J:Circ. Res.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 1 0.25 0.15 1.15
2 INT156238 Binding of F2rl1 and Tnfsf14 1 3 0.08 2.85 1.08
3 INT91395 MMP2 Positive_regulation of CALCA 1 1 0.36 0.17 1.07
4 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 2 0.09 2.4 0.81
5 INT82767 Binding of HP and MLRG 1 1 0.00 0 0.71
6 INT109065 Pdyn Positive_regulation of Gene_expression of Gata4 1 2 0.00 0 0.58
7 INT128431 SLC6A4 Regulation of S100A4 1 2 0.48 0.65 0.53
8 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 1 0.09 1.26 0.42
9 INT156237 Binding of F2r and Tnfsf14 1 1 0.02 1.14 0.4
10 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 1 0.09 1.15 0.4
11 INT157147 LSS Positive_regulation of PTGIR 1 1 0.09 0.96 0.36
12 INT157148 LSS Negative_regulation of TNF 1 1 0.25 0.74 0.35
13 INT156235 Tnfsf14 Positive_regulation of F2r 1 1 0.03 1.03 0.35
14 INT157150 Positive_regulation of PTGIR Negative_regulation of Gene_expression of TNF 1 1 0.12 0.97 0.34
15 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 1 0.01 0 0.29
16 INT128432 HTR1B Regulation of S100A4 1 1 0.49 0.28 0.24
17 INT118840 VEGFA Regulation of Positive_regulation of Mb 1 1 0.05 0.36 0.23
18 INT118838 Gene_expression of Vegfa Positive_regulation of Gene_expression of Mb 1 1 0.44 0.4 0.22
19 INT157146 LSS Negative_regulation of Positive_regulation of TNF 1 1 0.25 1.08 0.21
20 INT157151 LSS Positive_regulation of CPOX 1 1 0.17 0.89 0.05
21 INT118839 VEGFA Positive_regulation of Mb 1 1 0.13 0.15 0.03
22 INT164618 Binding of SLCO2B1 and Positive_regulation of ABCC1 1 2 0.52 0.18 0
23 INT164622 SLCO2B1 Positive_regulation of Gene_expression of ABCC1 1 2 0.52 0.18 0
24 INT164624 Binding of SLCO2B1 and Positive_regulation of ABCC4 1 1 0.41 0.09 0
25 INT164620 Binding of SLCO2B1 and Positive_regulation of ABCC5 1 1 0.41 0.09 0
26 INT164623 SLCO2B1 Positive_regulation of ABCC5 1 1 0.41 0.09 0
27 INT164619 SLCO2B1 Positive_regulation of ABCC4 1 1 0.41 0.09 0
28 INT164625 SLCO2B1 Positive_regulation of ABCC1 1 2 0.52 0.18 0
29 INT164621 Binding of SLCO2B1 and Positive_regulation of Gene_expression of ABCC1 1 2 0.52 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
2 INT64202 Positive_regulation of Trpv1 1 643 0.70 249.66 397.42
3 INT76660 Gene_expression of Trpv1 1 691 0.78 329.46 386.42
4 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
5 INT4941 Positive_regulation of Oprd1 2 345 0.70 74.26 304.41
6 INT9381 Positive_regulation of TRPV1 4 523 0.70 187.4 276.05
7 INT49750 Negative_regulation of CPOX 2 735 0.58 360.06 274.19
8 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
9 INT5972 Gene_expression of IL1B 2 948 0.78 510.91 263.97
10 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
11 INT87687 Positive_regulation of Trpv1 2 409 0.70 210.24 257.59
12 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
13 INT5597 Gene_expression of Pdyn 2 433 0.78 62.97 235.47
14 INT626 Localization of CALCA 2 289 0.81 125.39 221.15
