J:Curr. Med. Chem.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 2 0.01 0 2.44
2 INT135868 Zfp821 Positive_regulation of Binding of ACAA1 1 2 0.00 0 2.11
3 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 1 0.47 0.74 0.85
4 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 1 0.04 2.26 0.82
5 INT156668 Gh Positive_regulation of Igf1 5 2 0.22 2.07 0.57
6 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 2 0.28 0.88 0.56
7 INT132438 Binding of AGT and OXTR 1 1 0.08 1.03 0.53
8 INT153766 Edn1 Positive_regulation of Gtf3a 1 1 0.04 1.25 0.41
9 INT152453 Gsk3b Regulation of Nfkb1 1 3 0.02 1.68 0.36
10 INT151902 PLG Positive_regulation of Protein_catabolism of F13A1 1 1 0.00 0.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
2 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
3 INT18357 Gene_expression of TRPV1 2 825 0.78 307.11 382.81
4 INT6580 Negative_regulation of Ptgs1 2 929 0.59 381.53 376.26
5 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
6 INT5059 Positive_regulation of TNF 3 1050 0.70 896.51 322.81
7 INT34869 Negative_regulation of PTGS2 4 778 0.59 366.76 319.85
8 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
9 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
10 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
11 INT24326 Gene_expression of Ngf 1 346 0.78 218.67 184.71
12 INT867 Gene_expression of IFNA1 3 930 0.78 594.85 168.03
13 INT51921 Gene_expression of Cpox 1 501 0.73 229.81 157.81
14 INT5116 Gene_expression of IL2 2 670 0.78 291.13 146.69
15 INT48953 Positive_regulation of Nos2 2 486 0.70 239.85 131.87
16 INT5008 Localization of Calca 2 204 0.81 80.35 125.16
17 INT5010 Gene_expression of Calca 3 197 0.78 85.76 118.75
18 INT9235 Negative_regulation of Gene_expression of TNF 2 346 0.59 252.98 118.61
19 INT50674 Gene_expression of PTGS2 2 459 0.78 253.33 118.51
20 INT104000 Phosphorylation of Grin2b 1 73 0.82 48.34 93.48
21 INT214 Localization of AVP 1 370 0.81 208.51 91.09
22 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
23 INT74376 Gene_expression of Cnr1 1 173 0.78 73.43 89.7
24 INT71789 Positive_regulation of MAPK1 1 396 0.70 234.44 89.27
25 INT21793 Positive_regulation of Ngf 1 154 0.70 94.78 85.27
26 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
27 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
28 INT4153 Binding of Insrr 2 109 0.40 17.99 72.15
29 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
30 INT11937 Localization of Il6 1 228 0.81 139.83 64.39
31 INT65730 Gene_expression of Cnr2 2 129 0.78 60.15 63.1
32 INT6894 Gene_expression of CNR1 1 168 0.78 74.07 62.84
33 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
34 INT9196 Gene_expression of PTGS1 3 215 0.77 96.99 60.5
35 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
36 INT5506 Positive_regulation of Gene_expression of Pomc 1 132 0.70 26.78 54.3
37 INT97674 Positive_regulation of Localization of Calca 4 70 0.69 27.71 51.79
38 INT76620 Gene_expression of Cnr2 1 93 0.78 34.7 50.14
39 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
40 INT4776 Localization of TAC1 1 82 0.78 16.89 45.21
41 INT49105 Gene_expression of Vcam1 1 157 0.78 157.27 43.01
42 INT28265 Positive_regulation of Calca 3 62 0.70 29.1 41.17
