J:Clinical Interventions in Aging

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT173059 Binding of KDR and VEGFA 43 2 0.43 29.63 1.1
2 INT185417 Binding of ALOX5 and PLA2G2A 4 1 0.16 3.13 0.9
3 INT209881 Binding of TNFRSF11B and TNFSF11 8 1 0.36 8.92 0.86
4 INT270762 IL1B Positive_regulation of IL1B Negative_regulation of IKBKB 1 2 0.02 1.13 0.66
5 INT270763 IL1B Negative_regulation of IKBKB 1 2 0.04 1.13 0.66
6 INT270099 Negative_regulation of Binding of CPOX and PLA2G2A 1 1 0.01 0.51 0.59
7 INT270100 Negative_regulation of Binding of ALOX5 and PLA2G2A 1 1 0.01 0.51 0.59
8 INT270103 Binding of CPOX and PLA2G2A 1 1 0.01 0.5 0.58
9 INT270102 ALOX5 Negative_regulation of PLA2G2A 1 1 0.01 0.49 0.57
10 INT270101 CPOX Negative_regulation of PLA2G2A 1 1 0.01 0.48 0.56
11 INT27730 Binding of ALB and Shbg 2 1 0.01 0.44 0.5
12 INT222299 Binding of CYP19A1 and AIS 2 1 0.25 1.65 0.31
13 INT224458 TNF Positive_regulation of Gene_expression of Nfkb1 2 1 0.34 1.47 0.26
14 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 1 0.15 0.86 0.26
15 INT246576 EEF1A2 Negative_regulation of Negative_regulation of NOSTRIN 1 1 0.04 0.63 0.24
16 INT270135 Binding of ESR1 and RALA 1 2 0.11 0.37 0.22
17 INT246468 GHS Regulation of Gh 1 2 0.05 1.12 0.19
18 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 4 0.10 2.15 0.16
19 INT326605 Binding of HTR1A and KCNH2 1 1 0.00 0.45 0.14
20 INT334541 Binding of HIVEP1 and TNF 1 1 0.01 1.32 0.13
21 INT269784 Crp Positive_regulation of Vcam1 1 1 0.00 1.6 0.11
22 INT269783 Crp Positive_regulation of Sele 1 1 0.00 1.69 0.11
23 INT269785 Crp Positive_regulation of ICAM1 1 1 0.00 1.68 0.11
24 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 2 0.36 0.77 0.1
25 INT246466 GHS Positive_regulation of GHS Regulation of Gh 1 1 0.01 0.6 0.1
26 INT246478 Binding of SERPINE1 and ANGPTL5 1 2 0.01 1.32 0.1
27 INT246467 GHS Regulation of Localization of Gh 1 1 0.03 0.52 0.09
28 INT308225 Alb Positive_regulation of Binding of EIF4G2 1 1 0.02 0.33 0.09
29 INT270777 Binding of DMD and BPs 1 1 0.01 0.33 0.09
30 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 1 0.10 0.96 0.08
31 INT270201 Binding of CD28 and Cd86 1 1 0.10 0.58 0.08
32 INT270203 Binding of CD28 and Apc 1 1 0.04 0.58 0.08
33 INT270197 Binding of Apc and Cd86 1 1 0.02 0.58 0.08
34 INT270202 Binding of CD28 and Cd80 1 1 0.09 0.58 0.08
35 INT270198 Binding of Apc and Cd80 1 1 0.02 0.58 0.08
36 INT246539 EGF Negative_regulation of Gene_expression of PDGFA 1 1 0.06 0.38 0.07
37 INT246538 PDGFA Negative_regulation of Gene_expression of EGF 1 1 0.06 0.38 0.07
38 INT270199 Icos Positive_regulation of Localization of Il10 1 1 0.03 0.63 0.06
39 INT270134 BPs Negative_regulation of FDPS 1 1 0.01 0.36 0.05
40 INT326625 Binding of ALB and Trf 1 1 0.01 0.64 0.04
41 INT183614 Binding of ESR1 and TMED4 2 1 0.02 0.13 0.03
42 INT269759 PTH Positive_regulation of DMD 2 1 0.06 0.37 0.03
43 INT246480 Binding of ALB and SHBG 2 1 0.14 1.45 0.03
44 INT270206 Hdl1 Positive_regulation of Gene_expression of IL2 1 1 0.01 0.35 0.03
45 INT270775 PTH Regulation of DMD 1 1 0.09 0.64 0.03
46 INT270776 PTH Regulation of Negative_regulation of DMD 1 1 0.09 0.3 0.03
47 INT257590 Pth Positive_regulation of DMD 2 2 0.02 0.44 0
48 INT270116 DMD Regulation of St13 1 1 0.01 0.09 0
