J:Curr. Pharm. Des.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT110726 Binding of ALB and LTF 1 2 0.01 0 0.81
2 INT129415 KNG1 Positive_regulation of Trpv1 1 1 0.05 0.39 0.76
3 INT111839 Binding of Cnr1 and Cnr2 1 1 0.05 0.53 0.6
4 INT81228 Negative_regulation of Adk Positive_regulation of Ado 1 1 0.04 0.26 0.59
5 INT129413 sc Negative_regulation of Trpv1 1 1 0.01 0.22 0.55
6 INT111840 Binding of Cnr1 and sar 1 1 0.04 0.45 0.52
7 INT110727 Binding of HBM and LTF 1 1 0.00 0 0.41
8 INT123101 Binding of APP and Ache 1 1 0.07 0.32 0.11
9 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 1 0.13 0.61 0.09
10 INT133489 CREB1 Positive_regulation of Csnk2b 1 1 0.08 0.42 0.03
11 INT133482 CREB1 Positive_regulation of KCNMA1 1 1 0.01 0.43 0.03
12 INT133490 AKT1 Positive_regulation of Csnk2b 1 1 0.02 0.42 0.03
13 INT133491 CREB1 Positive_regulation of Phosphorylation of Csnk2b 1 1 0.08 0.42 0.03
14 INT133483 AKT1 Positive_regulation of KCNMA1 1 1 0.00 0.43 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 3 2008 0.81 518.3 1408.65
2 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
3 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
4 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
5 INT49750 Negative_regulation of CPOX 5 735 0.58 360.06 274.19
6 INT87687 Positive_regulation of Trpv1 4 409 0.70 210.24 257.59
7 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
8 INT2391 Negative_regulation of PTGS1 3 501 0.59 207.62 205.6
9 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
10 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
11 INT49439 Gene_expression of Cpox 1 508 0.73 326.97 130.17
12 INT62124 Gene_expression of NOS1 1 444 0.78 218.08 114.85
13 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
14 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
15 INT98621 Regulation of Trpv1 1 121 0.62 79.24 75.23
16 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
17 INT7344 Gene_expression of TAC1 1 132 0.75 35.48 68.26
18 INT9196 Gene_expression of PTGS1 4 215 0.77 96.99 60.5
19 INT50672 Positive_regulation of CPOX 1 205 0.44 125.93 60.06
20 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
21 INT5759 Positive_regulation of Ptgs1 2 127 0.69 53.45 53.04
22 INT83199 Gene_expression of Nos3 1 193 0.78 100.72 51.57
23 INT35975 Regulation of Cpox 2 109 0.39 57.88 49.69
24 INT654 Localization of REN 2 250 0.81 75.12 47.86
25 INT2463 Localization of CCK 1 101 0.81 37.54 47.59
26 INT63383 Binding of Cnr1 2 77 0.48 22.28 44.61
27 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
28 INT61925 Negative_regulation of Adk 5 53 0.59 22.46 40.38
29 INT50673 Positive_regulation of Gene_expression of CPOX 1 156 0.54 97.31 37.03
30 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
31 INT67039 Positive_regulation of Cpox 1 144 0.65 98.4 33.77
32 INT9655 Regulation of Il6 1 98 0.62 70.92 31.95
33 INT65960 Gene_expression of BCL2 1 352 0.78 312.03 30.73
34 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
35 INT2408 Regulation of CCK 3 37 0.61 10.01 26.66
36 INT7832 Localization of Cck 1 39 0.81 6.81 26.54
37 INT276 Regulation of Ache 1 83 0.62 16.75 25.99
38 INT76095 Positive_regulation of ISYNA1 1 117 0.55 79.73 25.86
39 INT11014 Phosphorylation of CREB1 2 72 0.81 26.35 25.64
40 INT2140 Regulation of REN 1 104 0.62 28.24 24.49
41 INT63419 Gene_expression of PTGES 2 109 0.77 40.83 23.67
42 INT14731 Positive_regulation of TGFB1 1 78 0.67 52.57 22.23
43 INT17848 Binding of PTGS2 1 70 0.46 32.1 20.6
44 INT89396 Phosphorylation of AKT1 2 225 0.82 111.66 19.61
45 INT133478 Phosphorylation of Csnk2b 2 29 0.37 1.19 18.73
46 INT55335 Binding of Cpox 2 49 0.34 15.48 18.46
47 INT87861 Gene_expression of Il18 2 33 0.78 30.44 18.42
48 INT17442 Gene_expression of ALOX5 1 110 0.75 51.55 18.29
49 INT83198 Positive_regulation of Nos3 1 78 0.64 35.69 17.71