43 INT1931 Positive_regulation of Gene_expression of POMC 1 116 0.70 37.26 38.67
44 INT12892 Negative_regulation of TIMP1 1 136 0.58 83.13 36.54
45 INT12608 Regulation of CNR1 1 62 0.60 24.36 36.02
46 INT65055 Negative_regulation of Nfkb1 1 83 0.58 44.85 34.94
47 INT20380 Gene_expression of Il5 2 172 0.78 104.75 34.78
48 INT67613 Positive_regulation of PPARG 3 94 0.70 69.15 34.38
49 INT47710 Negative_regulation of GRIN1 1 71 0.57 25.57 34.24
50 INT14559 Gene_expression of Igf1 7 254 0.78 112 34.17
51 INT50308 Binding of Cnr1 2 61 0.48 14.41 33.52
52 INT10763 Localization of IL2 1 157 0.80 81.11 33.21
53 INT4727 Regulation of TAC1 1 60 0.47 6.74 32.83
54 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
55 INT9655 Regulation of Il6 1 98 0.62 70.92 31.95
56 INT7082 Gene_expression of CRH 1 180 0.78 64.66 31.74
57 INT5117 Negative_regulation of Gene_expression of IL2 1 118 0.59 52.33 29.96
58 INT9053 Negative_regulation of ALOX5 3 97 0.58 40.34 29.94
59 INT67912 Gene_expression of GRIN1 1 75 0.77 28.99 29.28
60 INT15000 Transcription of Oprd1 1 32 0.72 5.7 29.22
61 INT9650 Gene_expression of LPA 1 141 0.75 104.57 29
62 INT16814 Negative_regulation of COX5A 2 74 0.57 33.72 28.63
63 INT10506 Gene_expression of PTAFR 2 86 0.76 37.57 28.58
64 INT5206 Gene_expression of AR 4 316 0.78 113.83 27.29
65 INT16428 Positive_regulation of Gtf3a 1 135 0.20 106.44 26.67
66 INT81496 Gene_expression of CNR2 1 68 0.75 30.04 24.92
67 INT55583 Localization of IFNA1 1 135 0.78 85.07 24.13
68 INT14556 Positive_regulation of Igf1 5 105 0.69 52.21 24.04
69 INT15390 Positive_regulation of Edn1 1 64 0.70 47.36 23.8
70 INT86534 Positive_regulation of MAPK14 2 81 0.62 57.81 23.62
71 INT88327 Gene_expression of P2rx7 1 109 0.77 48.86 22.41
72 INT30887 Negative_regulation of Ngf 1 56 0.59 32.96 20.86
73 INT15796 Regulation of IL2 1 66 0.61 25.43 20.62
74 INT5372 Localization of LHB 1 55 0.68 9.47 19
75 INT17237 Regulation of Esr1 1 74 0.43 49.09 17.25
76 INT34057 Negative_regulation of Gene_expression of IFNA1 2 65 0.58 43.46 17.25
77 INT35998 Positive_regulation of Gene_expression of Calca 2 31 0.70 16.16 16.98
78 INT93037 Regulation of Grin2b 1 26 0.57 11.9 16.92
79 INT912 Localization of FSHR 1 91 0.79 23.61 15.58
80 INT18513 Binding of GRIN1 1 32 0.47 9.44 15.08
81 INT7475 Positive_regulation of Hdl1 2 138 0.67 175.81 15.05
82 INT1888 Protein_catabolism of F13A1 1 97 0.99 63.48 14.82
83 INT65263 Positive_regulation of Gene_expression of Igf1 4 61 0.69 25.69 14.49
84 INT74375 Positive_regulation of Gene_expression of Cnr1 1 24 0.70 14.25 13.66
85 INT121241 Positive_regulation of P2rx7 1 65 0.69 40.94 13.59
86 INT91703 Negative_regulation of Myoz1 3 78 0.58 53.78 13.5
87 INT15921 Positive_regulation of Serpine1 1 85 0.68 81.24 13.4
88 INT81629 Positive_regulation of Fas 2 58 0.70 59.63 12.94
89 INT5452 Regulation of CRH 1 56 0.62 15.32 12.42
90 INT83601 Binding of CNR2 2 30 0.47 7.79 12.37
91 INT69158 Localization of IL4 1 48 0.71 31.3 11.98
92 INT65057 Regulation of Nfkb1 1 28 0.47 16.48 11.62
93 INT8546 Positive_regulation of MUC16 2 99 0.69 74.98 11.26
94 INT67401 Gene_expression of Il12a 1 25 0.55 20.04 11.12
95 INT8065 Binding of AGT 1 54 0.48 20.54 10.85
