J:Clin. Cancer Res.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT122163 Binding of TNF and TNFRSF1B 6 1 0.44 6.06 2.41
2 INT144035 IL6 Positive_regulation of STAT3 4 1 0.31 2.58 0.56
3 INT114043 Binding of CREM and FOS 1 1 0.04 0.17 0.19
4 INT114045 Binding of CREM and JUN 1 1 0.03 0.17 0.19
5 INT114044 Positive_regulation of Binding of CREM and JUN 1 1 0.04 0.17 0.19
6 INT101060 TNF Positive_regulation of Binding of Nfkb1 and Nfkb1 1 1 0.07 1.22 0.18
7 INT101062 TNF Positive_regulation of Binding of Nfkb1 1 1 0.13 1.22 0.18
8 INT101063 TNF Positive_regulation of Localization of Nfkb1 1 1 0.13 1.22 0.18
9 INT125000 Binding of Esr1 and Tas2r108 1 1 0.04 0.33 0.1
10 INT139476 Edn1 Positive_regulation of Ednra 1 1 0.00 1.07 0.1
11 INT105268 VEGFA Positive_regulation of KDR 2 1 0.18 0.22 0.05
12 INT105267 Negative_regulation of VEGFA Positive_regulation of KDR 1 1 0.16 0.22 0.05
13 INT97430 Binding of B2M and HLA-B 1 1 0.00 0.66 0.04
14 INT144030 STAT3 Regulation of CCND1 2 1 0.09 1.05 0
15 INT144032 STAT3 Regulation of BCL2 2 1 0.07 0.86 0
16 INT84741 Binding of PBK and Cea 1 1 0.25 0.43 0
17 INT145337 Binding of PYGO1 and Positive_regulation of Transcription of WISP1 1 1 0.07 0 0
18 INT121314 Tgfb1 Positive_regulation of Egfr 1 2 0.08 0.16 0
19 INT139719 Binding of CYP2C9 and UGT1A6 1 1 0.19 0.1 0
20 INT144033 STAT6 Positive_regulation of Positive_regulation of STAT3 1 1 0.04 0.08 0
21 INT145336 Binding of PYGO1 and Positive_regulation of Transcription of DKK1 1 1 0.07 0 0
22 INT145333 Binding of BCL9 and Positive_regulation of Transcription of DKK1 1 1 0.41 0 0
23 INT121316 Tgfb1 Negative_regulation of Xrcc1 1 1 0.06 0.08 0
24 INT121318 Tgfb1 Negative_regulation of Ercc1 1 1 0.06 0.08 0
25 INT84739 Binding of Ighg1 and Cea 1 1 0.31 0.43 0
26 INT145332 Binding of PYGO1 and Positive_regulation of Transcription of FGF20 1 1 0.07 0 0
27 INT121320 Negative_regulation of Egfr Negative_regulation of Tgfb1 Positive_regulation of Ercc1 1 1 0.07 0.08 0
28 INT145338 Binding of PYGO1 and Positive_regulation of Transcription of CCND1 1 1 0.07 0 0
29 INT121313 Tgfb1 Positive_regulation of Ercc1 1 1 0.07 0.08 0
30 INT121315 Negative_regulation of Egfr Negative_regulation of Ercc1 1 1 0.42 0.08 0
31 INT145335 Binding of BCL9 and Positive_regulation of Transcription of FGF20 1 1 0.41 0 0
32 INT121319 Negative_regulation of Egfr Negative_regulation of Tgfb1 Positive_regulation of Xrcc1 1 1 0.07 0.08 0
33 INT145339 Binding of PYGO1 and Positive_regulation of Transcription of MYC 1 1 0.05 0 0
34 INT144031 STAT3 Regulation of BCL2L1 1 1 0.11 0.06 0
35 INT145340 Binding of BCL9 and Positive_regulation of Transcription of WISP1 1 1 0.43 0 0
36 INT144042 STAT3 Regulation of Birc5 1 1 0.47 0.06 0
37 INT144029 STAT3 Regulation of FIGF 1 1 0.12 0.06 0
38 INT121317 Tgfb1 Positive_regulation of Xrcc1 1 1 0.07 0.08 0
39 INT145331 Binding of BCL9 and Positive_regulation of Transcription of MYC 1 1 0.29 0 0
40 INT144034 STAT6 Positive_regulation of STAT3 1 1 0.04 0.1 0
41 INT145334 Binding of BCL9 and Positive_regulation of Transcription of CCND1 1 1 0.41 0 0
