J:Clin. Exp. Pharmacol. Physiol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT123451 Binding of YY1 and Adra2a 1 4 0.37 0 2.98
2 INT69709 NPL Positive_regulation of Localization of POMC 2 1 0.36 1.22 1.51
3 INT79123 Binding of Pnoc and Oprm1 3 1 0.14 0 0.91
4 INT61505 ABAT Negative_regulation of Localization of CRH 1 1 0.09 0 0.57
5 INT49225 Mdk Regulation of Tac1 1 1 0.00 0 0.53
6 INT21828 Binding of POMC and Serpinb1a 1 1 0.02 0 0.36
7 INT10906 Agt Regulation of Localization of Nppb 1 1 0.10 0.19 0.1
8 INT10904 Edn1 Regulation of Localization of Nppb 1 3 0.22 0.54 0.1
9 INT137632 Rasa1 Regulation of Ednrb 1 1 0.05 0 0.08
10 INT10901 Edn1 Positive_regulation of Localization of Nppb 1 3 0.39 0.68 0
11 INT10903 Apoa2 Positive_regulation of Nppb 1 1 0.08 0.17 0
12 INT10909 Edn1 Positive_regulation of Nppb 1 1 0.39 0.16 0
13 INT10902 Edn1 Regulation of Avp 1 2 0.27 0.35 0
14 INT10907 Apoa2 Positive_regulation of Localization of Nppb 1 1 0.09 0.23 0
15 INT10905 Edn1 Regulation of Agt 1 2 0.11 0.35 0
16 INT10910 Apoa2 Positive_regulation of Apoa2 Positive_regulation of Nppb 1 1 0.02 0.17 0
17 INT10908 Avp Positive_regulation of Localization of Nppb 1 1 0.42 0.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 3 2008 0.81 518.3 1408.65
2 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
3 INT1912 Gene_expression of Calca 7 1152 0.78 453.25 739.84
4 INT3439 Localization of Abat 2 1017 0.78 112.39 727.06
5 INT728 Positive_regulation of Penk 2 1068 0.70 186.9 636.87
6 INT2543 Positive_regulation of Calca 4 787 0.70 331.13 592.08
7 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
8 INT443 Localization of POMC 25 1020 0.81 284.52 443.17
9 INT5895 Gene_expression of Oprm1 1 525 0.78 120.67 407.29
10 INT64202 Positive_regulation of Trpv1 1 643 0.70 249.66 397.42
11 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
12 INT1395 Negative_regulation of Penk 3 537 0.59 87.33 389.81
13 INT2540 Negative_regulation of Calca 2 538 0.59 172.11 384.38
14 INT720 Positive_regulation of POMC 6 807 0.70 237.37 353.83
15 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
16 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
17 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
18 INT477 Localization of Avp 6 813 0.81 131.58 300.4
19 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
20 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
21 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
22 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
23 INT738 Regulation of POMC 7 459 0.62 111.19 243.74
24 INT1562 Localization of Crh 2 499 0.81 126.74 236.68
25 INT1665 Positive_regulation of Pag1 1 270 0.68 186.63 229.87
26 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
27 INT2211 Negative_regulation of Abat 1 267 0.59 66.51 200.98
28 INT6488 Gene_expression of Tnf 5 484 0.78 339.61 191.58
29 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
30 INT3440 Negative_regulation of Localization of Abat 1 221 0.57 33.94 180.36
31 INT49441 Negative_regulation of Cpox 1 494 0.59 303.22 177.46
32 INT5930 Positive_regulation of Oprm1 1 221 0.70 31.19 172.93
33 INT739 Negative_regulation of POMC 2 358 0.59 102.28 166.77
34 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
35 INT768 Positive_regulation of Oprl1 2 179 0.70 40.05 156.93
36 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
37 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