96 INT36453 Binding of ABCA1 1 48 0.45 19.9 10.84
97 INT65058 Binding of Nfkb1 1 36 0.45 19.87 10.02
98 INT97439 Positive_regulation of Il5 1 46 0.60 25.6 9.47
99 INT95342 Gene_expression of GRIN2B 1 21 0.75 4.99 9.32
100 INT45209 Positive_regulation of PLA2G2A 1 37 0.69 33.21 9.02
101 INT35366 Binding of AR 1 87 0.47 30.52 8.9
102 INT117553 Regulation of MIF 1 10 0.56 12.76 8.67
103 INT51922 Localization of Cpox 1 24 0.68 12.05 8.59
104 INT62944 Regulation of Icam1 2 33 0.47 23.52 7.94
105 INT81399 Regulation of Vcam1 2 24 0.46 23.53 7.68
106 INT11957 Negative_regulation of LPA 1 52 0.59 39.09 6.84
107 INT142344 Transcription of Igf1 2 22 0.69 7.55 6.77
108 INT126984 Positive_regulation of Gene_expression of Il5 2 29 0.69 20.61 6.72
109 INT13406 Negative_regulation of CASP1 1 25 0.57 10.61 6.36
110 INT121370 Positive_regulation of MIF 1 22 0.70 17.79 6.08
111 INT151032 Localization of Igf1 2 49 0.76 26.32 5.71
112 INT57502 Positive_regulation of Gene_expression of CRH 1 30 0.70 23.37 5.7
113 INT7126 Negative_regulation of PLA2G2A 2 26 0.58 12.97 5.64
114 INT1755 Gene_expression of GBE1 4 28 0.26 8.32 5.18
115 INT143925 Negative_regulation of Ptges 1 18 0.42 10.5 5.18
116 INT92541 Localization of Grin2b 1 11 0.75 2.85 5.14
117 INT83442 Negative_regulation of MIF 7 18 0.57 9.51 5.12
118 INT86475 Binding of ACAA1 2 7 0.28 1.83 5.11
119 INT923 Positive_regulation of Localization of FSHR 1 14 0.43 2.48 4.96
120 INT15920 Regulation of Serpine1 1 34 0.42 17.36 4.89
121 INT11030 Binding of LPA 1 70 0.48 40.35 4.81
122 INT12104 Positive_regulation of PLG 2 45 0.68 28.94 4.81
123 INT5205 Localization of AR 1 43 0.80 12.87 4.63
124 INT10896 Regulation of PTAFR 1 16 0.61 4.22 4.5
125 INT79692 Negative_regulation of PPARG 1 24 0.59 16 4.31
126 INT153189 Gene_expression of Sema3a 2 19 0.75 14.37 4.21
127 INT48518 Gene_expression of ANPEP 5 51 0.78 22.88 4.18
128 INT108823 Binding of COX5A 1 8 0.47 4.06 4.14
129 INT82871 Protein_catabolism of MMP1 1 13 0.96 10.71 4.09
130 INT144830 Positive_regulation of Gene_expression of P2rx7 1 22 0.68 9.78 3.92
131 INT116642 Negative_regulation of Gsk3b 1 13 0.57 7.16 3.83
132 INT142174 Regulation of Gene_expression of Igf1 1 28 0.60 11.86 3.77
133 INT16723 Regulation of GBE1 1 16 0.11 4.3 3.7
134 INT63979 Regulation of Sele 1 13 0.54 10.64 3.7
135 INT71885 Protein_catabolism of Nfkb1 1 8 0.53 5.34 3.69
136 INT69155 Positive_regulation of Localization of IL4 1 13 0.40 10.18 3.56
137 INT73802 Regulation of Selp 1 17 0.60 8.72 3.51
138 INT105222 Positive_regulation of Plau 1 18 0.54 8.52 3.5
139 INT43985 Regulation of LPA 1 29 0.62 20.79 3.29
140 INT10476 Binding of ALOX5 1 26 0.36 7.69 3.2
141 INT144828 Binding of P2rx7 1 19 0.47 7.84 3.16
142 INT79553 Localization of Il12a 1 9 0.31 5.85 3.16
143 INT66367 Gene_expression of Gsk3b 2 16 0.45 9.75 3.07
144 INT81494 Positive_regulation of Gene_expression of CNR2 1 7 0.62 1.54 2.95
145 INT11371 Positive_regulation of Localization of LHB 1 8 0.47 1.4 2.93
146 INT8545 Negative_regulation of MUC16 1 19 0.57 15.96 2.81
147 INT38673 Negative_regulation of KRT20 1 38 0.42 22.49 2.77
148 INT16715 Positive_regulation of Transcription of Oprd1 1 3 0.66 0.6 2.74
