J:Drug Metab. Dispos.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT56458 Binding of GPM6A and IGHG3 4 5 0.02 0 3.31
2 INT129903 Nr1i2 Regulation of Cyp3a11 1 4 0.64 1.26 1.9
3 INT92369 Binding of CYP2D6 and RYBP 1 2 0.25 0.15 1.73
4 INT52076 Binding of RYBP and Abt1 1 1 0.01 0.28 1.08
5 INT145181 RYBP Positive_regulation of Gene_expression of Cyp3a62 1 1 0.02 0.07 0.86
6 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 1 0.17 0.09 0.81
7 INT90959 PPIG Regulation of CYP2C9 1 1 0.43 0 0.75
8 INT92370 Binding of CYP2B6 and CYP2D6 1 1 0.21 0 0.73
9 INT67809 Ugt2b1 Negative_regulation of Ugt2b7 1 1 0.47 0 0.7
10 INT135471 Binding of CYP2B6 and UGT2B7 1 2 0.49 0 0.63
11 INT73920 Binding of CCNT1 and CYP2B6 1 1 0.19 0.17 0.56
12 INT61660 Binding of CHAT and CYP21A2 1 1 0.00 0 0.4
13 INT112455 Binding of IGHG3 and UGT2B7 1 1 0.07 0 0.35
14 INT112456 Binding of GPM6A and UGT2B7 1 1 0.10 0 0.35
15 INT112454 UGT2B7 Positive_regulation of GPM6A 1 1 0.13 0 0.33
16 INT56633 Gusb Regulation of Mgst1 1 1 0.03 0.06 0.24
17 INT56632 Ugt2b17 Regulation of Mgst1 1 1 0.04 0.06 0.24
18 INT87092 Binding of PPP4C and MBD2 1 1 0.05 0 0.16
19 INT65883 Binding of CYP1A1 and PPP4C 1 2 0.02 0 0.15
20 INT120866 Binding of UGT2B4 and UGT2B7 1 1 0.39 0 0.11
21 INT64188 ART3 Negative_regulation of HSD17B2 1 1 0.00 0 0.09
22 INT145622 Binding of PKLR and UGT1A3 1 1 0.01 0 0.06
23 INT145623 Binding of PKLR and UGT2B4 1 1 0.02 0 0.06
24 INT145626 Binding of PKLR and UGT1A1 1 1 0.02 0 0.06
25 INT145621 Binding of PKLR and UGT2B7 1 1 0.02 0 0.06
26 INT145624 Binding of PKLR and UGT1A9 1 1 0.02 0 0.06
27 INT145625 Binding of PKLR and UGT2B17 1 1 0.01 0 0.06
28 INT100609 Gnrhr Regulation of Cyp2c22 1 2 0.02 0.19 0
29 INT87093 CYP3A Positive_regulation of Protein_catabolism of PPP4C 1 1 0.36 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
2 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
3 INT1395 Negative_regulation of Penk 2 537 0.59 87.33 389.81
4 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
5 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
6 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
7 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
8 INT293 Protein_catabolism of Penk 3 161 1.00 11.71 98.45
9 INT77435 Positive_regulation of Nos2 3 343 0.70 208.49 91.43
10 INT22967 Positive_regulation of RYBP 6 94 0.56 37.04 85.92
11 INT8962 Gene_expression of Cpe 1 110 0.71 39.67 71.67
12 INT15613 Negative_regulation of Ptgs2 2 160 0.59 71.08 65.08
13 INT5095 Localization of Ghrh 1 185 0.81 28.09 62.08
14 INT546 Binding of ALB 3 311 0.48 85.98 60.14
15 INT18883 Negative_regulation of RYBP 10 53 0.56 21.14 57.52
16 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
17 INT11180 Binding of RYBP 7 52 0.46 13.86 42.53
