J:Current Medicinal Chemistry

From wiki-pain
Jump to: navigation, search

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT162500 AHR Regulation of CYP1A1 3 2 0.19 0.18 0.51
2 INT162503 AHR Regulation of CYP1A2 3 2 0.61 0.18 0.5
3 INT162499 Binding of AHR and NEUROD1 3 2 0.25 0.19 0.49
4 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 2 0.14 1.01 0.47
5 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 2 0.41 1 0.46
6 INT162502 NEUROD1 Regulation of CYP1A1 2 1 0.07 0.09 0.25
7 INT162501 NEUROD1 Regulation of CYP1A2 2 1 0.22 0.09 0.25
8 INT162931 TXNRD1 Negative_regulation of Phosphorylation of NQO1 1 1 0.13 0.5 0.23
9 INT268679 Binding of HDAC1 and NCOR2 3 1 0.17 2.8 0.07
10 INT284916 IL1RN Negative_regulation of HDAC4 1 1 0.00 1.66 0.03
11 INT284919 XRCC6 Negative_regulation of BAX 1 1 0.01 0.64 0
12 INT284920 Binding of HDAC1 and NCOR1 1 1 0.03 0.13 0
13 INT284918 RUNX1T1 Regulation of DNMT1 1 1 0.21 1.09 0
14 INT284917 RUNX1T1 Regulation of HDAC9 1 1 0.19 1.09 0
15 INT284914 Binding of HDAC1 and NCK1 1 1 0.00 0.13 0
16 INT284915 Binding of CDKN2B and HIST2H3C 1 1 0.05 0.43 0
17 INT284995 Binding of HDAC1 and Sin3a 1 1 0.00 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT50058 Negative_regulation of Cpox 7 907 0.58 426.28 428.29
2 INT5235 Negative_regulation of TNF 5 924 0.59 772.91 331.98
3 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
4 INT2391 Negative_regulation of PTGS1 3 501 0.59 207.62 205.6
5 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
6 INT69440 Gene_expression of ROS1 1 752 0.78 477.64 103.83
7 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
8 INT15913 Negative_regulation of CYP2D6 2 174 0.59 22.45 70.91
9 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
10 INT50672 Positive_regulation of CPOX 1 205 0.44 125.93 60.06
11 INT48235 Negative_regulation of NPEPPS 2 72 0.46 44.54 25.03
12 INT89396 Phosphorylation of AKT1 2 225 0.82 111.66 19.61
13 INT4420 Positive_regulation of GOT1 1 103 0.64 88.4 18.38
14 INT28215 Gene_expression of CDKN1A 1 196 0.76 113.9 18.3
15 INT133647 Negative_regulation of HDAC9 8 149 0.57 106.84 17.9
16 INT50404 Negative_regulation of CYP1A2 3 49 0.59 8.61 17.35
17 INT6480 Positive_regulation of IL1RN 1 59 0.69 33.7 16.66
18 INT97245 Gene_expression of AKT1 2 217 0.77 119.63 15.59
19 INT74449 Positive_regulation of B4GALNT1 1 53 0.30 34.49 14.96
20 INT75502 Positive_regulation of CDKN1A 6 123 0.68 70.75 14.74
21 INT39507 Positive_regulation of TXNRD1 1 37 0.68 12.47 14.25
22 INT27242 Gene_expression of PGR 1 153 0.75 98.77 12.79
23 INT22210 Gene_expression of CYP1A2 1 45 0.78 4.95 10.66
24 INT57162 Positive_regulation of Gene_expression of CDKN1A 1 64 0.68 35.3 9.69
25 INT68899 Binding of CYP1A2 3 19 0.48 2.33 5.73
26 INT125066 Negative_regulation of HDAC4 2 56 0.49 41.55 5.42
27 INT55419 Regulation of CYP1A2 1 19 0.62 5.3 4.75
