J:Clin. Exp. Rheumatol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 1 0.59 9.37 4.48
2 INT165627 Binding of COMT and SLTM 1 1 0.09 0.86 0.88
3 INT54992 Il6 Negative_regulation of Prl 1 1 0.00 0.86 0.84
4 INT92045 Binding of ALB and SERPINA1 1 1 0.30 1.37 0.64
5 INT58342 Calca Negative_regulation of Localization of IL1B 1 1 0.00 0.6 0.58
6 INT160520 Binding of HSD11B1 and Crp 1 1 0.02 0.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 1 2008 0.81 518.3 1408.65
2 INT796 Gene_expression of Penk 4 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
4 INT6483 Gene_expression of TNF 6 3152 0.78 2515.62 929.82
5 INT1912 Gene_expression of Calca 2 1152 0.78 453.25 739.84
6 INT2543 Positive_regulation of Calca 3 787 0.70 331.13 592.08
7 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
8 INT50058 Negative_regulation of Cpox 1 907 0.58 426.28 428.29
9 INT9238 Gene_expression of IL6 10 1575 0.78 1135.66 424.22
10 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
11 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
12 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
13 INT162 Regulation of Prl 2 794 0.62 165.01 322.24
14 INT34869 Negative_regulation of PTGS2 7 778 0.59 366.76 319.85
15 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
16 INT10832 Gene_expression of IL8 5 1050 0.78 698.72 270
17 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
18 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
19 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
20 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
21 INT22548 Positive_regulation of Casp3 3 483 0.70 258.78 213.07
22 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
23 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
24 INT6488 Gene_expression of Tnf 2 484 0.78 339.61 191.58
25 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
26 INT3448 Positive_regulation of Gh 1 521 0.69 180.03 161.18
27 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
28 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
29 INT13353 Positive_regulation of Tnf 2 332 0.70 248.75 148.1
30 INT5116 Gene_expression of IL2 3 670 0.78 291.13 146.69
31 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
32 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
33 INT1878 Binding of HLA-B 6 440 0.48 321.16 127.36
34 INT9235 Negative_regulation of Gene_expression of TNF 2 346 0.59 252.98 118.61
35 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
36 INT1530 Regulation of Gh 1 382 0.61 115.96 112.47
37 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
38 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
39 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
40 INT1760 Gene_expression of PTGER2 6 524 0.57 226.94 96.4
41 INT1635 Gene_expression of Vip 6 245 0.78 53.36 88.13
42 INT1498 Gene_expression of Gh 2 521 0.75 220.84 81.16
43 INT12476 Negative_regulation of TRPV1 1 124 0.59 47.95 77.98
44 INT749 Gene_expression of HLA-B 11 341 0.75 224.12 77.37
45 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
46 INT5969 Gene_expression of Il1a 1 221 0.75 96.31 71.38
47 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