49 INT269772 Binding of NOVA2 and LMOD1 1 2 0.06 0 0
50 INT270780 BPs Positive_regulation of DMD 1 1 0.02 0 0
51 INT270759 Binding of HSD11B1 and TERT 1 1 0.07 1.67 0
52 INT270770 Binding of DMD and PTH 1 3 0.10 0.16 0
53 INT269771 Binding of ARHGDIB and NOVA2 1 1 0.05 0 0
54 INT270204 TNF Positive_regulation of Il4 1 1 0.01 0.53 0
55 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 1 0.08 0.68 0
56 INT270778 Binding of TNFSF11 and CALCRL 1 1 0.00 0.44 0
57 INT270145 TNF Positive_regulation of IL2 1 1 0.01 0.53 0
58 INT270205 TNF Positive_regulation of Gene_expression of Csf2 1 1 0.06 0.55 0
59 INT269770 Binding of DIO2 and NOVA2 1 3 0.07 0 0
60 INT270200 TNF Positive_regulation of Il5 1 1 0.02 0.53 0
61 INT246469 Binding of IGF1 and Gh 1 1 0.03 0.2 0
62 INT270122 Binding of Pth and Pc 1 2 0.05 0.1 0
63 INT270121 Binding of Pth and Pthlh 1 2 0.08 0.56 0
64 INT269769 Gh Regulation of Gene_expression of Igf1 1 1 0.04 0.98 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
2 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
3 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
4 INT6483 Gene_expression of TNF 5 3152 0.78 2515.62 929.82
5 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
6 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
7 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
8 INT1045 Localization of LH 1 1211 0.81 87.04 456.25
9 INT9238 Gene_expression of IL6 2 1575 0.78 1135.66 424.22
10 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
11 INT439 Localization of Gnrh1 1 976 0.81 100.96 363.25
12 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
13 INT5059 Positive_regulation of TNF 5 1050 0.70 896.51 322.81
14 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
15 INT49750 Negative_regulation of CPOX 10 735 0.58 360.06 274.19
16 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
17 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
18 INT9659 Gene_expression of Il6 4 991 0.78 715.11 265.57
19 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
20 INT5972 Gene_expression of IL1B 3 948 0.78 510.91 263.97
21 INT68684 Gene_expression of VEGFA 4 2371 0.78 1742.52 259.2
22 INT1893 Localization of Gh 45 1041 0.79 340.23 256.58
23 INT1893 Localization of Gh 5 1041 0.79 340.23 256.58
24 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
25 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
26 INT6482 Positive_regulation of Gene_expression of TNF 4 659 0.70 569.88 210
27 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
28 INT50670 Gene_expression of CPOX 4 763 0.76 442.13 195.02
29 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
30 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
31 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
32 INT15516 Gene_expression of Crp 9 711 0.77 615.33 173.09
33 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
34 INT159 Negative_regulation of Localization of Prl 1 416 0.59 55.34 171.8
35 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
36 INT5127 Localization of Lhb 4 488 0.80 50.48 162.66
37 INT3448 Positive_regulation of Gh 12 521 0.69 180.03 161.18
38 INT3448 Positive_regulation of Gh 2 521 0.69 180.03 161.18
39 INT2910 Regulation of Abat 1 169 0.62 36.95 153.53
40 INT15515 Positive_regulation of Crp 6 700 0.70 604.24 150.15
