J:Clin Mol Allergy

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT189671 DAG1 Positive_regulation of PRKCA 3 1 0.12 0.71 0.82
2 INT226371 IL18 Positive_regulation of IL4 4 1 0.05 2.49 0.79
3 INT300551 TBX21 Regulation of Hand1 2 1 0.10 0.44 0.48
4 INT184380 Binding of Fcgrt and IgG 3 1 0.27 1.85 0.38
5 INT300751 Binding of IGHE and Hand2 1 1 0.04 0 0.34
6 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 1 0.00 0 0.34
7 INT300732 IL33 Positive_regulation of IL13 1 1 0.00 0 0.34
8 INT300728 IL33 Positive_regulation of IL4 1 1 0.00 0 0.33
9 INT300729 IL18 Positive_regulation of IL13 1 1 0.00 0 0.33
10 INT183464 UGCG Regulation of TNF 1 1 0.25 0.38 0.31
11 INT300742 Stat6 Regulation of Hand2 1 1 0.01 0.06 0.3
12 INT300752 GATA3 Regulation of Hand2 1 1 0.01 0.06 0.3
13 INT177961 Binding of CCR3 and CCL11 1 1 0.04 0.73 0.26
14 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 1 0.01 0.71 0.25
15 INT177960 Binding of IL5 and CCL11 1 1 0.03 0.71 0.25
16 INT335462 IGHE Regulation of Positive_regulation of PRKCA 1 1 0.07 0 0.23
17 INT335464 Binding of DAG1 and PRKCA 1 1 0.03 0 0.22
18 INT177962 IL4 Positive_regulation of VCAM1 1 1 0.02 0.97 0.2
19 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 1 0.00 0 0.17
20 INT335459 ABCA1 Positive_regulation of ITPR3 1 1 0.00 0 0.15
21 INT232018 Binding of SERPING1 and KNG1 1 1 0.15 0.81 0.14
22 INT194383 Il13 Positive_regulation of Gene_expression of Il4 1 1 0.00 1.75 0.13
23 INT335460 FPR1 Positive_regulation of PIK3CD 1 1 0.17 0 0.13
24 INT300731 IL10 Negative_regulation of Gene_expression of IGHE 1 1 0.03 0.23 0.13
25 INT232015 SERPING1 Negative_regulation of F12 2 1 0.24 1.19 0.12
26 INT232017 F12 Positive_regulation of PLG 1 1 0.03 0.52 0.11
27 INT306452 Binding of MBL2 and TLR4 1 1 0.38 0.37 0.1
28 INT306453 MBL2 Regulation of Binding of TLR4 1 1 0.48 0.37 0.1
29 INT232019 F12 Positive_regulation of TRGC1 1 1 0.00 0.57 0.09
30 INT194385 Il13 Positive_regulation of Gene_expression of IGHE 1 1 0.00 0.8 0.09
31 INT232010 PLG Positive_regulation of TRGC1 1 1 0.08 0.51 0.09
32 INT232011 SERPING1 Regulation of Negative_regulation of SERPINE1 1 1 0.01 0.45 0.07
33 INT190932 R3hdm1 Negative_regulation of Fcer2a 1 1 0.00 0.8 0.07
34 INT232009 Positive_regulation of F12 Negative_regulation of Localization of KNG1 1 1 0.01 0.19 0.05
35 INT232013 SERPING1 Negative_regulation of C1S 1 1 0.24 0.72 0.04
36 INT232012 SERPING1 Negative_regulation of C1R 1 1 0.18 0.72 0.04
37 INT195195 IL4 Regulation of Gene_expression of IGHE 1 1 0.10 0.68 0.04
38 INT195199 Gene_expression of IL4 Positive_regulation of Gene_expression of IGHE 1 2 0.08 1.76 0
39 INT232016 SERPING1 Regulation of C1S 1 1 0.15 0.57 0
40 INT195198 Gene_expression of IL5 Positive_regulation of Gene_expression of IGHE 1 2 0.09 1.76 0
41 INT324976 IgG Negative_regulation of Gene_expression of Fcer2a 1 1 0.02 0.79 0
42 INT195197 Gene_expression of IL9 Positive_regulation of Gene_expression of IGHE 1 2 0.05 1.77 0
43 INT195196 IL13 Positive_regulation of Gene_expression of IGHE 1 2 0.06 1.79 0
44 INT324975 Fcgrt Positive_regulation of Gene_expression of IgG 1 1 0.27 0.84 0