48 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
49 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
50 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
51 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
52 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
53 INT6477 Gene_expression of IL1RN 1 213 0.77 114.69 58.62
54 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
55 INT9408 Positive_regulation of Crp 2 296 0.69 242.27 57.35
56 INT4509 Gene_expression of IGG 1 426 0.76 293.69 56.64
57 INT8700 Positive_regulation of Positive_regulation of Calca 1 56 0.67 21.69 53.66
58 INT9234 Negative_regulation of Gene_expression of IL6 4 171 0.59 101.61 53.15
59 INT66029 Negative_regulation of Tnf 1 100 0.59 84.28 48.16
60 INT55670 Negative_regulation of Gene_expression of Tnf 1 83 0.59 57.16 46.33
61 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
62 INT3361 Positive_regulation of Esr1 2 273 0.69 208.53 44.81
63 INT49552 Negative_regulation of Positive_regulation of Casp3 1 76 0.55 36.04 44.78
64 INT69992 Negative_regulation of Hmox2 1 93 0.50 49.01 44.07
65 INT5307 Regulation of Tnf 1 87 0.62 78.71 43.4
66 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
67 INT13556 Gene_expression of CD4 1 367 0.78 230.82 41.74
68 INT5454 Localization of CRH 1 124 0.79 79.18 41.53
69 INT3987 Positive_regulation of IGHE 1 316 0.70 283.2 40.16
70 INT163134 Gene_expression of ACR 1 78 0.65 30.39 38.48
71 INT9239 Regulation of Gene_expression of IL6 2 106 0.61 75.24 36.53
72 INT67613 Positive_regulation of PPARG 1 94 0.70 69.15 34.38
73 INT17381 Gene_expression of Tbxa2r 2 146 0.78 65.01 34.15
74 INT16960 Gene_expression of Crp 1 166 0.76 116.21 34.07
75 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
76 INT7082 Gene_expression of CRH 2 180 0.78 64.66 31.74
77 INT9993 Positive_regulation of Gene_expression of IL2 1 131 0.69 46.27 30.04
78 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
79 INT16814 Negative_regulation of COX5A 1 74 0.57 33.72 28.63
80 INT56072 Negative_regulation of NFKB1 1 94 0.59 53.16 28.19
81 INT11361 Gene_expression of SERPINE1 5 183 0.78 136.45 27.97
82 INT13995 Gene_expression of gr 9 96 0.74 48.21 26.54
83 INT5966 Localization of Il1a 2 50 0.78 22.91 26.54
84 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
85 INT7584 Gene_expression of Crh 1 112 0.78 39.15 25.33
86 INT22549 Positive_regulation of Positive_regulation of Casp3 2 48 0.56 29.5 23.7
87 INT9292 Positive_regulation of SGCG 1 93 0.67 35.13 23.48
88 INT100026 Gene_expression of Tnfrsf1b 1 73 0.72 43.26 23.23
89 INT93738 Gene_expression of Tnfrsf1a 1 63 0.74 57.66 23.09
90 INT1876 Positive_regulation of HLA-B 3 82 0.69 52.16 21.08
91 INT9237 Regulation of Gene_expression of IL1B 1 49 0.62 30.69 20.34
92 INT69304 Negative_regulation of Il10 1 47 0.59 36.88 19.79
93 INT53574 Regulation of Tnf 1 45 0.62 40.68 19.71
94 INT89484 Gene_expression of TNFRSF11B 1 119 0.76 53.57 19.67
95 INT1764 Negative_regulation of Gene_expression of PTGER2 4 81 0.34 34.74 19.45
96 INT135629 Binding of COMT 1 33 0.48 16.68 19.37
97 INT10565 Gene_expression of MRXS5 3 94 0.53 37.35 19.08
98 INT18010 Positive_regulation of CD40LG 1 122 0.70 100.8 18.46