42 INT117173 OCM Regulation of Transcription of AR 1 1 0.18 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 5 1575 0.78 1135.66 424.22
3 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
4 INT5059 Positive_regulation of TNF 3 1050 0.70 896.51 322.81
5 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
6 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
7 INT49750 Negative_regulation of CPOX 3 735 0.58 360.06 274.19
8 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
9 INT50670 Gene_expression of CPOX 6 763 0.76 442.13 195.02
10 INT24326 Gene_expression of Ngf 1 346 0.78 218.67 184.71
11 INT10194 Positive_regulation of IL6 11 702 0.70 600.62 183.38
12 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
13 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
14 INT51921 Gene_expression of Cpox 2 501 0.73 229.81 157.81
15 INT65054 Positive_regulation of Nfkb1 5 285 0.70 149.33 126.73
16 INT50674 Gene_expression of PTGS2 5 459 0.78 253.33 118.51
17 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
18 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
19 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
20 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
21 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
22 INT7180 Negative_regulation of Trib3 1 180 0.51 68.48 88.01
23 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
24 INT749 Gene_expression of HLA-B 1 341 0.75 224.12 77.37
25 INT12001 Regulation of Ngf 1 97 0.62 54.64 76.25
26 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
27 INT56298 Gene_expression of IL4 1 306 0.78 182.18 72.92
28 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
29 INT5861 Gene_expression of Egr1 1 203 0.78 49.35 68.13
30 INT4960 Positive_regulation of CSF2 3 285 0.70 256.73 65.73
31 INT103924 Positive_regulation of Akt1 1 359 0.69 158.94 60.34
32 INT50672 Positive_regulation of CPOX 1 205 0.44 125.93 60.06
33 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
34 INT31116 Gene_expression of Casp3 1 192 0.78 78.21 57.43
35 INT69876 Negative_regulation of Nfkb1 1 147 0.58 89.81 55.5
36 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
37 INT82650 Gene_expression of Bcl2 2 312 0.78 211.71 55.03
38 INT117713 Phosphorylation of Akt1 1 275 0.82 95.82 54.34
39 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
40 INT53083 Gene_expression of Ptgs2 2 153 0.78 90.04 50.39
41 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
42 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
43 INT106525 Phosphorylation of Akt1 1 436 0.82 183.81 47.82
44 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
45 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
46 INT52531 Gene_expression of Nfkb1 2 153 0.75 82.84 42.9
47 INT114751 Gene_expression of Mapk1 1 137 0.76 60.14 39.98
48 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
49 INT55135 Positive_regulation of Gene_expression of PTGS2 1 137 0.70 80.32 38.46
50 INT77307 Gene_expression of Bcl2 2 399 0.77 319.77 38
51 INT62827 Positive_regulation of ICAM1 1 184 0.70 180.95 36.28
52 INT65055 Negative_regulation of Nfkb1 1 83 0.58 44.85 34.94