149 INT21740 Localization of TAC3 1 7 0.73 1.46 2.6
150 INT51683 Regulation of Gene_expression of PTAFR 2 11 0.60 5.06 2.59
151 INT135866 Positive_regulation of Positive_regulation of Chrne 2 1 0.12 0 2.43
152 INT30857 Binding of OXTR 1 10 0.48 2.27 2.42
153 INT135862 Positive_regulation of Chrne 2 1 0.17 0 2.36
154 INT144829 Localization of P2rx7 1 12 0.79 2.92 2.12
155 INT98225 Regulation of Il5 1 8 0.45 5.07 2.06
156 INT105536 Regulation of Myoz1 2 6 0.17 3.45 2.01
157 INT66929 Positive_regulation of Localization of Cpox 2 6 0.25 4.68 1.98
158 INT156666 Positive_regulation of Localization of Igf1 4 11 0.62 6.94 1.95
159 INT40104 Binding of Cysltr1 4 11 0.38 4.56 1.95
160 INT142341 Positive_regulation of Transcription of Igf1 1 8 0.49 2.44 1.95
161 INT153762 Positive_regulation of Gene_expression of Sema3a 2 6 0.49 4.56 1.65
162 INT107012 Binding of EPRS 1 5 0.30 2.92 1.63
163 INT128699 Regulation of Il12a 1 3 0.45 3.36 1.59
164 INT81222 Binding of RNF130 1 9 0.47 5.38 1.54
165 INT15407 Positive_regulation of Positive_regulation of Edn1 1 5 0.62 3.69 1.49
166 INT34312 Regulation of Gene_expression of CRH 1 6 0.46 1.97 1.48
167 INT135864 Gene_expression of Chrne 2 6 0.65 0.76 1.47
168 INT128769 Negative_regulation of Localization of IFNA1 1 8 0.24 6.85 1.35
169 INT107158 Binding of Fam20b 2 2 0.26 1.64 1.11
170 INT132435 Negative_regulation of ADAM17 1 2 0.50 3.75 1.02
171 INT135863 Gene_expression of Olfr1014 1 1 0.04 0 1.02
172 INT129425 Negative_regulation of Ldlr 1 22 0.42 17.15 0.97
173 INT115471 Binding of Sele 1 5 0.36 4.06 0.94
174 INT101222 Negative_regulation of MAPK4 1 4 0.05 1.27 0.88
175 INT135865 Gene_expression of Zfp821 1 1 0.06 0 0.81
176 INT117245 Gene_expression of CRHR1 1 3 0.51 3.45 0.73
177 INT91467 Negative_regulation of Negative_regulation of COX5A 1 2 0.41 0.89 0.64
178 INT151903 Positive_regulation of Positive_regulation of PLG 1 3 0.45 1.53 0.48
179 INT129429 Negative_regulation of Stat1 1 2 0.41 1.09 0.44
180 INT153763 Gene_expression of Mcm3 1 2 0.33 1.39 0.4
181 INT153764 Positive_regulation of Gene_expression of Mcm3 1 1 0.03 1.14 0.4
182 INT145801 Negative_regulation of Binding of Cysltr1 1 2 0.39 1.89 0.35
183 INT86784 Positive_regulation of TDD 1 2 0.36 0.06 0.24
184 INT154627 Regulation of SLC38A3 1 1 0.08 0.36 0.24
185 INT129422 Negative_regulation of Gmps 1 2 0.02 1.22 0.19
186 INT158535 Gene_expression of Gm13546 1 1 0.00 0.13 0.14
187 INT134953 Regulation of Ctse 1 2 0.06 0.32 0.13
188 INT129427 Transcription of PPA1 1 1 0.00 0.24 0.12
189 INT129426 Transcription of ATP8A2 1 1 0.23 0.24 0.12
190 INT129423 Negative_regulation of Impdh1 1 2 0.11 0.62 0.11
191 INT129424 Negative_regulation of Dhfr 1 1 0.06 0.24 0.11
192 INT129419 Negative_regulation of Negative_regulation of Gmps 1 1 0.01 0.24 0.11
193 INT129421 Negative_regulation of Negative_regulation of Dhfr 1 1 0.06 0.24 0.11
194 INT129420 Negative_regulation of Negative_regulation of Impdh1 1 1 0.03 0.24 0.11
195 INT152449 Regulation of Protein_catabolism of Gsk3b 1 1 0.12 0.49 0
196 INT152451 Regulation of Gene_expression of Gsk3b 2 1 0.12 0.57 0
197 INT152448 Protein_catabolism of Gsk3b 1 1 0.28 0.49 0
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