15 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
16 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
17 INT2867 Gene_expression of CALCA 2 247 0.78 78.78 138.47
18 INT5595 Positive_regulation of Pdyn 1 223 0.70 48.37 130.14
19 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
20 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
21 INT4860 Positive_regulation of CALCA 2 148 0.00 73.35 97.61
22 INT4822 Localization of Ca2 5 417 0.80 99.57 96.45
23 INT3537 Positive_regulation of Car2 1 413 0.56 103.51 94.35
24 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
25 INT25363 Negative_regulation of Trpv1 1 144 0.59 64.78 75.7
26 INT98621 Regulation of Trpv1 1 121 0.62 79.24 75.23
27 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
28 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
29 INT19511 Localization of Il6 1 212 0.81 118.17 67.67
30 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
31 INT50672 Positive_regulation of CPOX 4 205 0.44 125.93 60.06
32 INT7491 Localization of Pdyn 1 80 0.81 3.94 58.77
33 INT4241 Regulation of CALCA 1 87 0.62 28.19 55.29
34 INT72182 Gene_expression of Mcpt1 2 167 0.75 123.7 52.15
35 INT26500 Gene_expression of MMP2 1 201 0.78 110.57 46.9
36 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
37 INT935 Localization of Gtf3a 3 124 0.70 35.72 43.3
38 INT11406 Positive_regulation of Localization of CALCA 2 49 0.70 20.64 42.8
39 INT48222 Positive_regulation of Localization of IL8 1 123 0.59 78.04 37.2
40 INT53577 Negative_regulation of Localization of TNF 1 110 0.59 59.28 35.23
41 INT64171 Regulation of CPOX 1 109 0.36 55.36 32.96
42 INT65698 Localization of CCL2 1 118 0.81 77.54 32.69
43 INT1159 Negative_regulation of Agt 4 133 0.59 40.14 31.67
44 INT22239 Negative_regulation of TAC1 1 52 0.57 12.96 31.41
45 INT5418 Negative_regulation of Alox5 1 108 0.57 42.09 31.17
46 INT8531 Transcription of PDYN 1 56 0.72 19.51 30.99
47 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
48 INT98522 Gene_expression of Accn3 3 68 0.78 26.95 28.6
49 INT94658 Positive_regulation of F2rl1 1 51 0.70 33.65 27.46
50 INT5596 Negative_regulation of Gene_expression of Pdyn 1 41 0.59 5.34 24.36
51 INT34488 Negative_regulation of MMP2 4 85 0.59 41.98 21.72
52 INT16396 Negative_regulation of CEBPZ 1 76 0.48 30.03 21.6
53 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
54 INT67608 Gene_expression of Pparg 2 41 0.78 25.09 19.53
55 INT30312 Binding of Pdyn 1 30 0.37 4.2 18.23
56 INT90937 Negative_regulation of Gene_expression of Trpv1 1 34 0.59 22.74 18.12
57 INT97984 Negative_regulation of SLC6A4 2 45 0.59 15.43 18.09
58 INT6782 Gene_expression of SCN5A 1 156 0.78 33.13 17.88
59 INT36054 Transcription of IL1B 1 53 0.72 32.64 17.31
60 INT110767 Localization of Mcpt1 1 43 0.68 24.3 16.74
61 INT19929 Negative_regulation of Positive_regulation of TNF 1 52 0.59 38.16 16.51
62 INT109535 Gene_expression of Vegfa 1 116 0.75 84.61 14.89
