J:Clinical Ophthalmology (Auckland, N.Z.)

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT54972 Binding of EDNRA and EDNRB 7 1 0.52 3.31 0.97
2 INT111080 Binding of CA1 and CA2 2 1 0.02 1.62 0.73
3 INT178097 Binding of EDN1 and EDNRA 7 2 0.21 5.97 0.62
4 INT114341 Agt Positive_regulation of AGT 3 1 0.01 1.15 0.43
5 INT274080 Binding of ARHGAP4 and Map3k5 1 1 0.41 1.92 0.2
6 INT274094 EDN1 Positive_regulation of AGT 1 1 0.16 0.95 0.2
7 INT325470 MMP3 Positive_regulation of MMP9 1 1 0.17 0.9 0.2
8 INT274156 Negative_regulation of Cabin1 Negative_regulation of Gene_expression of Vegfa 1 1 0.08 0.28 0.09
9 INT340505 Binding of Twist1 and Mgat4b 1 1 0.01 0.45 0.08
10 INT311432 Binding of TSHR and TAOK1 1 1 0.12 1.05 0.07
11 INT274095 Binding of EDNRA and OPA1 1 1 0.12 0.65 0.04
12 INT274078 Binding of Mapk8 and Gmcl1 1 1 0.05 0.68 0.04
13 INT274285 AGT Positive_regulation of Gene_expression of VEGFA 1 1 0.01 0.98 0.03
14 INT274288 AGT Positive_regulation of Gene_expression of Vegfa 1 1 0.07 0.98 0.03
15 INT274284 AGT Positive_regulation of Binding of VEGFA 1 1 0.01 0.99 0.03
16 INT346947 Binding of VEGFA and amd 1 1 0.01 0.1 0
17 INT272300 Binding of LPA and PLG 1 1 0.09 0.66 0
18 INT272301 Negative_regulation of Binding of LPA and PLG 1 1 0.08 0.68 0
19 INT273774 Binding of GPER and RB1 1 1 0.01 0.45 0
20 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 1 0.07 0.58 0
21 INT274096 Binding of EDN1 and EDNRA Positive_regulation of Positive_regulation of EDN1 1 1 0.22 0.78 0
22 INT274099 Binding of FANCB and VEGFA 1 1 0.10 0.33 0
23 INT274076 Binding of Map3k5 and Gmcl1 1 1 0.06 1.23 0
24 INT273772 BCKDHA Positive_regulation of Positive_regulation of NARFL 1 1 0.03 1.21 0
25 INT274077 Binding of Tnfrsf1b and Positive_regulation of Mapk8 1 1 0.14 0.97 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT49750 Negative_regulation of CPOX 8 735 0.58 360.06 274.19
2 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
3 INT68684 Gene_expression of VEGFA 20 2371 0.78 1742.52 259.2
4 INT68684 Gene_expression of VEGFA 14 2371 0.78 1742.52 259.2
5 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
6 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
7 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
8 INT867 Gene_expression of IFNA1 3 930 0.78 594.85 168.03
9 INT15515 Positive_regulation of Crp 2 700 0.70 604.24 150.15
10 INT1033 Positive_regulation of Ca2 3 507 0.68 131.76 147.64
11 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
12 INT812 Localization of INS 3 1026 0.81 515.6 145.31
13 INT115386 Gene_expression of Ppara 1 779 0.77 549.99 128.36
14 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
15 INT62124 Gene_expression of NOS1 1 444 0.78 218.08 114.85
16 INT48593 Positive_regulation of NOS1 2 420 0.68 226.15 114.71
17 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
18 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
19 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
20 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
21 INT48767 Negative_regulation of NOS1 2 312 0.59 154.25 90.32
22 INT2520 Negative_regulation of Ca2 2 271 0.57 72.13 83.71
23 INT2520 Negative_regulation of Ca2 5 271 0.57 72.13 83.71
24 INT84546 Positive_regulation of Ppara 1 481 0.70 334.21 83.45
25 INT68682 Positive_regulation of VEGFA 4 640 0.70 454.14 81.65
26 INT68682 Positive_regulation of VEGFA 7 640 0.70 454.14 81.65
27 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
28 INT1724 Negative_regulation of ACE 20 437 0.59 315.64 74.48