45 INT177958 IGHE Positive_regulation of TNF 1 1 0.03 2.23 0
46 INT195200 IL10 Positive_regulation of Gene_expression of IGHE 1 2 0.07 1.78 0
47 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 1 0.03 2.23 0
48 INT190931 Fcer2a Positive_regulation of Gene_expression of R3hdm1 1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 7 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
4 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
5 INT10832 Gene_expression of IL8 2 1050 0.78 698.72 270
6 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
7 INT626 Localization of CALCA 2 289 0.81 125.39 221.15
8 INT6482 Positive_regulation of Gene_expression of TNF 8 659 0.70 569.88 210
9 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
10 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
11 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
12 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
13 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
14 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
15 INT20374 Gene_expression of Il4 19 515 0.76 306.15 114.12
16 INT60526 Gene_expression of IL10 3 449 0.78 292.71 107.84
17 INT915 Positive_regulation of PRL 1 342 0.70 141.96 104.31
18 INT18009 Positive_regulation of CRP 1 518 0.70 553.03 103.74
19 INT11587 Gene_expression of CSF2 5 645 0.78 544.38 93.89
20 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
21 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
22 INT56298 Gene_expression of IL4 6 306 0.78 182.18 72.92
23 INT7344 Gene_expression of TAC1 1 132 0.75 35.48 68.26
24 INT7134 Localization of KNG1 6 127 0.79 65.73 67.97
25 INT9489 Gene_expression of SFTPA1 1 112 0.66 55.38 66.45
26 INT3375 Gene_expression of IGHE 55 535 0.77 387.47 65.46
27 INT11807 Gene_expression of Il2 1 266 0.78 112 64.97
28 INT822 Gene_expression of ESR1 3 529 0.78 302.16 63.64
29 INT546 Binding of ALB 1 311 0.48 85.98 60.14
30 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
31 INT4509 Gene_expression of IGG 9 426 0.76 293.69 56.64
32 INT20382 Gene_expression of Hand2 3 211 0.66 142.26 51.05
33 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
34 INT48718 Positive_regulation of PRKCA 3 109 0.69 36.16 46.49
35 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
36 INT11406 Positive_regulation of Localization of CALCA 1 49 0.70 20.64 42.8
37 INT4004 Gene_expression of IGHG3 1 321 0.71 221.03 42.33
38 INT61619 Gene_expression of IL12A 1 194 0.77 146.07 41.97
39 INT13556 Gene_expression of CD4 1 367 0.78 230.82 41.74
40 INT3987 Positive_regulation of IGHE 49 316 0.70 283.2 40.16
41 INT3758 Gene_expression of ALB 3 326 0.78 184.65 38.75
42 INT8835 Localization of SFTPA1 3 65 0.68 32.81 38.65
43 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
44 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
45 INT8837 Positive_regulation of TAC1 1 59 0.67 21.94 35.97
46 INT20380 Gene_expression of Il5 2 172 0.78 104.75 34.78
47 INT73498 Gene_expression of IL13 4 117 0.44 83.85 32.26
48 INT13186 Positive_regulation of Il4 2 113 0.68 71.22 31.4
49 INT608 Negative_regulation of KNG1 2 98 0.43 72.36 31.23