28 INT35765 Gene_expression of TXNRD1 1 47 0.56 9.16 4.43
29 INT38963 Binding of Lsd 1 7 0.41 1.91 4.12
30 INT85677 Positive_regulation of Gpbar1 1 24 0.68 8.41 4.09
31 INT170455 Gene_expression of Atp8a1 1 66 0.75 24.63 3.94
32 INT103350 Gene_expression of DNMT1 3 15 0.67 9.77 3.83
33 INT193281 Binding of CAP1 2 7 0.07 4.57 3.53
34 INT12923 Negative_regulation of Atp9a 1 17 0.35 7.87 3.52
35 INT124579 Localization of BAX 1 35 0.78 30.31 3.43
36 INT172551 Negative_regulation of INCENP 2 38 0.07 20.83 3.14
37 INT75499 Positive_regulation of Positive_regulation of CDKN1A 2 12 0.60 7.28 2.84
38 INT89401 Negative_regulation of Phosphorylation of AKT1 1 68 0.58 35.61 2.8
39 INT221097 Negative_regulation of Atp8a1 3 15 0.57 10.52 2.65
40 INT169987 Transcription of GOPC 1 45 0.60 21.88 2.61
41 INT142724 Negative_regulation of A4GALT 1 11 0.53 8.23 2.61
42 INT167153 Gene_expression of A4GALT 1 10 0.49 10.45 1.71
43 INT121513 Positive_regulation of A4GALT 1 21 0.63 16.06 1.59
44 INT82866 Localization of Atp9a 1 13 0.78 6.95 1.56
45 INT68359 Positive_regulation of HPGDS 1 9 0.32 4.63 1.18
46 INT260447 Binding of HDAC1 1 8 0.23 4.47 1.12
47 INT103882 Gene_expression of MECP2 1 17 0.76 10.47 0.96
48 INT192564 Binding of HAT1 1 5 0.15 2.77 0.96
49 INT74019 Regulation of TSC1 1 27 0.35 23.61 0.79
50 INT146521 Negative_regulation of Positive_regulation of CDKN1A 1 6 0.42 3.29 0.79
51 INT157282 Localization of CYP1A2 1 5 0.75 0.54 0.76
52 INT201859 Positive_regulation of Gene_expression of DNMT1 1 4 0.60 6.43 0.75
53 INT284955 Localization of HDAC1 1 2 0.47 1.71 0.74
54 INT230001 Binding of DEFA1 1 3 0.06 3.53 0.68
55 INT166024 Protein_catabolism of AKT1 1 5 0.46 2.6 0.64
56 INT134951 Gene_expression of NQO1 1 14 0.78 7.87 0.61
57 INT161622 Negative_regulation of Adamts4 2 1 0.28 1.37 0.59
58 INT111609 Gene_expression of CTNNA1 1 3 0.46 3.2 0.57
59 INT177842 Negative_regulation of HDAC1 1 6 0.31 4.65 0.49
60 INT231565 Positive_regulation of YWHAE 1 4 0.23 3.07 0.49
61 INT61884 Positive_regulation of HIST2H4A 4 3 0.10 2.87 0.48
62 INT146400 Positive_regulation of DNMT1 1 4 0.45 0.91 0.43
63 INT163489 Binding of CDH1 2 13 0.19 8.63 0.35
64 INT82797 Transcription of CDKN1A 1 11 0.69 8.01 0.32
65 INT278723 Binding of HIST2H3C 2 2 0.04 1.74 0.28
66 INT284938 Regulation of DNMT1 1 2 0.22 1.17 0.24
67 INT162933 Phosphorylation of NQO1 1 1 0.69 0.5 0.23
68 INT284968 Positive_regulation of CDA 1 2 0.05 0.34 0.15
69 INT284981 Protein_catabolism of RAF1 1 2 0.08 1.62 0.12
70 INT258077 Negative_regulation of Gene_expression of DNMT1 1 2 0.30 1.27 0.12
71 INT162937 Regulation of Regulation of CYP1A2 1 1 0.45 0 0.12
72 INT162936 Regulation of Gene_expression of CYP1A2 1 1 0.45 0 0.12
73 INT258063 Negative_regulation of DNMT1 1 3 0.28 1.36 0.11
74 INT284989 Localization of INTS2 1 2 0.43 1.64 0.11
75 INT284953 Protein_catabolism of CDA 1 1 0.07 1.18 0.1
