J:Circulation

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT19972 Hdl1 Regulation of Ptgir 1 2 0.00 2.77 0.99
2 INT42073 Binding of PPBP and Tbxa2r 1 1 0.01 0.26 0.1
3 INT41172 OPA1 Positive_regulation of RTCA 1 1 0.18 0.16 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
2 INT5059 Positive_regulation of TNF 4 1050 0.70 896.51 322.81
3 INT5979 Gene_expression of Oprd1 1 428 0.78 75.64 320.32
4 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
5 INT54571 Positive_regulation of NFKB1 13 263 0.70 138.99 87.32
6 INT8357 Gene_expression of KNG1 2 153 0.75 77.26 68.66
7 INT46 Localization of Ren 1 233 0.81 46.15 62.44
8 INT17401 Gene_expression of IGF1 4 475 0.78 232.18 62.07
9 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
10 INT5058 Positive_regulation of IFNA1 4 356 0.70 245.75 60.52
11 INT14740 Gene_expression of TGFB1 2 272 0.78 168.48 60.18
12 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
13 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
14 INT314 Positive_regulation of Ren 2 212 0.70 66.68 55.56
15 INT49993 Positive_regulation of Gene_expression of Il6 1 149 0.70 88.07 53.78
16 INT375 Positive_regulation of REN 4 293 0.70 152.46 47.55
17 INT26500 Gene_expression of MMP2 5 201 0.78 110.57 46.9
18 INT16364 Gene_expression of HLA-DRA 2 234 0.78 118.81 45.01
19 INT47939 Gene_expression of Selp 5 171 0.76 87.54 39.03
20 INT1705 Gene_expression of pCA 4 126 0.65 88.65 34.81
21 INT17381 Gene_expression of Tbxa2r 12 146 0.78 65.01 34.15
22 INT1116 Regulation of Ren 1 103 0.62 27.66 33.26
23 INT8915 Gene_expression of Igf1 1 199 0.78 78.58 32.51
24 INT48693 Regulation of VEGFA 1 268 0.62 191.88 31.52
25 INT10915 Gene_expression of ITGAM 2 164 0.78 92.42 29.78
26 INT660 Negative_regulation of REN 2 194 0.59 82.06 29.46
27 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
28 INT5653 Positive_regulation of ELANE 1 136 0.70 72.78 27.94
29 INT6717 Negative_regulation of YY1 1 45 0.57 15.35 27.8
30 INT9296 Negative_regulation of PLEK 2 100 0.57 36.65 27.52
31 INT2609 Localization of ELANE 3 111 0.81 50.22 26.63
32 INT50490 Regulation of PTGS2 1 80 0.48 39.51 25.85
33 INT1704 Positive_regulation of PCa 2 68 0.59 34.92 23.36
34 INT55170 Gene_expression of NFKB1 8 97 0.77 52.75 23.04
35 INT1221 Regulation of SGCG 1 65 0.60 24.21 22.94
36 INT66208 Positive_regulation of Positive_regulation of NFKB1 2 45 0.68 20.17 22.62
37 INT14733 Positive_regulation of Gene_expression of TGFB1 2 71 0.69 49.89 22.2
38 INT8580 Gene_expression of ELANE 2 132 0.75 62.98 21.79
39 INT16396 Negative_regulation of CEBPZ 1 76 0.48 30.03 21.6
40 INT9079 Gene_expression of PPBP 3 52 0.75 31.2 21.52
41 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
42 INT48144 Gene_expression of Fgf2 3 117 0.78 43 20.48
43 INT49487 Gene_expression of Sele 1 65 0.76 68.11 19.41
44 INT9552 Positive_regulation of TNNI3 5 209 0.70 128.67 19.15
45 INT77675 Gene_expression of Saa 1 40 0.58 43.37 18.69
46 INT6791 Binding of NA 1 55 0.46 5.36 17.59
47 INT12081 Localization of TGFB1 1 64 0.81 35.4 17.47
48 INT1767 Positive_regulation of PROC 2 83 0.67 54.14 17
49 INT10187 Gene_expression of Il2ra 3 91 0.78 52.67 16.66