63 INT5430 Gene_expression of Scn8a 1 37 0.75 4.58 14.82
64 INT42979 Positive_regulation of INSRR 1 47 0.32 12.24 14.38
65 INT104674 Positive_regulation of F2rl1 3 35 0.65 27.76 14.16
66 INT23344 Gene_expression of Alox5 1 60 0.75 28.2 13.82
67 INT4931 Localization of IFNG 1 53 0.78 33.25 13.65
68 INT62441 Gene_expression of ABCC1 4 56 0.78 21.01 12.93
69 INT101494 Regulation of Positive_regulation of Trpv1 1 18 0.62 6.57 12.9
70 INT13409 Gene_expression of NEUROD1 1 52 0.75 14.17 12.23
71 INT10654 Negative_regulation of SGSM3 1 31 0.57 12.24 11.7
72 INT52918 Positive_regulation of Prkca 1 13 0.64 1.67 11
73 INT111223 Positive_regulation of HMOX1 4 47 0.70 39.14 10.92
74 INT10120 Negative_regulation of Positive_regulation of Pdyn 1 14 0.58 6.05 10.19
75 INT109578 Positive_regulation of Accn3 1 16 0.70 9.09 10.05
76 INT33094 Regulation of Localization of Ca2 1 28 0.38 8.65 9.96
77 INT83450 Positive_regulation of Localization of CCL2 1 28 0.70 22.14 9.83
78 INT28312 Gene_expression of ABCA1 2 85 0.72 37.69 9.27
79 INT93191 Gene_expression of Accn2 2 22 0.76 10.04 8.91
80 INT6019 Positive_regulation of NEUROD1 1 37 0.67 17.3 8.89
81 INT17028 Positive_regulation of Scn7a 1 35 0.41 9.83 7.44
82 INT15092 Positive_regulation of SLC6A4 1 17 0.67 7.32 6.7
83 INT34767 Gene_expression of PTGIR 1 36 0.42 14.79 6.69
84 INT18460 Positive_regulation of Transcription of PDYN 1 11 0.67 2.14 6.61
85 INT116641 Phosphorylation of Gsk3a 2 12 0.71 4.3 6.22
86 INT49027 Gene_expression of TYRP1 1 35 0.75 9.81 6.06
87 INT78913 Positive_regulation of Gene_expression of ABCC1 3 22 0.67 5.95 5.82
88 INT82451 Negative_regulation of HMOX1 2 18 0.51 13.29 5.74
89 INT84909 Positive_regulation of SUGT1 1 22 0.08 22.01 5.43
90 INT90202 Protein_catabolism of MMP2 1 15 0.94 7.47 5.41
91 INT34770 Negative_regulation of PTGIR 2 16 0.41 8.52 5.21
92 INT52915 Positive_regulation of Positive_regulation of Prkca 1 4 0.64 0.31 5.21
93 INT90848 Localization of F2rl1 1 23 0.80 3.15 5.2
94 INT68591 Regulation of TYRP1 1 14 0.44 3.93 5.05
95 INT58766 Gene_expression of ANGPT2 1 41 0.67 21.65 4.82
96 INT87156 Phosphorylation of Marcks 1 8 0.40 2.48 4.8
97 INT110768 Transcription of Mcpt1 1 12 0.52 7.66 4.71
98 INT17742 Localization of S100B 1 44 0.80 17.14 4.65
99 INT84911 Gene_expression of SUGT1 1 43 0.11 19.85 4.54
100 INT18995 Binding of CEL 1 23 0.47 14.46 4.5
101 INT75530 Regulation of SGSM3 1 11 0.60 7.22 4.48
102 INT66366 Positive_regulation of Gsk3b 1 15 0.68 6.56 4.27
103 INT118835 Positive_regulation of Vegfa 1 18 0.59 11.2 3.91
104 INT116643 Phosphorylation of Pik3cb 1 12 0.80 4.73 3.87
105 INT116642 Negative_regulation of Gsk3b 2 13 0.57 7.16 3.83
106 INT54886 Negative_regulation of ANGPT2 3 25 0.42 9.33 3.79
107 INT120596 Gene_expression of ABCC4 1 11 0.78 2.51 3.76
108 INT67474 Negative_regulation of B3GAT1 1 9 0.57 5.43 3.73
109 INT116645 Regulation of Pik3cb 3 11 0.41 3.78 3.43
110 INT106318 Gene_expression of S100A4 1 21 0.75 12.13 3.23
