J:Drugs

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT96228 COX5A Regulation of Ak1 1 1 0.01 0.6 0.6
2 INT150243 POMC Positive_regulation of Mc3r 1 1 0.05 0.88 0.52
3 INT150244 POMC Positive_regulation of Mc3r Regulation of POMC 1 1 0.03 0.88 0.52
4 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 1 0.15 0.7 0.26
5 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 1 0.11 0.7 0.26
6 INT27675 Plg Positive_regulation of Protein_catabolism of F13A1 1 1 0.00 0.75 0.2
7 INT65677 Binding of CGA and FSHR 2 1 0.25 0.29 0.16
8 INT65676 Binding of CGA and PLOD1 3 1 0.23 1.68 0.1
9 INT37547 Binding of GP1BA and F8 1 1 0.03 0.15 0.07
10 INT98350 Positive_regulation of IFNA1 Positive_regulation of SGCG 1 1 0.14 0.23 0
11 INT101591 Binding of RAC1 and RAC3 1 1 0.13 0.52 0
12 INT109502 GBE1 Negative_regulation of HIVEP1 1 2 0.00 1.85 0
13 INT98348 IFNA1 Positive_regulation of SGCG 1 1 0.14 0.22 0
14 INT98349 IFNA1 Positive_regulation of Gene_expression of SGCG 1 1 0.14 0.22 0
15 INT78634 ATM Positive_regulation of AGT 1 1 0.17 0.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 3 2008 0.81 518.3 1408.65
2 INT158 Localization of Prl 7 2431 0.81 378.96 952.2
3 INT1912 Gene_expression of Calca 2 1152 0.78 453.25 739.84
4 INT2543 Positive_regulation of Calca 1 787 0.70 331.13 592.08
5 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
6 INT50058 Negative_regulation of Cpox 17 907 0.58 426.28 428.29
7 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
8 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
9 INT157 Positive_regulation of Localization of Prl 2 790 0.70 104.54 374.78
10 INT287 Localization of Cck 1 518 0.81 86.84 364.04
11 INT439 Localization of Gnrh1 1 976 0.81 100.96 363.25
12 INT5235 Negative_regulation of TNF 4 924 0.59 772.91 331.98
13 INT5979 Gene_expression of Oprd1 1 428 0.78 75.64 320.32
14 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
15 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
16 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
17 INT1893 Localization of Gh 15 1041 0.79 340.23 256.58
18 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
19 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
20 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
21 INT528 Gene_expression of Prl 1 693 0.78 217.18 192.2
22 INT159 Negative_regulation of Localization of Prl 2 416 0.59 55.34 171.8
23 INT867 Gene_expression of IFNA1 4 930 0.78 594.85 168.03
24 INT5127 Localization of Lhb 1 488 0.80 50.48 162.66
25 INT3448 Positive_regulation of Gh 1 521 0.69 180.03 161.18
26 INT51921 Gene_expression of Cpox 1 501 0.73 229.81 157.81
27 INT6042 Binding of Oprm1 1 248 0.48 31.77 154.34
28 INT6108 Gene_expression of Npy 1 292 0.78 110.65 148.21
29 INT425 Localization of PRL 1 455 0.81 189.64 144.8
30 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
31 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
32 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
33 INT7395 Localization of GNRH1 1 399 0.81 62.88 117.68
34 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
35 INT90 Localization of Gast 9 400 0.81 137.67 113
36 INT1530 Regulation of Gh 3 382 0.61 115.96 112.47
37 INT3038 Gene_expression of INS 2 1583 0.78 1174.16 107.01
38 INT397 Localization of SST 2 232 0.81 58.05 101.19