29 INT11380 Negative_regulation of IL1B 1 215 0.59 125.62 72.35
30 INT15913 Negative_regulation of CYP2D6 1 174 0.59 22.45 70.91
31 INT79494 Positive_regulation of Gene_expression of VEGFA 9 577 0.70 442.94 69.73
32 INT79494 Positive_regulation of Gene_expression of VEGFA 3 577 0.70 442.94 69.73
33 INT8357 Gene_expression of KNG1 1 153 0.75 77.26 68.66
34 INT5374 Gene_expression of Esr1 4 412 0.77 263.89 67.34
35 INT13286 Gene_expression of Ca2 1 317 0.67 71.58 65.01
36 INT822 Gene_expression of ESR1 2 529 0.78 302.16 63.64
37 INT17401 Gene_expression of IGF1 1 475 0.78 232.18 62.07
38 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
39 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
40 INT1759 Gene_expression of TIMP1 3 267 0.77 133.87 59.29
41 INT16258 Gene_expression of Ntf3 1 121 0.78 53.93 59.03
42 INT11491 Positive_regulation of KNG1 3 128 0.67 60.41 58.74
43 INT3920 Localization of Ldha 1 241 0.81 83.08 58.72
44 INT73048 Gene_expression of MMP9 2 268 0.77 159.75 57.81
45 INT48232 Gene_expression of MMP1 2 245 0.78 96.31 57.72
46 INT48891 Positive_regulation of Il10 1 143 0.70 101.42 56.72
47 INT4509 Gene_expression of IGG 3 426 0.76 293.69 56.64
48 INT82650 Gene_expression of Bcl2 1 312 0.78 211.71 55.03
49 INT117713 Phosphorylation of Akt1 1 275 0.82 95.82 54.34
50 INT1032 Regulation of Ca2 2 202 0.52 54.91 53.03
51 INT62543 Gene_expression of Icam1 1 231 0.78 187.58 52.71
52 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
53 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
54 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
55 INT3361 Positive_regulation of Esr1 2 273 0.69 208.53 44.81
56 INT80124 Negative_regulation of VEGFA 8 450 0.58 311.19 44.53
57 INT80124 Negative_regulation of VEGFA 18 450 0.58 311.19 44.53
58 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
59 INT13556 Gene_expression of CD4 1 367 0.78 230.82 41.74
60 INT9094 Gene_expression of COL7A1 2 277 0.77 143.42 38.73
61 INT68975 Gene_expression of Mmp9 1 111 0.78 79.57 38.55
62 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
63 INT3253 Negative_regulation of Localization of INS 2 205 0.59 130.39 36.61
64 INT3971 Positive_regulation of Alb 1 175 0.70 98.46 36.45
65 INT101992 Localization of VEGFA 5 413 0.81 258.23 36.15
66 INT84260 Positive_regulation of Mapk8 1 124 0.69 72.84 35.98
67 INT59466 Gene_expression of ISYNA1 2 204 0.77 112.57 35.48
68 INT59466 Gene_expression of ISYNA1 2 204 0.77 112.57 35.48
69 INT79060 Gene_expression of NOS2 1 116 0.78 69.25 34.84
70 INT1705 Gene_expression of pCA 1 126 0.65 88.65 34.81
71 INT8905 Gene_expression of EDN1 4 215 0.78 157.1 34.19
72 INT95734 Phosphorylation of Mapk8 1 108 0.82 49.92 33.52
73 INT1116 Regulation of Ren 1 103 0.62 27.66 33.26
74 INT6302 Binding of IFNA1 1 196 0.48 133.85 32.73
75 INT99610 Localization of MMP9 1 126 0.79 48.46 32.67
76 INT51685 Gene_expression of LTB4R 1 87 0.58 68.69 31.72
77 INT48693 Regulation of VEGFA 1 268 0.62 191.88 31.52
78 INT608 Negative_regulation of KNG1 2 98 0.43 72.36 31.23
79 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
80 INT99688 Negative_regulation of Gene_expression of VEGFA 3 274 0.58 201.8 31.1
81 INT99688 Negative_regulation of Gene_expression of VEGFA 1 274 0.58 201.8 31.1
82 INT719 Negative_regulation of SGCG 2 96 0.57 47.91 30.22
83 INT5117 Negative_regulation of Gene_expression of IL2 1 118 0.59 52.33 29.96
84 INT64113 Positive_regulation of Gene_expression of NOS1 1 110 0.60 71.03 29.72
85 INT724 Negative_regulation of Alb 3 151 0.59 93.57 29.65
86 INT9650 Gene_expression of LPA 1 141 0.75 104.57 29
87 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
88 INT8097 Gene_expression of EGF 1 122 0.77 75.94 28.47
89 INT4459 Positive_regulation of Arc 2 74 0.69 33.61 28.29
90 INT12129 Gene_expression of CYP3A4 1 107 0.78 23.11 27.6
91 INT73314 Gene_expression of Arc 6 133 0.78 67.78 27.44
92 INT37296 Binding of Esr1 1 117 0.43 62.51 27.33
93 INT21687 Positive_regulation of ras 1 143 0.58 97.34 27.31
94 INT79395 Gene_expression of Twist1 1 193 0.77 100.06 26.34
95 INT79395 Gene_expression of Twist1 1 193 0.77 100.06 26.34
96 INT1761 Positive_regulation of PTGER2 1 135 0.49 90.17 26.26
97 INT62710 Gene_expression of HGF 1 160 0.78 88.27 26.14
98 INT3777 Positive_regulation of NARFL 40 256 0.56 302.43 25.74
99 INT3777 Positive_regulation of NARFL 80 256 0.56 302.43 25.74
100 INT48766 Regulation of NOS1 1 73 0.61 37.01 24.59
101 INT79061 Positive_regulation of NOS2 1 92 0.65 58.89 23.96
102 INT34487 Localization of MMP2 1 56 0.81 31.41 23.61
103 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
104 INT96741 Gene_expression of Cxcr4 1 62 0.78 32.3 22.14
105 INT35711 Positive_regulation of Sdcbp 2 110 0.60 50.45 22.11
106 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
107 INT48692 Binding of VEGFA 6 345 0.48 210.3 21.31
108 INT48692 Binding of VEGFA 13 345 0.48 210.3 21.31
109 INT5328 Positive_regulation of CD4 2 191 0.69 133.43 21.31
110 INT99068 Gene_expression of Mapk8 9 62 0.78 33.57 21.25
111 INT48144 Gene_expression of Fgf2 5 117 0.78 43 20.48
112 INT68683 Regulation of Gene_expression of VEGFA 1 143 0.62 104.19 20.14
113 INT51055 Positive_regulation of TIMP1 2 103 0.69 50.07 19.86
114 INT51055 Positive_regulation of TIMP1 1 103 0.69 50.07 19.86
115 INT8662 Positive_regulation of EDN1 12 144 0.70 125.34 19.59
116 INT2006 Gene_expression of fc 1 104 0.34 64.91 19.08
117 INT81194 Binding of CPOX 2 40 0.29 23.7 18.95
118 INT50403 Negative_regulation of CYP2C19 1 55 0.59 8.97 17.79
119 INT72564 Localization of Il10 1 41 0.78 28.62 17.6
120 INT50579 Binding of CYP3A4 1 84 0.48 17.52 17.45
121 INT50404 Negative_regulation of CYP1A2 1 49 0.59 8.61 17.35
122 INT69203 Positive_regulation of Ntf3 1 43 0.66 19.16 16.49
123 INT1981 Negative_regulation of NARFL 90 219 0.47 223.48 16.41
124 INT1981 Negative_regulation of NARFL 86 219 0.47 223.48 16.41
125 INT6850 Gene_expression of SPANXB1 1 34 0.46 15.91 16.38
126 INT6853 Positive_regulation of SPANXB1 1 17 0.40 14.05 16.14
127 INT59929 Negative_regulation of CYP2C9 1 60 0.59 16.33 15.39
128 INT79227 Negative_regulation of Gene_expression of Icam1 1 45 0.59 41.65 14.97
129 INT109535 Gene_expression of Vegfa 1 116 0.75 84.61 14.89
130 INT9191 Localization of EDN1 3 94 0.81 57.01 14.78
131 INT8989 Binding of Npr1 1 25 0.36 5.52 14.58
132 INT61548 Positive_regulation of Fgf2 2 72 0.70 32.18 14.49
133 INT8904 Positive_regulation of Gene_expression of EDN1 2 66 0.70 65.4 14.42
134 INT1982 Regulation of NARFL 21 119 0.49 116.2 14.35
135 INT1982 Regulation of NARFL 30 119 0.49 116.2 14.35
136 INT92823 Positive_regulation of Gene_expression of MMP1 1 65 0.68 25.69 14.31
137 INT20665 Gene_expression of ACE 4 87 0.78 51.71 14.19
138 INT17035 Positive_regulation of TFPI 2 55 0.61 34.88 14.18
139 INT1758 Positive_regulation of Gene_expression of TIMP1 1 62 0.69 31.72 13.98
140 INT9649 Positive_regulation of LPA 2 105 0.69 74.75 13.89
141 INT79703 Gene_expression of Agtr1a 1 46 0.76 14.18 13.77
142 INT67855 Negative_regulation of PPIG 1 64 0.57 17.83 13.54
143 INT3962 Regulation of AGT 3 50 0.62 20.96 13.01
144 INT10870 Regulation of IgG 1 67 0.59 43.27 12.74
145 INT21979 Negative_regulation of EDN1 1 52 0.58 24.65 12.55
146 INT158124 Gene_expression of COL5A2 1 136 0.69 72.3 12.44
147 INT11793 Negative_regulation of CA2 2 78 0.57 19.63 12.35
148 INT70905 Positive_regulation of EDNRA 1 49 0.67 24.33 11.79
149 INT93715 Negative_regulation of MMP9 1 69 0.55 36.05 11.73
150 INT53038 Positive_regulation of Agtr1a 2 35 0.67 23.76 11.68
151 INT398 Localization of AGT 3 45 0.78 16.97 11.54
152 INT14204 Protein_catabolism of KNG1 3 41 0.96 20.94 11.47
153 INT10874 Negative_regulation of Twist1 4 89 0.50 36.84 11.32
154 INT8065 Binding of AGT 2 54 0.48 20.54 10.85
155 INT4605 Negative_regulation of Gene_expression of INS 1 220 0.58 139.66 10.75
156 INT1180 Gene_expression of Ren 1 63 0.77 27.33 10.51
157 INT150540 Binding of TLR2 1 50 0.45 35.86 10.43
158 INT89282 Regulation of MMP9 1 39 0.60 25.45 10.34
159 INT10184 Regulation of EDN1 3 44 0.62 23.78 10.06
160 INT126031 Negative_regulation of Gene_expression of MMP9 1 40 0.57 22.71 9.79
161 INT11679 Negative_regulation of F13A1 2 55 0.54 33.69 9.43
162 INT23094 Positive_regulation of Positive_regulation of Ca2 1 29 0.49 6.8 9.35
163 INT33220 Negative_regulation of ras 2 110 0.58 70.21 9.19
164 INT20664 Binding of ACE 1 60 0.48 35.27 9.16
165 INT80037 Gene_expression of BAK1 26 58 0.75 39.49 9.08
166 INT120967 Negative_regulation of Phosphorylation of Akt1 1 47 0.57 23.67 8.98
167 INT860 Regulation of ALB 1 48 0.60 25.11 8.95
168 INT59165 Binding of fc 1 67 0.36 37.51 8.68
169 INT22383 Binding of IL2 1 59 0.48 39.06 8.56
170 INT43820 Positive_regulation of Twist1 1 75 0.59 42.15 8.47
171 INT43820 Positive_regulation of Twist1 3 75 0.59 42.15 8.47
172 INT86705 Gene_expression of BTG3 1 41 0.65 37.29 8.29
173 INT66460 Negative_regulation of Cabin1 12 15 0.43 8.98 8.03
174 INT76091 Positive_regulation of NOS3 1 48 0.61 18.4 7.92
175 INT54978 Binding of EDNRA 2 36 0.41 14.97 7.86
176 INT119940 Positive_regulation of Gene_expression of Arc 2 36 0.70 18.87 7.85
177 INT21685 Gene_expression of ras 1 115 0.66 85.6 7.76
178 INT4022 Negative_regulation of PLA2G1B 1 30 0.59 10.41 7.58
179 INT99071 Positive_regulation of Gene_expression of Mapk8 2 16 0.55 9.87 7.58
180 INT76892 Gene_expression of FGFR1 1 45 0.69 23.6 7.56
181 INT157959 Binding of AQP4 1 32 0.48 43.44 7.44
182 INT14732 Positive_regulation of FN1 1 46 0.69 31.17 7.33
183 INT144945 Negative_regulation of Icam1 2 27 0.50 26.23 7.08
184 INT42038 Localization of ACE 3 26 0.80 8.88 7.06
185 INT21579 Negative_regulation of Gene_expression of TIMP1 1 25 0.57 12.41 6.94
186 INT138799 Regulation of Gene_expression of Ppara 1 40 0.60 29.42 6.89
187 INT11957 Negative_regulation of LPA 1 52 0.59 39.09 6.84
188 INT52180 Binding of Aes 2 38 0.42 23.16 6.7
189 INT22781 Binding of COL7A1 28 76 0.48 41.59 6.66
190 INT43721 Gene_expression of Vegfa 1 49 0.77 36.18 6.63
191 INT35712 Regulation of Sdcbp 2 19 0.23 5.3 6.58
192 INT89131 Negative_regulation of NOS2 1 20 0.58 9.68 6.56
193 INT9951 Gene_expression of ANGPTL5 1 45 0.53 37.2 6.44
194 INT934 Regulation of Gtf3a 1 25 0.35 11.35 6.34
195 INT11826 Positive_regulation of LDLR 1 62 0.62 45.09 6.21
196 INT4561 Gene_expression of PLG 2 32 0.75 17.59 6.21
197 INT8683 Positive_regulation of F3 1 31 0.67 42.89 6.21
198 INT64689 Positive_regulation of Gene_expression of Fgf2 4 30 0.70 12.05 6.2
199 INT95607 Regulation of MMP1 1 19 0.60 7.86 6.18
200 INT49025 Positive_regulation of TYR 2 14 0.69 7.15 5.84
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