 INT2296 Positive_regulation of Gene_expression of Prl 3 137 0.70 36.96 35.39
110 INT326 Gene_expression of Gnrhr 2 105 0.76 35.87 34.93
111 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
112 INT2732 Gene_expression of VIP 3 74 0.78 24.57 33.72
113 INT4727 Regulation of TAC1 1 60 0.47 6.74 32.83
114 INT2330 Regulation of CB 3 78 0.10 20.46 32.6
115 INT13897 Localization of Sst 1 65 0.81 14.91 32.24
116 INT11087 Positive_regulation of Drd2 4 54 0.69 12.4 31.43
117 INT1179 Negative_regulation of Ace 1 157 0.59 67.03 30.46
118 INT19396 Regulation of Rac1 1 66 0.53 37.41 30.01
119 INT64113 Positive_regulation of Gene_expression of NOS1 3 110 0.60 71.03 29.72
120 INT651 Positive_regulation of PTGS1 2 93 0.69 37.27 29.18
121 INT23463 Positive_regulation of Gene_expression of CALCA 2 47 0.70 18.14 28.76
122 INT10506 Gene_expression of PTAFR 5 86 0.76 37.57 28.58
123 INT1196 Positive_regulation of Positive_regulation of POMC 1 51 0.70 15.99 28.58
124 INT7035 Regulation of CGA 1 87 0.45 29.04 28.45
125 INT6364 Gene_expression of Edn1 1 123 0.78 73.76 28.43
126 INT8698 Localization of Nka1 1 50 0.78 5.8 27.67
127 INT9296 Negative_regulation of PLEK 1 100 0.57 36.65 27.52
128 INT7894 Negative_regulation of Vip 1 59 0.59 11.76 27.36
129 INT703 Positive_regulation of Pth 1 177 0.70 127.09 27.26
130 INT97 Negative_regulation of Adrb1 2 102 0.59 32.44 26.9
131 INT5378 Regulation of Gene_expression of Fos 1 47 0.60 14.47 26.41
132 INT20462 Binding of ESR1 1 210 0.44 102.7 26.34
133 INT63769 Regulation of Ngf 2 44 0.62 21.82 25.84
134 INT2614 Gene_expression of CGA 2 187 0.78 105.89 24.77
135 INT12484 Binding of Drd2 1 45 0.48 15.17 24.72
136 INT48766 Regulation of NOS1 3 73 0.61 37.01 24.59
137 INT47459 Gene_expression of Rac1 1 101 0.68 45.27 24.33
138 INT4756 Positive_regulation of Nrtim1 2 37 0.33 14.6 24.12
139 INT6726 Positive_regulation of Edn1 1 118 0.70 65.96 24.07
140 INT4809 Gene_expression of PTGDS 1 103 0.76 52.94 24.01
141 INT18894 Gene_expression of CPP 1 44 0.77 23.05 23.05
142 INT6270 Binding of HTR1D 2 55 0.47 9.54 22.86
143 INT11077 Positive_regulation of Htr3a 1 63 0.67 15.61 22.7
144 INT7383 Localization of VIP 3 53 0.81 17.7 22.65
145 INT8699 Gene_expression of Nka1 2 45 0.67 6.41 22.56
146 INT12114 Positive_regulation of Tnfrsf1a 1 46 0.69 36.26 22.54
147 INT70504 Regulation of Gene_expression of NOS1 3 30 0.51 21.72 21.72
148 INT9079 Gene_expression of PPBP 2 52 0.75 31.2 21.52
149 INT8358 Negative_regulation of Localization of CALCA 1 25 0.59 11.79 21.51
150 INT5916 Positive_regulation of HTR1A 1 51 0.67 18.27 21.38
151 INT955 Gene_expression of GHRH 1 126 0.78 59.91 20.74
152 INT49774 Binding of DRD2 1 48 0.48 17.42 20.73
153 INT1512 Binding of Prl 1 73 0.48 26.22 20.63
154 INT82434 Positive_regulation of LEP 2 117 0.70 95.45 20.22
155 INT9782 Binding of HTR1B 1 43 0.47 12.08 19.83
