J:Comp Hepatol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT88024 Ifng Positive_regulation of Gene_expression of Faslg 2 2 0.50 1.19 0.53
2 INT173120 Binding of PPARA and NR1H4 8 3 0.09 2.79 0.23
3 INT234724 Binding of NPC1 and Cxcl1 1 1 0.00 0.33 0.21
4 INT189321 Binding of Apoa1 and Hdlcl1 1 1 0.00 0.68 0.2
5 INT234720 Cxcl1 Positive_regulation of Gene_expression of Faslg 1 1 0.08 0.2 0.16
6 INT234719 Cxcl1 Regulation of Gene_expression of Faslg 1 1 0.08 0.2 0.15
7 INT234721 olt Regulation of Gene_expression of Cxcl1 1 1 0.01 0.2 0.15
8 INT178351 Binding of Il6 and Hp 1 1 0.00 0.61 0.14
9 INT173200 PPA1 Positive_regulation of Myc 1 1 0.08 0.5 0.12
10 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 1 0.18 0.48 0.12
11 INT173129 PTGS2 Regulation of IER3 1 1 0.01 0.36 0.12
12 INT173122 PPA1 Positive_regulation of HRAS 1 1 0.08 0.5 0.12
13 INT173125 PPA1 Positive_regulation of JUN 1 1 0.06 0.5 0.12
14 INT173119 PPA1 Regulation of IER3 1 1 0.00 0.36 0.12
15 INT173126 CYP8B1 Positive_regulation of PPARA 1 1 0.25 0.39 0.1
16 INT173124 PPA1 Regulation of ZFP37 1 1 0.00 0.44 0.1
17 INT179869 COL1A1 Positive_regulation of SOCS3 1 2 0.04 0.99 0.1
18 INT179871 IK Positive_regulation of SOCS3 1 2 0.01 1 0.1
19 INT173130 Binding of INS and PPARA 2 1 0.04 1.8 0.08
20 INT179872 Binding of HGF and MET 7 2 0.09 4.69 0.07
21 INT212440 STAT3 Regulation of Phosphorylation of SOAT1 1 1 0.11 1.42 0.05
22 INT212442 HGF Positive_regulation of MET 2 1 0.21 1.25 0.04
23 INT179868 HGF Positive_regulation of Binding of HGF and MET 1 1 0.05 0.35 0.04
24 INT173199 CNOT4 Regulation of Regulation of Myc 1 1 0.01 0.66 0.03
25 INT353544 Egf Regulation of Gene_expression of ONECUT1 1 1 0.00 0.08 0
26 INT353540 Egf Positive_regulation of Hgf 1 1 0.23 0.08 0
27 INT173127 Binding of INS and SORBS1 1 1 0.02 0.22 0
28 INT353542 Pik3cb Regulation of Gene_expression of ONECUT1 1 1 0.00 0.08 0
29 INT173123 Binding of HNF4A and PPARA 1 2 0.10 0.19 0
30 INT178921 SERPINB1 Positive_regulation of DNASE1 1 1 0.00 0.32 0
31 INT178938 Binding of Casp9 and Apaf1 1 1 0.01 0.74 0
32 INT210493 Binding of HGF and TEP1 1 1 0.01 0.19 0
33 INT244709 Binding of Ldha and Gpt 1 1 0.01 1.32 0
34 INT210494 Binding of EGF and TEP1 1 1 0.02 0.19 0
35 INT353543 Hgf Regulation of Gene_expression of ONECUT1 1 1 0.00 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5228 Positive_regulation of Fos 1 934 0.70 209.8 503.87
2 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
3 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
4 INT9852 Positive_regulation of Gpt 7 563 0.70 364.64 146.82
5 INT3038 Gene_expression of INS 2 1583 0.78 1174.16 107.01
6 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
7 INT77435 Positive_regulation of Nos2 3 343 0.70 208.49 91.43
8 INT86024 Gene_expression of PPARA 28 736 0.78 497.93 91.14
9 INT71789 Positive_regulation of MAPK1 5 396 0.70 234.44 89.27
10 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
