J:Clinical Medicine Insights. Oncology

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT173059 Binding of KDR and VEGFA 43 2 0.43 29.63 1.1
2 INT71904 Binding of ESR1 and PGR 6 1 0.34 3.79 0.27
3 INT314686 TP53 Regulation of Gene_expression of MDM2 1 1 0.21 0.96 0.03
4 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 1 0.27 0.97 0.03
5 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 1 0.33 0.97 0.03
6 INT289608 Binding of CDK2 and CCNE2 5 3 0.06 4.89 0
7 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 1 0.32 1.16 0
8 INT314741 Binding of VEGFA and Akt1 1 1 0.36 0.66 0
9 INT326167 Binding of CD4 and Tmed8 1 1 0.47 0.29 0
10 INT314692 Binding of TBX2 and TBX3 1 1 0.27 0.84 0
11 INT314742 Binding of RAD51 and Brca2 1 1 0.06 1.05 0
12 INT314693 Binding of TBX2 and TBX5 1 1 0.16 0.84 0
13 INT314743 Binding of RAD51 and Brca1 1 1 0.06 1.06 0
14 INT314740 Binding of ESR1 and Brca1 1 1 0.16 0.69 0
15 INT314682 Binding of TBX2 and TBX4 1 1 0.16 0.84 0
16 INT314687 ESR1 Regulation of PGR 1 1 0.27 0.88 0
17 INT314683 NUDT6 Positive_regulation of FGF1 1 1 0.02 1.17 0
18 INT314744 Binding of KDR and Akt1 1 1 0.13 0.66 0
19 INT314688 Binding of CCNE1 and CDK2 1 2 0.04 1.41 0
20 INT314678 Binding of CCNE1 and CCNE2 1 2 0.03 1.41 0
21 INT314745 Binding of TP53 and Brca1 1 1 0.18 1.17 0
22 INT314689 Binding of KITLG and UBR1 1 1 0.00 0.71 0
23 INT314691 ERBB2 Negative_regulation of TP53 1 1 0.28 1.23 0
24 INT314685 TBX2 Negative_regulation of CDKN2A 1 1 0.32 1.16 0
25 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 1 0.34 1.16 0
26 INT314679 NEU1 Negative_regulation of TP53 1 1 0.12 1.23 0
27 INT314684 Binding of CCND1 and ESR1 1 1 0.22 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT68684 Gene_expression of VEGFA 12 2371 0.78 1742.52 259.2
2 INT90091 Gene_expression of GOPC 2 967 0.67 366.22 103.6
3 INT68682 Positive_regulation of VEGFA 2 640 0.70 454.14 81.65
4 INT79494 Positive_regulation of Gene_expression of VEGFA 5 577 0.70 442.94 69.73
5 INT822 Gene_expression of ESR1 12 529 0.78 302.16 63.64
6 INT17564 Gene_expression of Gpt 2 322 0.75 208.51 60.36
7 INT106525 Phosphorylation of Akt1 1 436 0.82 183.81 47.82
8 INT671 Positive_regulation of Cea 1 221 0.69 164.5 47.79
9 INT157666 Positive_regulation of GOPC 1 335 0.60 120.19 42.75
10 INT13556 Gene_expression of CD4 4 367 0.78 230.82 41.74
11 INT1624 Gene_expression of Cea 1 212 0.76 180.44 34.21
12 INT234 Binding of Alb 1 151 0.48 52.34 32.97
13 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
14 INT28361 Gene_expression of TP53 4 443 0.78 384.86 28.8
15 INT20462 Binding of ESR1 1 210 0.44 102.7 26.34
16 INT823 Negative_regulation of ESR1 1 144 0.58 63.72 22.52
17 INT48692 Binding of VEGFA 2 345 0.48 210.3 21.31
18 INT5328 Positive_regulation of CD4 1 191 0.69 133.43 21.31