39 INT5865 Positive_regulation of Localization of Gh 4 282 0.69 84.86 93.5
40 INT214 Localization of AVP 1 370 0.81 208.51 91.09
41 INT6437 Binding of YY1 2 154 0.47 26.3 90.46
42 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
43 INT4289 Positive_regulation of Localization of Gnrh1 1 202 0.70 12.3 84.01
44 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
45 INT1498 Gene_expression of Gh 2 521 0.75 220.84 81.16
46 INT920 Localization of PLOD1 1 223 0.81 42.25 78.7
47 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
48 INT2055 Regulation of Gnrh1 1 185 0.62 23.65 71.26
49 INT6490 Negative_regulation of ADCY1 1 145 0.58 26.25 70.96
50 INT7134 Localization of KNG1 2 127 0.79 65.73 67.97
51 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
52 INT1599 Positive_regulation of ADCY1 1 146 0.67 30.05 64.9
53 INT46 Localization of Ren 1 233 0.81 46.15 62.44
54 INT3950 Gene_expression of Ptger2 2 293 0.77 122.28 62.42
55 INT5058 Positive_regulation of IFNA1 2 356 0.70 245.75 60.52
56 INT546 Binding of ALB 1 311 0.48 85.98 60.14
57 INT3161 Regulation of Localization of Gh 4 163 0.61 35.43 59.45
58 INT1759 Gene_expression of TIMP1 1 267 0.77 133.87 59.29
59 INT48232 Gene_expression of MMP1 1 245 0.78 96.31 57.72
60 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
61 INT249 Localization of GHRH 1 215 0.80 78.02 51.87
62 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
63 INT5338 Regulation of Npy 1 92 0.62 25.54 51.24
64 INT2197 Gene_expression of Gnrh1 1 184 0.78 40.04 50.57
65 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
66 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
67 INT7093 Negative_regulation of CYP2B6 2 146 0.58 37.3 48.39
68 INT654 Localization of REN 2 250 0.81 75.12 47.86
69 INT375 Positive_regulation of REN 3 293 0.70 152.46 47.55
70 INT2262 Negative_regulation of Lhb 1 142 0.59 25.47 44.81
71 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
72 INT69992 Negative_regulation of Hmox2 4 93 0.50 49.01 44.07
73 INT1894 Negative_regulation of Localization of Gh 3 168 0.58 64.12 43.56
74 INT89 Positive_regulation of Gast 2 187 0.70 80.49 42.07
75 INT29496 Gene_expression of MMP3 1 136 0.75 49.49 41.78
76 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
77 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
78 INT9094 Gene_expression of COL7A1 1 277 0.77 143.42 38.73
79 INT65889 Gene_expression of RETNLB 1 73 0.34 60.98 38.3
80 INT11854 Gene_expression of Il1rl1 1 57 0.77 30.19 38.25
81 INT385 Gene_expression of Agt 1 182 0.78 63.62 37.91
82 INT4449 Positive_regulation of NA 1 179 0.55 40.26 37.82
83 INT11439 Positive_regulation of Csf2 1 105 0.69 62.63 37.77
84 INT14009 Gene_expression of Sst 1 66 0.77 19.6 37.3
85 INT48222 Positive_regulation of Localization of IL8 1 123 0.59 78.04 37.2
86 INT5711 Positive_regulation of Localization of Lhb 1 90 0.70 10.92 36.76
87 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
88 INT390 Positive_regulation of Agt 1 170 0.70 61.47 36.08
89 INT1361 Negative_regulation of Gnrhr 2 118 0.58 57.77 35.54
90 INT10796 Gene_expression of CYP2B6 2 131 0.77 30.14 35.27
91 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
92 INT4403 Binding of CYP2B6 1 113 0.48 21.17 33.83
93 INT3913 Positive_regulation of ABAT 1 47 0.69 22.73 33.4
94 INT234 Binding of Alb 1 151 0.48 52.34 32.97