50 INT28950 Positive_regulation of Gene_expression of IGF1 1 99 0.69 46.9 16.47
51 INT899 Gene_expression of F13A1 6 122 0.70 78.02 16.26
52 INT25517 Regulation of NFKB1 1 41 0.61 22.28 16.09
53 INT3793 Regulation of CEBPZ 1 59 0.61 20.91 15.83
54 INT19963 Gene_expression of COL1A1 1 118 0.59 42.11 15.15
55 INT1888 Protein_catabolism of F13A1 2 97 0.99 63.48 14.82
56 INT11636 Positive_regulation of SERPINE1 1 85 0.69 68.73 14.8
57 INT663 Negative_regulation of Adrb3 1 55 0.59 15.95 14.68
58 INT95 Positive_regulation of Adrb1 2 34 0.62 11.95 14.41
59 INT11069 Positive_regulation of Pf4 8 35 0.68 27.7 13.96
60 INT15684 Positive_regulation of Serpine1 1 65 0.70 43.51 13.67
61 INT11071 Positive_regulation of PPBP 3 43 0.68 26.85 13.43
62 INT15921 Positive_regulation of Serpine1 3 85 0.68 81.24 13.4
63 INT26545 Gene_expression of Hras1 1 173 0.78 79.54 13.21
64 INT27242 Gene_expression of PGR 1 153 0.75 98.77 12.79
65 INT20102 Gene_expression of Serpine1 1 102 0.78 65.99 12.61
66 INT55687 Localization of TIMP1 1 47 0.74 30.24 12.31
67 INT21160 Gene_expression of Sell 2 28 0.64 19.37 12.18
68 INT11121 Positive_regulation of NPPA 1 64 0.70 34.09 11.96
69 INT4047 Binding of F13A1 1 105 0.43 66.54 11.81
70 INT3602 Negative_regulation of Shbg 2 148 0.53 69.05 11.65
71 INT1735 Gene_expression of HSD11B1 1 199 0.75 257.87 11.5
72 INT14962 Gene_expression of Pf4 4 27 0.76 22.48 10.88
73 INT18412 Binding of PLEK 1 49 0.47 17.82 10.72
74 INT1734 Negative_regulation of HSD11B1 1 116 0.57 125.13 10.52
75 INT5788 Gene_expression of IL2RA 2 60 0.75 40.67 9.98
76 INT59 Regulation of Adrb1 1 25 0.42 8.32 9.78
77 INT15449 Positive_regulation of Plat 3 32 0.69 12.76 9.71
78 INT10139 Positive_regulation of F13A1 4 64 0.56 44.75 9.69
79 INT53983 Gene_expression of Opcml 2 30 0.78 10.35 9.69
80 INT11859 Positive_regulation of Tbxa2r 1 44 0.61 22.62 9.61
81 INT3366 Localization of PLEK 2 44 0.78 15.83 9.55
82 INT18145 Positive_regulation of Gene_expression of Tbxa2r 7 30 0.66 18.91 9.52
83 INT11679 Negative_regulation of F13A1 2 55 0.54 33.69 9.43
84 INT9899 Gene_expression of Vwf 1 91 0.74 45.06 9.13
85 INT6019 Positive_regulation of NEUROD1 1 37 0.67 17.3 8.89
86 INT5458 Negative_regulation of Tbxa2r 1 31 0.54 10.58 8.89
87 INT29411 Positive_regulation of ADRB2 1 13 0.65 5.42 8.78
88 INT34777 Localization of IGF1 2 82 0.80 42.68 8.62
89 INT26795 Gene_expression of Mtpn 1 44 0.62 27.66 8.62
90 INT65661 Positive_regulation of Ado 2 13 0.52 4.75 8.54
91 INT96 Binding of Adrb1 1 18 0.48 2.8 8.52
92 INT13435 Positive_regulation of RTCA 1 31 0.60 7.19 8.5
93 INT70896 Gene_expression of PDGFB 1 48 0.65 33.55 8.39
94 INT19829 Negative_regulation of Gene_expression of Tbxa2r 3 32 0.56 12.78 8.3
95 INT44003 Gene_expression of F3 1 40 0.75 27.92 8.29
96 INT51458 Negative_regulation of Gene_expression of Selp 1 29 0.57 12.64 8.1
97 INT25152 Gene_expression of SAA1 1 37 0.75 53.56 8.07
98 INT34009 Binding of Tbxa2r 1 33 0.36 17.98 8.01
99 INT26551 Positive_regulation of Gene_expression of KNG1 1 19 0.67 11.05 7.98
100 INT2271 Gene_expression of F2 1 51 0.76 30.21 7.97
