J:Drug design, development and therapy

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 2 0.52 12.7 7.73
2 INT155484 Binding of CD86 and CTLA4 15 2 0.52 8.85 6.09
3 INT194647 Binding of CD28 and CD80 15 1 0.40 4.9 3.22
4 INT186126 Binding of CD28 and CTLA4 9 2 0.52 4.13 3.12
5 INT54972 Binding of EDNRA and EDNRB 7 2 0.52 3.31 0.97
6 INT278827 Binding of EDN1 and EDNRB 3 5 0.17 2.7 0.67
7 INT178097 Binding of EDN1 and EDNRA 7 3 0.21 5.97 0.62
8 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 2 0.16 1.24 0.49
9 INT158400 Binding of CD80 and CD86 3 1 0.36 0.76 0.48
10 INT284229 Binding of ITIH4 and Ccr5 1 2 0.10 0.27 0.31
11 INT284137 EDNRB Regulation of EDNRA 1 1 0.07 0.09 0.3
12 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 1 0.12 0.45 0.22
13 INT284142 ERAS Regulation of PAH 1 1 0.10 0.55 0.2
14 INT284138 ERAS Regulation of Positive_regulation of PAH 1 1 0.10 0.55 0.2
15 INT244093 Binding of C2 and Arhgap4 3 1 0.23 0.38 0.19
16 INT345924 IL6 Regulation of Gene_expression of SPHAR 1 1 0.00 0.21 0.18
17 INT284230 Positive_regulation of Binding of ITIH4 and Ccr5 1 1 0.10 0 0.17
18 INT284213 Binding of Cd4 and Mela 1 1 0.06 0.6 0.14
19 INT284224 Binding of Cd4 and Hivan1 1 1 0.01 0.6 0.14
20 INT284226 Negative_regulation of Binding of Ccr5 and Hivan1 1 1 0.01 0.27 0.14
21 INT284217 Binding of Ccr5 and Hivan1 1 1 0.01 0.27 0.14
22 INT284219 Binding of Ccr5 and Avpr1b 1 1 0.01 0.46 0.12
23 INT284214 Binding of Cd4 and Eclc 1 1 0.05 0.37 0.12
24 INT284218 Binding of Cxcr4 and Avpr1b 1 1 0.00 0.46 0.12
25 INT284211 Binding of Avpr1b and Eclc 1 1 0.00 0.46 0.12
26 INT284215 Binding of C2 and Eclc 1 1 0.01 0.37 0.12
27 INT284228 Binding of ITIH4 and Eclc 1 1 0.02 0.29 0.12
28 INT284208 Binding of Ccr5 and Eclc 1 1 0.08 0.3 0.12
29 INT284223 Positive_regulation of Binding of Avpr1b and Eclc 1 1 0.00 0.46 0.12
30 INT284140 Binding of EDNRB and PAH 1 1 0.08 0.1 0.1
31 INT284220 Binding of Ccr5 and Mela 1 2 0.12 0.23 0.1
32 INT284141 Binding of EDNRA and PAH 1 1 0.05 0.1 0.09
33 INT284222 Binding of Ccr5 and Musd1 1 2 0.01 0.5 0.07
34 INT284210 Binding of C2 and Cd4 1 1 0.03 0.32 0.07
35 INT284216 Binding of Ccr5 and Arhgap4 1 1 0.02 0.31 0.07
36 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 1 0.13 0.18 0.06
37 INT284209 Negative_regulation of Binding of Ccr5 and Mela 1 1 0.14 0.12 0.05
38 INT185756 Binding of ITIH4 and Cd4 2 1 0.05 1.22 0.04
39 INT284212 Binding of Cd4 and Musd1 1 1 0.01 0.26 0.04
40 INT284225 Binding of Cd4 and Ccr5 1 1 0.30 0.26 0.04
41 INT331897 Binding of PDE5A and Pde5a 1 1 0.02 0.64 0.03
42 INT284221 Binding of Mela and Avpr1b 1 1 0.00 0.07 0
43 INT349079 Binding of CD80 and Cd86 1 1 0.22 0 0
44 INT284143 EDN1 Positive_regulation of CA2 1 1 0.03 0.37 0
45 INT313871 Pde5a Positive_regulation of Pah 1 1 0.49 0.97 0
46 INT349050 Binding of EPCAM and ZNF845 1 2 0.02 1.54 0
47 INT284232 Binding of TP53 and HNRNPUL1 1 1 0.26 0.88 0
48 INT349077 Binding of HLA-E and KLRD1 1 1 0.00 0.16 0
49 INT284231 Binding of TP53 and C4orf3 1 1 0.02 0.88 0