19 INT56749 Gene_expression of PCNA 5 219 0.77 111.25 18.42
20 INT68681 Transcription of VEGFA 2 132 0.71 80.47 17.03
21 INT13510 Gene_expression of ERBB2 26 530 0.78 405.68 16.79
22 INT65856 Positive_regulation of TP53 3 138 0.67 112.65 16.71
23 INT92354 Localization of ESR1 1 77 0.75 33.04 15.51
24 INT20420 Gene_expression of MYC 1 99 0.75 49.32 14.36
25 INT94774 Regulation of CDKN2A 2 43 0.60 44.41 13.99
26 INT78472 Gene_expression of CDKN2A 2 223 0.78 173.76 13.61
27 INT27242 Gene_expression of PGR 7 153 0.75 98.77 12.79
28 INT79545 Positive_regulation of Gene_expression of ESR1 2 82 0.64 39.42 12.18
29 INT170601 Positive_regulation of Gene_expression of GOPC 1 122 0.43 42.79 11.68
30 INT36798 Gene_expression of Mki67 10 178 0.77 132 8.24
31 INT15687 Regulation of ESR1 1 91 0.60 40.42 7.95
32 INT57748 Positive_regulation of Gene_expression of TP53 3 85 0.69 79.55 7.49
33 INT182440 Gene_expression of CCNE2 9 39 0.53 22.07 7.44
34 INT75501 Gene_expression of CCND1 14 90 0.76 60.86 5.93
35 INT125467 Positive_regulation of Gene_expression of CDKN2A 1 35 0.63 39.07 5.56
36 INT89794 Positive_regulation of CDKN2A 2 58 0.67 50.18 5.38
37 INT81796 Binding of AGRP 3 62 0.36 37.19 5.3
38 INT15376 Positive_regulation of Gene_expression of ERBB2 17 215 0.70 168.54 5.23
39 INT60585 Regulation of TP53 6 59 0.59 54.55 5.21
40 INT99549 Gene_expression of CDKN1B 2 30 0.75 17 5.15
41 INT249561 Positive_regulation of Psmd1 3 12 0.37 7.32 5.06
42 INT62684 Negative_regulation of TP53 1 66 0.58 66.09 4.62
43 INT133630 Negative_regulation of Gene_expression of ESR1 2 42 0.52 23.89 4.57
44 INT141665 Gene_expression of AGRP 2 83 0.67 43.43 4.24
45 INT75688 Binding of KITLG 1 24 0.30 11.73 4.06
46 INT185246 Gene_expression of Psmd1 2 26 0.50 8.89 3.73
47 INT86369 Positive_regulation of Gene_expression of PCNA 4 40 0.67 26.66 3.57
48 INT178631 Phosphorylation of ESR1 1 21 0.75 9.16 3.36
49 INT20419 Negative_regulation of Gene_expression of MYC 1 19 0.57 9.7 3.29
50 INT10353 Positive_regulation of PGR 1 34 0.70 21.84 3.28
51 INT75500 Negative_regulation of Gene_expression of CCND1 1 21 0.57 11.59 3.24
52 INT8103 Binding of TP53 2 46 0.44 40.2 2.96
53 INT51150 Positive_regulation of HTC2 1 10 0.67 6.8 2.95
54 INT85078 Positive_regulation of PCNA 1 36 0.49 17.06 2.81
55 INT90875 Negative_regulation of CCND1 1 31 0.42 26.22 2.66
56 INT188756 Positive_regulation of AGRP 1 43 0.60 23.67 2.51
57 INT92141 Negative_regulation of CDKN2A 2 53 0.57 44.23 2.48
58 INT34830 Regulation of PGR 2 14 0.45 6.99 2.32
59 INT50558 Negative_regulation of PCNA 1 31 0.57 13.97 2.3
60 INT120220 Gene_expression of ANIB1 4 4 0.65 1.82 1.92
61 INT93886 Positive_regulation of Gene_expression of PGR 3 19 0.52 15.78 1.89
62 INT65855 Localization of TP53 2 18 0.76 17.08 1.89