11 INT10359 Gene_expression of Ifng 1 159 0.78 79.6 72.14
12 INT5969 Gene_expression of Il1a 1 221 0.75 96.31 71.38
13 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
14 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
15 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
16 INT6486 Positive_regulation of Tnf 3 168 0.70 123.47 66.05
17 INT67614 Positive_regulation of PPARA 17 438 0.68 293.28 63.61
18 INT17564 Gene_expression of Gpt 24 322 0.75 208.51 60.36
19 INT14740 Gene_expression of TGFB1 2 272 0.78 168.48 60.18
20 INT55344 Gene_expression of Ros1 3 396 0.54 217.64 59.98
21 INT3920 Localization of Ldha 2 241 0.81 83.08 58.72
22 INT6669 Negative_regulation of Positive_regulation of Fos 1 98 0.59 23.5 56.82
23 INT82650 Gene_expression of Bcl2 1 312 0.78 211.71 55.03
24 INT117713 Phosphorylation of Akt1 1 275 0.82 95.82 54.34
25 INT4345 Gene_expression of Gtf3a 5 157 0.67 80.75 48.47
26 INT374 Positive_regulation of Ldha 6 212 0.70 107.08 47.43
27 INT55670 Negative_regulation of Gene_expression of Tnf 1 83 0.59 57.16 46.33
28 INT71786 Phosphorylation of MAPK1 1 256 0.82 110.09 46.17
29 INT613 Gene_expression of Alb 5 268 0.78 149.84 42.78
30 INT85943 Negative_regulation of Nos2 2 161 0.59 108.56 42.65
31 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
32 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
33 INT3758 Gene_expression of ALB 3 326 0.78 184.65 38.75
34 INT48933 Gene_expression of Mapk3 3 93 0.75 44.39 37.92
35 INT103094 Binding of PPARA 10 308 0.47 177.26 34.75
36 INT18893 Positive_regulation of CPP 1 81 0.69 38.03 34.33
37 INT48924 Positive_regulation of Mapk3 3 107 0.67 50.53 34.05
38 INT84825 Gene_expression of CD36 1 121 0.78 43.73 33.23
39 INT14823 Gene_expression of MET 9 103 0.75 51.92 32.48
40 INT22939 Gene_expression of Csf2 2 164 0.78 85.1 32.22
41 INT129207 Gene_expression of Cxcl1 14 114 0.75 68.54 30.82
42 INT65960 Gene_expression of BCL2 1 352 0.78 312.03 30.73
43 INT11650 Negative_regulation of Gpt 4 122 0.59 69.15 30.36
44 INT72375 Phosphorylation of Mapk3 5 87 0.80 43.66 30.27
45 INT17331 Positive_regulation of JUN 1 132 0.69 60.4 27.03
46 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
47 INT5966 Localization of Il1a 1 50 0.78 22.91 26.54
48 INT62710 Gene_expression of HGF 3 160 0.78 88.27 26.14
49 INT12124 Gene_expression of MAPK1 2 141 0.75 82.4 25.58
50 INT100423 Gene_expression of Bax 2 141 0.75 98.43 24.48
51 INT40776 Gene_expression of Akt1 7 99 0.77 34.91 24.39
52 INT86534 Positive_regulation of MAPK14 2 81 0.62 57.81 23.62
53 INT18894 Gene_expression of CPP 1 44 0.77 23.05 23.05
54 INT4369 Gene_expression of Ldha 13 157 0.76 88.12 22.45
55 INT101517 Negative_regulation of PPARA 7 168 0.57 112.24 21.41
56 INT11157 Binding of EGF 1 88 0.48 53.73 21.25
57 INT171820 Localization of Fig4 2 144 0.65 27.38 20.88
58 INT66281 Transcription of Nos2 2 81 0.71 39.49 20.37
59 INT89396 Phosphorylation of AKT1 2 225 0.82 111.66 19.61
60 INT25222 Positive_regulation of Gene_expression of Ifng 2 32 0.50 24.18 19.58