50 INT54302 Positive_regulation of Gene_expression of Il4 8 126 0.68 86.18 30.75
51 INT77652 Negative_regulation of Gene_expression of IL8 1 99 0.59 67.57 30.21
52 INT10915 Gene_expression of ITGAM 1 164 0.78 92.42 29.78
53 INT3076 Regulation of KNG1 2 52 0.60 20.39 27.89
54 INT8698 Localization of Nka1 1 50 0.78 5.8 27.67
55 INT14690 Localization of CSF2 2 124 0.80 85.17 27.26
56 INT69157 Gene_expression of IL5 11 127 0.77 102.58 26.81
57 INT3167 Binding of KNG1 1 48 0.48 23.26 26.77
58 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
59 INT14884 Positive_regulation of Gene_expression of SFTPA1 1 32 0.25 20.37 26.09
60 INT8836 Positive_regulation of SFTPA1 2 36 0.47 28.37 23.59
61 INT8775 Binding of IGHE 10 167 0.48 102.61 23.54
62 INT134651 Binding of TLR4 1 89 0.48 66.96 23.19
63 INT8699 Gene_expression of Nka1 1 45 0.67 6.41 22.56
64 INT84732 Positive_regulation of Hand2 1 81 0.69 62.07 22
65 INT14700 Regulation of IFNA1 1 111 0.45 66.16 21.52
66 INT85952 Positive_regulation of AR 1 168 0.67 64.36 20.66
67 INT20379 Localization of Il4 3 85 0.73 51.22 20.55
68 INT62042 Positive_regulation of Gene_expression of IL4 3 67 0.56 42.05 20.39
69 INT12265 Positive_regulation of IgG 4 168 0.63 104.89 19.76
70 INT7336 Positive_regulation of VIP 3 60 0.70 24.2 19.62
71 INT56301 Positive_regulation of IL4 2 68 0.56 54.51 18.65
72 INT3952 Negative_regulation of ALB 2 116 0.59 72.18 18.35
73 INT55880 Negative_regulation of Gene_expression of CCL2 1 49 0.59 22.37 18.09
74 INT112017 Regulation of Hand2 2 77 0.36 62.23 18.04
75 INT80755 Gene_expression of CD40 2 88 0.75 53.68 17.86
76 INT13790 Binding of HTR1A 1 52 0.47 18.83 17.59
77 INT29555 Positive_regulation of CALM1 1 58 0.69 14.09 17.37
78 INT3364 Binding of SGCG 1 87 0.47 31.93 17.24
79 INT2120 Gene_expression of CD79A 1 159 0.78 111.69 17.16
80 INT94467 Positive_regulation of Hand1 1 71 0.58 59 16.96
81 INT104045 Regulation of Hand1 1 65 0.35 51.32 16.26
82 INT75929 Gene_expression of IL9 2 61 0.43 24.71 16.17
83 INT9220 Gene_expression of Ighg1 10 125 0.77 85.74 15.92
84 INT25223 Positive_regulation of Gene_expression of IFNG 1 41 0.67 36.97 15.89
85 INT4719 Positive_regulation of Nka1 1 27 0.67 4.16 15.42
86 INT75434 Gene_expression of Il13 1 27 0.52 26.19 15.4
87 INT2064 Positive_regulation of BTG3 1 29 0.49 25.58 15.37
88 INT16167 Negative_regulation of DMD 6 186 0.57 108.71 15.25
89 INT16166 Positive_regulation of DMD 7 348 0.67 133.22 15.06
90 INT25493 Gene_expression of TFPI 1 74 0.76 39.44 14.78
91 INT14131 Regulation of HTR1A 1 34 0.60 9.61 14.74
92 INT3796 Gene_expression of Ighm 4 130 0.77 69.61 13.78
93 INT173505 Localization of Hand2 3 63 0.57 45.32 13.66
94 INT14997 Positive_regulation of FPR1 1 21 0.66 9.82 13.2
95 INT87235 Negative_regulation of Il4 1 54 0.48 31.51 13.15
96 INT61624 Positive_regulation of Gene_expression of IL12A 1 50 0.56 33.07 13.07
97 INT10870 Regulation of IgG 1 67 0.59 43.27 12.74
98 INT2129 Positive_regulation of F2 2 83 0.70 58.95 12.63
99 INT125477 Gene_expression of HHIP 1 91 0.78 31.18 12.57
100 INT69158 Localization of IL4 1 48 0.71 31.3 11.98
101 INT39244 Gene_expression of TMPO 2 137 0.77 14.55 11.83
102 INT65713 Localization of ICAM1 2 42 0.81 39.55 11.49
103 INT55886 Negative_regulation of Gene_expression of Il4 2 47 0.57 26.04 11.42
104 INT15238 Positive_regulation of NPY 1 24 0.67 11.86 11.26
105 INT13240 Gene_expression of TF 2 94 0.76 57.81 10.99
106 INT48912 Localization of NOS1 2 52 0.77 24.14 10.92
107 INT86729 Positive_regulation of CDCP1 2 37 0.07 18.74 10.76
108 INT701 Localization of IGHE 3 87 0.80 40.5 10.62
109 INT15804 Gene_expression of ISG20 1 83 0.75 44.33 10.58
110 INT7411 Localization of FGFR3 1 40 0.78 4.77 10.24
111 INT95565 Positive_regulation of IL12A 1 47 0.56 33.96 10.16
112 INT2378 Negative_regulation of SERPINE1 1 47 0.59 34.55 9.9
113 INT35164 Negative_regulation of IGHE 25 96 0.58 76.3 9.74
114 INT3988 Positive_regulation of Gene_expression of IGHE 18 98 0.68 91.46 9.61
115 INT107307 Transcription of IFNA1 1 30 0.52 18.16 9.61
116 INT132586 Negative_regulation of Hand2 1 40 0.30 26.58 9.28
117 INT28312 Gene_expression of ABCA1 2 85 0.72 37.69 9.27
118 INT85966 Gene_expression of Cd40lg 1 50 0.73 30.9 9.11
119 INT1118 Gene_expression of C6orf25 2 73 0.77 47.24 9.1
120 INT15991 Gene_expression of FPR1 1 27 0.59 8.22 9.01
121 INT8903 Gene_expression of IFNA2 2 58 0.71 38.23 8.68
122 INT20205 Binding of IgG 2 108 0.46 66.68 8.57
123 INT102658 Negative_regulation of Gene_expression of CSF2 1 42 0.50 38.63 8.32
124 INT86705 Gene_expression of BTG3 1 41 0.65 37.29 8.29
125 INT725 Negative_regulation of IgG 2 62 0.41 37.21 8.16
126 INT2971 Regulation of IGHE 4 42 0.61 28.81 7.87
127 INT15165 Positive_regulation of Localization of Nka1 1 7 0.66 1.19 7.78
128 INT69160 Positive_regulation of IL5 3 41 0.65 36.04 7.75
129 INT46221 Positive_regulation of Gene_expression of IgG 1 46 0.53 33.66 7.7
130 INT39417 Gene_expression of Fcer2a 22 65 0.76 32.1 7.37
131 INT1127 Negative_regulation of IGHG3 1 32 0.28 21.1 7.37
132 INT22275 Negative_regulation of TBXA2R 1 25 0.54 8.67 7.34
133 INT16618 Negative_regulation of SERPING1 18 81 0.59 86.28 7.17
134 INT93003 Binding of CD40 1 28 0.47 20.25 7.13
135 INT93046 Positive_regulation of Gene_expression of Hand2 2 27 0.47 24.54 7.01
136 INT3757 Positive_regulation of Gene_expression of ALB 1 45 0.69 23.73 6.85
137 INT132822 Localization of IL13 2 26 0.67 22.85 6.66
138 INT16068 Gene_expression of SERPINB1 1 27 0.60 20.51 6.56
139 INT73499 Positive_regulation of IL13 1 23 0.39 20.03 6.53
140 INT3795 Positive_regulation of Ighm 1 46 0.68 22.43 6.47
141 INT57720 Localization of IGHG3 2 33 0.74 20.24 6.25
142 INT8683 Positive_regulation of F3 1 31 0.67 42.89 6.21
143 INT39416 Gene_expression of Cd79a 3 81 0.64 45.17 6.08
144 INT8803 Gene_expression of IL3 1 32 0.78 21.06 6.01
145 INT69153 Positive_regulation of Gene_expression of IL5 1 22 0.32 23.59 5.7
146 INT53684 Negative_regulation of Gene_expression of ITGAM 1 23 0.59 14.36 5.66
147 INT11480 Positive_regulation of Localization of KNG1 2 15 0.30 6.39 5.5
148 INT65712 Positive_regulation of Localization of ICAM1 2 14 0.70 16.72 5.5
149 INT96234 Localization of Il13 1 11 0.62 10.94 5.48
150 INT13396 Gene_expression of DMD 5 125 0.75 57.81 5.45
151 INT56299 Transcription of IL4 2 15 0.64 10.2 5.44
152 INT97145 Positive_regulation of TBK1 1 14 0.12 15.32 5.43
153 INT183467 Negative_regulation of TBK1 1 6 0.12 9.89 5.41
154 INT69156 Localization of IL5 2 21 0.68 14.95 5.37
155 INT171562 Regulation of IL4 1 19 0.36 12.12 5.33
156 INT178763 Binding of HHIP 2 37 0.08 6.3 5.29
157 INT62041 Negative_regulation of Gene_expression of IGHE 4 37 0.58 37.86 5.27
158 INT30738 Negative_regulation of Gene_expression of ALB 1 32 0.59 19.01 5.04
159 INT11493 Positive_regulation of KLK1 1 21 0.67 9.22 5
160 INT59320 Transcription of Il2 1 32 0.69 6.39 4.95
161 INT12104 Positive_regulation of PLG 1 45 0.68 28.94 4.81
162 INT144481 Gene_expression of SERPING1 15 55 0.77 50.4 4.75
163 INT2848 Localization of ABCA1 1 23 0.70 10.64 4.73
164 INT55114 Gene_expression of CRS 1 42 0.58 26.86 4.69
165 INT82354 Positive_regulation of PECAM1 1 25 0.34 22.93 4.69
166 INT87322 Binding of ITGAL 1 23 0.47 15.73 4.68
167 INT87632 Positive_regulation of Gene_expression of PECAM1 1 32 0.45 29.47 4.66
168 INT73503 Positive_regulation of Gene_expression of IL13 1 16 0.37 14.6 4.23
169 INT110343 Negative_regulation of PIK3CD 5 22 0.40 5.84 4.2
170 INT48518 Gene_expression of ANPEP 1 51 0.78 22.88 4.18
171 INT194380 Negative_regulation of Gene_expression of IL5 1 22 0.42 15.78 4.1
172 INT172677 Gene_expression of SHE 3 65 0.59 25.86 3.85
173 INT179542 Positive_regulation of C3 1 27 0.52 19.39 3.83
174 INT9223 Localization of Ighg1 2 22 0.78 11.03 3.67
175 INT16165 Regulation of DMD 1 114 0.60 35.13 3.64
176 INT170528 Negative_regulation of Gene_expression of CD4 1 25 0.41 17.98 3.6
177 INT40712 Gene_expression of EPX 1 9 0.78 5.93 3.6
178 INT21406 Negative_regulation of Gene_expression of IgG 1 20 0.41 9.36 3.58
179 INT9999 Regulation of Gene_expression of IGHE 6 32 0.60 15.75 3.53
180 INT73500 Regulation of IL13 1 12 0.36 10.37 3.53
181 INT16966 Positive_regulation of CRS 1 23 0.60 22.5 3.49
182 INT171021 Negative_regulation of IL5 1 18 0.41 14.74 3.39
183 INT188355 Binding of Cd28 1 25 0.34 8.29 3.38
184 INT171998 Binding of DMD 1 58 0.47 38.13 3.35
185 INT85971 Positive_regulation of Gene_expression of Cd40lg 1 14 0.66 7.61 3.29
186 INT28130 Positive_regulation of ABCA1 2 18 0.61 7.08 3.22
187 INT93913 Positive_regulation of CD40 1 21 0.58 23.47 3.1
188 INT11488 Negative_regulation of KLK1 4 15 0.57 9.92 3.06
189 INT10136 Negative_regulation of PLAT 1 23 0.42 11.18 3.02
190 INT50765 Positive_regulation of Fcer2a 4 23 0.68 10.22 2.92
191 INT11815 Regulation of Il2 1 16 0.59 4.81 2.83
192 INT7142 Positive_regulation of DLD 1 22 0.60 7.69 2.76
193 INT91319 Positive_regulation of CD63 2 6 0.63 3.86 2.76
194 INT68235 Positive_regulation of IgG2a 1 39 0.49 30.96 2.75
195 INT98226 Negative_regulation of Cd79a 1 5 0.49 3.99 2.66
196 INT24871 Negative_regulation of Binding of IGHE 1 10 0.58 2.87 2.64
197 INT83642 Gene_expression of CD63 8 22 0.77 10.06 2.63
198 INT156130 Binding of SERPING1 7 29 0.42 26.16 2.52
199 INT28815 Gene_expression of Ighd 2 18 0.65 11.02 2.48
200 INT49930 Binding of Ighg1 3 21 0.37 13.27 2.43
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