38 INT2451 Positive_regulation of Avp 1 355 0.70 102.66 147.69
39 INT3300 Positive_regulation of Gene_expression of Calca 3 179 0.70 77.76 144.2
40 INT1414 Regulation of Oprl1 1 169 0.62 32.05 139.99
41 INT1273 Gene_expression of Avp 4 356 0.78 90.56 138.7
42 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
43 INT49439 Gene_expression of Cpox 1 508 0.73 326.97 130.17
44 INT695 Binding of POMC 1 304 0.48 56.66 126.85
45 INT65054 Positive_regulation of Nfkb1 1 285 0.70 149.33 126.73
46 INT6128 Positive_regulation of Localization of POMC 15 256 0.70 68.77 121.64
47 INT8243 Positive_regulation of Il6 1 451 0.70 358.24 119.28
48 INT4207 Regulation of Avp 6 267 0.62 63.72 115.33
49 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
50 INT5940 Negative_regulation of Avp 1 236 0.59 67.86 101.2
51 INT74058 Gene_expression of Nos1 1 260 0.78 80.04 95.71
52 INT1281 Negative_regulation of Maoa 4 203 0.59 22.47 91.66
53 INT69764 Positive_regulation of Cnr1 1 126 0.70 67.8 91.49
54 INT214 Localization of AVP 1 370 0.81 208.51 91.09
55 INT6437 Binding of YY1 2 154 0.47 26.3 90.46
56 INT10166 Localization of Tnf 3 237 0.81 153.95 88.64
57 INT5780 Regulation of Gene_expression of Calca 1 90 0.62 59.52 85.03
58 INT4857 Regulation of Tacr1 1 115 0.62 39.01 84.52
59 INT2893 Localization of Oxt 3 219 0.80 28.96 79.43
60 INT2155 Negative_regulation of Sst 1 111 0.59 16.58 77.74
61 INT4358 Positive_regulation of Localization of Avp 2 195 0.70 30.79 77.58
62 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
63 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
64 INT10274 Positive_regulation of Il1b 1 123 0.70 79.76 73.56
65 INT1080 Negative_regulation of Ache 2 343 0.59 108.51 72.4
66 INT6656 Gene_expression of YY1 1 135 0.75 24.73 72.16
67 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
68 INT15913 Negative_regulation of CYP2D6 1 174 0.59 22.45 70.91
69 INT451 Regulation of Oxt 2 142 0.62 22.07 69.42
70 INT66416 Regulation of Pnoc 1 66 0.61 17.32 68.91
71 INT8357 Gene_expression of KNG1 1 153 0.75 77.26 68.66
72 INT7344 Gene_expression of TAC1 1 132 0.75 35.48 68.26
73 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
74 INT6486 Positive_regulation of Tnf 1 168 0.70 123.47 66.05
75 INT5941 Gene_expression of Oxt 3 164 0.76 22.63 65.47
76 INT66531 Gene_expression of Pnoc 1 88 0.78 22.9 65.11
77 INT480 Negative_regulation of Localization of Avp 4 151 0.59 27.64 63.72
78 INT46 Localization of Ren 6 233 0.81 46.15 62.44
79 INT3950 Gene_expression of Ptger2 1 293 0.77 122.28 62.42
80 INT4760 Negative_regulation of Gene_expression of Calca 1 93 0.59 34.19 60.3
81 INT13938 Positive_regulation of Nkx1-1 1 64 0.68 30.83 58.75
82 INT11491 Positive_regulation of KNG1 3 128 0.67 60.41 58.74
83 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
84 INT5453 Regulation of Localization of POMC 8 114 0.62 20.56 56.34
85 INT5506 Positive_regulation of Gene_expression of Pomc 1 132 0.70 26.78 54.3
86 INT4891 Transcription of Calca 2 81 0.72 35.27 53.75
87 INT771 Regulation of Nts 1 93 0.61 13.13 53.57
88 INT6034 Binding of Gabrg1 1 115 0.47 17.48 51.92
89 INT937 Positive_regulation of Oxt 1 195 0.70 37.82 49.3
90 INT1197 Negative_regulation of Localization of POMC 9 109 0.59 28.29 48.02
91 INT654 Localization of REN 4 250 0.81 75.12 47.86
92 INT29144 Gene_expression of Rvm 1 41 0.52 29.23 47.76
93 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