101 INT67424 Positive_regulation of Gene_expression of Selp 3 36 0.68 17.08 7.95
102 INT17686 Negative_regulation of Hdl1 1 72 0.36 81.85 7.74
103 INT15918 Gene_expression of Serpine1 1 60 0.62 41.73 7.72
104 INT20348 Negative_regulation of Tbxa2r 4 47 0.59 19.88 7.68
105 INT165 Regulation of HRH1 2 12 0.45 1.76 7.57
106 INT11042 Localization of Tbxa2r 1 26 0.76 10.15 7.24
107 INT10513 Gene_expression of Plat 3 44 0.76 19.49 7.17
108 INT21938 Positive_regulation of Atp7b 1 26 0.10 11.33 7.1
109 INT64370 Gene_expression of Neurod1 1 22 0.75 5.19 7.1
110 INT11858 Localization of Tbxa2r 3 39 0.80 21.24 7.09
111 INT66210 Regulation of Positive_regulation of NFKB1 1 16 0.60 9.46 7.08
112 INT717 Regulation of F2 2 29 0.61 17.46 6.99
113 INT2733 Negative_regulation of Tbxas1 3 33 0.57 12.12 6.97
114 INT64792 Positive_regulation of Gene_expression of ITGAM 1 39 0.69 23.21 6.71
115 INT64052 Positive_regulation of FGFR1 1 26 0.52 28.47 6.36
116 INT9494 Positive_regulation of Gene_expression of Igf1 1 34 0.67 17.77 6.26
117 INT48270 Negative_regulation of RNF130 3 44 0.57 21.31 6.14
118 INT11896 Negative_regulation of Atp7b 2 15 0.11 6.01 6.09
119 INT2890 Positive_regulation of MB 1 39 0.70 29.58 6.01
120 INT19941 Negative_regulation of Pf4 1 13 0.42 10.35 5.97
121 INT18677 Gene_expression of F3 1 50 0.65 30.86 5.86
122 INT53684 Negative_regulation of Gene_expression of ITGAM 1 23 0.59 14.36 5.66
123 INT15367 Gene_expression of OPA1 1 35 0.67 24.9 5.45
124 INT3647 Positive_regulation of Gene_expression of F13A1 1 20 0.41 15.71 5.02
125 INT11493 Positive_regulation of KLK1 1 21 0.67 9.22 5
126 INT34870 Positive_regulation of OPA1 1 18 0.59 10.66 5
127 INT11064 Positive_regulation of NPR1 1 24 0.49 14.63 4.78
128 INT4577 Negative_regulation of Thra 6 24 0.56 3.75 4.73
129 INT19967 Gene_expression of C9orf3 1 18 0.75 26.51 4.6
130 INT26546 Positive_regulation of Gene_expression of Hras1 1 35 0.70 16.59 4.54
131 INT4283 Positive_regulation of Cbs 1 10 0.46 6.85 4.44
132 INT19965 Positive_regulation of COL1A1 2 23 0.45 14.49 4.38
133 INT19966 Positive_regulation of C9orf3 3 19 0.67 21.88 4.38
134 INT9080 Regulation of PPBP 2 17 0.44 5.75 4.3
135 INT63977 Positive_regulation of Sele 1 28 0.68 18.49 4.17
136 INT10754 Positive_regulation of Gene_expression of PCa 1 18 0.41 21.81 4.17
137 INT50872 Positive_regulation of Tnni3 1 24 0.64 13.51 3.95
138 INT51831 Negative_regulation of ITGA2B 1 20 0.57 10.59 3.91
139 INT9748 Negative_regulation of Sysbp1 1 28 0.35 8.93 3.87
140 INT48143 Gene_expression of Fgf1 3 32 0.78 8.2 3.72
141 INT67423 Regulation of Gene_expression of Selp 1 16 0.60 7.4 3.68
142 INT70897 Positive_regulation of Gene_expression of PDGFB 1 15 0.57 13.04 3.52
143 INT70895 Localization of PDGFB 1 20 0.52 8.98 3.4
144 INT3881 Positive_regulation of Protein_catabolism of F13A1 2 21 0.41 20 3.28
145 INT4479 Negative_regulation of Positive_regulation of REN 1 17 0.56 6.1 3.27
146 INT70885 Gene_expression of Pdgfb 1 48 0.67 42.27 3.19
147 INT1924 Regulation of PLAT 1 11 0.60 6.3 3.16
148 INT35143 Negative_regulation of ANGPTL5 1 28 0.54 18.59 3.14
149 INT25674 Positive_regulation of Gene_expression of ELANE 1 16 0.60 7.46 3.12