63 INT48792 Regulation of ERBB2 1 48 0.57 36.56 1.8
64 INT65684 Gene_expression of MDM2 1 30 0.62 24.94 1.55
65 INT306844 Localization of CCNE2 2 6 0.21 3.81 1.52
66 INT52962 Binding of ERBB2 1 77 0.47 50.03 1.49
67 INT96838 Negative_regulation of Gene_expression of ERBB2 1 25 0.57 15.83 1.34
68 INT63905 Regulation of RB1 2 13 0.62 12.67 1.28
69 INT201466 Positive_regulation of Gene_expression of CCNE2 5 13 0.20 8.62 1.26
70 INT160013 Gene_expression of CCND2 3 7 0.42 5.98 1.18
71 INT142829 Transcription of CREB1 1 9 0.46 3.37 1.03
72 INT86559 Negative_regulation of KITLG 1 8 0.41 3.54 0.99
73 INT44375 Negative_regulation of ZBTB7A 1 3 0.57 0.95 0.95
74 INT201465 Positive_regulation of CCNE2 2 6 0.13 3.13 0.92
75 INT81795 Negative_regulation of AGRP 1 23 0.41 10.93 0.87
76 INT71649 Localization of ERBB2 1 23 0.78 13.63 0.83
77 INT173082 Positive_regulation of Binding of VEGFA 2 20 0.48 11.16 0.79
78 INT102813 Regulation of Gene_expression of TP53 1 25 0.59 25.95 0.75
79 INT54546 Binding of CREB1 1 9 0.41 3.44 0.72
80 INT128498 Regulation of CCND1 3 17 0.39 12.51 0.58
81 INT94165 Negative_regulation of RB1 1 30 0.52 27.29 0.51
82 INT75498 Positive_regulation of Gene_expression of CCND1 7 21 0.68 19.4 0.51
83 INT45878 Gene_expression of NEU1 1 14 0.65 7.28 0.47
84 INT139399 Regulation of Gene_expression of PCNA 1 14 0.56 6.06 0.43
85 INT155490 Binding of Mki67 4 13 0.19 13.38 0.41
86 INT189755 Gene_expression of CCND3 2 42 0.65 10.88 0.39
87 INT83212 Positive_regulation of Gene_expression of Mki67 2 21 0.55 17.53 0.39
88 INT101902 Negative_regulation of Mki67 1 12 0.39 7.92 0.34
89 INT163630 Negative_regulation of Dpyd 1 3 0.58 0.52 0.34
90 INT36797 Regulation of Mki67 3 13 0.24 8.76 0.3
91 INT153772 Negative_regulation of Localization of ESR1 1 7 0.54 4.42 0.27
92 INT186057 Binding of CCND1 1 8 0.31 5.92 0.26
93 INT314729 Regulation of Localization of TP53 2 1 0.30 2.5 0.25
94 INT113989 Regulation of Gene_expression of CCND1 1 11 0.44 7.57 0.24
95 INT179889 Negative_regulation of CDKN1B 1 4 0.57 1.71 0.21
96 INT88744 Positive_regulation of Gene_expression of MDM2 2 9 0.43 7.82 0.2
97 INT63067 Localization of MYC 1 13 0.78 6.93 0.19
98 INT89690 Binding of Brca2 1 2 0.37 1.8 0.18
99 INT89689 Binding of Brca1 2 2 0.37 2.55 0.18
100 INT201464 Regulation of CCNE2 2 3 0.08 2.79 0.16
101 INT13804 Gene_expression of Slx 1 2 0.75 1.26 0.14
102 INT314750 Gene_expression of Mpst 3 1 0.29 3.43 0.14
103 INT188757 Positive_regulation of Gene_expression of AGRP 1 12 0.44 5.86 0.13
104 INT197627 Localization of RB1 1 3 0.69 4.16 0.13
105 INT314724 Regulation of Localization of RB1 1 1 0.15 1.25 0.13
106 INT314749 Positive_regulation of Gene_expression of Psmd1 2 1 0.17 2.83 0.13
107 INT201462 Binding of CDK2 1 12 0.39 5.2 0.12
