J:Dig. Dis. Sci.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT27123 Binding of Pomc and Cck 2 1 0.31 0 1.38
2 INT84091 Negative_regulation of Nka1 Regulation of Vip 1 1 0.00 0 0.93
3 INT84089 Nka1 Regulation of Localization of Vip 1 1 0.00 0 0.92
4 INT84088 Nka1 Regulation of Vip 1 1 0.01 0 0.92
5 INT23858 VIP Regulation of FUT3 1 1 0.02 0 0.88
6 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 1 0.01 0.66 0.86
7 INT84087 B3GAT1 Positive_regulation of Localization of SST 1 1 0.06 0 0.83
8 INT84102 B3GAT1 Positive_regulation of Localization of Glp1r 1 1 0.09 0 0.83
9 INT84103 TACR1 Regulation of Nka1 1 1 0.00 0 0.81
10 INT84104 TACR1 Negative_regulation of TACR1 Regulation of Nka1 1 1 0.00 0 0.81
11 INT16014 Ptafr Regulation of Ns5atp9 1 2 0.32 1.17 0.78
12 INT123556 Shfm1 Regulation of Mpo 1 1 0.09 0.88 0.76
13 INT84090 Nka1 Positive_regulation of Localization of Vip 1 1 0.00 0 0.74
14 INT30904 SST Negative_regulation of Localization of Gast 2 1 0.08 0.49 0.71
15 INT150863 Grtp1 Negative_regulation of Gpt 1 1 0.09 0.58 0.71
16 INT147201 Binding of CCL2 and Hsp70-2os 1 1 0.00 0.76 0.57
17 INT74548 Prkcg Regulation of Tecr 1 1 0.48 0 0.43
18 INT23566 Sst Negative_regulation of Positive_regulation of Cck 1 1 0.04 0 0.34
19 INT120716 Binding of AKT1 and TEP1 1 1 0.05 0.46 0.21
20 INT104702 KNG1 Negative_regulation of Anpep 1 1 0.11 0.47 0.19
21 INT19042 ESR1 Positive_regulation of GGT5 1 1 0.03 0.6 0.17
22 INT19045 ESR1 Positive_regulation of Salpa1 1 1 0.02 0.6 0.17
23 INT81559 Amelx Positive_regulation of Positive_regulation of Mat2a 1 1 0.09 0.19 0.11
24 INT142418 Lep Positive_regulation of Gene_expression of Ghrl 1 1 0.48 1.66 0.09
25 INT77649 Positive_regulation of JUN Positive_regulation of Transcription of IL8 1 1 0.01 0.79 0.09
26 INT115717 TNF Regulation of Gene_expression of PLAU 1 1 0.49 0.56 0.09
27 INT115720 TNF Regulation of Gene_expression of PLAUR 1 1 0.49 0.56 0.09
28 INT115718 TNF Regulation of PLAU 1 1 0.31 0.48 0.08
29 INT31987 NTS Positive_regulation of Binding of GDA 1 1 0.50 0 0.08
30 INT115719 IL1B Regulation of PLAU 1 1 0.49 0.48 0.08
31 INT31986 NTS Positive_regulation of Binding of SOD1 1 1 0.16 0 0.08
32 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 1 0.63 0.51 0
33 INT114713 Binding of IGF1R and SRC 1 1 0.33 0.6 0
34 INT114711 SRC Positive_regulation of Gene_expression of INSRR 1 1 0.01 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 4 2008 0.81 518.3 1408.65
2 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
3 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
4 INT58061 Gene_expression of Trpv1 1 1117 0.78 451.54 637.59
5 INT2543 Positive_regulation of Calca 2 787 0.70 331.13 592.08
6 INT50058 Negative_regulation of Cpox 3 907 0.58 426.28 428.29
7 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
8 INT2540 Negative_regulation of Calca 4 538 0.59 172.11 384.38
9 INT6580 Negative_regulation of Ptgs1 3 929 0.59 381.53 376.26
10 INT287 Localization of Cck 6 518 0.81 86.84 364.04
11 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
12 INT16260 Gene_expression of Bdnf 1 671 0.78 283.44 339.1
13 INT5059 Positive_regulation of TNF 3 1050 0.70 896.51 322.81
14 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
15 INT9131 Positive_regulation of Prkcg 1 431 0.70 130.8 302.41
16 INT9158 Gene_expression of Tnf 7 722 0.78 522.01 277.68
17 INT2365 Positive_regulation of Cck 5 354 0.70 87.8 277.41
18 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
19 INT10832 Gene_expression of IL8 7 1050 0.78 698.72 270
20 INT5972 Gene_expression of IL1B 3 948 0.78 510.91 263.97
21 INT3948 Regulation of Cck 1 291 0.62 58.07 255.88
22 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
23 INT1005 Localization of Sst 1 385 0.81 26.31 244.56
24 INT1902 Gene_expression of Cck 4 348 0.78 70.33 241.92
25 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
26 INT1308 Localization of Pomc 2 457 0.81 66.83 217.5
27 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
28 INT16259 Positive_regulation of Bdnf 3 336 0.70 183.48 209.82
29 INT48955 Gene_expression of Nos2 9 753 0.78 403.87 208.08
30 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
31 INT9132 Negative_regulation of Prkcg 1 279 0.59 88.05 203.47
32 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
33 INT943 Negative_regulation of Cck 3 205 0.59 38.42 174.78
34 INT15516 Gene_expression of Crp 3 711 0.77 615.33 173.09
35 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
36 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
37 INT51921 Gene_expression of Cpox 2 501 0.73 229.81 157.81
38 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
39 INT13353 Positive_regulation of Tnf 2 332 0.70 248.75 148.1
40 INT1033 Positive_regulation of Ca2 2 507 0.68 131.76 147.64
41 INT9852 Positive_regulation of Gpt 2 563 0.70 364.64 146.82
42 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
43 INT2867 Gene_expression of CALCA 6 247 0.78 78.78 138.47
44 INT48953 Positive_regulation of Nos2 5 486 0.70 239.85 131.87
45 INT695 Binding of POMC 1 304 0.48 56.66 126.85
46 INT65054 Positive_regulation of Nfkb1 7 285 0.70 149.33 126.73
47 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
48 INT90 Localization of Gast 22 400 0.81 137.67 113
49 INT7362 Gene_expression of Sst 1 185 0.78 41.73 111.37
50 INT8413 Gene_expression of Ptgs1 2 248 0.78 110.17 108.58
51 INT47243 Gene_expression of Prkcg 1 195 0.78 58.05 108.44
52 INT9012 Localization of Vip 24 283 0.81 31.71 106.16
53 INT12082 Localization of IL6 2 365 0.81 241.78 105.78
54 INT12569 Localization of Oprd1 1 94 0.81 23.81 104.56
55 INT69440 Gene_expression of ROS1 6 752 0.78 477.64 103.83
56 INT10272 Gene_expression of Il1b 1 194 0.78 121.02 103.03
57 INT89054 Positive_regulation of Gene_expression of Trpv1 1 156 0.70 90.78 102.03
58 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
59 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
60 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
61 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
62 INT74058 Gene_expression of Nos1 1 260 0.78 80.04 95.71
63 INT1004 Regulation of Sst 3 140 0.62 18.52 94.84
64 INT10166 Localization of Tnf 1 237 0.81 153.95 88.64
65 INT1635 Gene_expression of Vip 2 245 0.78 53.36 88.13
66 INT54571 Positive_regulation of NFKB1 2 263 0.70 138.99 87.32
67 INT5610 Positive_regulation of Insr 1 140 0.69 37.26 86.24
68 INT4798 Gene_expression of Nts 1 169 0.77 29.56 86.04
69 INT5780 Regulation of Gene_expression of Calca 1 90 0.62 59.52 85.03
70 INT4830 Binding of Trpv1 1 158 0.48 45.11 84.2
71 INT4631 Positive_regulation of Sst 1 127 0.70 17.37 83.29
72 INT403 Localization of Trh 3 241 0.81 28.55 81.45
73 INT64636 Positive_regulation of Gene_expression of Nos2 3 242 0.70 147.52 79.53
74 INT749 Gene_expression of HLA-B 1 341 0.75 224.12 77.37
75 INT10274 Positive_regulation of Il1b 2 123 0.70 79.76 73.56
76 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
77 INT2055 Regulation of Gnrh1 1 185 0.62 23.65 71.26
78 INT49995 Positive_regulation of Gene_expression of Tnf 3 187 0.70 125.07 70.54
79 INT5993 Positive_regulation of Nts 2 122 0.70 26.82 70.45
80 INT10837 Positive_regulation of Gene_expression of IL8 2 294 0.70 190.08 70.34
81 INT8388 Positive_regulation of Vip 8 142 0.70 39.72 67.61
82 INT5374 Gene_expression of Esr1 1 412 0.77 263.89 67.34
83 INT9489 Gene_expression of SFTPA1 1 112 0.66 55.38 66.45
84 INT6176 Positive_regulation of Htr1a 1 117 0.67 28.23 66.17
85 INT6486 Positive_regulation of Tnf 1 168 0.70 123.47 66.05
86 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
87 INT47690 Regulation of Bdnf 1 118 0.62 53.02 64.5
88 INT83419 Gene_expression of Mors1 2 57 0.68 12.11 63.66
89 INT6761 Binding of CALCA 1 100 0.48 26.71 62.05
90 INT8363 Localization of Nts 2 135 0.81 14.29 61.71
91 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
92 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
93 INT546 Binding of ALB 1 311 0.48 85.98 60.14
94 INT1536 Negative_regulation of NA 2 244 0.55 52.67 59.79
95 INT3920 Localization of Ldha 2 241 0.81 83.08 58.72
96 INT6477 Gene_expression of IL1RN 4 213 0.77 114.69 58.62
97 INT48891 Positive_regulation of Il10 1 143 0.70 101.42 56.72
98 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
99 INT52800 Negative_regulation of Gene_expression of Tnf 2 142 0.59 92.27 55.47
100 INT5034 Negative_regulation of Insr 1 100 0.55 28.08 54.5
101 INT117223 Gene_expression of TLR4 6 348 0.78 206.18 54.42
102 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
103 INT771 Regulation of Nts 1 93 0.61 13.13 53.57
104 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
105 INT62543 Gene_expression of Icam1 4 231 0.78 187.58 52.71
106 INT49017 Negative_regulation of Gene_expression of Nos2 4 169 0.59 80.64 52.67
107 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
108 INT5118 Regulation of SST 7 97 0.62 34.35 51.74
109 INT12345 Gene_expression of Il2 1 142 0.78 59.17 51.21
110 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
111 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
112 INT2323 Gene_expression of Trh 1 146 0.78 29.92 49.5
113 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
114 INT17915 Gene_expression of Insr 2 141 0.75 47.45 48.59
115 INT32718 Gene_expression of OPRD1 1 82 0.76 9.43 48.38
116 INT671 Positive_regulation of Cea 1 221 0.69 164.5 47.79
117 INT5025 Positive_regulation of Gene_expression of Cck 2 63 0.70 10.96 47.11
118 INT2406 Gene_expression of CCK 1 85 0.78 28.04 46.67
119 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
120 INT8824 Regulation of Vip 5 95 0.62 15.7 43.63
121 INT935 Localization of Gtf3a 2 124 0.70 35.72 43.3
122 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
123 INT89 Positive_regulation of Gast 5 187 0.70 80.49 42.07
124 INT5539 Negative_regulation of Mme 1 75 0.59 28.91 41.84
125 INT2364 Localization of Sct 1 134 0.80 26.21 41.47
126 INT30 Gene_expression of Gast 4 158 0.78 99 41.45
127 INT69437 Positive_regulation of ROS1 2 328 0.58 222.83 40.56
128 INT77307 Gene_expression of Bcl2 3 399 0.77 319.77 38
129 INT9082 Positive_regulation of ESR1 2 238 0.69 148.51 36.69
130 INT5743 Localization of NA 3 104 0.59 14.35 35.29
131 INT692 Negative_regulation of SST 2 72 0.59 28.68 34.52
132 INT74563 Positive_regulation of Gene_expression of ROS1 5 258 0.61 168.18 34.08
133 INT16960 Gene_expression of Crp 1 166 0.76 116.21 34.07
134 INT2732 Gene_expression of VIP 1 74 0.78 24.57 33.72
135 INT65536 Negative_regulation of Positive_regulation of Nfkb1 3 77 0.59 38.86 33.33
136 INT52350 Gene_expression of CD14 1 184 0.75 71.37 33.13
137 INT51698 Positive_regulation of Gene_expression of Prkcg 1 44 0.68 14.02 32.9
138 INT691 Binding of SST 1 67 0.48 24.66 32.67
139 INT14497 Gene_expression of GRP 1 82 0.78 17.67 32.27
140 INT35406 Localization of Tnf 2 94 0.81 64.63 31.65
141 INT9347 Localization of Il1b 1 58 0.81 26.13 31.53
142 INT608 Negative_regulation of KNG1 1 98 0.43 72.36 31.23
143 INT2278 Regulation of Localization of Gast 7 81 0.62 16.93 30.64
144 INT11650 Negative_regulation of Gpt 2 122 0.59 69.15 30.36
145 INT77652 Negative_regulation of Gene_expression of IL8 3 99 0.59 67.57 30.21
146 INT9133 Negative_regulation of Positive_regulation of Prkcg 1 37 0.59 10.95 30.06
147 INT28 Regulation of Gast 8 106 0.62 26.37 29.85
148 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
149 INT7412 Positive_regulation of SST 3 71 0.70 24.44 29.48
150 INT91 Positive_regulation of Localization of Gast 3 96 0.70 23.22 29.36
151 INT5300 Regulation of Insr 3 54 0.60 11.33 29.26
152 INT4868 Gene_expression of GAL 1 75 0.78 22.23 29.02
153 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
154 INT48853 Positive_regulation of BDNF 1 82 0.69 43.92 27.99
155 INT9296 Negative_regulation of PLEK 1 100 0.57 36.65 27.52
156 INT7894 Negative_regulation of Vip 1 59 0.59 11.76 27.36
157 INT703 Positive_regulation of Pth 1 177 0.70 127.09 27.26
158 INT17331 Positive_regulation of JUN 2 132 0.69 60.4 27.03
159 INT7281 Binding of Sst 1 42 0.48 5.48 26.57
160 INT10273 Positive_regulation of Gene_expression of Il1b 1 47 0.68 31.15 26.21
161 INT53949 Positive_regulation of Gene_expression of Cpox 1 82 0.65 38.12 25.93
162 INT50490 Regulation of PTGS2 1 80 0.48 39.51 25.85
163 INT5622 Gene_expression of Nppa 1 101 0.78 49.46 25.31
164 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
165 INT17625 Localization of GCG 2 210 0.80 55.69 24.97
166 INT29 Negative_regulation of Gast 2 74 0.59 24.85 24.96
167 INT10836 Negative_regulation of IL8 1 95 0.59 52.59 24.71
168 INT288 Positive_regulation of Sct 3 88 0.70 32.83 24.5
169 INT47459 Gene_expression of Rac1 2 101 0.68 45.27 24.33
170 INT18400 Localization of Glp1r 8 97 0.80 11.96 24.32
171 INT96557 Binding of Bdnf 2 46 0.47 21.74 24.26
172 INT70503 Regulation of Gene_expression of Nos2 1 71 0.62 44 24.01
173 INT58301 Positive_regulation of Mpo 2 87 0.70 80.19 23.99
174 INT66026 Gene_expression of Cxcl1 1 74 0.78 31.87 23.37
175 INT15458 Gene_expression of NPY 1 50 0.76 22.67 23.03
176 INT1221 Regulation of SGCG 4 65 0.60 24.21 22.94
177 INT76123 Gene_expression of Lep 3 193 0.78 94.17 22.76
178 INT66208 Positive_regulation of Positive_regulation of NFKB1 1 45 0.68 20.17 22.62
179 INT103842 Gene_expression of Cftr 2 53 0.78 59.59 21.82
180 INT693 Negative_regulation of Localization of SST 1 46 0.59 8.57 21.75
181 INT14700 Regulation of IFNA1 1 111 0.45 66.16 21.52
182 INT74059 Positive_regulation of Gene_expression of Nos1 1 55 0.70 11.5 21.39
183 INT5096 Positive_regulation of Gtf3a 1 79 0.60 42.26 20.62
184 INT12951 Negative_regulation of Cat 1 126 0.57 64.39 20.61
185 INT6699 Positive_regulation of ADRA1D 1 65 0.70 22.72 20.31
186 INT27018 Gene_expression of PTGER1 5 68 0.75 31.76 20.12
187 INT7253 Negative_regulation of Localization of Gast 6 70 0.59 21.06 20.06
188 INT46016 Gene_expression of Ngfr 2 69 0.77 41.22 19.8
189 INT20305 Gene_expression of Cyp2e1 1 53 0.78 19.75 19.54
190 INT86187 Positive_regulation of AKT1 1 199 0.69 122.13 19.44
191 INT74286 Regulation of Il10 1 42 0.44 28.06 19.44
192 INT49487 Gene_expression of Sele 4 65 0.76 68.11 19.41
193 INT10565 Gene_expression of MRXS5 1 94 0.53 37.35 19.08
194 INT11509 Localization of Slc4a4 16 66 0.67 2.34 19.05
195 INT14546 Positive_regulation of Localization of Ca2 1 93 0.67 31.09 18.72
196 INT77675 Gene_expression of Saa 1 40 0.58 43.37 18.69
197 INT18010 Positive_regulation of CD40LG 1 122 0.70 100.8 18.46
198 INT10833 Regulation of Gene_expression of IL8 1 68 0.62 38.74 18.46
199 INT10286 Positive_regulation of Positive_regulation of Cck 2 20 0.70 4.05 18.46
200 INT3952 Negative_regulation of ALB 2 116 0.59 72.18 18.35
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