J:Core Evidence

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT194647 Binding of CD28 and CD80 15 2 0.40 4.9 3.22
2 INT115367 Binding of IL6 and IL6R 12 3 0.07 8.16 2.36
3 INT194646 Binding of CD28 and CD86 7 1 0.40 2.69 2.21
4 INT241750 Binding of CD4 and ITIH4 14 1 0.18 5.72 1.53
5 INT70226 Binding of TAC1 and B3GAT1 4 2 0.24 4.5 1.26
6 INT320120 MTX1 Positive_regulation of PTEN 1 1 0.04 0.09 0.82
7 INT320152 IL6 Positive_regulation of IL1RN 2 1 0.23 2.59 0.66
8 INT283980 Binding of IL12A and IL23A 2 1 0.24 1.33 0.57
9 INT291556 Binding of ESR1 and Sec22b 2 1 0.00 0.86 0.5
10 INT320121 Binding of PTEN and TNF 1 2 0.05 0.76 0.49
11 INT132792 IL4 Positive_regulation of IL6 4 1 0.28 1.81 0.47
12 INT353109 Binding of VEGFA and Aes 1 2 0.02 3.93 0.43
13 INT155009 IL23A Positive_regulation of Gene_expression of IL17A 2 1 0.17 0.62 0.39
14 INT287380 Binding of VEGFA and Kdr 12 3 0.18 11.97 0.34
15 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 1 0.13 0.35 0.34
16 INT353010 Binding of GJA8 and TNF 1 2 0.02 0.24 0.33
17 INT353128 Negative_regulation of Binding of TAC1 and B3GAT1 1 2 0.29 1.95 0.33
18 INT353009 Binding of GJA8 and VSIG1 1 1 0.00 0 0.29
19 INT132801 IL4 Positive_regulation of Localization of IL6 2 1 0.26 1.47 0.26
20 INT325312 IL20 Positive_regulation of Phosphorylation of STAT3 1 1 0.13 0.58 0.24
21 INT325316 IL22 Positive_regulation of Phosphorylation of STAT3 1 1 0.19 0.58 0.24
22 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 1 0.02 0.37 0.24
23 INT325315 Binding of STAT3 and TH1L 1 1 0.16 0.6 0.23
24 INT325313 IL23A Positive_regulation of Gene_expression of IL22 1 1 0.20 0.48 0.23
25 INT325314 Binding of IL12A and STAT3 1 1 0.19 0.6 0.22
26 INT325317 Binding of IL12A and TH1L 1 1 0.18 0.59 0.22
27 INT339903 Binding of SCN5A and ZGLP1 1 1 0.01 0.18 0.22
28 INT339901 Binding of INS and SCN5A 1 1 0.01 0.18 0.2
29 INT353041 IL4 Positive_regulation of Localization of IL1B 1 1 0.02 0.99 0.16
30 INT353036 IL4 Positive_regulation of Localization of IL10 1 1 0.03 0.99 0.16
31 INT353040 IL4 Positive_regulation of IL8 1 1 0.02 0.99 0.16
32 INT353037 IL4 Positive_regulation of IL2 1 1 0.02 0.99 0.16
33 INT353038 IL4 Positive_regulation of Localization of IL2 1 1 0.02 0.99 0.16
34 INT353039 IL4 Positive_regulation of Localization of IL8 1 1 0.02 0.99 0.16
35 INT353011 GJA8 Regulation of USE1 1 1 0.00 0.35 0.13
36 INT325295 Binding of SGCA and C14orf166 1 1 0.04 0.54 0.08
37 INT353070 ADAM17 Positive_regulation of TNF 1 1 0.19 1.66 0.08
38 INT234802 Binding of AQP2 and AVPR2 2 1 0.15 0.84 0.07
39 INT320160 Binding of FCER2 and IGHG3 1 1 0.00 0.35 0.06
40 INT320161 Binding of IGHE and IGHG3 1 1 0.02 0.35 0.06
41 INT353105 Binding of Aes and Rgs9bp 1 1 0.01 0.35 0.05
42 INT353104 Binding of amd and Gtf3a 1 1 0.01 1.53 0.03
43 INT278293 Binding of DBP and SHBG 2 1 0.02 1.34 0
44 INT352995 IPMK Regulation of PDGFA 1 1 0.00 0.66 0
45 INT353106 Binding of amd and C3 1 1 0.09 1.69 0
46 INT353108 Binding of VEGFA and Pgf 1 4 0.02 2.17 0
47 INT352994 IPMK Regulation of VEGFA 1 1 0.00 0.66 0
48 INT353107 Binding of VEGFA and Vegfb 1 2 0.02 1.08 0