61 INT86187 Positive_regulation of AKT1 1 199 0.69 122.13 19.44
62 INT1278 Negative_regulation of Ldha 5 93 0.59 37.66 19.36
63 INT712 Positive_regulation of LDHA 8 160 0.70 175.25 19.11
64 INT91462 Positive_regulation of Phosphorylation of MAPK1 1 99 0.67 40.28 18.99
65 INT93734 Positive_regulation of Gene_expression of Bcl2 1 76 0.70 61.95 18.46
66 INT56749 Gene_expression of PCNA 1 219 0.77 111.25 18.42
67 INT3952 Negative_regulation of ALB 2 116 0.59 72.18 18.35
68 INT28215 Gene_expression of CDKN1A 1 196 0.76 113.9 18.3
69 INT77620 Gene_expression of Fas 2 146 0.78 72.4 16.61
70 INT20622 Gene_expression of LDHA 5 107 0.76 77.97 16.3
71 INT10721 Gene_expression of BDNF-AS 1 119 0.76 72.8 16.29
72 INT80972 Gene_expression of Tp53 1 104 0.78 102.74 16.02
73 INT65659 Positive_regulation of STAT3 1 132 0.70 69.56 15.95
74 INT98647 Positive_regulation of Mdk 1 65 0.59 32.93 15.67
75 INT97245 Gene_expression of AKT1 6 217 0.77 119.63 15.59
76 INT19963 Gene_expression of COL1A1 1 118 0.59 42.11 15.15
77 INT103096 Regulation of PPARA 3 113 0.60 62.47 14.57
78 INT18526 Positive_regulation of Aap 2 19 0.56 12.28 14.57
79 INT100139 Positive_regulation of Gene_expression of PPARA 4 160 0.63 97.78 14.53
80 INT11340 Positive_regulation of SLC17A5 1 120 0.67 113.52 14.5
81 INT17565 Regulation of Gpt 6 85 0.60 43.64 13.68
82 INT18720 Localization of Csf2 2 72 0.67 13.65 13.41
83 INT14572 Binding of INS 2 205 0.48 175.43 13.38
84 INT22213 Localization of Gpt 1 52 0.78 34.05 12.94
85 INT48927 Regulation of Mapk3 1 25 0.60 14.06 12.82
86 INT1827 Gene_expression of Aap 1 11 0.67 9.37 12.66
87 INT12156 Positive_regulation of MET 3 43 0.67 17.75 12.64
88 INT24876 Gene_expression of CD34 1 172 0.78 91.02 12.39
89 INT61946 Positive_regulation of HGF 6 57 0.69 38.93 11.99
90 INT150851 Positive_regulation of Cxcl1 6 45 0.57 20.83 11.88
91 INT4605 Negative_regulation of Gene_expression of INS 1 220 0.58 139.66 10.75
92 INT110178 Phosphorylation of MAPK14 1 40 0.68 19.38 10.37
93 INT173159 Localization of PPARA 1 96 0.74 64.55 10.26
94 INT88020 Positive_regulation of Fas 2 32 0.70 19.78 9.97
95 INT169997 Positive_regulation of Gene_expression of Tp53 1 37 0.70 47.3 9.85
96 INT33099 Negative_regulation of INSRR 1 32 0.40 13.82 9.85
97 INT7995 Positive_regulation of Lta 2 28 0.66 14.98 9.8
98 INT122584 Negative_regulation of Gene_expression of PPARA 3 56 0.58 37.61 9.76
99 INT62166 Positive_regulation of Gene_expression of Gpt 3 64 0.50 39.13 9.69
100 INT102110 Positive_regulation of Gene_expression of Bax 2 42 0.67 35.77 9.51
101 INT101105 Positive_regulation of FUT1 4 62 0.30 55.96 9.28
102 INT86851 Gene_expression of Faslg 16 45 0.75 24.42 9.21
103 INT6510 Gene_expression of AFP 1 130 0.78 119.2 9.19
104 INT13010 Gene_expression of TYR 1 38 0.65 14.81 8.84
105 INT57057 Gene_expression of APC 3 131 0.78 122.24 8.7
106 INT70017 Positive_regulation of BCL2 1 87 0.67 66.62 8.68
107 INT119831 Gene_expression of PTEN 1 55 0.75 40.37 8.57