150 INT10517 Localization of Plat 1 16 0.47 8.44 3.11
151 INT68846 Gene_expression of Tfrc 2 22 0.32 10.1 3.06
152 INT27465 Positive_regulation of F12 1 21 0.70 8.09 3.06
153 INT10057 Gene_expression of Ldlr 1 35 0.67 23.99 3.05
154 INT14960 Positive_regulation of Serpinc1 2 17 0.68 12.71 3.02
155 INT5913 Binding of OPA1 1 12 0.41 9.33 2.92
156 INT41358 Localization of Pf4 1 11 0.79 6.06 2.89
157 INT32394 Regulation of Pf4 3 12 0.23 6.07 2.85
158 INT3605 Negative_regulation of OPA1 2 14 0.38 10.88 2.84
159 INT10516 Localization of Vwf 1 30 0.79 7.54 2.77
160 INT84811 Gene_expression of Ado 1 6 0.51 2.65 2.74
161 INT64791 Negative_regulation of Sell 2 8 0.57 4.17 2.73
162 INT5460 Positive_regulation of EDAR 1 10 0.23 8.18 2.71
163 INT47503 Gene_expression of HPS1 1 12 0.58 7.96 2.7
164 INT26205 Positive_regulation of Positive_regulation of NPR1 1 3 0.24 1.57 2.52
165 INT38144 Positive_regulation of HRH1 2 7 0.57 2.57 2.51
166 INT4686 Gene_expression of Cys1 1 32 0.66 36.24 2.49
167 INT25166 Regulation of Tbxa2r 1 12 0.43 5.94 2.47
168 INT25208 Gene_expression of IGF2 1 43 0.74 30.64 2.31
169 INT3533 Binding of REN 1 24 0.37 10.84 2.16
170 INT3821 Negative_regulation of C1s 1 13 0.42 7.89 2.08
171 INT35689 Localization of C3 1 17 0.75 5.3 1.98
172 INT38268 Positive_regulation of BEST1 1 16 0.17 14.54 1.93
173 INT24643 Gene_expression of Hdlcl1 1 30 0.73 26.83 1.9
174 INT13999 Positive_regulation of Positive_regulation of NEUROD1 1 5 0.67 4.07 1.86
175 INT9106 Positive_regulation of F3 2 8 0.22 4.92 1.85
176 INT20347 Positive_regulation of PF4 1 5 0.67 2.91 1.72
177 INT14961 Positive_regulation of Gene_expression of Pf4 1 4 0.30 3.42 1.7
178 INT46766 Negative_regulation of Il2ra 1 9 0.57 5.27 1.64
179 INT17693 Localization of PF4 1 2 0.68 1.26 1.56
180 INT46643 Negative_regulation of HYAL1 1 7 0.37 4.65 1.55
181 INT10753 Regulation of Gene_expression of PCa 1 8 0.23 7.16 1.49
182 INT64371 Positive_regulation of Gene_expression of Neurod1 1 4 0.64 1.56 1.45
183 INT21805 Negative_regulation of Hdlbp 1 7 0.30 9.66 1.43
184 INT48269 Negative_regulation of FANCB 1 16 0.56 5.34 1.38
185 INT23278 Negative_regulation of Binding of F13A1 1 6 0.39 3.54 1.37
186 INT37799 Gene_expression of Apob 1 13 0.56 10.59 1.36
187 INT44529 Positive_regulation of Pdgfb 1 11 0.43 7.98 1.36
188 INT24685 Localization of Serpine1 1 12 0.59 7.76 1.32
189 INT67006 Positive_regulation of TTPA 1 5 0.49 2.31 1.29
190 INT11496 Negative_regulation of F12 1 6 0.59 3.41 1.27
191 INT22067 Positive_regulation of IL2RB 1 11 0.70 5.74 1.23
192 INT50873 Regulation of Tnni3 1 4 0.13 2.36 1.22
193 INT48554 Positive_regulation of SP1 1 12 0.49 3.64 1.2
194 INT20100 Binding of Serpine1 2 16 0.29 6.78 1.18
195 INT70886 Positive_regulation of Gene_expression of Pdgfb 1 13 0.45 12.57 1.17
196 INT6599 Binding of ITGA2 1 4 0.35 3.6 1.16
197 INT3068 Positive_regulation of Ppr1 2 4 0.45 1.26 1.1
198 INT24019 Negative_regulation of HPS1 1 7 0.37 7.94 1.04
199 INT17692 Negative_regulation of C5AR1 1 5 0.57 2.99 1.04
200 INT1940 Localization of PIK3C2A 1 8 0.78 7.28 1.01
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