94 INT5781 Gene_expression of Edn1 1 190 0.78 99.1 46
95 INT989 Negative_regulation of Trh 1 90 0.59 15.45 43.63
96 INT5454 Localization of CRH 8 124 0.79 79.18 41.53
97 INT2364 Localization of Sct 3 134 0.80 26.21 41.47
98 INT2531 Positive_regulation of Cebpz 4 166 0.00 43.08 38.86
99 INT4925 Binding of Tacr1 2 57 0.48 17.39 38.38
100 INT927 Gene_expression of Oxt 2 184 0.78 44.71 35.79
101 INT49 Negative_regulation of Ren 3 129 0.59 37.48 35.62
102 INT316 Regulation of Cebpz 1 105 0.00 27.21 35.41
103 INT65055 Negative_regulation of Nfkb1 1 83 0.58 44.85 34.94
104 INT946 Negative_regulation of Nts 1 60 0.57 4.61 34.44
105 INT96624 Positive_regulation of Positive_regulation of Trpv1 1 62 0.70 20.5 34.28
106 INT65536 Negative_regulation of Positive_regulation of Nfkb1 1 77 0.59 38.86 33.33
107 INT1116 Regulation of Ren 2 103 0.62 27.66 33.26
108 INT6277 Positive_regulation of Gene_expression of Pomc 1 76 0.70 21.45 31.09
109 INT117632 Gene_expression of Trpm8 1 99 0.78 29.41 30.9
110 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
111 INT1158 Regulation of Agt 3 106 0.61 29.4 30.29
112 INT50 Negative_regulation of Localization of Ren 3 87 0.59 14.94 30.22
113 INT6196 Regulation of Nppa 1 83 0.62 30.31 30.18
114 INT9053 Negative_regulation of ALOX5 1 97 0.58 40.34 29.94
115 INT5298 Negative_regulation of MTHFS 1 70 0.57 27.07 28.11
116 INT703 Positive_regulation of Pth 2 177 0.70 127.09 27.26
117 INT3167 Binding of KNG1 4 48 0.48 23.26 26.77
118 INT8205 Negative_regulation of Nppa 1 77 0.59 26.43 25.72
119 INT5622 Gene_expression of Nppa 1 101 0.78 49.46 25.31
120 INT12484 Binding of Drd2 1 45 0.48 15.17 24.72
121 INT6385 Regulation of Man2a2 1 48 0.61 7.8 24.68
122 INT5690 Negative_regulation of Binding of Oprd1 1 36 0.59 8.29 24.52
123 INT2140 Regulation of REN 1 104 0.62 28.24 24.49
124 INT3028 Negative_regulation of Oxt 1 76 0.58 18.52 24.4
125 INT37889 Gene_expression of P2ry2 1 75 0.65 26.01 23.8
126 INT8699 Gene_expression of Nka1 1 45 0.67 6.41 22.56
127 INT20575 Gene_expression of Akr1d1 1 48 0.57 6.2 22.5
128 INT66753 Negative_regulation of Positive_regulation of Tnf 1 45 0.59 35.28 22.33
129 INT8248 Binding of Adra2a 5 43 0.48 6.72 22.17
130 INT11893 Positive_regulation of Ptger2 1 96 0.69 31.49 21.92
131 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
132 INT3589 Positive_regulation of SCN5A 1 101 0.57 46.01 21.73
133 INT2894 Negative_regulation of Localization of Oxt 1 43 0.58 4.59 20.85
134 INT53575 Regulation of Gene_expression of Tnf 2 46 0.62 34.35 20.63
135 INT12951 Negative_regulation of Cat 1 126 0.57 64.39 20.61
136 INT53574 Regulation of Tnf 2 45 0.62 40.68 19.71
137 INT66751 Negative_regulation of Localization of Tnf 3 48 0.59 26 19.36
138 INT6351 Positive_regulation of Gabbr1 1 40 0.64 11.99 19
139 INT55335 Binding of Cpox 1 49 0.34 15.48 18.46
140 INT17442 Gene_expression of ALOX5 2 110 0.75 51.55 18.29
141 INT3118 Negative_regulation of Positive_regulation of POMC 2 33 0.59 9.42 18.07
142 INT58495 Positive_regulation of Positive_regulation of Oprm1 1 22 0.49 2.44 17.66
143 INT17237 Regulation of Esr1 1 74 0.43 49.09 17.25
144 INT111416 Positive_regulation of Trpm8 2 65 0.70 14.62 17.13
145 INT10056 Positive_regulation of Fabp6 1 77 0.59 36.99 16.8
146 INT213 Negative_regulation of Localization of AVP 1 46 0.59 19.78 16.79
147 INT4616 Regulation of Maoa 3 40 0.62 6.09 15.94