108 INT45914 Gene_expression of Apcs 3 22 0.65 24.25 8.48
109 INT91370 Phosphorylation of STAT3 11 123 0.82 49.25 8.42
110 INT4159 Gene_expression of Hp 3 33 0.72 12.49 8.39
111 INT17024 Gene_expression of COL1A2 1 69 0.77 36.38 8.29
112 INT2271 Gene_expression of F2 2 51 0.76 30.21 7.97
113 INT127853 Localization of Ephb1 1 20 0.74 5.47 7.96
114 INT112191 Positive_regulation of Transcription of Nos2 1 22 0.66 12.4 7.74
115 INT85751 Positive_regulation of Positive_regulation of Nos2 2 40 0.60 23.53 7.72
116 INT72372 Positive_regulation of Phosphorylation of Mapk3 2 30 0.67 13.6 7.69
117 INT88014 Positive_regulation of Gene_expression of Fas 2 29 0.50 14.84 7.47
118 INT121496 Gene_expression of TERT 1 107 0.78 45.6 7.42
119 INT102107 Negative_regulation of Gene_expression of Bax 2 30 0.57 29.48 7.33
120 INT6511 Positive_regulation of AFP 1 76 0.70 70.15 7.28
121 INT20274 Regulation of Aap 1 9 0.45 5.55 7.27
122 INT8579 Gene_expression of Apoa1 1 13 0.76 35.89 7.21
123 INT16631 Negative_regulation of APC 2 46 0.57 30.53 7.11
124 INT75497 Regulation of JUN 1 28 0.61 11.04 7.09
125 INT102749 Positive_regulation of Positive_regulation of CASP3 1 32 0.67 26.07 6.93
126 INT57232 Binding of Casp3 1 22 0.36 9.42 6.2
127 INT4422 Positive_regulation of Gene_expression of Alb 1 30 0.50 18.56 6.12
128 INT128587 Localization of Mapk14 1 15 0.81 8.41 6.1
129 INT52311 Positive_regulation of JUNB 1 12 0.40 4.48 6.02
130 INT27591 Negative_regulation of Gene_expression of Alb 1 30 0.58 17.03 5.99
131 INT19086 Negative_regulation of COL1A1 1 32 0.38 16.77 5.98
132 INT93684 Gene_expression of STAT3 3 66 0.78 34.42 5.94
133 INT115594 Gene_expression of Cd80 1 9 0.67 7.8 5.92
134 INT130111 Regulation of Positive_regulation of MAPK1 1 14 0.36 11.01 5.9
135 INT104330 Negative_regulation of CDKN1A 1 57 0.58 39.93 5.88
136 INT49025 Positive_regulation of TYR 1 14 0.69 7.15 5.84
137 INT86025 Positive_regulation of Positive_regulation of PPARA 1 34 0.52 22.89 5.74
138 INT150853 Negative_regulation of Cxcl1 4 22 0.49 12.61 5.72
139 INT86023 Transcription of PPARA 2 60 0.66 25.8 5.7
140 INT121494 Transcription of TERT 1 64 0.69 10.03 5.55
141 INT22943 Positive_regulation of Positive_regulation of Gpt 1 23 0.47 16.09 5.55
142 INT183689 Positive_regulation of Gene_expression of Cxcl1 6 21 0.58 9.13 5.5
143 INT80657 Gene_expression of SLC17A5 1 50 0.75 39.98 5.44
144 INT71779 Positive_regulation of Gene_expression of MAPK1 2 27 0.47 21.41 5.39
145 INT186063 Phosphorylation of SOAT1 2 29 0.28 11.77 5.34
146 INT70613 Negative_regulation of Gene_expression of BCL2 1 48 0.59 38.91 5.22
147 INT39900 Positive_regulation of Gene_expression of Ldha 8 36 0.50 20.35 5.22
148 INT106667 Gene_expression of NDRG1 1 18 0.70 9.96 5.14
149 INT73262 Negative_regulation of BCL2 1 67 0.57 61.01 5.07
150 INT88019 Positive_regulation of Gene_expression of Faslg 5 16 0.67 11.31 5.05
151 INT65927 Transcription of Gtf3a 2 20 0.47 9.27 4.97
