J:EMBO J

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT333303 Zic2 Regulation of Gene_expression of Slc6a4 1 8 0.60 0.47 0.91
2 INT333296 Gtf3a Regulation of Gene_expression of Slc6a4 1 2 0.01 0 0.74
3 INT333305 Zic2 Positive_regulation of Transcription of Slc6a4 1 2 0.68 0 0.66
4 INT333302 Zic2 Positive_regulation of Slc6a4 1 3 0.68 0.11 0.57
5 INT333309 Binding of Htr1b and Adcy1 1 2 0.01 0 0.53
6 INT312662 Binding of CSTF2 and DSE 1 5 0.06 0.1 0.53
7 INT210160 Binding of TNFRSF8 and TXN 1 17 0.47 4.16 0.48
8 INT333298 Zic2 Regulation of Transcription of Slc6a4 1 1 0.44 0.09 0.2
9 INT333299 Zic2 Regulation of Transcription of Ephb1 1 1 0.50 0.09 0.17
10 INT219601 Pde4a Negative_regulation of Twist1 1 1 0.10 0 0.16
11 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 1 0.10 0 0.16
12 INT219597 Prkaca Positive_regulation of Pde4d 1 1 0.29 0 0.15
13 INT210161 INCENP Positive_regulation of TNFRSF8 1 1 0.02 0.93 0.12
14 INT219599 Pde4d Regulation of Prkaca 1 1 0.28 0 0.12
15 INT210157 Binding of TNFRSF8 and TNFSF8 1 7 0.13 1.5 0.1
16 INT219600 Pde4d Regulation of Binding of Prkaca 1 1 0.28 0 0.09
17 INT219602 Binding of Prkaca and Pde4d 1 1 0.23 0 0.09
18 INT333308 Zic2 Positive_regulation of Transcription of Gtf3a 1 1 0.01 0.1 0.08
19 INT333304 Zic2 Positive_regulation of Gene_expression of Slc6a4 1 5 0.68 0.1 0.06
20 INT333297 Gtf3a Positive_regulation of Gene_expression of Slc6a4 1 1 0.01 0.1 0.06
21 INT210146 Binding of EGFR and TXN 1 1 0.15 0.09 0.06
22 INT210155 TXN Positive_regulation of Gene_expression of TNFRSF8 1 1 0.49 0.22 0.05
23 INT210156 Binding of TNFSF8 and TXN 1 1 0.10 0.4 0.04
24 INT210151 TNFSF8 Positive_regulation of Positive_regulation of TNFRSF8 1 1 0.14 0.14 0.04
25 INT210158 TNFSF8 Positive_regulation of TNFRSF8 1 1 0.13 0.14 0.04
26 INT333301 Binding of Slc6a4 and Zic2 1 4 0.47 0 0.03
27 INT210154 TXN Regulation of Gene_expression of FASLG 1 1 0.09 0.23 0.03
28 INT333307 Gene_expression of Zic2 Positive_regulation of Gene_expression of Slc6a4 1 1 0.45 0.05 0.03
29 INT210159 Binding of PRDX1 and TXN 1 2 0.21 0 0
30 INT219596 Binding of Pde4a and Pde4d 1 1 0.28 0.31 0
31 INT235075 Ptger2 Positive_regulation of Positive_regulation of Nos2 1 1 0.00 0.43 0
32 INT210163 Binding of FAS and TXN 1 1 0.19 0 0
33 INT333294 Binding of Zic2 and Gli1 1 1 0.03 0 0
34 INT210162 TXN Negative_regulation of TNFRSF8 1 1 0.37 0.15 0
35 INT312661 Binding of CSTF2 and CPSF3 1 1 0.06 0.08 0
36 INT312659 DSE Positive_regulation of Binding of CSTF2 and DSE 1 1 0.06 0 0
37 INT210153 Regulation of Binding of TNFRSF8 and TXN 1 2 0.44 0.49 0
38 INT210147 Binding of TXN and TNFRSF6B 1 1 0.01 0 0
39 INT333293 Binding of Zic1 and Gli1 1 1 0.01 0 0