49 INT353125 Negative_regulation of Binding of VEGFA and Kdr 1 6 0.04 5.92 0
50 INT353110 Binding of VEGFA and Eo 1 2 0.00 0.67 0
51 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 3 0.13 5.03 0
52 INT353061 HSD11B1 Regulation of Gene_expression of LEP 1 3 0.20 5.03 0
53 INT353129 Binding of CD4 and CXCR4 1 1 0.13 1.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
2 INT6483 Gene_expression of TNF 13 3152 0.78 2515.62 929.82
3 INT155 Positive_regulation of Prl 7 1233 0.70 317.93 457.82
4 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
5 INT9238 Gene_expression of IL6 7 1575 0.78 1135.66 424.22
6 INT9238 Gene_expression of IL6 3 1575 0.78 1135.66 424.22
7 INT439 Localization of Gnrh1 2 976 0.81 100.96 363.25
8 INT5235 Negative_regulation of TNF 3 924 0.59 772.91 331.98
9 INT5235 Negative_regulation of TNF 20 924 0.59 772.91 331.98
10 INT5059 Positive_regulation of TNF 4 1050 0.70 896.51 322.81
11 INT5059 Positive_regulation of TNF 10 1050 0.70 896.51 322.81
12 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
13 INT477 Localization of Avp 1 813 0.81 131.58 300.4
14 INT6852 Localization of TNF 7 883 0.81 705.95 270.84
15 INT6852 Localization of TNF 14 883 0.81 705.95 270.84
16 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
17 INT5972 Gene_expression of IL1B 2 948 0.78 510.91 263.97
18 INT5972 Gene_expression of IL1B 4 948 0.78 510.91 263.97
19 INT68684 Gene_expression of VEGFA 12 2371 0.78 1742.52 259.2
20 INT6481 Binding of TNF 8 624 0.48 510.2 214.82
21 INT6481 Binding of TNF 3 624 0.48 510.2 214.82
22 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
23 INT6482 Positive_regulation of Gene_expression of TNF 3 659 0.70 569.88 210
24 INT528 Gene_expression of Prl 1 693 0.78 217.18 192.2
25 INT10194 Positive_regulation of IL6 3 702 0.70 600.62 183.38
26 INT10194 Positive_regulation of IL6 3 702 0.70 600.62 183.38
27 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
28 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
29 INT9852 Positive_regulation of Gpt 2 563 0.70 364.64 146.82
30 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
31 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
32 INT812 Localization of INS 8 1026 0.81 515.6 145.31
33 INT9660 Regulation of TNF 3 363 0.62 312.94 139.99
34 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
35 INT1047 Negative_regulation of LH 2 314 0.59 53.71 135.89
36 INT1878 Binding of HLA-B 2 440 0.48 321.16 127.36
37 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
38 INT17612 Gene_expression of CRP 6 676 0.78 580.61 119.03
39 INT17612 Gene_expression of CRP 15 676 0.78 580.61 119.03
40 INT9235 Negative_regulation of Gene_expression of TNF 2 346 0.59 252.98 118.61
41 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
42 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
43 INT11051 Positive_regulation of Gene_expression of IL6 2 415 0.69 319.21 109.3
44 INT11051 Positive_regulation of Gene_expression of IL6 2 415 0.69 319.21 109.3
45 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
46 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
47 INT3038 Gene_expression of INS 90 1583 0.78 1174.16 107.01
