J:Clin. Pharmacol. Ther.

From wiki-pain
Jump to: navigation, search

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 1 0.43 0.1 0.62
2 INT2686 Binding of Thra and SGSM3 1 1 0.36 0.1 0.61
3 INT2685 S100A6 Positive_regulation of Regulation of Thra 1 1 0.47 0.09 0.58
4 INT2684 S100A6 Regulation of Regulation of Thra 1 1 0.45 0.09 0.58
5 INT544 Binding of ALB and GC 1 1 0.13 0 0.55
6 INT4107 Binding of CSF2 and PAPPA 1 1 0.15 0 0.14
7 INT99476 Binding of CYP3A4 and ABCB1 2 1 0.28 0 0.08
8 INT121551 Binding of CYP2B6 and Regulation of CYP3A 1 1 0.21 0 0
9 INT96893 Binding of CYP3A4 and Orm2 1 1 0.07 0 0
10 INT121550 Binding of CYP2B6 and Regulation of CDH17 1 1 0.01 0 0
11 INT96894 Binding of CYP3A4 and Orm1 1 1 0.00 0 0
12 INT125313 CALCA Regulation of CALCA Positive_regulation of CEBPZ 1 1 0.09 0.06 0
13 INT125315 CALCA Positive_regulation of CEBPZ 1 1 0.15 0.06 0
14 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 1 0.08 0 0
15 INT125314 CALCA Regulation of CEBPZ 1 1 0.09 0.06 0
16 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 5 1020 0.81 284.52 443.17
2 INT6580 Negative_regulation of Ptgs1 3 929 0.59 381.53 376.26
3 INT720 Positive_regulation of POMC 3 807 0.70 237.37 353.83
4 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
5 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
6 INT49750 Negative_regulation of CPOX 7 735 0.58 360.06 274.19
7 INT10832 Gene_expression of IL8 4 1050 0.78 698.72 270
8 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
9 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
10 INT767 Localization of Gnrhr 5 565 0.80 106.68 214.57
11 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
12 INT50670 Gene_expression of CPOX 2 763 0.76 442.13 195.02
13 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
14 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
15 INT51921 Gene_expression of Cpox 3 501 0.73 229.81 157.81
16 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
17 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
18 INT812 Localization of INS 3 1026 0.81 515.6 145.31
19 INT48895 Gene_expression of Il10 1 333 0.78 221.2 138.52
20 INT6128 Positive_regulation of Localization of POMC 3 256 0.70 68.77 121.64
21 INT50674 Gene_expression of PTGS2 7 459 0.78 253.33 118.51
22 INT1438 Localization of Pomc 4 360 0.81 101.26 116.47
23 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
24 INT10838 Positive_regulation of IL8 2 381 0.70 295.51 101.62
25 INT397 Localization of SST 1 232 0.81 58.05 101.19
26 INT4860 Positive_regulation of CALCA 3 148 0.00 73.35 97.61
27 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
28 INT214 Localization of AVP 1 370 0.81 208.51 91.09
29 INT1309 Positive_regulation of Localization of Gnrhr 2 152 0.69 24.25 81.56
30 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
31 INT15913 Negative_regulation of CYP2D6 13 174 0.59 22.45 70.91
32 INT10837 Positive_regulation of Gene_expression of IL8 2 294 0.70 190.08 70.34
33 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
34 INT462 Regulation of Pomc 1 157 0.62 41.67 67.27
35 INT46 Localization of Ren 5 233 0.81 46.15 62.44
36 INT9196 Gene_expression of PTGS1 4 215 0.77 96.99 60.5
37 INT546 Binding of ALB 5 311 0.48 85.98 60.14
38 INT770 Regulation of Localization of Gnrhr 1 127 0.61 17.91 58.23
39 INT48232 Gene_expression of MMP1 2 245 0.78 96.31 57.72
40 INT5453 Regulation of Localization of POMC 1 114 0.62 20.56 56.34
41 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
42 INT251 Regulation of INS 2 398 0.62 232.47 55.04
43 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
44 INT249 Localization of GHRH 1 215 0.80 78.02 51.87
45 INT5118 Regulation of SST 1 97 0.62 34.35 51.74
46 INT8490 Negative_regulation of CALCA 1 87 0.59 29.73 51.34
47 INT1199 Positive_regulation of INS 2 579 0.70 399.64 50.43
48 INT7093 Negative_regulation of CYP2B6 3 146 0.58 37.3 48.39
49 INT1197 Negative_regulation of Localization of POMC 1 109 0.59 28.29 48.02
50 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
51 INT4656 Localization of RYBP 3 49 0.77 5.28 46.21
52 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
53 INT29496 Gene_expression of MMP3 2 136 0.75 49.49 41.78
54 INT957 Positive_regulation of GHRH 3 136 0.70 36.84 40.52
55 INT3252 Negative_regulation of INS 2 428 0.59 271.65 39.52
56 INT55135 Positive_regulation of Gene_expression of PTGS2 4 137 0.70 80.32 38.46
57 INT56870 Gene_expression of CYP2D6 2 87 0.78 8.83 37.53
58 INT3253 Negative_regulation of Localization of INS 1 205 0.59 130.39 36.61
59 INT3971 Positive_regulation of Alb 1 175 0.70 98.46 36.45
60 INT8837 Positive_regulation of TAC1 1 59 0.67 21.94 35.97
61 INT49 Negative_regulation of Ren 3 129 0.59 37.48 35.62
62 INT10796 Gene_expression of CYP2B6 2 131 0.77 30.14 35.27
63 INT2274 Regulation of Localization of INS 2 101 0.62 41.55 34.79
64 INT4403 Binding of CYP2B6 2 113 0.48 21.17 33.83
65 INT11764 Positive_regulation of ENG 1 78 0.61 27.65 33.69
66 INT1116 Regulation of Ren 2 103 0.62 27.66 33.26
67 INT234 Binding of Alb 3 151 0.48 52.34 32.97
68 INT20307 Positive_regulation of Cyp2e1 2 70 0.70 23.59 32.49
69 INT22239 Negative_regulation of TAC1 1 52 0.57 12.96 31.41
70 INT10797 Binding of CYP2D6 3 86 0.48 15.09 31.16
71 INT10285 Binding of ADRA1D 11 102 0.47 25.82 31.11
72 INT719 Negative_regulation of SGCG 1 96 0.57 47.91 30.22
73 INT50 Negative_regulation of Localization of Ren 2 87 0.59 14.94 30.22
74 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
75 INT11554 Negative_regulation of CSF2 2 129 0.59 108.55 29.44
76 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
77 INT1196 Positive_regulation of Positive_regulation of POMC 1 51 0.70 15.99 28.58
78 INT22211 Positive_regulation of CYP3A4 6 110 0.70 22 28.27
79 INT12129 Gene_expression of CYP3A4 1 107 0.78 23.11 27.6
80 INT10799 Localization of ENG 1 63 0.78 18.67 27.28
81 INT3559 Negative_regulation of Localization of Gnrhr 1 73 0.58 18.89 26.41
82 INT53949 Positive_regulation of Gene_expression of Cpox 1 82 0.65 38.12 25.93
83 INT2040 Positive_regulation of CYP2B6 5 95 0.69 34.3 25.6
84 INT8779 Binding of TAC1 2 50 0.47 11.19 25.57
85 INT9781 Binding of INSRR 1 64 0.31 19.1 25.2
86 INT17625 Localization of GCG 1 210 0.80 55.69 24.97
87 INT2140 Regulation of REN 2 104 0.62 28.24 24.49
88 INT825 Negative_regulation of ADRA1D 1 54 0.58 20.25 22.78
89 INT7678 Localization of Alb 3 142 0.81 80.93 22.49
90 INT39914 Negative_regulation of Cyp1a2 3 44 0.58 10.04 22
91 INT5916 Positive_regulation of HTR1A 1 51 0.67 18.27 21.38
92 INT60779 Negative_regulation of CYP3A 11 63 0.59 8.38 21.27
93 INT955 Gene_expression of GHRH 1 126 0.78 59.91 20.74