18 INT48075 Positive_regulation of Il1b 1 71 0.67 48.63 40.48
19 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
20 INT56870 Gene_expression of CYP2D6 14 87 0.78 8.83 37.53
21 INT2416 Negative_regulation of MAOA 1 92 0.59 42.24 36.5
22 INT10796 Gene_expression of CYP2B6 29 131 0.77 30.14 35.27
23 INT234 Binding of Alb 2 151 0.48 52.34 32.97
24 INT22939 Gene_expression of Csf2 1 164 0.78 85.1 32.22
25 INT10684 Negative_regulation of Protein_catabolism of Penk 1 41 0.59 2.33 28.63
26 INT22211 Positive_regulation of CYP3A4 5 110 0.70 22 28.27
27 INT3760 Positive_regulation of ALB 2 142 0.70 87.46 26.7
28 INT18884 Regulation of RYBP 2 25 0.38 11.43 23.2
29 INT1221 Regulation of SGCG 1 65 0.60 24.21 22.94
30 INT47859 Negative_regulation of Cyp2e1 3 41 0.59 16.92 21.72
31 INT28001 Gene_expression of Gpm6a 1 23 0.66 16.66 21.09
32 INT8765 Positive_regulation of Cyp3a23/3a1 2 63 0.67 22.28 20.39
33 INT52457 Gene_expression of ABCB1 3 129 0.78 38.68 19.88
34 INT20305 Gene_expression of Cyp2e1 2 53 0.78 19.75 19.54
35 INT712 Positive_regulation of LDHA 2 160 0.70 175.25 19.11
36 INT56749 Gene_expression of PCNA 2 219 0.77 111.25 18.42
37 INT4420 Positive_regulation of GOT1 2 103 0.64 88.4 18.38
38 INT14111 Positive_regulation of Cyp2c22 4 41 0.67 7.24 17.88
39 INT73362 Negative_regulation of Abcb1a 3 46 0.59 8.78 17.81
40 INT53393 Positive_regulation of Cyp3a62 1 25 0.70 7.56 17.69
41 INT8056 Regulation of Positive_regulation of Penk 1 34 0.59 4.71 17.66
42 INT50579 Binding of CYP3A4 1 84 0.48 17.52 17.45
43 INT50404 Negative_regulation of CYP1A2 1 49 0.59 8.61 17.35
44 INT10056 Positive_regulation of Fabp6 1 77 0.59 36.99 16.8
45 INT4853 Regulation of Hrh2 1 42 0.45 22.34 16.65
46 INT20336 Positive_regulation of CYP2E1 4 48 0.70 19.26 15.66
47 INT59929 Negative_regulation of CYP2C9 4 60 0.59 16.33 15.39
48 INT505 Positive_regulation of GPT 2 89 0.67 69.38 14.94
49 INT9904 Gene_expression of CYP2E1 3 64 0.78 13.11 14.65
50 INT20611 Gene_expression of Asap1 1 55 0.65 23.71 14.62
51 INT19408 Negative_regulation of Cyp2c22 9 37 0.59 6.23 14.22
52 INT46797 Negative_regulation of Cyp3a62 4 27 0.59 7.06 13.97
53 INT18773 Localization of ALB 2 117 0.80 69.18 13.8
54 INT55874 Binding of GPM6A 3 20 0.34 4.2 13.63
55 INT67855 Negative_regulation of PPIG 1 64 0.57 17.83 13.54
56 INT53747 Positive_regulation of Cyp2e1 4 34 0.70 29.03 13.39
57 INT20495 Regulation of Protein_catabolism of Penk 2 17 0.62 0.96 13.3
58 INT62441 Gene_expression of ABCC1 3 56 0.78 21.01 12.93
59 INT60865 Gene_expression of G2e3 1 20 0.73 2.1 12.76
60 INT152 Negative_regulation of MBD2 4 31 0.38 3.95 11.31
61 INT10798 Positive_regulation of CYP2D6 3 24 0.56 5.82 11.31
62 INT71189 Gene_expression of Cyp1a2 1 24 0.78 11.39 11.12