48 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
49 INT18009 Positive_regulation of CRP 4 518 0.70 553.03 103.74
50 INT18009 Positive_regulation of CRP 3 518 0.70 553.03 103.74
51 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
52 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
53 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
54 INT214 Localization of AVP 6 370 0.81 208.51 91.09
55 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
56 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
57 INT54571 Positive_regulation of NFKB1 1 263 0.70 138.99 87.32
58 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
59 INT68682 Positive_regulation of VEGFA 7 640 0.70 454.14 81.65
60 INT749 Gene_expression of HLA-B 1 341 0.75 224.12 77.37
61 INT1724 Negative_regulation of ACE 5 437 0.59 315.64 74.48
62 INT1724 Negative_regulation of ACE 19 437 0.59 315.64 74.48
63 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
64 INT56298 Gene_expression of IL4 3 306 0.78 182.18 72.92
65 INT10837 Positive_regulation of Gene_expression of IL8 1 294 0.70 190.08 70.34
66 INT79494 Positive_regulation of Gene_expression of VEGFA 4 577 0.70 442.94 69.73
67 INT6849 Localization of IL1B 3 229 0.81 112.56 69.63
68 INT3375 Gene_expression of IGHE 3 535 0.77 387.47 65.46
69 INT822 Gene_expression of ESR1 4 529 0.78 302.16 63.64
70 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
71 INT2056 Negative_regulation of Gnrh1 2 175 0.59 33.43 63.32
72 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
73 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
74 INT546 Binding of ALB 1 311 0.48 85.98 60.14
75 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
76 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
77 INT48901 Negative_regulation of IL6 2 186 0.57 136.33 57.87
78 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
79 INT251 Regulation of INS 1 398 0.62 232.47 55.04
80 INT251 Regulation of INS 3 398 0.62 232.47 55.04
81 INT9234 Negative_regulation of Gene_expression of IL6 2 171 0.59 101.61 53.15
82 INT50405 Negative_regulation of CYP3A4 2 238 0.59 53.65 51.51
83 INT50405 Negative_regulation of CYP3A4 5 238 0.59 53.65 51.51
84 INT62630 Positive_regulation of CNR1 1 86 0.70 40.34 51.51
85 INT6473 Positive_regulation of Gene_expression of IL1B 4 204 0.70 117.23 50.86
86 INT1199 Positive_regulation of INS 13 579 0.70 399.64 50.43
87 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
88 INT17881 Gene_expression of LEP 4 278 0.78 221.61 48.31
89 INT117598 Regulation of ACR 11 118 0.26 41.25 48.01
90 INT117598 Regulation of ACR 6 118 0.26 41.25 48.01
91 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
92 INT683 Positive_regulation of AVP 4 173 0.70 74.55 46.41
93 INT1322 Positive_regulation of Localization of INS 5 293 0.70 120.86 45.98
94 INT145266 Gene_expression of IL17A 1 154 0.75 109.83 45.33
95 INT619 Positive_regulation of Positive_regulation of Prl 1 116 0.70 22.69 45.06
96 INT2262 Negative_regulation of Lhb 5 142 0.59 25.47 44.81
97 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
98 INT80124 Negative_regulation of VEGFA 3 450 0.58 311.19 44.53
99 INT170054 Negative_regulation of Gopc 2 280 0.38 117.89 42.4