41 INT15515 Positive_regulation of Crp 2 700 0.70 604.24 150.15
42 INT5116 Gene_expression of IL2 9 670 0.78 291.13 146.69
43 INT812 Localization of INS 1 1026 0.81 515.6 145.31
44 INT1047 Negative_regulation of LH 3 314 0.59 53.71 135.89
45 INT64161 Positive_regulation of Prkca 1 213 0.70 85.06 129.91
46 INT65600 Positive_regulation of Casp3 1 376 0.70 198.44 128.03
47 INT8243 Positive_regulation of Il6 2 451 0.70 358.24 119.28
48 INT7395 Localization of GNRH1 8 399 0.81 62.88 117.68
49 INT7395 Localization of GNRH1 1 399 0.81 62.88 117.68
50 INT1793 Localization of CGA 4 379 0.81 67.38 114.69
51 INT1793 Localization of CGA 1 379 0.81 67.38 114.69
52 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
53 INT1530 Regulation of Gh 3 382 0.61 115.96 112.47
54 INT7362 Gene_expression of Sst 1 185 0.78 41.73 111.37
55 INT3038 Gene_expression of INS 16 1583 0.78 1174.16 107.01
56 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
57 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
58 INT397 Localization of SST 2 232 0.81 58.05 101.19
59 INT2159 Regulation of Localization of Gnrh1 1 200 0.62 13.28 99.07
60 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
61 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
62 INT5865 Positive_regulation of Localization of Gh 13 282 0.69 84.86 93.5
63 INT5865 Positive_regulation of Localization of Gh 1 282 0.69 84.86 93.5
64 INT1281 Negative_regulation of Maoa 3 203 0.59 22.47 91.66
65 INT214 Localization of AVP 1 370 0.81 208.51 91.09
66 INT1639 Negative_regulation of OPRM1 1 107 0.59 13.86 90.37
67 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
68 INT48408 Gene_expression of ICAM1 3 494 0.78 340.08 88.6
69 INT5780 Regulation of Gene_expression of Calca 1 90 0.62 59.52 85.03
70 INT68682 Positive_regulation of VEGFA 2 640 0.70 454.14 81.65
71 INT1498 Gene_expression of Gh 38 521 0.75 220.84 81.16
72 INT1498 Gene_expression of Gh 3 521 0.75 220.84 81.16
73 INT920 Localization of PLOD1 2 223 0.81 42.25 78.7
74 INT1497 Negative_regulation of Gh 20 415 0.59 192.95 74.71
75 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
76 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
77 INT1080 Negative_regulation of Ache 16 343 0.59 108.51 72.4
78 INT12720 Positive_regulation of Il1 2 246 0.70 195.97 72.05
79 INT15913 Negative_regulation of CYP2D6 1 174 0.59 22.45 70.91
80 INT79494 Positive_regulation of Gene_expression of VEGFA 2 577 0.70 442.94 69.73
81 INT2123 Positive_regulation of Gnrh1 1 209 0.70 24.2 68.97
82 INT5374 Gene_expression of Esr1 4 412 0.77 263.89 67.34
83 INT1046 Gene_expression of LH 3 180 0.77 29.75 66.87
84 INT3375 Gene_expression of IGHE 2 535 0.77 387.47 65.46
85 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
86 INT15514 Negative_regulation of Crp 1 275 0.59 194.6 64.86
87 INT11937 Localization of Il6 1 228 0.81 139.83 64.39
88 INT822 Gene_expression of ESR1 2 529 0.78 302.16 63.64
89 INT822 Gene_expression of ESR1 4 529 0.78 302.16 63.64
90 INT67614 Positive_regulation of PPARA 2 438 0.68 293.28 63.61
91 INT9657 Positive_regulation of Gene_expression of Il6 1 237 0.70 180.45 63.6
92 INT5095 Localization of Ghrh 6 185 0.81 28.09 62.08
93 INT17401 Gene_expression of IGF1 8 475 0.78 232.18 62.07
94 INT17401 Gene_expression of IGF1 1 475 0.78 232.18 62.07
95 INT1169 Negative_regulation of Bche 18 322 0.59 149.22 61.27