53 INT1624 Gene_expression of Cea 2 212 0.76 180.44 34.21
54 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
55 INT65536 Negative_regulation of Positive_regulation of Nfkb1 2 77 0.59 38.86 33.33
56 INT10248 Gene_expression of KRT20 8 436 0.78 231.96 32.88
57 INT114881 Gene_expression of Akt1 1 227 0.78 102.49 31.81
58 INT65960 Gene_expression of BCL2 1 352 0.78 312.03 30.73
59 INT52690 Positive_regulation of Ptgs2 1 65 0.68 39.51 30.02
60 INT52712 Negative_regulation of PRKCA 2 64 0.57 23.11 28.43
61 INT112707 Negative_regulation of Akt1 2 89 0.59 28.85 27.76
62 INT37296 Binding of Esr1 1 117 0.43 62.51 27.33
63 INT5206 Gene_expression of AR 2 316 0.78 113.83 27.29
64 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
65 INT65537 Positive_regulation of Positive_regulation of Nfkb1 2 52 0.67 30.6 26.35
66 INT53949 Positive_regulation of Gene_expression of Cpox 2 82 0.65 38.12 25.93
67 INT63769 Regulation of Ngf 1 44 0.62 21.82 25.84
68 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
69 INT9781 Binding of INSRR 1 64 0.31 19.1 25.2
70 INT40776 Gene_expression of Akt1 3 99 0.77 34.91 24.39
71 INT27933 Gene_expression of NCOR2 1 65 0.72 31.35 24.23
72 INT22708 Gene_expression of MUC1 1 297 0.78 232.71 24.19
73 INT6726 Positive_regulation of Edn1 1 118 0.70 65.96 24.07
74 INT35716 Positive_regulation of NCOR2 1 45 0.60 18 23.54
75 INT5055 Positive_regulation of IFNG 1 89 0.69 64.03 23.05
76 INT1221 Regulation of SGCG 1 65 0.60 24.21 22.94
77 INT4535 Localization of PROC 1 106 0.73 76.24 21.1
78 INT28216 Gene_expression of HRAS 3 173 0.75 93.97 20.78
79 INT85952 Positive_regulation of AR 2 168 0.67 64.36 20.66
80 INT78694 Positive_regulation of Gene_expression of Casp3 1 46 0.66 18.64 19.62
81 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
82 INT19509 Localization of Ifng 1 55 0.78 28.25 18.67
83 INT28215 Gene_expression of CDKN1A 1 196 0.76 113.9 18.3
84 INT13510 Gene_expression of ERBB2 8 530 0.78 405.68 16.79
85 INT2432 Positive_regulation of Cp 1 41 0.67 31.1 16.68
86 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
87 INT19929 Negative_regulation of Positive_regulation of TNF 1 52 0.59 38.16 16.51
88 INT22900 Positive_regulation of Cd4 1 126 0.67 82.77 16.43
89 INT65659 Positive_regulation of STAT3 6 132 0.70 69.56 15.95
90 INT11685 Regulation of CSF2 1 99 0.59 58.82 15.9
91 INT6381 Negative_regulation of Chat 1 51 0.59 19.68 15.86
92 INT9783 Gene_expression of INSRR 1 81 0.50 32.99 15.52
93 INT116465 Gene_expression of Birc5 1 241 0.78 192.31 15.32
94 INT505 Positive_regulation of GPT 1 89 0.67 69.38 14.94
95 INT109535 Gene_expression of Vegfa 2 116 0.75 84.61 14.89
96 INT105387 Gene_expression of HIF1A 1 116 0.77 98.62 14.66
97 INT11340 Positive_regulation of SLC17A5 1 120 0.67 113.52 14.5
98 INT42979 Positive_regulation of INSRR 1 47 0.32 12.24 14.38
99 INT109511 Gene_expression of Bax 1 133 0.78 113.22 14.36
100 INT50671 Regulation of Gene_expression of CPOX 2 45 0.54 30.99 13.83
101 INT52714 Regulation of PRKCA 1 28 0.61 7.73 13.66
102 INT4931 Localization of IFNG 1 53 0.78 33.25 13.65
103 INT78480 Localization of Nfkb1 1 39 0.80 23.14 13.64