111 INT72256 Binding of Accn3 1 6 0.47 2.01 3.2
112 INT164633 Gene_expression of EGFL7 1 23 0.53 10.46 3.1
113 INT66367 Gene_expression of Gsk3b 1 16 0.45 9.75 3.07
114 INT109061 Gene_expression of PRKD1 1 5 0.58 1.8 3.04
115 INT21610 Positive_regulation of ANGPT2 1 23 0.41 13.28 3.03
116 INT106325 Localization of Prkca 1 3 0.05 0.7 2.94
117 INT51993 Gene_expression of PSMA5 1 5 0.75 2.59 2.92
118 INT29938 Positive_regulation of ANTXRL 1 7 0.07 1.83 2.86
119 INT115070 Binding of Accn3 1 4 0.47 3.8 2.7
120 INT86602 Binding of KCNH2 1 14 0.36 4.65 2.58
121 INT19292 Protein_catabolism of CALCA 1 7 0.76 0.8 2.53
122 INT111016 Gene_expression of F2rl1 1 11 0.73 3.58 2.37
123 INT114433 Positive_regulation of Positive_regulation of F2rl1 1 4 0.49 3.5 2.29
124 INT82768 Binding of MLRG 3 5 0.23 0.54 2.22
125 INT106317 Negative_regulation of Gene_expression of S100A4 1 6 0.41 2.86 2.11
126 INT111018 Binding of F2rl1 3 5 0.30 3.11 2.02
127 INT131638 Localization of Scn8a 1 2 0.53 0 1.99
128 INT128030 Gene_expression of GJA1 1 23 0.75 7.81 1.88
129 INT109071 Positive_regulation of Phosphorylation of Marcks 1 2 0.20 0.48 1.88
130 INT109059 Gene_expression of PRKCZ 1 2 0.65 0.64 1.87
131 INT128453 Positive_regulation of S100A4 5 8 0.67 3.24 1.84
132 INT101493 Positive_regulation of F2rl3 2 6 0.45 2.18 1.8
133 INT91396 Positive_regulation of Negative_regulation of MMP2 1 3 0.33 0.97 1.8
134 INT118833 Positive_regulation of Gene_expression of Vegfa 1 11 0.65 8.14 1.7
135 INT119346 Positive_regulation of PTGIR 2 9 0.58 6.2 1.61
136 INT156229 Binding of Tnfsf14 4 5 0.23 4.69 1.6
137 INT156231 Binding of F2r 1 9 0.23 3.78 1.57
138 INT89871 Gene_expression of Gata4 3 11 0.69 1.05 1.53
139 INT933 Regulation of Localization of Gtf3a 1 6 0.11 2.3 1.47
140 INT992 Regulation of S100A4 2 21 0.60 1.47 1.46
141 INT36588 Protein_catabolism of Calca 1 7 0.87 1.98 1.31
142 INT131136 Binding of Accn2 1 3 0.36 1.44 1.23
143 INT67471 Negative_regulation of Gene_expression of PTGIR 1 6 0.12 2.42 1.21
144 INT164634 Regulation of EGFL7 2 4 0.09 3.06 1.15
145 INT21546 Regulation of ABCA1 1 16 0.40 4.21 1.04
146 INT128444 Phosphorylation of SLC6A4 1 2 0.61 0.49 1.02
147 INT109075 Positive_regulation of Transcription of NKX2-5 1 1 0.67 0 1.02
148 INT109069 Transcription of Gata4 1 4 0.64 0.52 1.01
149 INT109070 Positive_regulation of Transcription of Gata4 1 1 0.03 0 1.01
150 INT109074 Transcription of NKX2-5 1 1 0.69 0 1.01
151 INT116646 Regulation of Negative_regulation of Gsk3b 1 2 0.44 0.39 0.99
152 INT105445 Localization of HMOX1 1 5 0.71 3.11 0.98
153 INT118538 Binding of ANG 1 5 0.47 3.02 0.92
154 INT101495 Regulation of Positive_regulation of F2rl1 1 1 0.26 0.88 0.91
155 INT156227 Gene_expression of Tnfsf14 2 3 0.65 3.12 0.9
156 INT109063 Negative_regulation of Localization of Prkca 1 1 0.02 0 0.84
157 INT109060 Regulation of Gene_expression of PRKCZ 1 1 0.03 0 0.83