95 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
96 INT1159 Negative_regulation of Agt 1 133 0.59 40.14 31.67
97 INT5069 Negative_regulation of Mthfs 3 69 0.57 22.54 31.36
98 INT608 Negative_regulation of KNG1 1 98 0.43 72.36 31.23
99 INT10285 Binding of ADRA1D 2 102 0.47 25.82 31.11
100 INT2278 Regulation of Localization of Gast 2 81 0.62 16.93 30.64
101 INT28 Regulation of Gast 3 106 0.62 26.37 29.85
102 INT7412 Positive_regulation of SST 1 71 0.70 24.44 29.48
103 INT2389 Regulation of PTGS1 2 86 0.61 31.23 28.95
104 INT16814 Negative_regulation of COX5A 3 74 0.57 33.72 28.63
105 INT10506 Gene_expression of PTAFR 1 86 0.76 37.57 28.58
106 INT5298 Negative_regulation of MTHFS 2 70 0.57 27.07 28.11
107 INT5135 Negative_regulation of GNRH1 2 106 0.58 36.63 27.71
108 INT37296 Binding of Esr1 1 117 0.43 62.51 27.33
109 INT97 Negative_regulation of Adrb1 1 102 0.59 32.44 26.9
110 INT2040 Positive_regulation of CYP2B6 1 95 0.69 34.3 25.6
111 INT48235 Negative_regulation of NPEPPS 1 72 0.46 44.54 25.03
112 INT5131 Gene_expression of GNRH1 1 109 0.78 28.79 23.94
113 INT44954 Gene_expression of APP 3 191 0.78 105.86 23.9
114 INT9292 Positive_regulation of SGCG 1 93 0.67 35.13 23.48
115 INT1221 Regulation of SGCG 1 65 0.60 24.21 22.94
116 INT825 Negative_regulation of ADRA1D 2 54 0.58 20.25 22.78
117 INT3330 Gene_expression of AGT 3 149 0.76 98.65 22.73
118 INT91891 Gene_expression of Kit 2 268 0.78 158.89 22.67
119 INT8640 Positive_regulation of HSD11B1 4 332 0.67 377.84 22.36
120 INT7715 Regulation of Drd2 2 35 0.62 10.79 22.3
121 INT39914 Negative_regulation of Cyp1a2 1 44 0.58 10.04 22
122 INT3299 Positive_regulation of AGT 2 126 0.68 79.45 21.91
123 INT693 Negative_regulation of Localization of SST 1 46 0.59 8.57 21.75
124 INT9079 Gene_expression of PPBP 1 52 0.75 31.2 21.52
125 INT2978 Gene_expression of Tbxa2r 4 76 0.77 28.4 21.27
126 INT60779 Negative_regulation of CYP3A 1 63 0.59 8.38 21.27
127 INT3593 Gene_expression of ADRA1D 1 70 0.75 29.48 20.87
128 INT49774 Binding of DRD2 1 48 0.48 17.42 20.73
129 INT8765 Positive_regulation of Cyp3a23/3a1 1 63 0.67 22.28 20.39
130 INT519 Negative_regulation of Comt 2 52 0.59 17.65 20.39
131 INT76336 Negative_regulation of PDE5A 3 192 0.59 112.02 20.09
132 INT7253 Negative_regulation of Localization of Gast 4 70 0.59 21.06 20.06
133 INT13454 Positive_regulation of Positive_regulation of Gh 1 49 0.68 14.53 18.49
134 INT4420 Positive_regulation of GOT1 2 103 0.64 88.4 18.38
135 INT9900 Positive_regulation of Vwf 1 80 0.69 51.85 18.13
136 INT1060 Negative_regulation of Pla2g1b 1 50 0.57 22.91 18.12
137 INT48 Positive_regulation of Localization of Ren 2 69 0.70 12.47 18.03
138 INT667 Negative_regulation of Hrh2 1 38 0.58 18.11 18.01
139 INT6782 Gene_expression of SCN5A 1 156 0.78 33.13 17.88
140 INT62826 Negative_regulation of Gene_expression of ICAM1 1 75 0.58 46.39 17.72
141 INT13790 Binding of HTR1A 1 52 0.47 18.83 17.59
142 INT1578 Negative_regulation of Localization of PRL 1 52 0.59 20.62 17.18
143 INT1533 Negative_regulation of AGT 3 105 0.42 46.54 16.92
144 INT213 Negative_regulation of Localization of AVP 1 46 0.59 19.78 16.79
145 INT653 Negative_regulation of Localization of REN 1 67 0.59 20.33 16.7
146 INT4853 Regulation of Hrh2 1 42 0.45 22.34 16.65
147 INT2243 Localization of GAST 1 67 0.81 34.54 16.19
148 INT7667 Regulation of Gene_expression of Npy 1 28 0.60 16.65 16.11
149 INT912 Localization of FSHR 1 91 0.79 23.61 15.58
150 INT7475 Positive_regulation of Hdl1 2 138 0.67 175.81 15.05
151 INT1888 Protein_catabolism of F13A1 1 97 0.99 63.48 14.82
152 INT170 Negative_regulation of Adrb1 2 52 0.55 13.46 14.78
153 INT663 Negative_regulation of Adrb3 4 55 0.59 15.95 14.68
154 INT34952 Regulation of ABAT 1 28 0.61 6.05 14.39
155 INT69743 Gene_expression of Hmox2 1 36 0.78 20.77 14.26
156 INT20071 Positive_regulation of HTR2A 1 33 0.67 10.89 14
157 INT35029 Positive_regulation of Gene_expression of Ptger2 2 66 0.43 26.37 13.99
158 INT18773 Localization of ALB 2 117 0.80 69.18 13.8
159 INT18012 Gene_expression of EPO 2 169 0.78 108.36 13.75
160 INT67855 Negative_regulation of PPIG 1 64 0.57 17.83 13.54
161 INT3623 Negative_regulation of CTSB 2 49 0.55 27.39 13.52
162 INT132178 Binding of CD80 1 41 0.47 15.55 12.98
163 INT30961 Binding of HTR2A 1 33 0.47 11.44 12.86
164 INT83201 Gene_expression of NOS3 3 93 0.78 47.16 12.48
165 INT29745 Binding of APP 1 47 0.48 26.49 12.4
166 INT50580 Binding of PPIG 1 39 0.36 11.17 12.34
167 INT14204 Protein_catabolism of KNG1 1 41 0.96 20.94 11.47
168 INT3597 Positive_regulation of Pla2g1b 2 37 0.63 17.94 11.41
169 INT30008 Binding of Hrh1 1 17 0.45 6.8 11.41
170 INT40486 Positive_regulation of Positive_regulation of ADCY1 1 20 0.48 4.29 11.33
171 INT10798 Positive_regulation of CYP2D6 1 24 0.56 5.82 11.31
172 INT73959 Positive_regulation of NOSTRIN 1 49 0.61 31.1 11.27
173 INT138639 Gene_expression of Hcn4 1 32 0.75 13.85 11.25
174 INT14124 Negative_regulation of Adra1a 1 34 0.59 7.48 10.85
175 INT8801 Gene_expression of Csf3 3 71 0.74 45.6 10.83
176 INT83886 Negative_regulation of HMOX2 1 27 0.43 11.69 10.78
177 INT17349 Negative_regulation of Akr1b1 2 41 0.59 27.03 10.65
178 INT20131 Negative_regulation of Mthfs 1 18 0.57 7.93 10.54
179 INT1734 Negative_regulation of HSD11B1 2 116 0.57 125.13 10.52
180 INT95207 Negative_regulation of Pde5a 3 46 0.58 32.01 10.14
181 INT2407 Regulation of GAST 1 26 0.62 5.31 10.04
182 INT59 Regulation of Adrb1 1 25 0.42 8.32 9.78
183 INT9899 Gene_expression of Vwf 1 91 0.74 45.06 9.13
184 INT23178 Gene_expression of H1 1 38 0.68 13.37 9.09
185 INT48233 Negative_regulation of Gene_expression of MMP1 1 34 0.58 12.94 9.08
186 INT58841 Gene_expression of HTR2A 2 33 0.75 9.01 9.07
187 INT49325 Gene_expression of Cd34 1 102 0.78 82.75 8.97
188 INT6019 Positive_regulation of NEUROD1 1 37 0.67 17.3 8.89
189 INT8903 Gene_expression of IFNA2 5 58 0.71 38.23 8.68
190 INT2597 Negative_regulation of ACHE 1 82 0.59 46.36 8.62
191 INT16460 Negative_regulation of PPBP 1 21 0.57 13.86 8.54
192 INT16131 Negative_regulation of GBE1 1 37 0.30 10.32 8.15
193 INT107129 Positive_regulation of RLS 1 46 0.60 40.1 8.09
194 INT846 Positive_regulation of B2M 1 42 0.70 29.78 8.06
195 INT76091 Positive_regulation of NOS3 1 48 0.61 18.4 7.92
196 INT86411 Negative_regulation of Negative_regulation of TNF 1 24 0.42 17.6 7.89
197 INT5164 Negative_regulation of Ldlr 2 83 0.58 55.01 7.87
198 INT12334 Positive_regulation of CYP3A 1 34 0.70 6.77 7.85
199 INT17686 Negative_regulation of Hdl1 1 72 0.36 81.85 7.74
200 INT72884 Positive_regulation of Tenc1 1 13 0.42 14.01 7.67
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