108 INT187590 Gene_expression of Brca1 1 12 0.65 4.94 0.11
109 INT314712 Negative_regulation of Localization of MYC 1 2 0.22 1.43 0.11
110 INT284989 Localization of INTS2 1 2 0.43 1.64 0.11
111 INT314718 Negative_regulation of Localization of ERBB2 1 1 0.37 1.13 0.11
112 INT314714 Negative_regulation of Localization of INTS2 1 1 0.24 1.14 0.11
113 INT225189 Binding of CCNE2 2 5 0.10 2.27 0.1
114 INT213913 Gene_expression of NCOA3 1 3 0.50 1.11 0.1
115 INT174155 Negative_regulation of Brca1 1 4 0.36 1.77 0.07
116 INT207806 Phosphorylation of Atm 1 8 0.81 3.07 0.06
117 INT171527 Gene_expression of NCOR1 1 3 0.51 0.49 0.06
118 INT314713 Positive_regulation of Gene_expression of ZBTB7A 2 1 0.49 1.92 0.05
119 INT311668 Regulation of Regulation of TP53 2 2 0.36 3.58 0.04
120 INT314711 Positive_regulation of DMTF1 1 1 0.01 0.95 0.03
121 INT314732 Positive_regulation of Negative_regulation of DMTF1 1 1 0.02 0.97 0.03
122 INT314733 Negative_regulation of DMTF1 1 1 0.02 0.95 0.03
123 INT314719 Gene_expression of TBX2 7 1 0.54 6.86 0.03
124 INT314737 Gene_expression of ZBTB7A 1 1 0.75 0.96 0.03
125 INT293773 Positive_regulation of Gene_expression of CCND3 1 9 0.10 2.72 0
126 INT189752 Negative_regulation of Gene_expression of CCND3 1 6 0.09 1.89 0
127 INT171516 Gene_expression of NCOA2 1 4 0.25 0.63 0
128 INT314725 Gene_expression of CCNE1 2 3 0.52 2.45 0
129 INT212457 Phosphorylation of Brca1 1 2 0.51 0.96 0
130 INT314715 Positive_regulation of Gene_expression of CCND2 1 2 0.23 1.24 0
131 INT276370 Phosphorylation of MDM2 1 2 0.50 1.99 0
132 INT314726 Positive_regulation of TBX2 1 1 0.38 1.15 0
133 INT314735 Transcription of TBR1 1 1 0.00 0.8 0
134 INT314708 Gene_expression of Brca2 2 1 0.41 1.75 0
135 INT314720 Positive_regulation of BARD1 1 1 0.17 1.18 0
136 INT314723 Transcription of TBX6 1 1 0.34 0.81 0
137 INT314707 Regulation of Transcription of Brca2 1 1 0.27 0.56 0
138 INT314728 Positive_regulation of Binding of CCNE2 1 1 0.14 0.7 0
139 INT314706 Transcription of Brca1 1 1 0.43 0.53 0
140 INT314709 Negative_regulation of Fbxo4 1 1 0.41 0.71 0
141 INT314751 Positive_regulation of Gene_expression of Mpst 1 1 0.21 0.43 0
142 INT314710 Gene_expression of ZNF639 1 1 0.01 1 0
143 INT314705 Transcription of Brca2 1 1 0.42 0.56 0
144 INT314739 Transcription of TBX1 1 1 0.32 0.8 0
145 INT314738 Gene_expression of BRCA3 1 1 0.30 1.29 0
146 INT326166 Binding of Tmed8 1 1 0.35 0.29 0
147 INT314731 Positive_regulation of Gene_expression of TBX2 3 1 0.41 3.42 0
148 INT314716 Positive_regulation of Gene_expression of CCNE1 2 1 0.16 1.48 0
149 INT314734 Regulation of TBX2 1 1 0.10 1.22 0
150 INT314717 Positive_regulation of ZNF639 1 1 0.01 1.12 0
151 INT314727 Positive_regulation of BAP1 1 1 0.14 1.18 0
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