148 INT3466 Gene_expression of Ptger1 2 39 0.75 18.34 15.75
149 INT91285 Negative_regulation of P2rx2 1 29 0.57 12.74 15.48
150 INT615 Regulation of Alb 1 66 0.62 33.43 15.33
151 INT5674 Gene_expression of Adra2a 1 34 0.77 6.14 15.13
152 INT7786 Positive_regulation of Ptgdr 1 26 0.47 5.62 14.99
153 INT3545 Positive_regulation of Mtx1 1 27 0.42 11.97 14.83
154 INT7674 Regulation of ENG 2 42 0.30 11.41 14.44
155 INT69743 Gene_expression of Hmox2 1 36 0.78 20.77 14.26
156 INT5806 Regulation of Edn1 1 63 0.62 23.46 13.88
157 INT74465 Negative_regulation of Nkx1-1 1 22 0.46 8.51 13.63
158 INT655 Positive_regulation of Localization of REN 2 86 0.70 32.41 13.56
159 INT3174 Negative_regulation of Ptger2 1 43 0.38 20.95 13.43
160 INT3962 Regulation of AGT 1 50 0.62 20.96 13.01
161 INT17974 Positive_regulation of Localization of Oxt 1 34 0.69 4.45 12.9
162 INT60865 Gene_expression of G2e3 1 20 0.73 2.1 12.76
163 INT29745 Binding of APP 1 47 0.48 26.49 12.4
164 INT11288 Negative_regulation of CRH 1 44 0.00 16.69 12.37
165 INT8725 Gene_expression of Mln 1 32 0.77 14.9 12.22
166 INT3173 Negative_regulation of Localization of Sct 2 28 0.55 6.46 12.11
167 INT11121 Positive_regulation of NPPA 1 64 0.70 34.09 11.96
168 INT5649 Negative_regulation of Positive_regulation of Mpo 1 31 0.59 26.62 11.92
169 INT9084 Positive_regulation of Nppb 2 74 0.70 69.77 11.85
170 INT481 Regulation of Localization of Ren 2 37 0.62 5.95 11.61
171 INT13303 Positive_regulation of PTAFR 1 40 0.69 16.27 11.56
172 INT58775 Binding of G2e3 1 10 0.33 0.19 11.52
173 INT10798 Positive_regulation of CYP2D6 1 24 0.56 5.82 11.31
174 INT38255 Localization of Chkb 1 32 0.80 10.98 11.07
175 INT14132 Negative_regulation of HTR1A 1 25 0.57 4.93 10.91
176 INT7132 Localization of NPPA 1 53 0.81 19.79 10.86
177 INT5779 Positive_regulation of Transcription of Calca 1 15 0.62 5.61 10.86
178 INT14124 Negative_regulation of Adra1a 1 34 0.59 7.48 10.85
179 INT17349 Negative_regulation of Akr1b1 1 41 0.59 27.03 10.65
180 INT60434 Negative_regulation of Positive_regulation of Tnf 1 20 0.46 10.01 10.64
181 INT135022 Gene_expression of Cd14 4 79 0.76 36.37 10.63
182 INT11936 Positive_regulation of Positive_regulation of Il6 1 34 0.50 26.85 10.59
183 INT20131 Negative_regulation of Mthfs 1 18 0.57 7.93 10.54
184 INT8049 Regulation of Nts 1 18 0.53 6.15 10.39
185 INT1372 Regulation of Localization of REN 1 50 0.62 5.76 9.81
186 INT16356 Regulation of NPPA 6 33 0.62 13.24 9.53
187 INT25834 Positive_regulation of Dbp 1 59 0.68 24.34 9.32
188 INT5939 Regulation of Gene_expression of Oxt 1 27 0.51 2.84 9.1
189 INT1224 Gene_expression of Fabp6 1 34 0.64 23.69 9.08
190 INT76405 Positive_regulation of Hmox2 1 21 0.43 12.77 8.99
191 INT36449 Negative_regulation of G6PD 1 74 0.59 54.15 8.85
192 INT73234 Positive_regulation of Lbp 1 13 0.69 12.55 8.57
193 INT65661 Positive_regulation of Ado 6 13 0.52 4.75 8.54
194 INT8637 Negative_regulation of Dbp 1 112 0.50 33.28 8.4
195 INT17333 Positive_regulation of Positive_regulation of FOS 1 17 0.67 6.06 8.4
196 INT5114 Gene_expression of Ptgis 1 41 0.50 21.43 8.1
197 INT10899 Positive_regulation of Gene_expression of Edn1 1 32 0.70 24.88 7.65
198 INT298 Negative_regulation of ADRB3 1 23 0.59 6.82 7.56
199 INT15156 Positive_regulation of Localization of NPPA 1 21 0.70 8.61 6.97
200 INT20922 Positive_regulation of Localization of CRH 3 18 0.67 11.12 6.79
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