104 INT78472 Gene_expression of CDKN2A 8 223 0.78 173.76 13.61
105 INT96850 Negative_regulation of CCL2 1 42 0.59 24.89 12.55
106 INT81640 Positive_regulation of Gene_expression of Bcl2 1 106 0.69 84.58 11.63
107 INT20457 Regulation of Ptgs1 1 23 0.48 11.63 11.56
108 INT53082 Positive_regulation of Gene_expression of Ptgs2 1 47 0.64 25.39 11.39
109 INT8546 Positive_regulation of MUC16 1 99 0.69 74.98 11.26
110 INT48203 Positive_regulation of Tgfb1 1 67 0.70 41.31 11.07
111 INT52689 Regulation of Ptgs2 1 27 0.60 12.76 10.6
112 INT1934 Positive_regulation of Cys1 1 68 0.68 60.56 10.47
113 INT11205 Gene_expression of Prep 1 65 0.77 8.11 10.12
114 INT65058 Binding of Nfkb1 1 36 0.45 19.87 10.02
115 INT61171 Gene_expression of S100A8 10 92 0.76 57.74 9.98
116 INT5788 Gene_expression of IL2RA 4 60 0.75 40.67 9.98
117 INT80036 Positive_regulation of FAS 2 42 0.67 42.22 9.4
118 INT6727 Positive_regulation of Ednra 1 27 0.64 18.75 8.71
119 INT86672 Negative_regulation of Bcl2 1 50 0.53 34.16 8.37
120 INT29229 Regulation of NCOR2 1 20 0.42 5.75 8.08
121 INT2093 Gene_expression of GAST 1 50 0.78 32.32 7.98
122 INT6884 Negative_regulation of pr 1 20 0.42 13.18 7.97
123 INT111533 Positive_regulation of Gene_expression of Nfkb1 1 27 0.52 17.32 7.89
124 INT113705 Gene_expression of Egfr 4 228 0.78 149.05 7.59
125 INT121496 Gene_expression of TERT 4 107 0.78 45.6 7.42
126 INT103925 Negative_regulation of Positive_regulation of Akt1 1 32 0.58 15.19 7.39
127 INT82610 Positive_regulation of SRC 1 53 0.67 26.89 7.27
128 INT97055 Positive_regulation of Gene_expression of Trp53 1 51 0.70 45.7 7.25
129 INT16631 Negative_regulation of APC 1 46 0.57 30.53 7.11
130 INT11747 Positive_regulation of IL2RA 1 22 0.67 16.55 6.95
131 INT95117 Gene_expression of PDGFA 2 71 0.71 51.17 6.9
132 INT17618 Gene_expression of B2M 1 36 0.66 16.39 6.68
133 INT50387 Negative_regulation of AR 1 67 0.45 26.31 6.61
134 INT60700 Gene_expression of Itgax 1 93 0.71 51.89 6.57
135 INT59079 Transcription of PTGS2 1 30 0.72 14.21 6.52
136 INT65538 Regulation of Positive_regulation of Nfkb1 1 17 0.51 8.31 6.5
137 INT2039 Regulation of CYP2B6 1 30 0.60 7.75 6.43
138 INT21294 Gene_expression of OGFR 4 32 0.78 5.75 6.41
139 INT66227 Gene_expression of COX18 1 41 0.50 26.91 6.26
140 INT9819 Gene_expression of nt 1 15 0.55 5.09 6.25
141 INT27628 Gene_expression of IL2RG 4 28 0.75 20.95 6.16
142 INT64208 Gene_expression of Rtl1 1 18 0.75 7.51 6.16
143 INT114882 Positive_regulation of Gene_expression of Akt1 1 45 0.69 21.29 6.06
144 INT8803 Gene_expression of IL3 6 32 0.78 21.06 6.01
145 INT88873 Negative_regulation of Gene_expression of Nfkb1 1 24 0.56 9.93 5.97
146 INT93684 Gene_expression of STAT3 1 66 0.78 34.42 5.94
147 INT75501 Gene_expression of CCND1 1 90 0.76 60.86 5.93
148 INT9567 Binding of Nts 1 10 0.44 2.14 5.89
149 INT100422 Negative_regulation of Gene_expression of Bcl2 2 46 0.58 28.86 5.7
150 INT112124 Positive_regulation of Egfr 3 71 0.70 47.82 5.61
151 INT38671 Positive_regulation of KRT20 2 62 0.53 40.17 5.6
152 INT38670 Positive_regulation of Gene_expression of KRT20 2 68 0.69 23.25 5.55
153 INT48201 Localization of Tgfb1 5 27 0.59 13.65 5.54