94 INT6699 Positive_regulation of ADRA1D 3 65 0.70 22.72 20.31
95 INT9782 Binding of HTR1B 1 43 0.47 12.08 19.83
96 INT11628 Regulation of Localization of Pomc 1 44 0.61 10.46 18.66
97 INT48 Positive_regulation of Localization of Ren 1 69 0.70 12.47 18.03
98 INT667 Negative_regulation of Hrh2 1 38 0.58 18.11 18.01
99 INT50403 Negative_regulation of CYP2C19 2 55 0.59 8.97 17.79
100 INT50579 Binding of CYP3A4 2 84 0.48 17.52 17.45
101 INT50404 Negative_regulation of CYP1A2 1 49 0.59 8.61 17.35
102 INT213 Negative_regulation of Localization of AVP 1 46 0.59 19.78 16.79
103 INT4853 Regulation of Hrh2 1 42 0.45 22.34 16.65
104 INT984 Positive_regulation of Localization of GHRH 1 58 0.70 12.66 16.51
105 INT1214 Gene_expression of PGE 1 70 0.72 29.07 16.22
106 INT20336 Positive_regulation of CYP2E1 1 48 0.70 19.26 15.66
107 INT1154 Negative_regulation of CCK 1 24 0.59 9.3 15.32
108 INT1850 Binding of OXA1L 5 77 0.48 7.61 15.22
109 INT170 Negative_regulation of Adrb1 2 52 0.55 13.46 14.78
110 INT663 Negative_regulation of Adrb3 1 55 0.59 15.95 14.68
111 INT27266 Regulation of Gene_expression of Pomc 1 41 0.62 6.74 14.59
112 INT7523 Regulation of ADRA1D 3 42 0.45 11.63 14.52
113 INT11340 Positive_regulation of SLC17A5 1 120 0.67 113.52 14.5
114 INT92823 Positive_regulation of Gene_expression of MMP1 1 65 0.68 25.69 14.31
115 INT22276 Gene_expression of TBXA2R 3 65 0.77 23.22 14.21
116 INT67855 Negative_regulation of PPIG 1 64 0.57 17.83 13.54
117 INT60764 Positive_regulation of PPIG 2 39 0.67 17.08 13.48
118 INT50580 Binding of PPIG 1 39 0.36 11.17 12.34
119 INT102731 Regulation of ABCB1 1 29 0.62 5.36 11.67
120 INT1436 Negative_regulation of Localization of Pomc 2 41 0.58 10.85 11.26
121 INT70877 Gene_expression of PPIG 1 72 0.75 22.39 10.93
122 INT93129 Negative_regulation of KCNH2 1 42 0.54 9.63 10.85
123 INT16449 Binding of IGHG3 1 67 0.48 39.55 10.59
124 INT1934 Positive_regulation of Cys1 1 68 0.68 60.56 10.47
125 INT952 Negative_regulation of GHRH 2 57 0.56 25.3 10.34
126 INT55418 Regulation of CYP2D6 2 29 0.61 1.83 10.21
127 INT68372 Regulation of CYP2C9 4 28 0.62 5.64 9.53
128 INT132036 Negative_regulation of DPP4 6 126 0.59 63.24 9.51
129 INT26492 Negative_regulation of Localization of GCG 1 73 0.58 22.2 9.48
130 INT93490 Gene_expression of GPM6A 1 14 0.69 3.14 9.08
131 INT12991 Negative_regulation of Gene_expression of PTGS1 1 28 0.41 13.39 8.9
132 INT49205 Positive_regulation of B3GAT1 1 20 0.67 10.28 8.71
133 INT18391 Positive_regulation of GYPA 1 41 0.40 16.47 8.69
134 INT23229 Positive_regulation of H2-M3 4 11 0.04 1.87 8.56
135 INT197 Gene_expression of Hrh2 1 24 0.63 12.35 8.37
136 INT61599 Positive_regulation of CYP2C9 3 43 0.69 11.1 8.33
137 INT1925 Gene_expression of PLAT 2 47 0.75 34.76 7.88
138 INT12334 Positive_regulation of CYP3A 5 34 0.70 6.77 7.85
139 INT10284 Binding of ORM1 3 16 0.48 0.98 7.73
140 INT11042 Localization of Tbxa2r 1 26 0.76 10.15 7.24
141 INT49751 Negative_regulation of Positive_regulation of PTGS1 1 12 0.45 4.73 7.23
142 INT7743 Binding of Hrh2 1 19 0.47 7.75 7.11
143 INT717 Regulation of F2 2 29 0.61 17.46 6.99
144 INT63057 Regulation of CYP3A4 2 31 0.61 5.75 6.92
145 INT256 Localization of ADRA1D 1 11 0.78 2.91 6.85
146 INT12333 Regulation of CYP3A 1 18 0.62 2.25 6.74