99 INT10833 Regulation of Gene_expression of IL8 4 68 0.62 38.74 18.46
100 INT6480 Positive_regulation of IL1RN 1 59 0.69 33.7 16.66
101 INT8571 Gene_expression of B3GAT1 2 54 0.75 36.85 15.98
102 INT2383 Positive_regulation of CP 1 33 0.67 25.41 15.38
103 INT11636 Positive_regulation of SERPINE1 1 85 0.69 68.73 14.8
104 INT105387 Gene_expression of HIF1A 2 116 0.77 98.62 14.66
105 INT1873 Gene_expression of MRAP 2 51 0.76 31.75 13.92
106 INT91544 Gene_expression of CHI3L1 1 60 0.75 77.72 13.9
107 INT56651 Binding of HLA-DRB1 2 58 0.48 52.25 13.68
108 INT2673 Negative_regulation of PROC 1 93 0.57 50.34 12.79
109 INT125477 Gene_expression of HHIP 3 91 0.78 31.18 12.57
110 INT5452 Regulation of CRH 1 56 0.62 15.32 12.42
111 INT59080 Negative_regulation of Gene_expression of PTGS2 1 55 0.58 22.92 12.39
112 INT11359 Gene_expression of PLAU 6 84 0.76 49.54 12.31
113 INT46695 Positive_regulation of TNC 1 28 0.67 17.06 12.04
114 INT39587 Gene_expression of CP 3 42 0.65 31.48 11.87
115 INT744 Positive_regulation of PTH 1 130 0.70 95.02 11.7
116 INT787 Localization of Ptgs1 1 31 0.80 12.36 11.55
117 INT80756 Gene_expression of CD86 1 77 0.77 46.68 11.36
118 INT1762 Negative_regulation of PTGER2 1 64 0.43 28.21 11.27
119 INT11673 Positive_regulation of ECT 2 43 0.59 13.93 11.25
120 INT11794 Gene_expression of Cd2 1 27 0.76 17.31 10.99
121 INT53201 Negative_regulation of gr 1 35 0.50 17.76 10.62
122 INT10049 Negative_regulation of SERPINA1 2 56 0.59 44.52 9.93
123 INT3925 Negative_regulation of HLA-B 4 29 0.42 20.19 9.46
124 INT137400 Regulation of Mtx1 1 16 0.52 9.19 9.45
125 INT122952 Positive_regulation of COMT 1 13 0.50 8.1 8.89
126 INT97331 Positive_regulation of Timp1 2 20 0.45 13.32 8.57
127 INT4159 Gene_expression of Hp 1 33 0.72 12.49 8.39
128 INT725 Negative_regulation of IgG 3 62 0.41 37.21 8.16
129 INT17996 Binding of Crp 1 40 0.37 31.4 7.8
130 INT93914 Gene_expression of CD80 1 70 0.75 36.35 7.74
131 INT5284 Regulation of HLA-B 1 25 0.59 12.91 7.74
132 INT5409 Negative_regulation of G6pd 1 33 0.57 29.21 7.64
133 INT1123 Positive_regulation of CD79A 1 74 0.70 51.96 7.14
134 INT9397 Regulation of MET 1 17 0.60 8.36 7.04
135 INT10505 Gene_expression of Ptafr 1 18 0.62 10.7 6.83
136 INT90097 Localization of PTGS2 1 15 0.69 6.14 6.63
137 INT5455 Negative_regulation of Localization of CRH 1 16 0.49 7.31 6.41
138 INT28861 Binding of Gh 1 61 0.46 25.61 6.38
139 INT27628 Gene_expression of IL2RG 1 28 0.75 20.95 6.16
140 INT195 Gene_expression of C4a 1 16 0.48 15.55 6.1
141 INT7527 Gene_expression of SLTM 1 12 0.25 2.9 6.07
142 INT53196 Binding of Cd4 1 44 0.47 27.28 5.85
143 INT52819 Negative_regulation of NR3C1 1 14 0.50 7.22 5.84
144 INT105538 Negative_regulation of Tnfrsf1a 1 16 0.56 12.51 5.61
145 INT58338 Negative_regulation of Localization of Il1a 1 8 0.25 3.13 5.18
146 INT67597 Negative_regulation of Das 1 17 0.37 9.95 5.05
147 INT17110 Gene_expression of PSMD1 1 60 0.65 19.57 4.69
148 INT2836 Positive_regulation of PAEP 1 51 0.67 26.69 4.57
149 INT12194 Gene_expression of Trf 1 38 0.69 18.1 4.56
150 INT11354 Regulation of Gene_expression of SERPINE1 1 11 0.61 8.66 4.42