50 INT73599 Negative_regulation of Gene_expression of Cpox 1 47 0.55 19.89 17.26
51 INT8756 Gene_expression of Tac2 1 26 0.78 2.64 13.39
52 INT29745 Binding of APP 2 47 0.48 26.49 12.4
53 INT73959 Positive_regulation of NOSTRIN 1 49 0.61 31.1 11.27
54 INT51265 Phosphorylation of TNF 1 32 0.81 25.33 10.75
55 INT1252 Binding of Ache 2 46 0.48 9.94 10.25
56 INT95271 Negative_regulation of Nos3 1 46 0.53 24.1 9.71
57 INT59465 Negative_regulation of ISYNA1 1 41 0.49 21.9 9.46
58 INT37896 Positive_regulation of Gene_expression of PTGS1 1 37 0.67 17.28 9.27
59 INT12991 Negative_regulation of Gene_expression of PTGS1 1 28 0.41 13.39 8.9
60 INT9889 Gene_expression of Alox5 1 34 0.63 20.83 8.85
61 INT65661 Positive_regulation of Ado 1 13 0.52 4.75 8.54
62 INT65959 Positive_regulation of Gene_expression of BCL2 1 75 0.70 77.3 8.27
63 INT48877 Binding of Tacr1 1 16 0.43 5.26 8.04
64 INT76427 Regulation of Negative_regulation of Cpox 2 17 0.31 6.75 7.93
65 INT87271 Positive_regulation of Phosphorylation of CREB1 3 27 0.66 12.87 7.91
66 INT35307 Regulation of Adk 2 11 0.35 3.21 7.79
67 INT28165 Positive_regulation of ALOX5 1 38 0.47 10.8 5.37
68 INT63781 Regulation of Ado 3 8 0.34 3.78 5.19
69 INT81226 Gene_expression of Adk 1 9 0.64 9.28 4.81
70 INT118926 Regulation of PTGES 1 17 0.51 5.79 4.69
71 INT22080 Regulation of ras 1 40 0.53 36.24 4.44
72 INT26477 Regulation of ACE 1 26 0.45 16.31 4.33
73 INT109450 Positive_regulation of Phosphorylation of AKT1 2 62 0.64 25.18 4.21
74 INT63779 Localization of Ado 2 6 0.64 4.8 3.81
75 INT95119 Localization of CYCS 1 23 0.78 14.86 3.49
76 INT70089 Negative_regulation of Binding of APP 1 7 0.59 6.45 3.44
77 INT76342 Positive_regulation of Gene_expression of Alox5 1 9 0.56 5.29 2.87
78 INT89401 Negative_regulation of Phosphorylation of AKT1 1 68 0.58 35.61 2.8
79 INT114731 Phosphorylation of Camk2g 1 5 0.58 1.62 2.75
80 INT98919 Negative_regulation of Phosphorylation of CREB1 1 8 0.58 2.4 2.63
81 INT57811 Regulation of Localization of Cck 1 3 0.60 2.17 2.62
82 INT98557 Regulation of PDE4A 1 12 0.44 8.42 2.56
83 INT5180 Binding of Serpinc1 1 27 0.36 13.39 2.47
84 INT106513 Gene_expression of Ptges3 1 7 0.73 3.57 2.42
85 INT117893 Binding of Serpind1 1 15 0.41 24.59 2.41
86 INT19668 Regulation of SPANXA1 1 4 0.16 1.21 2.26
87 INT84388 Negative_regulation of PDE3B 1 16 0.57 11.25 2.18
88 INT10976 Negative_regulation of ENPP3 1 13 0.42 5.11 1.92
89 INT133480 Positive_regulation of Phosphorylation of Csnk2b 2 3 0.23 1.01 1.82
90 INT60999 Localization of Nos3 1 12 0.74 5.28 1.75
91 INT58114 Localization of sc 1 3 0.79 0.3 1.48
92 INT81224 Negative_regulation of Ado 1 3 0.29 1.28 1.46
93 INT111588 Gene_expression of Alox12 1 3 0.59 0.4 1.16
94 INT98134 Binding of BAX 1 17 0.39 11.45 0.93
95 INT99375 Positive_regulation of Binding of APP 1 3 0.61 1.63 0.83
96 INT119834 Phosphorylation of PTEN 3 12 0.79 6.78 0.75
97 INT46302 Binding of sar 1 6 0.36 2.37 0.7
98 INT133484 Negative_regulation of Localization of CYCS 1 4 0.42 2.77 0.7
99 INT129411 Positive_regulation of Gene_expression of Alox12 1 2 0.10 0.45 0.65
100 INT89595 Regulation of Adamts7 1 2 0.26 2.29 0.64
101 INT129412 Gene_expression of sc 1 1 0.01 0.23 0.56
102 INT129410 Positive_regulation of Phosphorylation of Camk2g 1 1 0.17 0.34 0.53
103 INT81225 Binding of Ado 1 1 0.25 0.26 0.44
104 INT103316 Localization of PDE4A 1 2 0.68 1.76 0.41
105 INT133488 Negative_regulation of Phosphorylation of PTEN 3 4 0.41 1.88 0.26
106 INT103315 Localization of Pde4c 1 1 0.00 0.86 0.25
107 INT108414 Negative_regulation of Regulation of ACE 1 1 0.43 0.67 0.17
108 INT132392 Negative_regulation of UOX 1 3 0.43 1.37 0.13
109 INT117894 Binding of Serpind1 1 1 0.03 0.06 0.13
110 INT133486 Negative_regulation of Binding of BAX 1 1 0.15 0.62 0.12
111 INT133479 Negative_regulation of Phosphorylation of Csnk2b 1 1 0.14 0.61 0.09
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