152 INT150856 Localization of Cxcl1 1 14 0.78 6.97 4.91
153 INT69215 Gene_expression of Col1a1 2 38 0.68 17.39 4.77
154 INT117920 Regulation of MAPK14 1 14 0.38 8.75 4.31
155 INT101858 Negative_regulation of BAX 1 25 0.57 23.77 4.16
156 INT91371 Negative_regulation of STAT3 3 34 0.59 25 4.08
157 INT111477 Gene_expression of KRT7 2 90 0.74 86.76 4.07
158 INT57525 Negative_regulation of Ltf 1 9 0.50 4.2 4.03
159 INT19158 Gene_expression of PAH 1 35 0.65 35.81 3.88
160 INT14778 Gene_expression of FCGR3A 1 25 0.75 16.25 3.86
161 INT38033 Regulation of HGF 2 26 0.45 14.96 3.81
162 INT63121 Binding of APC 3 29 0.41 23.02 3.8
163 INT4922 Negative_regulation of MET 7 19 0.57 13.97 3.7
164 INT84891 Gene_expression of PPARD 1 10 0.78 6.8 3.64
165 INT16644 Positive_regulation of Plg 2 16 0.60 6.38 3.62
166 INT47201 Gene_expression of RT1-EC2 1 7 0.38 3.15 3.49
167 INT38303 Binding of Gpt 4 21 0.47 15.84 3.43
168 INT74946 Negative_regulation of Gene_expression of HGF 1 14 0.58 6.29 3.39
169 INT129751 Regulation of Phosphorylation of Mapk3 1 11 0.55 3.91 3.35
170 INT9126 Negative_regulation of Xdh 1 20 0.58 8.58 3.28
171 INT94164 Phosphorylation of RB1 2 83 0.80 48.84 3.21
172 INT31955 Protein_catabolism of MET 2 7 0.96 2.95 3.06
173 INT173179 Binding of MAPK14 1 13 0.29 4.51 2.92
174 INT234717 Regulation of Cxcl1 1 10 0.41 6.14 2.9
175 INT15288 Regulation of Hp 1 11 0.60 3.68 2.89
176 INT140929 Gene_expression of Cd40 1 9 0.72 8.76 2.88
177 INT234716 Negative_regulation of Gene_expression of Cxcl1 1 10 0.48 9.31 2.86
178 INT132575 Binding of NR1H4 2 57 0.20 22.06 2.82
179 INT120717 Positive_regulation of TEP1 35 50 0.63 27.94 2.81
180 INT45565 Positive_regulation of Positive_regulation of Ldha 1 7 0.39 1.54 2.77
181 INT152906 Regulation of Gene_expression of Cxcl1 1 10 0.44 5.83 2.69
182 INT77925 Negative_regulation of TEP1 4 21 0.53 15.23 2.62
183 INT115593 Gene_expression of Cd86 1 15 0.57 6.55 2.62
184 INT68091 Localization of COL1A1 2 19 0.66 9.13 2.56
185 INT81377 Gene_expression of Dpp4 7 8 0.71 5.15 2.51
186 INT79261 Positive_regulation of Gene_expression of COL1A1 1 24 0.36 7.49 2.45
187 INT133194 Negative_regulation of TERT 1 23 0.48 4.01 2.45
188 INT111039 Gene_expression of Kras 2 20 0.60 15.42 2.39
189 INT61684 Localization of COL1A2 3 20 0.73 9.31 2.26
190 INT72865 Localization of Icam1 1 12 0.68 8.18 2.24
191 INT115193 Positive_regulation of Phosphorylation of STAT3 1 30 0.64 11.37 2.2
192 INT101516 Positive_regulation of PPARD 1 8 0.49 4.75 2.19
193 INT179885 Regulation of PTEN 1 8 0.26 11.88 2.18
194 INT72738 Positive_regulation of Prkg1 1 8 0.47 1.76 2.18
195 INT14 Regulation of LDHA 2 22 0.57 15.26 2.14
196 INT8237 Positive_regulation of Kng1 2 16 0.69 4.41 2.12
197 INT152174 Negative_regulation of Samsn1 1 5 0.14 6.46 2.1
198 INT62711 Binding of HGF 1 27 0.31 15.23 2.08
199 INT178339 Binding of Cxcl1 7 17 0.36 5.14 2.04
200 INT100371 Positive_regulation of Flt1 3 11 0.63 6.42 2.02
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