158 INT156228 Positive_regulation of Tnfsf14 2 1 0.28 2.39 0.83
159 INT109062 Gene_expression of NKX2-5 1 7 0.75 3.31 0.82
160 INT106319 Negative_regulation of S100A4 1 2 0.41 0.89 0.82
161 INT118834 Positive_regulation of Mb 3 6 0.66 1.68 0.79
162 INT128447 Positive_regulation of Localization of S100B 1 2 0.67 0.9 0.79
163 INT116644 Phosphorylation of Gsk3b 3 4 0.61 0.68 0.78
164 INT164632 Positive_regulation of EGFL7 1 8 0.32 3.03 0.71
165 INT84910 Gene_expression of GNB3 1 4 0.67 2.74 0.71
166 INT157156 Negative_regulation of Positive_regulation of PTGIR 2 1 0.12 1.78 0.71
167 INT131552 Gene_expression of ABCC5 1 3 0.50 1.38 0.7
168 INT128454 Positive_regulation of Phosphorylation of RNLS 2 1 0.13 0.56 0.7
169 INT164627 Positive_regulation of Gene_expression of ABCA1 2 9 0.61 3.95 0.67
170 INT128451 Positive_regulation of RNLS 1 2 0.50 1.28 0.67
171 INT108713 Negative_regulation of Kcnn4 1 4 0.31 1.57 0.66
172 INT122469 Negative_regulation of Negative_regulation of B3GAT1 1 1 0.41 0 0.62
173 INT122470 Negative_regulation of Negative_regulation of TAC1 1 1 0.41 0 0.62
174 INT111198 Gene_expression of Fasn 1 8 0.55 2.54 0.52
175 INT156226 Transcription of F2rl1 1 1 0.23 1.25 0.41
176 INT118837 Gene_expression of Mb 3 7 0.74 2.72 0.4
177 INT156230 Positive_regulation of Binding of F2rl1 1 1 0.21 1.11 0.4
178 INT156225 Positive_regulation of Binding of Tnfsf14 1 1 0.24 1.11 0.4
179 INT156232 Positive_regulation of Positive_regulation of Tnfsf14 1 1 0.21 1.15 0.4
180 INT128446 Positive_regulation of DYM 1 4 0.14 4.01 0.39
181 INT157157 Negative_regulation of Localization of HMOX1 1 1 0.37 0.74 0.37
182 INT128448 Negative_regulation of Positive_regulation of S100A4 1 1 0.41 0.29 0.35
183 INT128449 Phosphorylation of RNLS 1 1 0.22 0.28 0.35
184 INT109058 Positive_regulation of Gene_expression of Gata4 1 2 0.29 0 0.33
185 INT84908 Positive_regulation of GNB3 2 1 0.49 0.9 0.32
186 INT128450 Transcription of S100A4 1 2 0.67 0.25 0.31
187 INT128455 Positive_regulation of Transcription of S100A4 1 1 0.49 0.25 0.31
188 INT128456 Positive_regulation of Positive_regulation of S100A4 1 1 0.49 0.34 0.31
189 INT135772 Regulation of Positive_regulation of HMOX1 1 3 0.39 1.52 0.29
190 INT131151 Regulation of TRPC4 1 1 0.26 0.42 0.29
191 INT157155 Positive_regulation of LSS 2 1 0.26 1.92 0.25
192 INT108715 Gene_expression of Sod3 1 3 0.47 1.95 0.22
193 INT116647 Positive_regulation of Phosphorylation of Gsk3b 1 1 0.37 0.18 0.22
194 INT157154 Regulation of LSS 1 2 0.25 1.73 0.21
195 INT108717 Negative_regulation of Gene_expression of Sod3 1 2 0.25 0.8 0.16
196 INT108714 Positive_regulation of Zfp79-rs1 1 1 0.01 0.98 0.14
197 INT128452 Gene_expression of S100G 1 1 0.38 0.34 0.13
198 INT128445 Negative_regulation of Gene_expression of S100G 1 1 0.21 0.34 0.13
199 INT108712 Gene_expression of Tnnt1 1 3 0.47 2.61 0.12
200 INT108711 Gene_expression of Zfp79-rs1 1 1 0.01 0.81 0.12
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