100 INT13354 Transcription of TNF 1 108 0.72 85.81 42.32
101 INT61619 Gene_expression of IL12A 2 194 0.77 146.07 41.97
102 INT13556 Gene_expression of CD4 2 367 0.78 230.82 41.74
103 INT122953 Gene_expression of COMT 1 65 0.77 25.84 40.49
104 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
105 INT52732 Negative_regulation of CRP 4 169 0.59 138.47 40.33
106 INT3987 Positive_regulation of IGHE 3 316 0.70 283.2 40.16
107 INT88322 Gene_expression of CCR5 1 111 0.78 77.36 39.84
108 INT3252 Negative_regulation of INS 9 428 0.59 271.65 39.52
109 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
110 INT163134 Gene_expression of ACR 13 78 0.65 30.39 38.48
111 INT163134 Gene_expression of ACR 13 78 0.65 30.39 38.48
112 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
113 INT3253 Negative_regulation of Localization of INS 4 205 0.59 130.39 36.61
114 INT9239 Regulation of Gene_expression of IL6 1 106 0.61 75.24 36.53
115 INT9239 Regulation of Gene_expression of IL6 1 106 0.61 75.24 36.53
116 INT2416 Negative_regulation of MAOA 3 92 0.59 42.24 36.5
117 INT101992 Localization of VEGFA 2 413 0.81 258.23 36.15
118 INT3679 Gene_expression of AVP 4 171 0.78 72.9 35.23
119 INT72651 Gene_expression of TH1L 2 114 0.75 80.15 35.15
120 INT2274 Regulation of Localization of INS 1 101 0.62 41.55 34.79
121 INT53475 Gene_expression of MRI1 2 116 0.59 77.68 33.98
122 INT10763 Localization of IL2 1 157 0.80 81.11 33.21
123 INT10763 Localization of IL2 3 157 0.80 81.11 33.21
124 INT10248 Gene_expression of KRT20 2 436 0.78 231.96 32.88
125 INT132161 Gene_expression of MTX1 5 48 0.58 26.55 32.32
126 INT73498 Gene_expression of IL13 2 117 0.44 83.85 32.26
127 INT48693 Regulation of VEGFA 1 268 0.62 191.88 31.52
128 INT99688 Negative_regulation of Gene_expression of VEGFA 1 274 0.58 201.8 31.1
129 INT9993 Positive_regulation of Gene_expression of IL2 1 131 0.69 46.27 30.04
130 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
131 INT86437 Binding of IL6 2 154 0.48 121.22 29.3
132 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
133 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
134 INT22211 Positive_regulation of CYP3A4 3 110 0.70 22 28.27
135 INT22045 Gene_expression of IRF6 1 158 0.75 58.07 27.81
136 INT12129 Gene_expression of CYP3A4 1 107 0.78 23.11 27.6
137 INT64499 Positive_regulation of IRF6 1 123 0.49 52.73 27.51
138 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
139 INT20462 Binding of ESR1 10 210 0.44 102.7 26.34
140 INT79395 Gene_expression of Twist1 4 193 0.77 100.06 26.34
141 INT2261 Gene_expression of Lhb 4 121 0.77 42.78 26.04
142 INT130176 Positive_regulation of Gene_expression of CRP 4 125 0.66 137.06 25.9
143 INT76095 Positive_regulation of ISYNA1 2 117 0.55 79.73 25.86
144 INT11159 Gene_expression of EGFR 10 698 0.78 548.93 25.69
145 INT8779 Binding of TAC1 2 50 0.47 11.19 25.57
146 INT17625 Localization of GCG 5 210 0.80 55.69 24.97
147 INT17275 Gene_expression of HIVEP1 1 267 0.75 232.07 24.06
148 INT682 Negative_regulation of AVP 2 97 0.59 50.67 23.91
149 INT8775 Binding of IGHE 6 167 0.48 102.61 23.54
150 INT74423 Localization of IL10 2 91 0.80 61.6 22.95