96 INT66779 Binding of Pnoc 1 79 0.48 6.43 60.46
97 INT546 Binding of ALB 3 311 0.48 85.98 60.14
98 INT546 Binding of ALB 1 311 0.48 85.98 60.14
99 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
100 INT5710 Negative_regulation of Localization of Lhb 1 146 0.57 20.51 58.33
101 INT1316 Positive_regulation of Acot1 1 129 0.60 18.86 56.13
102 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
103 INT251 Regulation of INS 4 398 0.62 232.47 55.04
104 INT63975 Positive_regulation of Il10 1 175 0.68 134.13 54.69
105 INT20375 Gene_expression of Hand1 1 213 0.60 148.51 54.53
106 INT52611 Negative_regulation of Ptgs2 1 142 0.59 66.31 52.71
107 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
108 INT50405 Negative_regulation of CYP3A4 2 238 0.59 53.65 51.51
109 INT8490 Negative_regulation of CALCA 1 87 0.59 29.73 51.34
110 INT19775 Localization of Il1 1 183 0.78 145.5 50.91
111 INT6473 Positive_regulation of Gene_expression of IL1B 2 204 0.70 117.23 50.86
112 INT2197 Gene_expression of Gnrh1 1 184 0.78 40.04 50.57
113 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
114 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
115 INT22454 Regulation of Crp 2 213 0.62 160.67 49.24
116 INT17881 Gene_expression of LEP 2 278 0.78 221.61 48.31
117 INT17881 Gene_expression of LEP 4 278 0.78 221.61 48.31
118 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
119 INT374 Positive_regulation of Ldha 2 212 0.70 107.08 47.43
120 INT81498 Positive_regulation of Gene_expression of CCL2 1 107 0.70 53.89 45.22
121 INT3361 Positive_regulation of Esr1 2 273 0.69 208.53 44.81
122 INT80124 Negative_regulation of VEGFA 8 450 0.58 311.19 44.53
123 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
124 INT109910 Gene_expression of CCL16 1 104 0.74 76.1 43.97
125 INT25610 Positive_regulation of Gene_expression of Il1 1 136 0.67 104.43 43.86
126 INT1894 Negative_regulation of Localization of Gh 13 168 0.58 64.12 43.56
127 INT1894 Negative_regulation of Localization of Gh 2 168 0.58 64.12 43.56
128 INT73502 Positive_regulation of IL10 1 154 0.69 124.87 43.5
129 INT25383 Gene_expression of Csf2 1 222 0.76 152.93 43.32
130 INT52531 Gene_expression of Nfkb1 1 153 0.75 82.84 42.9
131 INT9233 Negative_regulation of Gene_expression of IL1B 2 114 0.59 56.99 41.82
132 INT65245 Gene_expression of Nos3 1 121 0.78 98.14 41.56
133 INT11939 Negative_regulation of Il6 2 138 0.59 87.46 41.24
134 INT57442 Phosphorylation of Prkca 2 98 0.70 31.58 41.04
135 INT52732 Negative_regulation of CRP 5 169 0.59 138.47 40.33
136 INT3987 Positive_regulation of IGHE 1 316 0.70 283.2 40.16
137 INT88322 Gene_expression of CCR5 1 111 0.78 77.36 39.84
138 INT3252 Negative_regulation of INS 4 428 0.59 271.65 39.52
139 INT47939 Gene_expression of Selp 1 171 0.76 87.54 39.03
140 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
141 INT9094 Gene_expression of COL7A1 7 277 0.77 143.42 38.73
142 INT9094 Gene_expression of COL7A1 1 277 0.77 143.42 38.73
143 INT50673 Positive_regulation of Gene_expression of CPOX 1 156 0.54 97.31 37.03
144 INT9082 Positive_regulation of ESR1 2 238 0.69 148.51 36.69
145 INT9082 Positive_regulation of ESR1 3 238 0.69 148.51 36.69
146 INT23330 Binding of Chrna7 1 79 0.48 10.06 35.5
147 INT20380 Gene_expression of Il5 1 172 0.78 104.75 34.78