63 INT62580 Gene_expression of Cyp2e1 3 31 0.78 15.4 11.08
64 INT70877 Gene_expression of PPIG 6 72 0.75 22.39 10.93
65 INT16449 Binding of IGHG3 4 67 0.48 39.55 10.59
66 INT19010 Negative_regulation of Localization of Ghrh 1 27 0.57 4.85 10.5
67 INT54473 Binding of ABCB1 2 30 0.48 8.65 10.38
68 INT55418 Regulation of CYP2D6 4 29 0.61 1.83 10.21
69 INT47860 Negative_regulation of Cyp1a2 2 20 0.57 6.06 10
70 INT104502 Gene_expression of Abcc2 9 26 0.78 8.37 9.65
71 INT68372 Regulation of CYP2C9 1 28 0.62 5.64 9.53
72 INT53746 Regulation of Cyp2e1 1 11 0.62 3.82 9.52
73 INT104499 Gene_expression of Abcc3 10 16 0.78 1.67 9.34
74 INT57665 Negative_regulation of Cyp2e1 4 35 0.59 8.05 9.29
75 INT3703 Negative_regulation of Grhpr 1 38 0.50 11.43 9.2
76 INT1224 Gene_expression of Fabp6 1 34 0.64 23.69 9.08
77 INT107087 Positive_regulation of Gene_expression of Cyp2e1 1 20 0.70 8.89 9.04
78 INT13467 Positive_regulation of ABCB1 2 36 0.68 9.68 8.95
79 INT82839 Negative_regulation of ABCB1 2 61 0.59 16.09 8.83
80 INT28181 Regulation of H2-M3 1 7 0.07 0.82 8.38
81 INT61599 Positive_regulation of CYP2C9 5 43 0.69 11.1 8.33
82 INT116121 Binding of Nfx1 7 1 0.41 0 8.06
83 INT19947 Negative_regulation of B3GAT2 2 10 0.57 4.2 7.95
84 INT12334 Positive_regulation of CYP3A 1 34 0.70 6.77 7.85
85 INT13675 Gene_expression of Cyp2c22 8 23 0.39 4.52 7.71
86 INT57922 Gene_expression of CYP2C9 6 65 0.78 22.24 7.53
87 INT113 Positive_regulation of MBD2 6 33 0.49 6.76 7.49
88 INT80981 Regulation of Abcb1a 2 19 0.62 1.86 7.2
89 INT22834 Negative_regulation of CYP21A2 2 28 0.58 23.07 7.13
90 INT58625 Gene_expression of Ugt2b1 6 19 0.77 1.95 7.05
91 INT63057 Regulation of CYP3A4 4 31 0.61 5.75 6.92
92 INT76025 Positive_regulation of Cyp3a11 5 20 0.69 5.88 6.91
93 INT18778 Gene_expression of Ugt1a2 1 17 0.35 9.91 6.87
94 INT270 Regulation of MAOA 1 17 0.60 2.58 6.84
95 INT17145 Binding of Cyp2c22 2 19 0.42 1.39 6.8
96 INT12333 Regulation of CYP3A 1 18 0.62 2.25 6.74
97 INT17143 Regulation of Cyp2c22 1 18 0.60 3.02 6.7
98 INT83745 Gene_expression of SULT2A1 2 34 0.59 15.96 6.66
99 INT7873 Positive_regulation of Ugt2b 4 36 0.70 0.72 6.59
100 INT1280 Negative_regulation of Pebp1 1 7 0.28 2.12 6.45
101 INT2039 Regulation of CYP2B6 4 30 0.60 7.75 6.43
102 INT112459 Localization of Gba 3 12 0.80 1.45 6.4
103 INT61238 Negative_regulation of Cyp2d2 3 4 0.58 0 6.38
104 INT13683 Regulation of Ugt1a6 1 9 0.28 2.5 6.33
105 INT20612 Positive_regulation of Asap1 1 36 0.68 24.35 6.06
106 INT129901 Gene_expression of Nr1i2 1 60 0.73 22.44 6.04
107 INT20331 Positive_regulation of CYP1A2 2 31 0.69 8.6 5.92
108 INT69316 Gene_expression of Cyp3a62 2 9 0.78 0.84 5.79
109 INT13685 Positive_regulation of Ugt2b17 1 13 0.69 3.3 5.75
110 INT104504 Positive_regulation of Gene_expression of Abcc3 6 9 0.70 0.42 5.57
111 INT185 Regulation of Cyp1a1 2 18 0.54 2.71 5.56
112 INT28000 Negative_regulation of Gpm6a 1 4 0.31 3.49 5.52
113 INT28088 Binding of Alb 1 34 0.47 11.06 5.48
114 INT62579 Negative_regulation of Gene_expression of Cyp2e1 1 8 0.59 2.95 5.48
115 INT18772 Positive_regulation of Gene_expression of CYP2B6 3 14 0.49 2.93 5.4
116 INT101168 Gene_expression of Tbpl1 1 23 0.75 10.88 5.38
117 INT23952 Gene_expression of Cyp2d4 1 18 0.78 4.76 5.31
118 INT78914 Positive_regulation of ABCC1 3 19 0.67 7.99 5.18
119 INT2435 Negative_regulation of Cyp1a1 2 15 0.58 3.32 5.16
120 INT186 Positive_regulation of Cyp1a1 2 30 0.70 5 5.02
121 INT71418 Binding of CES1 1 42 0.40 29.78 5.01
122 INT78890 Negative_regulation of UGT2B7 3 10 0.59 0.26 4.79
123 INT30925 Gene_expression of Mif-ps1 1 6 0.73 1.63 4.74
124 INT18779 Negative_regulation of Binding of RYBP 1 5 0.41 1.01 4.74
125 INT112458 Localization of Selenbp2 1 4 0.04 1.1 4.74
126 INT2848 Localization of ABCA1 1 23 0.70 10.64 4.73
127 INT61245 Positive_regulation of Cyp2b2 1 9 0.64 0.41 4.7
128 INT114718 Positive_regulation of Gene_expression of CYP3A4 1 17 0.49 4.69 4.69
129 INT54257 Binding of H2-M3 1 5 0.03 0.71 4.68
130 INT37652 Positive_regulation of Pgr 1 29 0.59 9.09 4.67
131 INT122419 Transcription of ABCC1 4 10 0.70 4.45 4.61
132 INT65881 Gene_expression of CYP2C19 5 21 0.76 1.19 4.57
133 INT125378 Gene_expression of UPB1 1 4 0.59 0.25 4.49
134 INT52088 Binding of Cyp2e1 3 8 0.48 2.5 4.43
135 INT20496 Positive_regulation of Protein_catabolism of Penk 1 7 0.50 0.86 4.42
136 INT30031 Gene_expression of Hba-a1 4 7 0.60 7.46 4.41
137 INT89233 Gene_expression of Abcc1 1 21 0.77 9.2 4.36
138 INT50581 Regulation of PPIG 2 26 0.55 8.96 4.32
139 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 3 7 0.50 2.39 4.31
140 INT57645 Gene_expression of GSTK1 1 54 0.62 21.05 4.2
141 INT20303 Regulation of Cyp2e1 2 11 0.61 2.46 3.84
142 INT120596 Gene_expression of ABCC4 1 11 0.78 2.51 3.76
143 INT112 Gene_expression of Pdia3 1 11 0.74 0.18 3.74
144 INT53395 Positive_regulation of Cyp2c6 1 6 0.70 0.07 3.73
145 INT50022 Positive_regulation of G2e3 1 10 0.42 0.47 3.72
146 INT116119 Gene_expression of Nfx1 3 1 0.75 0 3.72
147 INT1645 Negative_regulation of CSH1 3 20 0.42 1.71 3.7
148 INT187 Positive_regulation of Ephx1 6 17 0.69 0.51 3.69
149 INT18881 Binding of Asap1 1 7 0.41 4.28 3.66
150 INT100893 Positive_regulation of ABCC3 1 8 0.64 4.66 3.65
151 INT88549 Regulation of SLC35A2 1 8 0.60 0.7 3.52
152 INT14110 Positive_regulation of Positive_regulation of Cyp2c22 1 6 0.67 1.45 3.45
153 INT120865 Regulation of Cyp3a62 2 5 0.62 0.07 3.4
154 INT10059 Binding of CSH1 3 17 0.35 5.28 3.37
155 INT73251 Regulation of UGT2B7 3 5 0.62 0.21 3.35
156 INT8764 Positive_regulation of Positive_regulation of Cyp3a23/3a1 1 5 0.45 1.62 3.33
157 INT65120 Regulation of Ugt1a1 1 3 0.45 1.07 3.29
158 INT184 Regulation of Ephx1 1 10 0.60 0.54 3.27
159 INT66077 Regulation of CHPT1 1 12 0.38 6.1 3.23
160 INT55002 Gene_expression of ASAP1 1 46 0.64 22.8 3.2
161 INT76024 Negative_regulation of Cyp3a11 1 7 0.53 2.96 3.16
162 INT53388 Negative_regulation of Cyp2c11 3 18 0.53 2.66 3.11
163 INT29929 Gene_expression of Rb1 1 20 0.69 5.81 3.1
164 INT22944 Regulation of Grhpr 1 12 0.26 0.78 3
165 INT78891 Binding of UGT2B7 3 7 0.48 0.23 2.89
166 INT28934 Negative_regulation of Gene_expression of Cyp2c22 2 9 0.12 2.15 2.86
167 INT145180 Positive_regulation of Gene_expression of Cyp3a62 2 2 0.57 0.3 2.85
168 INT53656 Negative_regulation of SLC35A2 1 5 0.57 0.5 2.81
169 INT9853 Negative_regulation of Ugt2b 1 7 0.54 1.74 2.8
170 INT61231 Gene_expression of SULT1A1 8 14 0.75 3.01 2.76
171 INT90960 Positive_regulation of Gene_expression of CYP2D6 1 9 0.50 2.06 2.76
172 INT35946 Positive_regulation of Clu 3 12 0.69 4.92 2.73
173 INT145270 Gene_expression of ABCG2 2 19 0.75 7.87 2.69
174 INT89234 Positive_regulation of Gene_expression of Abcc1 1 10 0.50 3.56 2.66
175 INT111272 Gene_expression of ERPL1 4 3 0.14 0 2.64
176 INT74949 Protein_catabolism of Gpm6a 3 1 0.63 0 2.63
177 INT51753 Negative_regulation of Tfrc 2 7 0.41 3.47 2.62
178 INT20304 Transcription of Cyp2e1 1 11 0.70 2.5 2.57
179 INT58624 Positive_regulation of Ugt2b1 2 5 0.69 0.22 2.5
180 INT99409 Positive_regulation of SLC35A2 3 5 0.67 0.27 2.45
181 INT44979 Positive_regulation of Pnp 3 11 0.59 5.61 2.41
182 INT134504 Regulation of Gene_expression of Abcc3 2 4 0.57 0.47 2.39
183 INT80391 Negative_regulation of Cyp2b2 1 4 0.54 0.12 2.36
184 INT131332 Negative_regulation of Gene_expression of Abcc2 4 7 0.58 1.25 2.35
185 INT13684 Positive_regulation of Gss 2 5 0.40 0.44 2.32
186 INT129902 Regulation of Nr1i2 1 16 0.58 6.3 2.31
187 INT52785 Localization of G2e3 1 5 0.66 0.33 2.26
188 INT27644 Gene_expression of BRD2 1 23 0.65 6.97 2.23
189 INT125377 Localization of CYP2B6 1 5 0.78 0.59 2.23
190 INT13267 Binding of Pgr 1 15 0.40 3.5 2.22
191 INT10651 Positive_regulation of Ugt2b7 1 5 0.67 0.16 2.22
192 INT69314 Binding of CYP3A 1 16 0.48 1.78 2.19
193 INT3394 Negative_regulation of HPP1 1 5 0.42 1.14 2.16
194 INT143686 Negative_regulation of Gene_expression of CYP2D6 2 4 0.58 0.83 2.16
195 INT3723 Binding of PON1 1 9 0.46 5.83 2.13
196 INT53392 Positive_regulation of Cyp2b1 2 8 0.68 0.68 2.13
197 INT4125 Gene_expression of Gusb 1 6 0.62 2.32 2.13
198 INT52072 Negative_regulation of Ces1c 1 6 0.31 1.37 2.13
199 INT80862 Negative_regulation of CYP3A5 1 5 0.57 1.66 2.13
200 INT38374 Regulation of MBD2 3 8 0.10 0.72 2.09
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