151 INT49196 Gene_expression of SELE 1 105 0.78 107.29 22.92
152 INT823 Negative_regulation of ESR1 2 144 0.58 63.72 22.52
153 INT8640 Positive_regulation of HSD11B1 3 332 0.67 377.84 22.36
154 INT8483 Positive_regulation of Positive_regulation of TNF 1 73 0.67 60.35 22.03
155 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
156 INT23257 Regulation of CRP 1 127 0.62 100.05 21.87
157 INT23257 Regulation of CRP 1 127 0.62 100.05 21.87
158 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
159 INT48692 Binding of VEGFA 6 345 0.48 210.3 21.31
160 INT5328 Positive_regulation of CD4 7 191 0.69 133.43 21.31
161 INT5328 Positive_regulation of CD4 3 191 0.69 133.43 21.31
162 INT110638 Negative_regulation of COMT 3 43 0.59 21.03 21.05
163 INT6127 Regulation of Localization of AVP 1 60 0.62 15.12 20.84
164 INT62042 Positive_regulation of Gene_expression of IL4 1 67 0.56 42.05 20.39
165 INT82434 Positive_regulation of LEP 1 117 0.70 95.45 20.22
166 INT10442 Negative_regulation of CNR1 3 47 0.59 20.88 20.2
167 INT14701 Negative_regulation of IFNA1 1 118 0.54 84.19 20.08
168 INT86187 Positive_regulation of AKT1 1 199 0.69 122.13 19.44
169 INT5398 Positive_regulation of ALPP 1 178 0.70 110.52 19.18
170 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
171 INT70970 Binding of COPD 1 144 0.42 180.34 18.29
172 INT28642 Gene_expression of CXCR2 1 60 0.78 38.69 18.11
173 INT6782 Gene_expression of SCN5A 6 156 0.78 33.13 17.88
174 INT61626 Transcription of IL6 1 73 0.72 42.04 17.86
175 INT50403 Negative_regulation of CYP2C19 1 55 0.59 8.97 17.79
176 INT168263 Gene_expression of IL23A 2 57 0.58 47.1 17.67
177 INT84464 Gene_expression of DPP4 19 101 0.78 56.15 17.53
178 INT50579 Binding of CYP3A4 2 84 0.48 17.52 17.45
179 INT50579 Binding of CYP3A4 2 84 0.48 17.52 17.45
180 INT50404 Negative_regulation of CYP1A2 1 49 0.59 8.61 17.35
181 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
182 INT45142 Gene_expression of DCPS 1 109 0.56 84.71 16.87
183 INT213 Negative_regulation of Localization of AVP 1 46 0.59 19.78 16.79
184 INT6129 Positive_regulation of Localization of AVP 1 63 0.70 30.44 16.64
185 INT10834 Binding of IL8 1 65 0.48 41.66 16.53
186 INT10000 Regulation of Gene_expression of IL2 1 56 0.45 15.33 16.2
187 INT47742 Binding of Flvcr2 1 26 0.42 3.28 15.87
188 INT62681 Negative_regulation of LEP 1 93 0.59 66.97 15.77
189 INT4977 Binding of ITIH4 1 60 0.46 42.48 15.65
190 INT97245 Gene_expression of AKT1 1 217 0.77 119.63 15.59
191 INT171666 Regulation of GOPC 1 117 0.39 40.41 15.47
192 INT59929 Negative_regulation of CYP2C9 1 60 0.59 16.33 15.39
193 INT16167 Negative_regulation of DMD 2 186 0.57 108.71 15.25
194 INT2630 Positive_regulation of Shbg 6 134 0.70 65.26 15.19
195 INT75908 Regulation of LEP 2 77 0.60 60.16 15.19
196 INT73916 Gene_expression of Esr1 1 58 0.77 26.59 15.15
197 INT73916 Gene_expression of Esr1 1 58 0.77 26.59 15.15
198 INT16166 Positive_regulation of DMD 5 348 0.67 133.22 15.06
199 INT75540 Positive_regulation of TH1L 1 62 0.67 43.45 15.02
200 INT10709 Negative_regulation of CD4 1 106 0.59 95.6 14.89
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