148 INT692 Negative_regulation of SST 2 72 0.59 28.68 34.52
149 INT14559 Gene_expression of Igf1 6 254 0.78 112 34.17
150 INT14559 Gene_expression of Igf1 4 254 0.78 112 34.17
151 INT17381 Gene_expression of Tbxa2r 1 146 0.78 65.01 34.15
152 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
153 INT10763 Localization of IL2 3 157 0.80 81.11 33.21
154 INT913 Regulation of Localization of PLOD1 1 71 0.62 8.64 32.72
155 INT65698 Localization of CCL2 1 118 0.81 77.54 32.69
156 INT62830 Gene_expression of VCAM1 1 149 0.78 125.23 32.4
157 INT51685 Gene_expression of LTB4R 6 87 0.58 68.69 31.72
158 INT48693 Regulation of VEGFA 2 268 0.62 191.88 31.52
159 INT13186 Positive_regulation of Il4 1 113 0.68 71.22 31.4
160 INT56809 Binding of Tlr4 1 184 0.48 106.02 31.18
161 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
162 INT99688 Negative_regulation of Gene_expression of VEGFA 1 274 0.58 201.8 31.1
163 INT1079 Positive_regulation of Ache 2 104 0.70 23.52 30.28
164 INT5100 Positive_regulation of Ghrh 1 100 0.64 24.2 30.21
165 INT9993 Positive_regulation of Gene_expression of IL2 3 131 0.69 46.27 30.04
166 INT90792 Localization of Il10 1 144 0.80 87.88 30.03
167 INT19396 Regulation of Rac1 4 66 0.53 37.41 30.01
168 INT5117 Negative_regulation of Gene_expression of IL2 3 118 0.59 52.33 29.96
169 INT9053 Negative_regulation of ALOX5 3 97 0.58 40.34 29.94
170 INT7397 Negative_regulation of Localization of GNRH1 3 86 0.59 15.45 29.78
171 INT724 Negative_regulation of Alb 3 151 0.59 93.57 29.65
172 INT660 Negative_regulation of REN 2 194 0.59 82.06 29.46
173 INT8097 Gene_expression of EGF 1 122 0.77 75.94 28.47
174 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
175 INT5135 Negative_regulation of GNRH1 2 106 0.58 36.63 27.71
176 INT12129 Gene_expression of CYP3A4 2 107 0.78 23.11 27.6
177 INT6624 Gene_expression of Pth 12 135 0.76 110.27 27.54
178 INT37296 Binding of Esr1 1 117 0.43 62.51 27.33
179 INT5206 Gene_expression of AR 1 316 0.78 113.83 27.29
180 INT703 Positive_regulation of Pth 8 177 0.70 127.09 27.26
181 INT2569 Gene_expression of Ache 3 120 0.78 26.29 26.89
182 INT1638 Negative_regulation of PLOD1 3 92 0.59 21.69 26.61
183 INT7832 Localization of Cck 2 39 0.81 6.81 26.54
184 INT19856 Gene_expression of CD8A 2 240 0.75 147.86 26.39
185 INT9682 Positive_regulation of IGF1 6 238 0.70 120.03 26.36
186 INT20462 Binding of ESR1 7 210 0.44 102.7 26.34
187 INT20462 Binding of ESR1 7 210 0.44 102.7 26.34
188 INT79395 Gene_expression of Twist1 2 193 0.77 100.06 26.34
189 INT276 Regulation of Ache 1 83 0.62 16.75 25.99
190 INT2614 Gene_expression of CGA 1 187 0.78 105.89 24.77
191 INT64185 Gene_expression of TNFRSF11A 1 131 0.76 75.15 24.73
192 INT10836 Negative_regulation of IL8 1 95 0.59 52.59 24.71
193 INT10836 Negative_regulation of IL8 1 95 0.59 52.59 24.71
194 INT47459 Gene_expression of Rac1 1 101 0.68 45.27 24.33
195 INT47459 Gene_expression of Rac1 1 101 0.68 45.27 24.33
196 INT14556 Positive_regulation of Igf1 1 105 0.69 52.21 24.04
197 INT14556 Positive_regulation of Igf1 1 105 0.69 52.21 24.04
198 INT5131 Gene_expression of GNRH1 1 109 0.78 28.79 23.94
199 INT25607 Binding of Il1 1 82 0.47 64.4 23.9
200 INT7113 Negative_regulation of Localization of CGA 3 71 0.51 17.7 23.42
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