50 INT284184 Binding of Akt1 and Pdgfrb 1 1 0.00 0.14 0
51 INT349051 Binding of EPCAM and SCFV 1 1 0.03 1.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
2 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
3 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
4 INT1045 Localization of LH 1 1211 0.81 87.04 456.25
5 INT9238 Gene_expression of IL6 6 1575 0.78 1135.66 424.22
6 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
7 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
8 INT49750 Negative_regulation of CPOX 2 735 0.58 360.06 274.19
9 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
10 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
11 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
12 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
13 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
14 INT10194 Positive_regulation of IL6 3 702 0.70 600.62 183.38
15 INT15516 Gene_expression of Crp 2 711 0.77 615.33 173.09
16 INT867 Gene_expression of IFNA1 3 930 0.78 594.85 168.03
17 INT867 Gene_expression of IFNA1 4 930 0.78 594.85 168.03
18 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
19 INT9852 Positive_regulation of Gpt 3 563 0.70 364.64 146.82
20 INT5116 Gene_expression of IL2 2 670 0.78 291.13 146.69
21 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
22 INT812 Localization of INS 12 1026 0.81 515.6 145.31
23 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
24 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
25 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
26 INT11051 Positive_regulation of Gene_expression of IL6 4 415 0.69 319.21 109.3
27 INT3038 Gene_expression of INS 7 1583 0.78 1174.16 107.01
28 INT65500 Gene_expression of App 1 605 0.78 429.94 98.31
29 INT4860 Positive_regulation of CALCA 1 148 0.00 73.35 97.61
30 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
31 INT15913 Negative_regulation of CYP2D6 3 174 0.59 22.45 70.91
32 INT50971 Gene_expression of Ntrk1 1 180 0.75 73.52 62.28
33 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
34 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
35 INT103924 Positive_regulation of Akt1 1 359 0.69 158.94 60.34
36 INT546 Binding of ALB 1 311 0.48 85.98 60.14
37 INT546 Binding of ALB 1 311 0.48 85.98 60.14
38 INT48901 Negative_regulation of IL6 5 186 0.57 136.33 57.87
39 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
40 INT78899 Gene_expression of CCL5 1 155 0.77 84.02 55.09
41 INT50405 Negative_regulation of CYP3A4 2 238 0.59 53.65 51.51
42 INT50405 Negative_regulation of CYP3A4 3 238 0.59 53.65 51.51
43 INT8490 Negative_regulation of CALCA 2 87 0.59 29.73 51.34
44 INT20382 Gene_expression of Hand2 3 211 0.66 142.26 51.05
45 INT1199 Positive_regulation of INS 2 579 0.70 399.64 50.43
46 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
47 INT117598 Regulation of ACR 1 118 0.26 41.25 48.01
48 INT1322 Positive_regulation of Localization of INS 16 293 0.70 120.86 45.98
49 INT145266 Gene_expression of IL17A 1 154 0.75 109.83 45.33
50 INT6979 Positive_regulation of CA2 3 206 0.67 50.79 44.97
51 INT18522 Positive_regulation of Gene_expression of IFNA1 3 248 0.67 160.85 44.87
52 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
53 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
54 INT73502 Positive_regulation of IL10 2 154 0.69 124.87 43.5
55 INT13556 Gene_expression of CD4 1 367 0.78 230.82 41.74
56 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
57 INT3252 Negative_regulation of INS 8 428 0.59 271.65 39.52
58 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
59 INT56870 Gene_expression of CYP2D6 3 87 0.78 8.83 37.53
60 INT56870 Gene_expression of CYP2D6 1 87 0.78 8.83 37.53
61 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
62 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
63 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
64 INT3253 Negative_regulation of Localization of INS 2 205 0.59 130.39 36.61
65 INT17736 Gene_expression of Cfp 4 111 0.65 40.68 36.61
66 INT2416 Negative_regulation of MAOA 1 92 0.59 42.24 36.5
67 INT10796 Gene_expression of CYP2B6 1 131 0.77 30.14 35.27
68 INT72651 Gene_expression of TH1L 1 114 0.75 80.15 35.15
69 INT2274 Regulation of Localization of INS 1 101 0.62 41.55 34.79
70 INT8905 Gene_expression of EDN1 25 215 0.78 157.1 34.19
71 INT14559 Gene_expression of Igf1 1 254 0.78 112 34.17
72 INT49214 Gene_expression of Cd4 2 269 0.78 154.22 34.05
73 INT4403 Binding of CYP2B6 1 113 0.48 21.17 33.83
74 INT5489 Localization of CA2 2 172 0.80 39.46 33.56
75 INT234 Binding of Alb 1 151 0.48 52.34 32.97
76 INT6302 Binding of IFNA1 2 196 0.48 133.85 32.73
77 INT6302 Binding of IFNA1 4 196 0.48 133.85 32.73
78 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
79 INT62830 Gene_expression of VCAM1 2 149 0.78 125.23 32.4
80 INT132161 Gene_expression of MTX1 1 48 0.58 26.55 32.32
81 INT114881 Gene_expression of Akt1 4 227 0.78 102.49 31.81
82 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
83 INT9993 Positive_regulation of Gene_expression of IL2 1 131 0.69 46.27 30.04
84 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
85 INT28361 Gene_expression of TP53 13 443 0.78 384.86 28.8
86 INT23463 Positive_regulation of Gene_expression of CALCA 1 47 0.70 18.14 28.76
87 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
88 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
89 INT12129 Gene_expression of CYP3A4 1 107 0.78 23.11 27.6
90 INT6594 Gene_expression of HTR1D 4 60 0.75 10.15 27.13
91 INT49850 Negative_regulation of PDE4A 8 105 0.58 76.91 26.59
92 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
93 INT53482 Gene_expression of ITIH4 1 75 0.77 58.87 26.05
94 INT2040 Positive_regulation of CYP2B6 1 95 0.69 34.3 25.6
95 INT2040 Positive_regulation of CYP2B6 1 95 0.69 34.3 25.6
96 INT79979 Gene_expression of Ret 1 94 0.75 19.21 25.51
97 INT17625 Localization of GCG 3 210 0.80 55.69 24.97
98 INT12484 Binding of Drd2 3 45 0.48 15.17 24.72
99 INT23937 Gene_expression of EDNRA 4 103 0.65 55.63 24.67
100 INT147792 Gene_expression of COPD 2 230 0.70 287.13 24.1
101 INT79061 Positive_regulation of NOS2 2 92 0.65 58.89 23.96
102 INT58288 Positive_regulation of Gene_expression of Crp 1 83 0.61 82.23 23.7
103 INT50970 Positive_regulation of Ntrk1 2 51 0.57 29.38 22.83
104 INT5916 Positive_regulation of HTR1A 2 51 0.67 18.27 21.38
105 INT60779 Negative_regulation of CYP3A 1 63 0.59 8.38 21.27
106 INT76336 Negative_regulation of PDE5A 4 192 0.59 112.02 20.09
107 INT89396 Phosphorylation of AKT1 2 225 0.82 111.66 19.61
108 INT8662 Positive_regulation of EDN1 10 144 0.70 125.34 19.59
109 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
110 INT5398 Positive_regulation of ALPP 2 178 0.70 110.52 19.18
111 INT3060 Negative_regulation of Bche 2 94 0.59 46.75 18.51
112 INT4420 Positive_regulation of GOT1 7 103 0.64 88.4 18.38
113 INT68347 Negative_regulation of Cyp2d4 1 34 0.58 7.62 18.35
114 INT68347 Negative_regulation of Cyp2d4 1 34 0.58 7.62 18.35
115 INT70970 Binding of COPD 3 144 0.42 180.34 18.29
116 INT167679 Gene_expression of Ccr5 5 74 0.75 59.03 18.16
117 INT112017 Regulation of Hand2 1 77 0.36 62.23 18.04
118 INT71680 Gene_expression of CCL3 1 43 0.75 33.7 18.01
119 INT61626 Transcription of IL6 1 73 0.72 42.04 17.86
120 INT9358 Positive_regulation of HTR1B 2 26 0.67 11 17.51
121 INT50579 Binding of CYP3A4 1 84 0.48 17.52 17.45
122 INT65856 Positive_regulation of TP53 2 138 0.67 112.65 16.71
123 INT1020 Negative_regulation of BCHE 10 109 0.59 44.86 16.4
124 INT1020 Negative_regulation of BCHE 1 109 0.59 44.86 16.4
125 INT10721 Gene_expression of BDNF-AS 1 119 0.76 72.8 16.29
126 INT899 Gene_expression of F13A1 1 122 0.70 78.02 16.26
127 INT9220 Gene_expression of Ighg1 1 125 0.77 85.74 15.92
128 INT47742 Binding of Flvcr2 2 26 0.42 3.28 15.87
129 INT1752 Negative_regulation of Ache 3 109 0.59 42.05 15.73
130 INT4977 Binding of ITIH4 1 60 0.46 42.48 15.65
131 INT97245 Gene_expression of AKT1 1 217 0.77 119.63 15.59
132 INT16167 Negative_regulation of DMD 1 186 0.57 108.71 15.25
133 INT34590 Gene_expression of ALPP 1 199 0.75 89.85 15.1
134 INT16166 Positive_regulation of DMD 8 348 0.67 133.22 15.06
135 INT74449 Positive_regulation of B4GALNT1 2 53 0.30 34.49 14.96
136 INT7776 Gene_expression of Abcb1b 1 63 0.75 21.35 14.92
137 INT10709 Negative_regulation of CD4 1 106 0.59 95.6 14.89
138 INT9191 Localization of EDN1 14 94 0.81 57.01 14.78
139 INT11340 Positive_regulation of SLC17A5 1 120 0.67 113.52 14.5
140 INT8904 Positive_regulation of Gene_expression of EDN1 12 66 0.70 65.4 14.42
141 INT171134 Gene_expression of CD28 2 67 0.65 32.55 13.61
142 INT172171 Gene_expression of IL15 1 47 0.37 46.23 13.41
143 INT14572 Binding of INS 1 205 0.48 175.43 13.38
144 INT711 Positive_regulation of PIK3C2A 2 83 0.70 76.87 13.18
145 INT10016 Negative_regulation of CD8A 1 81 0.42 56.68 13.15
146 INT20376 Gene_expression of Ccl3 1 39 0.75 45.42 13.15
147 INT132178 Binding of CD80 1 41 0.47 15.55 12.98
148 INT36263 Positive_regulation of CEL 1 53 0.69 34.88 12.87
149 INT8210 Positive_regulation of Gene_expression of INS 2 188 0.68 146.57 12.83
150 INT125477 Gene_expression of HHIP 3 91 0.78 31.18 12.57
151 INT21979 Negative_regulation of EDN1 1 52 0.58 24.65 12.55
152 INT21979 Negative_regulation of EDN1 1 52 0.58 24.65 12.55
153 INT11793 Negative_regulation of CA2 1 78 0.57 19.63 12.35
154 INT9832 Gene_expression of Shbg 2 96 0.75 56.71 12.19
155 INT148207 Gene_expression of CTLA4 4 53 0.77 29.13 12.07
156 INT32203 Negative_regulation of Crp 1 48 0.58 32.77 11.89
157 INT70905 Positive_regulation of EDNRA 1 49 0.67 24.33 11.79
158 INT80756 Gene_expression of CD86 3 77 0.77 46.68 11.36
159 INT37541 Gene_expression of SPP1 4 113 0.77 68.54 11.35
160 INT4605 Negative_regulation of Gene_expression of INS 2 220 0.58 139.66 10.75
161 INT22210 Gene_expression of CYP1A2 1 45 0.78 4.95 10.66
162 INT22210 Gene_expression of CYP1A2 1 45 0.78 4.95 10.66
163 INT74272 Localization of CPOX 1 39 0.63 25.12 10.53
164 INT94454 Gene_expression of CD68 1 73 0.72 63.94 10.43
165 INT94859 Negative_regulation of Pde5a 1 67 0.43 33.66 10.28
166 INT55418 Regulation of CYP2D6 1 29 0.61 1.83 10.21
167 INT19132 Gene_expression of CYP27A1 2 83 0.75 34.31 10.17
168 INT95207 Negative_regulation of Pde5a 9 46 0.58 32.01 10.14
169 INT73504 Binding of CD28 1 35 0.45 15.99 10.04
170 INT103554 Positive_regulation of MTX1 1 19 0.45 11.23 10
171 INT19620 Binding of CD86 2 30 0.47 12.01 9.89
172 INT70134 Negative_regulation of TXK 1 124 0.23 81.96 9.59
173 INT26492 Negative_regulation of Localization of GCG 1 73 0.58 22.2 9.48
174 INT73497 Regulation of IL10 1 33 0.45 22.6 9.19
175 INT62829 Positive_regulation of VCAM1 2 39 0.70 38.42 9.15
176 INT48978 Negative_regulation of FOS 1 41 0.57 11.94 9.14
177 INT60436 Negative_regulation of COPD 1 76 0.37 84.22 9.08
178 INT23147 Negative_regulation of MRI1 2 26 0.38 14.33 8.96
179 INT3755 Positive_regulation of GBE1 1 29 0.40 8.99 8.91
180 INT150867 Regulation of COPD 1 54 0.48 71.38 8.8
181 INT144430 Gene_expression of Erbb2 1 137 0.77 103.87 8.66
182 INT2921 Positive_regulation of F8 2 53 0.59 41.56 8.56
183 INT10237 Binding of EDN1 6 40 0.48 16 8.48
184 INT15529 Gene_expression of GCG 1 51 0.75 18.55 8.35
185 INT61599 Positive_regulation of CYP2C9 1 43 0.69 11.1 8.33
186 INT17024 Gene_expression of COL1A2 1 69 0.77 36.38 8.29
187 INT39457 Positive_regulation of SOAT1 1 32 0.67 22.8 8.28
188 INT132278 Binding of CTLA4 2 32 0.39 18.69 8.17
189 INT16131 Negative_regulation of GBE1 1 37 0.30 10.32 8.15
190 INT54978 Binding of EDNRA 2 36 0.41 14.97 7.86
191 INT12334 Positive_regulation of CYP3A 1 34 0.70 6.77 7.85
192 INT69160 Positive_regulation of IL5 1 41 0.65 36.04 7.75
193 INT93914 Gene_expression of CD80 3 70 0.75 36.35 7.74
194 INT182320 Binding of MTX1 1 14 0.18 8.5 7.65
195 INT17867 Positive_regulation of Cyp1a2 1 39 0.69 2.58 7.57
196 INT65489 Regulation of Gene_expression of Crp 1 28 0.59 29.17 7.56
197 INT11823 Positive_regulation of GGT1 1 53 0.67 45.84 7.55
198 INT57922 Gene_expression of CYP2C9 1 65 0.78 22.24 7.53
199 INT78320 Gene_expression of EPCAM 8 57 0.75 50.34 7.53
200 INT17501 Negative_regulation of F2 3 70 0.58 32.23 7.51
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