151 INT11635 Positive_regulation of Gene_expression of SERPINE1 2 35 0.68 24.57 4.26
152 INT139533 Binding of Il23r 1 17 0.47 7.67 4.14
153 INT24280 Positive_regulation of SLTM 1 6 0.09 1.53 4.08
154 INT14682 Regulation of B3GAT1 1 9 0.54 3.9 4.06
155 INT125479 Positive_regulation of HHIP 1 38 0.44 12.39 3.75
156 INT99186 Negative_regulation of Negative_regulation of TRPV1 1 4 0.41 2.49 3.65
157 INT21406 Negative_regulation of Gene_expression of IgG 1 20 0.41 9.36 3.58
158 INT45818 Gene_expression of C4A 1 35 0.75 26.4 3.52
159 INT3183 Negative_regulation of MRXS5 1 15 0.41 6.56 3.45
160 INT45961 Gene_expression of Cspg4 1 22 0.78 7.21 3.43
161 INT158978 Localization of TNFRSF11B 3 19 0.78 11.8 3.32
162 INT47949 Positive_regulation of ELOVL1 1 19 0.42 29.78 3.3
163 INT85970 Positive_regulation of Cd40lg 1 21 0.53 8.51 3.16
164 INT17749 Positive_regulation of Gene_expression of MRXS5 1 15 0.23 8.02 3.15
165 INT43907 Binding of CD79A 1 28 0.48 28.11 3.04
166 INT64437 Gene_expression of IL1R1 1 9 0.65 6.22 2.99
167 INT99187 Negative_regulation of Positive_regulation of PPARG 1 5 0.42 5.07 2.99
168 INT159709 Binding of ERAP1 2 12 0.47 3.42 2.91
169 INT17417 Positive_regulation of Ighd 1 16 0.69 24.29 2.8
170 INT75685 Regulation of CD86 1 12 0.58 3.55 2.66
171 INT19621 Positive_regulation of CD86 1 23 0.69 14 2.58
172 INT50367 Negative_regulation of COX8A 1 10 0.57 5.13 2.38
173 INT11357 Negative_regulation of Gene_expression of PLAU 2 10 0.56 5.3 2.38
174 INT36052 Positive_regulation of Gene_expression of IL2RG 1 7 0.28 4.72 2.32
175 INT23620 Negative_regulation of C4A 1 24 0.57 15.1 2.23
176 INT19804 Negative_regulation of Hprt 1 18 0.59 20.6 2.17
177 INT55897 Positive_regulation of C4a 1 8 0.29 3.81 2.07
178 INT56342 Gene_expression of TTR 1 34 0.78 16.5 2.05
179 INT97579 Negative_regulation of Localization of PTGS2 1 2 0.08 2.37 1.99
180 INT93912 Positive_regulation of CD80 1 11 0.56 7.01 1.88
181 INT135187 Transcription of TNFRSF11B 1 9 0.70 3.53 1.87
182 INT78809 Negative_regulation of ADK 1 3 0.34 1.89 1.85
183 INT94934 Negative_regulation of COX1 1 3 0.57 3.27 1.75
184 INT147636 Regulation of CD80 1 3 0.60 1.27 1.73
185 INT122951 Regulation of Binding of HLA-B 1 4 0.39 3.08 1.65
186 INT25981 Regulation of RTCA 1 7 0.26 2.07 1.64
187 INT6904 Negative_regulation of Cd2 1 5 0.42 1.37 1.64
188 INT12890 Gene_expression of Ttr 1 15 0.63 7.68 1.6
189 INT37485 Regulation of RAPGEF5 2 10 0.44 6.64 1.51
190 INT55948 Phosphorylation of CAMP 1 4 0.80 0.52 1.49
191 INT79167 Localization of TNC 1 8 0.78 4.15 1.44
192 INT113268 Positive_regulation of Positive_regulation of Timp1 1 3 0.15 3.23 1.43
193 INT104600 Regulation of Gene_expression of gr 1 6 0.43 7.03 1.33
194 INT27911 Negative_regulation of Gene_expression of Ptafr 1 3 0.37 0.58 1.32
195 INT88396 Positive_regulation of CES1 1 6 0.49 2.93 1.29
196 INT145312 Localization of CHI3L1 2 8 0.78 12.71 1.26
197 INT163133 Gene_expression of ZBP1 1 28 0.65 18.59 1.25
198 INT162384 Gene_expression of Il23r 1 4 0.77 1.03 1.12
199 INT58341 Positive_regulation of Positive_regulation of ECT 1 2 0.43 0.73 0.98
200 INT82350 Gene_expression of Hm 3 5 0.15 0.64 0.92
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