147 INT612 Positive_regulation of Orm1 1 15 0.68 5.24 6.73
148 INT2039 Regulation of CYP2B6 1 30 0.60 7.75 6.43
149 INT25130 Positive_regulation of Negative_regulation of Ptgs1 1 14 0.50 5.07 6.29
150 INT15528 Positive_regulation of GCG 1 38 0.63 20.47 6.14
151 INT86600 Gene_expression of KCNH2 1 37 0.78 14.88 6.14
152 INT20331 Positive_regulation of CYP1A2 2 31 0.69 8.6 5.92
153 INT59969 Positive_regulation of Htr1a 1 12 0.67 5.07 5.73
154 INT5317 Positive_regulation of PGE 1 24 0.46 8.27 5.49
155 INT6276 Negative_regulation of Positive_regulation of Pomc 1 12 0.57 3.65 5.49
156 INT50491 Regulation of Gene_expression of PTGS1 1 17 0.47 6 5.4
157 INT65135 Binding of CYP2C19 1 17 0.48 1.82 5.2
158 INT14715 Negative_regulation of Positive_regulation of CALCA 2 5 0.43 2.22 5.2
159 INT12412 Binding of MPG 1 21 0.47 3.92 4.94
160 INT55419 Regulation of CYP1A2 1 19 0.62 5.3 4.75
161 INT102237 Positive_regulation of Gene_expression of MMP3 1 22 0.44 7.77 4.71
162 INT65514 Gene_expression of Cyp1a2 1 25 0.77 6.12 4.6
163 INT4679 Negative_regulation of RAPGEF5 1 55 0.57 47.51 4.55
164 INT59041 Negative_regulation of CYP2E1 1 17 0.59 5.47 4.51
165 INT47044 Positive_regulation of ORM1 2 5 0.68 0.58 4.46
166 INT50581 Regulation of PPIG 1 26 0.55 8.96 4.32
167 INT4711 Regulation of ELK3 2 17 0.62 2.36 4.26
168 INT16304 Negative_regulation of Positive_regulation of GHRH 1 9 0.51 2.56 4.25
169 INT21681 Positive_regulation of CD34 1 54 0.66 33.95 4.14
170 INT10650 Regulation of Ugt2b7 1 7 0.60 1.12 3.67
171 INT19538 Positive_regulation of MPG 1 8 0.67 3.21 3.57
172 INT545 Binding of GC 1 15 0.45 10.74 3.47
173 INT277 Negative_regulation of Adra2c 1 8 0.43 1.89 3.42
174 INT55875 Negative_regulation of GPM6A 1 4 0.31 0.06 3.31
175 INT3682 Binding of Ppr1 2 10 0.42 1.87 2.96
176 INT109833 Binding of GNB3 2 7 0.48 8.83 2.84
177 INT30870 Negative_regulation of Adra2b 1 8 0.44 4.5 2.8
178 INT42811 Binding of CCT6A 1 4 0.07 0 2.78
179 INT24880 Positive_regulation of HRH2 2 7 0.69 1.34 2.74
180 INT129961 Regulation of Gene_expression of MMP1 1 15 0.46 4.88 2.51
181 INT21671 Regulation of CHSY3 2 1 0.11 2.27 2.47
182 INT113081 Negative_regulation of Gene_expression of Cyp1a2 1 6 0.58 1.68 2.39
183 INT39798 Negative_regulation of Gss 1 5 0.51 2.51 2.38
184 INT56337 Regulation of Cyp1a2 1 8 0.27 1.09 2.33
185 INT34830 Regulation of PGR 1 14 0.45 6.99 2.32
186 INT3315 Negative_regulation of Positive_regulation of INS 1 31 0.57 14.73 2.27
187 INT10651 Positive_regulation of Ugt2b7 1 5 0.67 0.16 2.22
188 INT69314 Binding of CYP3A 3 16 0.48 1.78 2.19
189 INT20332 Positive_regulation of Positive_regulation of CYP1A2 2 4 0.69 0.68 2.17
190 INT27222 Gene_expression of ALPPL2 1 4 0.52 24.57 2.05
191 INT28188 Regulation of CYP2E1 1 11 0.62 0.48 2.03
192 INT57923 Gene_expression of CYP3A 1 12 0.71 2.62 2
193 INT31096 Binding of HRH2 1 7 0.37 2 2
194 INT9427 Binding of TBXA2R 1 8 0.31 2.71 1.91
195 INT21625 Negative_regulation of Gene_expression of Hrh2 1 2 0.40 2.4 1.88
196 INT1289 Negative_regulation of Fglu 1 6 0.01 3.1 1.82
197 INT32176 Negative_regulation of Negative_regulation of Adrb1 1 2 0.40 0.4 1.77
198 INT104774 Regulation of PGE 1 5 0.39 2.5 1.76
199 INT21822 Regulation of SULT1A1 3 3 0.62 0 1.75
200 INT36581 Binding of Orm1 1 6 0.48 0.47 1.73
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox