J:Clinics (Sao Paulo)

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT83616 Binding of IL6 and IL8 5 2 0.09 5.8 1.11
2 INT278292 Binding of CRP and ESR1 6 1 0.09 10.92 0.96
3 INT168295 PROC Regulation of Gene_expression of VEGFA 2 1 0.00 1.6 0.67
4 INT319718 Binding of Crebbp and Creb1 1 4 0.10 1.68 0.48
5 INT319729 Binding of Rela and Crebbp 1 2 0.02 0.88 0.37
6 INT355153 Gpt Positive_regulation of Positive_regulation of Ldha 1 1 0.02 1.33 0.3
7 INT355152 Gpt Positive_regulation of Gene_expression of Ldha 1 1 0.02 1.26 0.29
8 INT314484 TH Positive_regulation of RLS 1 2 0.01 1.66 0.29
9 INT266006 Binding of COL5A2 and SGCG 1 2 0.00 0.89 0.23
10 INT266005 Binding of DIO3 and SGCG 1 2 0.00 0.86 0.22
11 INT319703 Binding of Rela and Crebbp Positive_regulation of Binding of Rela 1 1 0.00 0.37 0.12
12 INT319726 Crebbp Positive_regulation of Binding of Rela 1 1 0.02 0.37 0.12
13 INT319731 Ep300 Positive_regulation of Binding of Rela 1 1 0.01 0.37 0.12
14 INT319727 Binding of Crebbp and Ep300 1 1 0.02 0.36 0.11
15 INT319735 Positive_regulation of Binding of IL6 and IL8 1 1 0.01 1.35 0.11
16 INT266003 Binding of COL5A2 and DIO3 1 1 0.01 0.43 0.11
17 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 1 0.03 0.36 0.11
18 INT266082 PROC Regulation of Localization of VEGFA 1 1 0.00 0.84 0.05
19 INT308432 Binding of PDE4A and Aip 1 3 0.05 3.1 0.05
20 INT266078 VEGFA Positive_regulation of DBI 1 1 0.10 0.45 0.04
21 INT266074 LGALS1 Regulation of Gene_expression of PAEP 1 1 0.14 0.43 0.03
22 INT266075 LIF Regulation of Gene_expression of PAEP 1 1 0.19 0.43 0.03
23 INT266070 LIF Regulation of Gene_expression of PAPPA 1 1 0.35 0.49 0.03
24 INT266072 LGALS1 Regulation of Gene_expression of LIF 1 1 0.17 0.43 0.03
25 INT266067 PAPPA Regulation of Gene_expression of LIF 1 1 0.35 0.49 0.03
26 INT266076 LIF Regulation of Gene_expression of LGALS1 1 1 0.17 0.43 0.03
27 INT266081 PAPPA Regulation of Gene_expression of LGALS1 1 1 0.24 0.49 0.03
28 INT266077 LGALS1 Regulation of Gene_expression of PAPPA 1 1 0.24 0.49 0.03
29 INT266073 PAPPA Regulation of Gene_expression of PAEP 1 1 0.27 0.49 0.03
30 INT319700 Ins1 Negative_regulation of Lipe 1 1 0.04 1.22 0.03
31 INT242015 Binding of Mdm2 and Trp53 3 1 0.16 5.74 0
32 INT308425 Binding of Pde2a and Aip 1 1 0.04 1.37 0
33 INT266080 Binding of PAPPA and MUC16 1 1 0.40 0.74 0
34 INT266068 Binding of CHKB and MUC16 1 1 0.22 0.74 0
35 INT308426 Binding of Pde4a and Aip 1 1 0.02 0.89 0
36 INT303845 Binding of PON1 and Pon1 1 1 0.01 1.33 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
2 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
3 INT439 Localization of Gnrh1 1 976 0.81 100.96 363.25
4 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
5 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
6 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
7 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
8 INT68684 Gene_expression of VEGFA 13 2371 0.78 1742.52 259.2
9 INT1893 Localization of Gh 7 1041 0.79 340.23 256.58
10 INT16868 Gene_expression of Il6 3 807 0.78 499.48 256.57
11 INT11009 Phosphorylation of Creb1 2 458 0.82 111.34 221.97
12 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
13 INT11313 Positive_regulation of Il6 2 526 0.70 331.27 201.59
14 INT10194 Positive_regulation of IL6 2 702 0.70 600.62 183.38
15 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
16 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
17 INT3448 Positive_regulation of Gh 1 521 0.69 180.03 161.18
18 INT9852 Positive_regulation of Gpt 6 563 0.70 364.64 146.82
19 INT812 Localization of INS 3 1026 0.81 515.6 145.31
20 INT48895 Gene_expression of Il10 6 333 0.78 221.2 138.52
21 INT11012 Positive_regulation of Creb1 5 258 0.70 84.4 132
22 INT252 Localization of GH1 1 529 0.80 227.4 122.05
23 INT17612 Gene_expression of CRP 3 676 0.78 580.61 119.03
24 INT62124 Gene_expression of NOS1 4 444 0.78 218.08 114.85
25 INT48593 Positive_regulation of NOS1 4 420 0.68 226.15 114.71
26 INT11011 Positive_regulation of Phosphorylation of Creb1 1 190 0.70 49.25 112.01
27 INT3038 Gene_expression of INS 12 1583 0.78 1174.16 107.01
28 INT69440 Gene_expression of ROS1 4 752 0.78 477.64 103.83
29 INT69440 Gene_expression of ROS1 2 752 0.78 477.64 103.83
30 INT18009 Positive_regulation of CRP 1 518 0.70 553.03 103.74
31 INT18009 Positive_regulation of CRP 2 518 0.70 553.03 103.74
32 INT10838 Positive_regulation of IL8 2 381 0.70 295.51 101.62
33 INT74058 Gene_expression of Nos1 2 260 0.78 80.04 95.71
34 INT9516 Negative_regulation of Gabrg1 1 149 0.53 27.83 91.02
35 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
36 INT10166 Localization of Tnf 1 237 0.81 153.95 88.64
37 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
38 INT68682 Positive_regulation of VEGFA 3 640 0.70 454.14 81.65
39 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
40 INT1498 Gene_expression of Gh 2 521 0.75 220.84 81.16
41 INT64636 Positive_regulation of Gene_expression of Nos2 1 242 0.70 147.52 79.53
42 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
43 INT58400 Negative_regulation of Tnf 2 182 0.59 129.97 71
44 INT58400 Negative_regulation of Tnf 2 182 0.59 129.97 71
45 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
46 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
47 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
48 INT19511 Localization of Il6 2 212 0.81 118.17 67.67
49 INT6176 Positive_regulation of Htr1a 1 117 0.67 28.23 66.17
50 INT3375 Gene_expression of IGHE 4 535 0.77 387.47 65.46
51 INT822 Gene_expression of ESR1 2 529 0.78 302.16 63.64
52 INT17564 Gene_expression of Gpt 7 322 0.75 208.51 60.36
53 INT55344 Gene_expression of Ros1 1 396 0.54 217.64 59.98
54 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
55 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
56 INT647 Gene_expression of SGCG 4 211 0.75 78.46 55.82
57 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
58 INT251 Regulation of INS 1 398 0.62 232.47 55.04
59 INT117223 Gene_expression of TLR4 1 348 0.78 206.18 54.42
60 INT249 Localization of GHRH 1 215 0.80 78.02 51.87
61 INT83199 Gene_expression of Nos3 1 193 0.78 100.72 51.57
62 INT1199 Positive_regulation of INS 3 579 0.70 399.64 50.43
63 INT2604 Positive_regulation of Got1 2 223 0.70 154.78 49.51
64 INT17881 Gene_expression of LEP 1 278 0.78 221.61 48.31
65 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
66 INT374 Positive_regulation of Ldha 2 212 0.70 107.08 47.43
67 INT531 Gene_expression of GH1 1 376 0.75 193.45 46.24
68 INT1322 Positive_regulation of Localization of INS 2 293 0.70 120.86 45.98
69 INT2275 Negative_regulation of Localization of Ins1 1 183 0.59 51.02 44.94
70 INT4216 Gene_expression of CD40LG 1 328 0.78 256.02 44.23
71 INT5307 Regulation of Tnf 1 87 0.62 78.71 43.4
72 INT50957 Negative_regulation of Il6 1 134 0.59 79.08 42.67
73 INT170054 Negative_regulation of Gopc 1 280 0.38 117.89 42.4
74 INT4004 Gene_expression of IGHG3 1 321 0.71 221.03 42.33
75 INT69437 Positive_regulation of ROS1 1 328 0.58 222.83 40.56
76 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
77 INT3987 Positive_regulation of IGHE 2 316 0.70 283.2 40.16
78 INT3252 Negative_regulation of INS 2 428 0.59 271.65 39.52
79 INT9094 Gene_expression of COL7A1 3 277 0.77 143.42 38.73
80 INT385 Gene_expression of Agt 11 182 0.78 63.62 37.91
81 INT64558 Negative_regulation of Nos1 1 88 0.58 26.76 36.78
82 INT3253 Negative_regulation of Localization of INS 1 205 0.59 130.39 36.61
83 INT101992 Localization of VEGFA 7 413 0.81 258.23 36.15
84 INT390 Positive_regulation of Agt 7 170 0.70 61.47 36.08
85 INT74563 Positive_regulation of Gene_expression of ROS1 1 258 0.61 168.18 34.08
86 INT16960 Gene_expression of Crp 1 166 0.76 116.21 34.07
87 INT1159 Negative_regulation of Agt 2 133 0.59 40.14 31.67
88 INT48693 Regulation of VEGFA 1 268 0.62 191.88 31.52
89 INT1158 Regulation of Agt 1 106 0.61 29.4 30.29
90 INT719 Negative_regulation of SGCG 1 96 0.57 47.91 30.22
91 INT64113 Positive_regulation of Gene_expression of NOS1 2 110 0.60 71.03 29.72
92 INT5653 Positive_regulation of ELANE 1 136 0.70 72.78 27.94
93 INT21687 Positive_regulation of ras 1 143 0.58 97.34 27.31
94 INT9647 Gene_expression of PROC 1 163 0.65 89.76 26.75
95 INT130176 Positive_regulation of Gene_expression of CRP 1 125 0.66 137.06 25.9
96 INT74688 Regulation of Nos1 2 55 0.62 22.16 25.3
97 INT68758 Positive_regulation of Ros1 1 125 0.46 82.72 25.27
98 INT76743 Gene_expression of Slc6a4 1 55 0.76 13.53 24.9
99 INT2614 Gene_expression of CGA 4 187 0.78 105.89 24.77
100 INT100423 Gene_expression of Bax 1 141 0.75 98.43 24.48
101 INT17275 Gene_expression of HIVEP1 5 267 0.75 232.07 24.06
102 INT70503 Regulation of Gene_expression of Nos2 1 71 0.62 44 24.01
103 INT4781 Gene_expression of TH 9 68 0.73 26.92 24.01
104 INT8775 Binding of IGHE 3 167 0.48 102.61 23.54
105 INT9292 Positive_regulation of SGCG 2 93 0.67 35.13 23.48
106 INT66026 Gene_expression of Cxcl1 4 74 0.78 31.87 23.37
107 INT5511 Negative_regulation of Gene_expression of Pomc 1 47 0.59 12.08 23.02
108 INT71875 Localization of Nfkb1 1 92 0.78 48.13 22.94
109 INT76123 Gene_expression of Lep 3 193 0.78 94.17 22.76
110 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
111 INT7678 Localization of Alb 1 142 0.81 80.93 22.49
112 INT106175 Positive_regulation of Positive_regulation of Creb1 1 37 0.70 13.89 22.46
113 INT4369 Gene_expression of Ldha 3 157 0.76 88.12 22.45
114 INT8640 Positive_regulation of HSD11B1 2 332 0.67 377.84 22.36
115 INT23257 Regulation of CRP 1 127 0.62 100.05 21.87
116 INT8580 Gene_expression of ELANE 2 132 0.75 62.98 21.79
117 INT3589 Positive_regulation of SCN5A 1 101 0.57 46.01 21.73
118 INT171820 Localization of Fig4 1 144 0.65 27.38 20.88
119 INT955 Gene_expression of GHRH 1 126 0.78 59.91 20.74
120 INT12951 Negative_regulation of Cat 3 126 0.57 64.39 20.61
121 INT68683 Regulation of Gene_expression of VEGFA 3 143 0.62 104.19 20.14
122 INT76336 Negative_regulation of PDE5A 2 192 0.59 112.02 20.09
123 INT75742 Binding of RLS 1 86 0.42 95.27 19.04
124 INT20631 Positive_regulation of CHKB 8 166 0.69 109.86 17.92
125 INT83198 Positive_regulation of Nos3 1 78 0.64 35.69 17.71
126 INT2120 Gene_expression of CD79A 2 159 0.78 111.69 17.16
127 INT61513 Positive_regulation of Gpx1 1 71 0.64 37.91 17.07
128 INT68681 Transcription of VEGFA 1 132 0.71 80.47 17.03
129 INT48892 Transcription of Il10 1 31 0.71 27.26 16.77
130 INT2432 Positive_regulation of Cp 1 41 0.67 31.1 16.68
131 INT117500 Gene_expression of Adipoq 1 90 0.74 67.79 16.58
132 INT984 Positive_regulation of Localization of GHRH 1 58 0.70 12.66 16.51
133 INT51576 Positive_regulation of Cxcl1 2 42 0.69 20.12 16.41
134 INT13716 Positive_regulation of TH 11 33 0.68 19.11 16
135 INT102680 Protein_catabolism of COL7A1 4 49 0.69 34.68 15.78
136 INT12950 Gene_expression of Cat 1 85 0.75 35.94 15.76
137 INT106745 Localization of CRP 1 65 0.81 66.44 15.21
138 INT2630 Positive_regulation of Shbg 11 134 0.70 65.26 15.19
139 INT93482 Localization of Rela 3 56 0.78 24.52 14.82
140 INT5904 Localization of MPO 2 62 0.81 36.37 14.64
141 INT11340 Positive_regulation of SLC17A5 1 120 0.67 113.52 14.5
142 INT10173 Binding of Tnf 2 45 0.48 35.6 14.32
143 INT10173 Binding of Tnf 2 45 0.48 35.6 14.32
144 INT54924 Gene_expression of RLS 4 67 0.62 83.2 14.25
145 INT39507 Positive_regulation of TXNRD1 3 37 0.68 12.47 14.25
146 INT17565 Regulation of Gpt 2 85 0.60 43.64 13.68
147 INT60764 Positive_regulation of PPIG 1 39 0.67 17.08 13.48
148 INT15921 Positive_regulation of Serpine1 2 85 0.68 81.24 13.4
149 INT16713 Binding of Creb1 13 53 0.48 20.24 13.06
150 INT83200 Positive_regulation of Gene_expression of Nos3 1 48 0.70 24.75 12.99
151 INT2578 Binding of Ins1 1 74 0.48 33.57 12.92
152 INT8210 Positive_regulation of Gene_expression of INS 3 188 0.68 146.57 12.83
153 INT2673 Negative_regulation of PROC 2 93 0.57 50.34 12.79
154 INT2385 Gene_expression of MIF 2 57 0.68 40.74 12.78
155 INT4199 Binding of Agt 1 76 0.48 21.06 12.66
156 INT73641 Regulation of Lep 1 45 0.62 26.2 12.59
157 INT55343 Localization of Ros1 1 39 0.60 34.51 12.5
158 INT158124 Gene_expression of COL5A2 12 136 0.69 72.3 12.44
159 INT21987 Positive_regulation of Rorb 2 30 0.33 12.7 12.24
160 INT3104 Negative_regulation of CGA 1 76 0.54 29.81 12.23
161 INT69436 Negative_regulation of Gene_expression of ROS1 1 81 0.38 46.58 12.22
162 INT9832 Gene_expression of Shbg 3 96 0.75 56.71 12.19
163 INT8547 Gene_expression of MUC16 6 116 0.78 75.97 12.18
164 INT79545 Positive_regulation of Gene_expression of ESR1 1 82 0.64 39.42 12.18
165 INT8629 Positive_regulation of COL7A1 1 72 0.69 40.66 12.09
166 INT117502 Positive_regulation of Adipoq 1 70 0.63 40.43 12.03
167 INT16772 Gene_expression of MPO 5 81 0.78 90.98 11.9
168 INT39587 Gene_expression of CP 1 42 0.65 31.48 11.87
169 INT3602 Negative_regulation of Shbg 1 148 0.53 69.05 11.65
170 INT142735 Regulation of RLS 1 33 0.53 45.83 11.35
171 INT8546 Positive_regulation of MUC16 2 99 0.69 74.98 11.26
172 INT82079 Positive_regulation of Lep 2 79 0.70 40 11.07
173 INT94438 Gene_expression of OLR1 16 86 0.78 80.38 11.03
174 INT3546 Binding of Oxt 1 54 0.48 9.75 10.81
175 INT4605 Negative_regulation of Gene_expression of INS 1 220 0.58 139.66 10.75
176 INT49129 Positive_regulation of GFAP 1 35 0.69 28.78 10.38
177 INT952 Negative_regulation of GHRH 1 57 0.56 25.3 10.34
178 INT94784 Binding of ROS1 1 113 0.40 71.57 10.26
179 INT56450 Negative_regulation of Gene_expression of Icam1 1 33 0.52 27.21 10.15
180 INT32344 Localization of LTF 3 30 0.80 15.28 10.09
181 INT11238 Positive_regulation of ADA 12 33 0.70 39.7 9.98
182 INT62166 Positive_regulation of Gene_expression of Gpt 4 64 0.50 39.13 9.69
183 INT3988 Positive_regulation of Gene_expression of IGHE 1 98 0.68 91.46 9.61
184 INT102110 Positive_regulation of Gene_expression of Bax 1 42 0.67 35.77 9.51
185 INT47744 Binding of Slc6a4 1 21 0.48 5.52 9.45
186 INT25834 Positive_regulation of Dbp 6 59 0.68 24.34 9.32
187 INT10533 Positive_regulation of Positive_regulation of Trib3 1 24 0.42 6.59 9.2
188 INT9548 Gene_expression of CHKB 8 99 0.65 50.86 9.03
189 INT4534 Regulation of PROC 1 38 0.33 19.81 8.99
190 INT14301 Binding of CSF2 2 82 0.48 67.95 8.98
191 INT55342 Negative_regulation of Gene_expression of Ros1 1 49 0.37 31.62 8.93
192 INT591 Negative_regulation of Serpinc1 7 44 0.57 31.73 8.82
193 INT48860 Regulation of Localization of Tnf 1 25 0.61 20.68 8.78
194 INT22798 Regulation of Shbg 1 64 0.60 26.71 8.76
195 INT386 Positive_regulation of Gene_expression of Agt 8 37 0.70 15.92 8.73
196 INT57057 Gene_expression of APC 4 131 0.78 122.24 8.7
197 INT117553 Regulation of MIF 3 10 0.56 12.76 8.67
198 INT28521 Gene_expression of HBG2 2 56 0.77 16.62 8.64
199 INT939 Gene_expression of PAEP 1 86 0.77 31.02 8.59
200 INT8637 Negative_regulation of Dbp 1 112 0.50 33.28 8.4
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