156 INT7336 Positive_regulation of VIP 3 60 0.70 24.2 19.62
157 INT75742 Binding of RLS 3 86 0.42 95.27 19.04
158 INT5372 Localization of LHB 1 55 0.68 9.47 19
159 INT13454 Positive_regulation of Positive_regulation of Gh 1 49 0.68 14.53 18.49
160 INT11275 Regulation of Fos 3 37 0.60 5.79 18.18
161 INT3118 Negative_regulation of Positive_regulation of POMC 1 33 0.59 9.42 18.07
162 INT117500 Gene_expression of Adipoq 2 90 0.74 67.79 16.58
163 INT59365 Gene_expression of HTR1A 4 41 0.75 16.31 16.57
164 INT10918 Gene_expression of ITGB2 1 93 0.76 71.8 16.34
165 INT22909 Positive_regulation of Chdh 2 26 0.68 28.69 16.13
166 INT11508 Positive_regulation of TGFBI 2 24 0.70 19.81 15.78
167 INT4719 Positive_regulation of Nka1 1 27 0.67 4.16 15.42
168 INT75908 Regulation of LEP 1 77 0.60 60.16 15.19
169 INT26729 Negative_regulation of Drd2 2 28 0.55 9.32 15.17
170 INT74098 Negative_regulation of Gene_expression of Nos1 3 36 0.59 16.25 14.82
171 INT95 Positive_regulation of Adrb1 2 34 0.62 11.95 14.41
172 INT20071 Positive_regulation of HTR2A 1 33 0.67 10.89 14
173 INT11069 Positive_regulation of Pf4 6 35 0.68 27.7 13.96
174 INT5806 Regulation of Edn1 1 63 0.62 23.46 13.88
175 INT22272 Negative_regulation of HTR2A 1 28 0.57 7.62 13.87
176 INT110 Regulation of Adrb3 1 33 0.60 8.09 13.84
177 INT73594 Positive_regulation of Gene_expression of ISYNA1 2 61 0.55 31.35 13.45
178 INT11071 Positive_regulation of PPBP 3 43 0.68 26.85 13.43
179 INT95427 Positive_regulation of Mmp3 1 39 0.70 15.28 13.36
180 INT39046 Positive_regulation of PTGER1 1 28 0.69 18.18 13.21
181 INT83200 Positive_regulation of Gene_expression of Nos3 3 48 0.70 24.75 12.99
182 INT22003 Negative_regulation of Cpe 1 25 0.58 6.23 12.94
183 INT30961 Binding of HTR2A 1 33 0.47 11.44 12.86
184 INT4137 Positive_regulation of C3 2 73 0.69 48.57 12.63
185 INT3040 Gene_expression of MIA3 2 81 0.24 53.61 12.62
186 INT5987 Positive_regulation of Positive_regulation of Oprl1 1 11 0.49 2.81 12.57
187 INT90909 Negative_regulation of Gene_expression of NOS1 1 44 0.55 23.83 12.47
188 INT10847 Gene_expression of LAMC2 1 39 0.75 27 12.09
189 INT11429 Gene_expression of ADCY1 1 26 0.74 5.89 11.93
190 INT53866 Gene_expression of Sstr4 1 17 0.77 6.67 11.83
191 INT14867 Gene_expression of Igh-6 2 47 0.67 30.05 11.75
192 INT1190 Positive_regulation of F2 1 53 0.70 46.41 11.64
193 INT13303 Positive_regulation of PTAFR 1 40 0.69 16.27 11.56
194 INT14420 Regulation of Nka1 2 12 0.45 3.82 11.33
195 INT70816 Negative_regulation of Fos 1 32 0.58 13 11.18
196 INT987 Localization of TRH 1 37 0.78 10.53 11.1
197 INT11208 Gene_expression of Cpe 1 23 0.78 2.42 11.09
198 INT9946 Regulation of Localization of LHB 1 27 0.52 2.47 11.08
199 INT14132 Negative_regulation of HTR1A 1 25 0.57 4.93 10.91
200 INT3637 Positive_regulation of Localization of Trh 1 33 0.70 2.13 10.55
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