154 INT92398 Negative_regulation of Localization of Nfkb1 1 17 0.42 11.24 5.4
155 INT95120 Positive_regulation of CASP9 1 76 0.67 67.55 5.33
156 INT87420 Gene_expression of BCL2L1 1 56 0.75 48.84 5.32
157 INT15376 Positive_regulation of Gene_expression of ERBB2 5 215 0.70 168.54 5.23
158 INT70613 Negative_regulation of Gene_expression of BCL2 1 48 0.59 38.91 5.22
159 INT233 Binding of Gast 1 31 0.42 17.07 5.21
160 INT15797 Positive_regulation of HLA-E 1 36 0.67 15.17 5.07
161 INT109513 Positive_regulation of Gene_expression of Bax 1 37 0.67 29.52 5.06
162 INT100059 Gene_expression of MUC4 2 30 0.75 31.58 4.95
163 INT122165 Binding of TNFRSF1B 1 8 0.28 7.46 4.87
164 INT99690 Negative_regulation of Positive_regulation of VEGFA 1 30 0.58 14.56 4.79
165 INT109972 Phosphorylation of Trp53 1 13 0.80 6.15 4.68
166 INT5205 Localization of AR 1 43 0.80 12.87 4.63
167 INT49805 Positive_regulation of MUC1 1 56 0.70 44.5 4.56
168 INT62813 Negative_regulation of ZNF398 1 12 0.09 6.2 4.49
169 INT55171 Gene_expression of RELA 2 80 0.75 17.17 4.47
170 INT79692 Negative_regulation of PPARG 2 24 0.59 16 4.31
171 INT87345 Phosphorylation of PTK2 2 110 0.82 59.39 4.28
172 INT20981 Binding of HRAS 1 42 0.48 24.49 4.23
173 INT119063 Gene_expression of BRCA1 5 24 0.67 30.04 4.17
174 INT17182 Binding of Cea 1 25 0.48 14.98 4.16
175 INT71882 Phosphorylation of Nfkb1 1 20 0.81 11.46 4.1
176 INT91371 Negative_regulation of STAT3 2 34 0.59 25 4.08
177 INT69681 Negative_regulation of Tgfb1 1 42 0.51 22.28 4
178 INT504 Gene_expression of GPT 1 42 0.75 27.54 3.99
179 INT80175 Positive_regulation of Gene_expression of HRAS 1 24 0.67 14.69 3.97
180 INT120715 Positive_regulation of Egfr 1 15 0.68 5.53 3.77
181 INT119506 Negative_regulation of Egfr 2 32 0.55 23.75 3.67
182 INT93399 Gene_expression of Ccnd1 2 38 0.58 21 3.65
183 INT95119 Localization of CYCS 1 23 0.78 14.86 3.49
184 INT72639 Gene_expression of Ntsr1 6 8 0.78 8.57 3.43
185 INT79270 Gene_expression of MKI67 1 113 0.77 63.52 3.38
186 INT118035 Positive_regulation of JAK1 1 23 0.67 10.57 3.29
187 INT78471 Regulation of Gene_expression of CDKN2A 1 13 0.45 12.52 3.28
188 INT75500 Negative_regulation of Gene_expression of CCND1 1 21 0.57 11.59 3.24
189 INT124954 Gene_expression of Egfr 4 26 0.75 15.08 3.12
190 INT120562 Negative_regulation of Egfr 1 108 0.59 79.38 3.11
191 INT117720 Negative_regulation of Gene_expression of Akt1 3 11 0.37 2.33 3.08
192 INT112365 Regulation of HIF1A 1 27 0.60 21.24 3.05
193 INT120601 Positive_regulation of Gene_expression of OGFR 2 9 0.70 2.73 3
194 INT78467 Negative_regulation of IL12A 1 18 0.38 11.29 2.98
195 INT21840 Positive_regulation of IL3 2 20 0.70 14.44 2.86
196 INT116463 Negative_regulation of Gene_expression of Birc5 1 40 0.59 33.99 2.74
197 INT87340 Negative_regulation of BCAR1 1 8 0.38 6.96 2.63
198 INT89929 Positive_regulation of Positive_regulation of STAT3 1 22 0.65 9.21 2.54
199 INT94042 Positive_regulation of Gene_expression of S100A8 7 15 0.67 13.52 2.44
200 INT73575 Positive_regulation of Ntsr1 3 5 0.60 2.97 2.43
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