76 INT174100 Gene_expression of YWHAE 4 14 0.31 12.42 0.08
77 INT181214 Negative_regulation of HLA-DQA2 1 4 0.03 1.46 0.08
78 INT284484 Positive_regulation of Gene_expression of YWHAE 1 3 0.23 3.4 0.08
79 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 1 0.20 0.81 0.08
80 INT284976 Protein_catabolism of HDAC2 1 1 0.28 0.8 0.08
81 INT245123 Gene_expression of CDKN2B 3 6 0.68 3.62 0.07
82 INT184989 Positive_regulation of CDKN2B 3 3 0.47 2.77 0.07
83 INT284952 Phosphorylation of HAT1 1 1 0.05 0 0.05
84 INT284979 Binding of HIST2H4A 1 2 0.05 2 0.04
85 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 1 0.20 1.59 0.04
86 INT284958 Negative_regulation of HDAC6 1 1 0.25 1.56 0.04
87 INT284992 Negative_regulation of HDAC8 2 1 0.21 2.36 0.04
88 INT208568 Gene_expression of LINS 1 3 0.06 0.38 0.03
89 INT284961 Protein_catabolism of FLT3 1 1 0.01 0.58 0.03
90 INT284971 Positive_regulation of Protein_catabolism of MTTP 1 1 0.45 0.54 0.03
91 INT284984 Protein_catabolism of MTTP 1 1 0.64 0.53 0.03
92 INT185001 Gene_expression of CDH13 1 5 0.46 4.71 0
93 INT274683 Localization of HIST2H4A 1 5 0.12 1.54 0
94 INT277612 Localization of HDAC9 1 3 0.45 0.55 0
95 INT284977 Binding of DNMT1 2 3 0.17 0.86 0
96 INT284972 Negative_regulation of CDKN2B 2 3 0.44 1.13 0
97 INT284943 Gene_expression of DNMT3A 1 2 0.39 1.46 0
98 INT169503 Gene_expression of MBD1 1 2 0.57 0.53 0
99 INT232975 Binding of KRT9 1 2 0.14 0.8 0
100 INT284945 Protein_catabolism of DNMT1 1 2 0.32 0.47 0
101 INT284963 Binding of XRCC6 1 2 0.36 1.57 0
102 INT284947 Positive_regulation of Gene_expression of DNMT3A 1 2 0.25 1.29 0
103 INT284937 Negative_regulation of Positive_regulation of CDKN2B 1 1 0.37 0.31 0
104 INT284983 Phosphorylation of UCK1 1 1 0.05 0 0
105 INT284957 Localization of HIST2H3C 1 1 0.07 0.42 0
106 INT284991 Localization of YWHAE 3 1 0.06 3.22 0
107 INT284974 Negative_regulation of YWHAE 1 1 0.04 0.59 0
108 INT284986 Positive_regulation of Localization of HIST2H4A 1 1 0.07 0.42 0
109 INT284939 Binding of RUNX1T1 1 1 0.36 1.19 0
110 INT284993 Positive_regulation of Protein_catabolism of DNMT1 1 1 0.22 0.26 0
111 INT284941 Transcription of CDKN2B 3 1 0.63 1.59 0
112 INT284970 Positive_regulation of Gene_expression of CDKN2B 1 1 0.61 0.55 0
113 INT284951 Positive_regulation of Positive_regulation of HIST2H3C 1 1 0.05 0.52 0
114 INT284959 Positive_regulation of Localization of INTS2 1 1 0.03 0.5 0
115 INT284966 Phosphorylation of DCK 1 1 0.03 0 0
116 INT284950 Gene_expression of MBD4 1 1 0.29 0.31 0
117 INT284988 Positive_regulation of Transcription of CDKN2B 1 1 0.44 1.1 0
118 INT284990 Positive_regulation of Positive_regulation of HIST2H4A 1 1 0.07 0.52 0
119 INT284942 Positive_regulation of Localization of HIST2H3C 1 1 0.05 0.42 0
120 INT284967 Positive_regulation of HIST2H3C 3 1 0.07 1.45 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox