J:Cytokine

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT126717 Binding of Il6 and Il6st 3 2 0.21 3.35 2.22
2 INT81920 Binding of IL1B and NFKB1 1 2 0.04 1.54 1.85
3 INT81914 Binding of HSF1 and NFKB1 1 2 0.05 1.54 1.85
4 INT126718 Binding of Il6 and Il6r 3 2 0.09 2.33 1.49
5 INT89943 Binding of Oprm1 and Il2 1 1 0.03 0.53 1.28
6 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 1 0.25 1.3 1.12
7 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 1 0.05 1.85 1.06
8 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 1 0.11 1.13 1.02
9 INT81919 Binding of HSF1 and IL1B 1 1 0.42 0.77 0.93
10 INT57746 Il1 Regulation of Gene_expression of Ltc4s 1 2 0.36 0.33 0.88
11 INT89936 Tlr4 Positive_regulation of Il6 3 1 0.49 0.95 0.7
12 INT81916 HSF1 Positive_regulation of FOS 1 1 0.76 0.66 0.59
13 INT81915 HSF1 Negative_regulation of IL1B 1 1 0.51 0.65 0.59
14 INT81917 HSF1 Positive_regulation of IL1B 1 1 0.41 0.65 0.59
15 INT81918 HSF1 Negative_regulation of FOS 1 1 0.64 0.66 0.59
16 INT61616 TNF Negative_regulation of Gene_expression of IL6 1 1 0.37 0.33 0.49
17 INT140574 Ifnb1 Positive_regulation of Il6 1 1 0.05 0.9 0.39
18 INT140569 Ifng Positive_regulation of Gene_expression of Il6 1 1 0.00 0.82 0.36
19 INT140571 Ifng Positive_regulation of Ifnb1 1 1 0.01 0.82 0.36
20 INT140575 Il6 Positive_regulation of Ifnb1 1 1 0.02 0.82 0.36
21 INT140572 Ifng Positive_regulation of Gene_expression of Ifnb1 1 1 0.01 0.82 0.36
22 INT140573 Positive_regulation of Ifng Positive_regulation of Ifnb1 1 1 0.01 0.83 0.36
23 INT89940 Ednrb Positive_regulation of Positive_regulation of TNF 1 1 0.01 0.09 0.14
24 INT89939 Ednrb Regulation of Gene_expression of TNF 1 1 0.00 0.09 0.13
25 INT89937 Ptger2 Regulation of Gene_expression of TNF 1 1 0.02 0.08 0.12

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 20 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 10 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 12 1050 0.70 896.51 322.81
5 INT6852 Localization of TNF 5 883 0.81 705.95 270.84
6 INT10832 Gene_expression of IL8 10 1050 0.78 698.72 270
7 INT5972 Gene_expression of IL1B 7 948 0.78 510.91 263.97
8 INT6482 Positive_regulation of Gene_expression of TNF 6 659 0.70 569.88 210
9 INT10194 Positive_regulation of IL6 5 702 0.70 600.62 183.38
10 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
11 INT55879 Gene_expression of CCL2 7 421 0.78 240.74 166.02
12 INT6042 Binding of Oprm1 1 248 0.48 31.77 154.34
13 INT5116 Gene_expression of IL2 4 670 0.78 291.13 146.69
14 INT9660 Regulation of TNF 3 363 0.62 312.94 139.99
15 INT48895 Gene_expression of Il10 1 333 0.78 221.2 138.52
16 INT8243 Positive_regulation of Il6 9 451 0.70 358.24 119.28
17 INT9235 Negative_regulation of Gene_expression of TNF 6 346 0.59 252.98 118.61
18 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
19 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
20 INT60526 Gene_expression of IL10 2 449 0.78 292.71 107.84
21 INT10272 Gene_expression of Il1b 2 194 0.78 121.02 103.03
22 INT10838 Positive_regulation of IL8 2 381 0.70 295.51 101.62
23 INT1760 Gene_expression of PTGER2 2 524 0.57 226.94 96.4
24 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
25 INT71789 Positive_regulation of MAPK1 2 396 0.70 234.44 89.27
26 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
27 INT54571 Positive_regulation of NFKB1 3 263 0.70 138.99 87.32
28 INT5056 Gene_expression of IFNG 3 216 0.78 137.52 74.57
29 INT10274 Positive_regulation of Il1b 1 123 0.70 79.76 73.56
30 INT9236 Regulation of Gene_expression of TNF 5 204 0.62 162.66 72.99
31 INT56298 Gene_expression of IL4 2 306 0.78 182.18 72.92
32 INT10359 Gene_expression of Ifng 1 159 0.78 79.6 72.14
33 INT12720 Positive_regulation of Il1 2 246 0.70 195.97 72.05
34 INT10837 Positive_regulation of Gene_expression of IL8 10 294 0.70 190.08 70.34
35 INT6849 Localization of IL1B 2 229 0.81 112.56 69.63
36 INT9657 Positive_regulation of Gene_expression of Il6 6 237 0.70 180.45 63.6
37 INT10706 Regulation of Il6 1 150 0.62 93.23 62.34
38 INT6477 Gene_expression of IL1RN 4 213 0.77 114.69 58.62
39 INT48891 Positive_regulation of Il10 4 143 0.70 101.42 56.72
40 INT117223 Gene_expression of TLR4 2 348 0.78 206.18 54.42
41 INT9234 Negative_regulation of Gene_expression of IL6 5 171 0.59 101.61 53.15
42 INT52264 Gene_expression of IK 2 180 0.77 90.87 51.87
43 INT12345 Gene_expression of Il2 1 142 0.78 59.17 51.21
44 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
45 INT9210 Regulation of IL6 4 166 0.62 125.61 49.95
46 INT16364 Gene_expression of HLA-DRA 2 234 0.78 118.81 45.01
47 INT73502 Positive_regulation of IL10 6 154 0.69 124.87 43.5
48 INT13354 Transcription of TNF 1 108 0.72 85.81 42.32
49 INT61619 Gene_expression of IL12A 2 194 0.77 146.07 41.97
50 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
51 INT48222 Positive_regulation of Localization of IL8 2 123 0.59 78.04 37.2
52 INT80690 Positive_regulation of MAPK8 2 223 0.68 125.63 36.75
53 INT9239 Regulation of Gene_expression of IL6 3 106 0.61 75.24 36.53
54 INT62827 Positive_regulation of ICAM1 1 184 0.70 180.95 36.28
55 INT6105 Positive_regulation of IL2 2 133 0.69 82.76 34.67
56 INT9655 Regulation of Il6 1 98 0.62 70.92 31.95
57 INT77652 Negative_regulation of Gene_expression of IL8 2 99 0.59 67.57 30.21
58 INT9993 Positive_regulation of Gene_expression of IL2 2 131 0.69 46.27 30.04
59 INT56072 Negative_regulation of NFKB1 1 94 0.59 53.16 28.19
60 INT1765 Positive_regulation of Gene_expression of PTGER2 1 140 0.51 68.68 27
61 INT10273 Positive_regulation of Gene_expression of Il1b 1 47 0.68 31.15 26.21
62 INT70048 Positive_regulation of Gene_expression of IL10 1 90 0.55 71.34 25.66
63 INT12124 Gene_expression of MAPK1 2 141 0.75 82.4 25.58
64 INT47075 Positive_regulation of Ptger2 2 142 0.70 78.55 25.47
65 INT114362 Localization of Hmgb1 1 127 0.78 120.28 23.26
66 INT5055 Positive_regulation of IFNG 1 89 0.69 64.03 23.05
67 INT74423 Localization of IL10 3 91 0.80 61.6 22.95
68 INT66208 Positive_regulation of Positive_regulation of NFKB1 3 45 0.68 20.17 22.62
69 INT8483 Positive_regulation of Positive_regulation of TNF 1 73 0.67 60.35 22.03
70 INT97798 Localization of IRF6 1 86 0.73 33.27 20.94
71 INT9237 Regulation of Gene_expression of IL1B 1 49 0.62 30.69 20.34
72 INT69304 Negative_regulation of Il10 1 47 0.59 36.88 19.79
73 INT25222 Positive_regulation of Gene_expression of Ifng 1 32 0.50 24.18 19.58
74 INT1764 Negative_regulation of Gene_expression of PTGER2 1 81 0.34 34.74 19.45
75 INT74286 Regulation of Il10 1 42 0.44 28.06 19.44
76 INT16445 Gene_expression of IL1A 2 60 0.78 44.46 19.19
77 INT10833 Regulation of Gene_expression of IL8 2 68 0.62 38.74 18.46
78 INT55880 Negative_regulation of Gene_expression of CCL2 2 49 0.59 22.37 18.09
79 INT55878 Regulation of Gene_expression of CCL2 3 34 0.62 15.71 17.97
80 INT71787 Positive_regulation of MAPK3 1 37 0.67 17.5 17.88
81 INT61626 Transcription of IL6 1 73 0.72 42.04 17.86
82 INT62826 Negative_regulation of Gene_expression of ICAM1 1 75 0.58 46.39 17.72
83 INT117220 Positive_regulation of TLR4 3 64 0.69 53.61 17.33
84 INT36054 Transcription of IL1B 1 53 0.72 32.64 17.31
85 INT6480 Positive_regulation of IL1RN 1 59 0.69 33.7 16.66
86 INT19929 Negative_regulation of Positive_regulation of TNF 1 52 0.59 38.16 16.51
87 INT10000 Regulation of Gene_expression of IL2 1 56 0.45 15.33 16.2
88 INT75929 Gene_expression of IL9 1 61 0.43 24.71 16.17
89 INT25517 Regulation of NFKB1 1 41 0.61 22.28 16.09
90 INT25223 Positive_regulation of Gene_expression of IFNG 1 41 0.67 36.97 15.89
91 INT10360 Positive_regulation of Ifng 1 33 0.68 21.73 15.19
92 INT49532 Regulation of Gene_expression of Il6 1 43 0.61 25.8 14.99
93 INT25266 Positive_regulation of Localization of IL1B 1 38 0.69 15.89 14.35
94 INT39733 Localization of NFKB1 1 59 0.79 22.76 13.99
95 INT80685 Gene_expression of MAPK8 2 90 0.72 51.91 13.36
96 INT72565 Localization of IL1RN 6 45 0.80 23.59 13.17
97 INT61624 Positive_regulation of Gene_expression of IL12A 1 50 0.56 33.07 13.07
98 INT117222 Positive_regulation of Gene_expression of TLR4 1 80 0.70 51.6 12.9
99 INT51014 Transcription of IL2 1 42 0.71 21.56 12.7
100 INT70050 Negative_regulation of IL10 1 56 0.58 37.45 12.39
101 INT39553 Gene_expression of Hmgb1 1 50 0.75 51.18 12.21
102 INT49509 Negative_regulation of Ptger2 1 53 0.42 24.87 11.66
103 INT50933 Transcription of Il6 2 38 0.72 24.31 11.58
104 INT67401 Gene_expression of Il12a 1 25 0.55 20.04 11.12
105 INT6474 Positive_regulation of Gene_expression of IL1RN 2 34 0.69 21.87 10.99
106 INT1763 Regulation of Gene_expression of PTGER2 1 43 0.36 23.98 10.95
107 INT11936 Positive_regulation of Positive_regulation of Il6 1 34 0.50 26.85 10.59
108 INT95565 Positive_regulation of IL12A 1 47 0.56 33.96 10.16
109 INT81929 Negative_regulation of Gene_expression of IL10 1 41 0.57 27.99 9.87
110 INT27882 Gene_expression of HSP90B2P 1 52 0.75 36.51 9.59
111 INT85418 Positive_regulation of Gene_expression of IL9 1 11 0.38 11.47 9.56
112 INT73497 Regulation of IL10 1 33 0.45 22.6 9.19
113 INT15768 Gene_expression of Il1a 3 20 0.71 9.31 8.78
114 INT61628 Negative_regulation of Gene_expression of IL4 1 31 0.55 20.96 8.18
115 INT114363 Positive_regulation of Hmgb1 1 50 0.67 48.92 8.15
116 INT71308 Gene_expression of CCL11 1 33 0.76 25.66 7.83
117 INT80686 Positive_regulation of Positive_regulation of MAPK8 2 42 0.68 26.95 7.63
118 INT103909 Gene_expression of NOD2 2 37 0.77 21.9 7.36
119 INT66210 Regulation of Positive_regulation of NFKB1 1 16 0.60 9.46 7.08
120 INT23034 Positive_regulation of Il1a 6 15 0.70 8.75 6.29
121 INT17779 Negative_regulation of Got1 1 12 0.40 3.5 6.08
122 INT75832 Positive_regulation of Positive_regulation of IL8 2 30 0.70 20.77 6.05
123 INT17551 Positive_regulation of Gene_expression of HLA-DRA 1 31 0.70 15.39 6
124 INT52907 Regulation of Gene_expression of HLA-DRA 1 28 0.34 5.94 5.96
125 INT10705 Binding of Il1b 1 9 0.36 2.8 5.53
126 INT56299 Transcription of IL4 1 15 0.64 10.2 5.44
127 INT71779 Positive_regulation of Gene_expression of MAPK1 2 27 0.47 21.41 5.39
128 INT16540 Gene_expression of Il1r2 1 14 0.61 3.29 5.2
129 INT64723 Regulation of Positive_regulation of IL6 1 13 0.61 12.59 5.19
130 INT66211 Positive_regulation of Localization of NFKB1 1 20 0.68 8.18 5.01
131 INT23035 Regulation of Il1a 1 6 0.60 5.69 4.25
132 INT15462 Negative_regulation of Il1a 1 4 0.59 4.68 4.17
133 INT132103 Positive_regulation of Gene_expression of MAPK8 2 26 0.46 16.54 3.94
134 INT34054 Regulation of Gene_expression of IFNG 1 8 0.42 3.69 3.76
135 INT118615 Negative_regulation of IL4 1 20 0.41 13.79 3.49
136 INT66919 Positive_regulation of HSF1 3 27 0.69 14.78 3.24
137 INT126716 Positive_regulation of Il6r 1 8 0.42 4.31 3.1
138 INT115579 Positive_regulation of Positive_regulation of Il10 1 7 0.68 4.82 2.91
139 INT89941 Positive_regulation of Il1r2 1 4 0.49 1.92 2.43
140 INT87284 Negative_regulation of Positive_regulation of MAPK3 1 7 0.41 2.65 2.38
141 INT64982 Positive_regulation of Ifnb1 1 10 0.48 6.16 2.35
142 INT16089 Gene_expression of Ltc4s 2 11 0.77 3.37 2.29
143 INT105378 Regulation of IL12A 1 6 0.26 8.82 2.15
144 INT94628 Gene_expression of CD1D 1 12 0.75 5.58 2.13
145 INT49988 Positive_regulation of Gene_expression of Il1a 2 2 0.47 1.49 2.11
146 INT117221 Positive_regulation of Gene_expression of NOD2 1 7 0.65 4.39 1.83
147 INT61627 Transcription of IFNG 1 6 0.69 4.28 1.83
148 INT81924 Positive_regulation of HSPA1B 2 1 0.03 1.47 1.82
149 INT38930 Regulation of IL36RN 1 4 0.21 2.14 1.8
150 INT81928 Positive_regulation of Binding of HSF1 2 4 0.49 3.04 1.67
151 INT81926 Binding of HSF1 2 10 0.47 5.05 1.53
152 INT78704 Binding of CCL11 1 10 0.37 11.38 1.44
153 INT14335 Gene_expression of Ifnb1 2 5 0.40 2.7 1.38
154 INT73904 Positive_regulation of Localization of IL1RN 1 2 0.69 1.5 1.38
155 INT81922 Regulation of Gene_expression of HSP90B2P 1 5 0.44 4.25 1.34
156 INT117219 Positive_regulation of NOD2 1 9 0.69 4.66 1.31
157 INT100621 Localization of HLA-DRA 1 7 0.40 2.86 1.2
158 INT70673 Regulation of IL11 1 5 0.45 2.89 1.2
159 INT145948 Binding of CCL24 1 2 0.33 2.1 1.17
160 INT132108 Gene_expression of IFI44 1 21 0.42 3.56 1.12
161 INT81921 Gene_expression of HSF1 1 17 0.76 9.19 1.08
162 INT50989 Regulation of Positive_regulation of Il1b 1 2 0.42 0.86 1.02
163 INT16446 Transcription of IL1A 1 4 0.69 1.76 0.96
164 INT81925 Positive_regulation of Positive_regulation of HSPA1B 1 1 0.02 0.74 0.91
165 INT81930 Positive_regulation of Gene_expression of HSF1 1 4 0.66 4.07 0.88
166 INT24860 Positive_regulation of CD1D 2 6 0.49 2.13 0.83
167 INT82262 Regulation of Lif 1 3 0.31 1.67 0.83
168 INT76015 Localization of DCSTAMP 2 3 0.14 1.04 0.77
169 INT81923 Negative_regulation of Gene_expression of HSF1 1 2 0.42 1.17 0.73
170 INT136147 Regulation of Ifnb1 1 2 0.44 1.75 0.72
171 INT145949 Gene_expression of CCL24 1 2 0.54 2.39 0.68
172 INT61623 Regulation of Positive_regulation of IL2 1 1 0.21 0.33 0.65
173 INT61622 Positive_regulation of Transcription of IFNG 1 1 0.26 0.29 0.63
174 INT104910 Binding of Il1rap 1 1 0.25 0.6 0.58
175 INT132104 Positive_regulation of Gene_expression of CD1D 1 2 0.03 0.55 0.57
176 INT140576 Positive_regulation of Regulation of Ifnb1 1 1 0.30 0.9 0.39
177 INT145947 Positive_regulation of CCL24 2 1 0.62 1.49 0.39
178 INT140577 Positive_regulation of Gene_expression of Ifnb1 1 1 0.30 0.81 0.36
179 INT132106 Positive_regulation of Gene_expression of IFI44 1 2 0.28 0.43 0.25
180 INT118614 Regulation of IFIT1 1 1 0.00 0.38 0.21
181 INT132107 Positive_regulation of Positive_regulation of CD1D 1 1 0.04 0.16 0.2
182 INT132105 Positive_regulation of Gene_expression of CDK20 1 1 0.25 0.16 0.2
183 INT132102 Gene_expression of CDK20 1 1 0.34 0.16 0.2
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