40 INT210150 TXN Regulation of TNFRSF8 1 1 0.26 0.2 0
41 INT235077 Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 1 0.07 0.53 0
42 INT312663 DSE Positive_regulation of Regulation of MC4R 1 1 0.37 0 0
43 INT210152 Positive_regulation of Binding of TNFRSF8 and TXN 1 2 0.49 0.49 0
44 INT333306 Ephb1 Regulation of Gene_expression of Slc6a4 1 1 0.19 0.21 0
45 INT333295 Gtf3a Positive_regulation of Slc6a4 1 1 0.01 0 0
46 INT333300 Positive_regulation of Zic2 Positive_regulation of Slc6a4 1 1 0.45 0 0
47 INT210164 Binding of TXN and TXNRD1 1 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 5 3152 0.78 2515.62 929.82
2 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
3 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
4 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
5 INT66280 Gene_expression of Nos2 3 534 0.78 330.78 157.07
6 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 11 1138 0.72 311.58 119.18
7 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
8 INT15898 Positive_regulation of Prkaca 2 199 0.70 50.89 87.54
9 INT21793 Positive_regulation of Ngf 1 154 0.70 94.78 85.27
10 INT25363 Negative_regulation of Trpv1 1 144 0.59 64.78 75.7
11 INT39565 Gene_expression of Ptger2 3 424 0.75 229.28 72.68
12 INT39565 Gene_expression of Ptger2 2 424 0.75 229.28 72.68
13 INT11318 Gene_expression of Gtf3a 2 274 0.52 183.82 60.89
14 INT103924 Positive_regulation of Akt1 1 359 0.69 158.94 60.34
15 INT96914 Phosphorylation of Mapk14 1 168 0.82 108.46 53.32
16 INT106525 Phosphorylation of Akt1 5 436 0.82 183.81 47.82
17 INT66383 Phosphorylation of Prkaca 3 143 0.80 30.85 43.38
18 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
19 INT77434 Positive_regulation of Gene_expression of Nos2 2 151 0.69 96.76 38.94
20 INT30169 Negative_regulation of Pde4a 4 107 0.58 81 36.23
21 INT114881 Gene_expression of Akt1 1 227 0.78 102.49 31.81
22 INT91775 Gene_expression of Slc6a4 39 102 0.78 26.45 28.23
23 INT66381 Regulation of Prkaca 2 40 0.62 13.38 27.96
24 INT74726 Negative_regulation of Slc6a4 9 61 0.59 21.01 27.84
25 INT123035 Gene_expression of Ephb1 7 38 0.78 28.84 27.32
26 INT79395 Gene_expression of Twist1 5 193 0.77 100.06 26.34
27 INT11159 Gene_expression of EGFR 1 698 0.78 548.93 25.69
28 INT47075 Positive_regulation of Ptger2 6 142 0.70 78.55 25.47
29 INT93738 Gene_expression of Tnfrsf1a 1 63 0.74 57.66 23.09
30 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 2 134 0.61 34.87 20.15
31 INT70614 Gene_expression of FAS 3 118 0.75 112.33 19.01
32 INT113399 Positive_regulation of Pla2g4a 2 36 0.67 33.83 18.78
33 INT92733 Negative_regulation of Ephb1 1 19 0.51 8.56 17.72
34 INT256282 Gene_expression of Efnb2 1 3 0.76 17.61 16.41
35 INT108780 Positive_regulation of Gene_expression of Ptger2 3 94 0.49 59.71 16.22
36 INT108780 Positive_regulation of Gene_expression of Ptger2 1 94 0.49 59.71 16.22
37 INT124371 Negative_regulation of Gsk3b 1 170 0.55 87.92 15.51
38 INT170335 Gene_expression of INCENP 1 176 0.54 91.62 15.31
39 INT25396 Localization of Ptger2 1 83 0.78 46.81 14.81
40 INT25396 Localization of Ptger2 2 83 0.78 46.81 14.81
41 INT124372 Gene_expression of Gsk3b 2 164 0.75 95.64 14.35
42 INT109304 Positive_regulation of Phosphorylation of Akt1 3 113 0.69 40.92 13.49
43 INT100096 Regulation of Slc6a4 1 24 0.62 7.25 12.28
44 INT122053 Positive_regulation of P2rx4 1 16 0.69 13.02 11.98
45 INT135909 Positive_regulation of Ephb1 1 11 0.70 8.94 11.78
46 INT49509 Negative_regulation of Ptger2 1 53 0.42 24.87 11.66
47 INT51265 Phosphorylation of TNF 2 32 0.81 25.33 10.75
48 INT15804 Gene_expression of ISG20 1 83 0.75 44.33 10.58
49 INT6431 Positive_regulation of Ass1 1 36 0.24 8.08 10.43
50 INT73223 Gene_expression of UPF1 1 78 0.41 31.44 9.94
51 INT66382 Positive_regulation of Phosphorylation of Prkaca 2 33 0.49 7.05 9.69
52 INT168991 Negative_regulation of P2rx4 2 9 0.43 12.77 9.39
53 INT135372 Positive_regulation of Gsk3b 2 72 0.70 50.03 9.28
54 INT87193 Gene_expression of Tnfrsf1b 1 30 0.58 29.4 9.22
55 INT40609 Binding of Prkaca 1 23 0.36 3.42 9.19
56 INT105777 Gene_expression of Pde4a 7 30 0.76 12.67 8.52
57 INT80034 Positive_regulation of Gene_expression of FAS 1 32 0.67 30.34 8.51
58 INT36798 Gene_expression of Mki67 2 178 0.77 132 8.24
59 INT116605 Binding of Nos2 1 28 0.37 16.88 8.18
60 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 2 61 0.55 13.63 8.17
61 INT136177 Gene_expression of P2rx4 1 8 0.75 6.74 8.05
62 INT101189 Transcription of Gtf3a 3 49 0.17 24.39 7.93
63 INT85751 Positive_regulation of Positive_regulation of Nos2 1 40 0.60 23.53 7.72
64 INT95133 Gene_expression of FASLG 2 38 0.75 44.09 7.51
65 INT147715 Regulation of Gene_expression of Ephb1 1 6 0.62 5.26 7.49
66 INT89309 Negative_regulation of Pde4b 1 21 0.53 12.81 7.32
67 INT8101 Binding of INCENP 1 42 0.31 16.2 6.68
68 INT52311 Positive_regulation of JUNB 1 12 0.40 4.48 6.02
69 INT15132 Gene_expression of TNFRSF1A 1 33 0.75 20.09 5.93
70 INT46886 Positive_regulation of Maoa 1 12 0.69 5.29 5.9
71 INT147263 Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 2 51 0.53 15.32 5.86
72 INT136664 Positive_regulation of Gene_expression of Twist1 2 49 0.69 25.91 5.41
73 INT124370 Positive_regulation of Gene_expression of Gsk3b 1 47 0.67 24.56 5.4
74 INT144735 Gene_expression of DDC 3 8 0.75 3.21 5.31
75 INT87022 Gene_expression of Apc 3 68 0.67 46.98 5.22
76 INT105775 Gene_expression of Pde4d 20 31 0.78 4.18 5.21
77 INT119711 Positive_regulation of Slc6a4 7 16 0.69 4.44 5.21
78 INT135374 Binding of Gsk3b 1 46 0.48 24.36 4.75
79 INT121471 Negative_regulation of Pde3a 2 24 0.34 13.79 4.73
80 INT122675 Negative_regulation of Gene_expression of Slc6a4 1 14 0.59 6.4 4.69
81 INT134657 Localization of Akt1 1 37 0.68 11.58 4.62
82 INT57691 Regulation of Gene_expression of Ptger2 1 23 0.40 17.08 4.61
83 INT96492 Gene_expression of NGFR 1 24 0.00 12.3 4.59
84 INT35765 Gene_expression of TXNRD1 2 47 0.56 9.16 4.43
85 INT39060 Gene_expression of Mpz 2 45 0.77 21.55 4.3
86 INT9098 Positive_regulation of DBP 1 30 0.69 15.77 4.26
87 INT167284 Phosphorylation of Gsk3b 8 88 0.82 36.03 4.21
88 INT126659 Gene_expression of Tph1 2 22 0.78 2.04 4.04
89 INT3817 Negative_regulation of Apc 2 29 0.58 22.12 3.91
90 INT105779 Gene_expression of Pde4b 1 7 0.73 3.33 3.91
91 INT2397 Gene_expression of Maoa 1 12 0.77 11.85 3.88
92 INT103021 Transcription of Slc6a4 12 16 0.70 3.93 3.77
93 INT116623 Localization of Prkaca 1 15 0.73 2.89 3.59
94 INT86082 Localization of Htr1b 1 4 0.73 2.77 3.46
95 INT171233 Binding of Ecm1 1 25 0.07 12.41 3.36
96 INT25393 Positive_regulation of Localization of Ptger2 2 19 0.32 9.69 3.23
97 INT25393 Positive_regulation of Localization of Ptger2 1 19 0.32 9.69 3.23
98 INT66599 Gene_expression of MC4R 3 16 0.78 12.37 3.12
99 INT68961 Positive_regulation of Positive_regulation of Ptger2 1 12 0.44 6.91 3.02
100 INT124438 Regulation of Gene_expression of Slc6a4 4 9 0.62 3.5 2.97
101 INT219564 Positive_regulation of Zglp1 2 18 0.46 5.19 2.87
102 INT116540 Binding of Twist1 3 35 0.48 16.32 2.85
103 INT212394 Gene_expression of Zic2 41 44 0.78 2.88 2.82
104 INT57957 Localization of TXNRD1 2 14 0.64 4.01 2.7
105 INT89852 Localization of Nos2 3 22 0.78 14.89 2.56
106 INT76341 Negative_regulation of Positive_regulation of Ptger2 1 12 0.25 6.63 2.42
107 INT27230 Gene_expression of LTBR 2 10 0.75 8.57 2.34
108 INT120726 Positive_regulation of Gene_expression of Slc6a4 11 4 0.68 0.51 2.34
109 INT313711 Gene_expression of Pet1 1 4 0.76 1.91 2.29
110 INT62331 Gene_expression of TNFRSF8 14 26 0.72 17.75 2.08
111 INT86083 Positive_regulation of Htr1b 1 5 0.45 2.01 2.05
112 INT190783 Binding of Adcy1 2 3 0.35 1.35 2.03
113 INT14360 Positive_regulation of DDC 2 7 0.70 2.97 2.02
114 INT69703 Gene_expression of TXN 13 20 0.71 3.57 2.01
115 INT15799 Positive_regulation of ISG20 1 18 0.38 9.78 2.01
116 INT81641 Gene_expression of Ctnnb1 5 23 0.72 14.93 1.97
117 INT125974 Localization of Slc6a4 1 5 0.66 2.27 1.97
118 INT181280 Regulation of Gene_expression of INCENP 1 5 0.07 4 1.78
119 INT53673 Gene_expression of Furin 1 6 0.40 1.99 1.54
120 INT100286 Localization of TXN 19 21 0.73 5.13 1.48
121 INT138699 Gene_expression of Pdgfc 1 5 0.30 3.32 1.46
122 INT102044 Regulation of ERVW-1 1 10 0.44 4.76 1.45
123 INT127679 Positive_regulation of Gene_expression of NGFR 1 7 0.67 4.98 1.43
124 INT126660 Positive_regulation of Gene_expression of Tph1 2 5 0.50 0.07 1.43
125 INT219579 Negative_regulation of Gene_expression of Twist1 1 12 0.43 9.07 1.36
126 INT151229 Positive_regulation of Cxam 8 10 0.15 6.13 1.35
127 INT333291 Positive_regulation of Gene_expression of DDC 3 1 0.49 0.13 1.35
128 INT268009 Gene_expression of Gpsm2 3 12 0.54 0.23 1.34
129 INT110434 Positive_regulation of Gene_expression of Apc 3 20 0.50 11.37 1.3
130 INT135924 Positive_regulation of Gene_expression of Pde4d 9 2 0.59 0 1.28
131 INT70615 Binding of TXNRD1 1 25 0.36 12.15 1.27
132 INT130774 Transcription of FASLG 1 5 0.67 2.02 1.22
133 INT203133 Gene_expression of Cxam 5 3 0.07 6.17 1.22
134 INT135926 Binding of Pde4b 1 5 0.34 0.93 1.21
135 INT219595 Positive_regulation of Gene_expression of Pde4a 1 3 0.39 2.81 1.11
136 INT124317 Regulation of Gene_expression of FASLG 1 2 0.23 1.54 1.1
137 INT75846 Positive_regulation of MC4R 1 7 0.70 5.73 1.05
138 INT105774 Negative_regulation of Gene_expression of Pde4a 1 3 0.42 0.4 1.03
139 INT219589 Binding of Pde4d 13 13 0.47 0.51 1.01
140 INT219568 Positive_regulation of Pde4d 8 9 0.49 1.74 1
141 INT261510 Gene_expression of DSE 1 3 0.45 1.73 0.99
142 INT129674 Regulation of Negative_regulation of Slc6a4 1 1 0.38 0.46 0.98
143 INT134660 Positive_regulation of Localization of Akt1 3 10 0.32 6.33 0.94
144 INT73091 Binding of TNFRSF8 17 21 0.44 6.64 0.93
145 INT177531 Binding of Pde4a 1 4 0.29 2.46 0.91
146 INT131649 Positive_regulation of Negative_regulation of Slc6a4 1 2 0.44 0.32 0.91
147 INT89856 Positive_regulation of Localization of Nos2 2 6 0.49 1.79 0.9
148 INT69705 Positive_regulation of TXN 5 8 0.63 2.35 0.89
149 INT168989 Phosphorylation of P2rx4 1 1 0.13 1.15 0.88
150 INT168990 Positive_regulation of Positive_regulation of Pla2g4a 1 2 0.43 2.14 0.86
151 INT174516 Regulation of Gene_expression of ISG20 1 6 0.27 4.2 0.85
152 INT68228 Positive_regulation of TNFRSF8 5 5 0.56 6.26 0.84
153 INT219590 Negative_regulation of Zglp1 1 4 0.39 1.93 0.83
154 INT202628 Gene_expression of Wnt1 4 20 0.67 9.2 0.82
155 INT219578 Negative_regulation of Pde4d 1 3 0.46 2.95 0.8
156 INT135923 Regulation of Gene_expression of Pde4d 2 2 0.44 0 0.8
157 INT210193 Binding of TXN 31 31 0.44 6.88 0.78
158 INT111289 Regulation of MC4R 2 4 0.43 1 0.78
159 INT235069 Localization of Cdh1 1 9 0.74 3.81 0.71
160 INT39999 Gene_expression of Gla 1 7 0.59 3.27 0.69
161 INT187793 Gene_expression of Csf1 1 10 0.77 22.35 0.66
162 INT63064 Gene_expression of PRM1 1 7 0.50 2.66 0.65
163 INT149013 Positive_regulation of Tph1 1 3 0.47 1.1 0.65
164 INT219580 Localization of Pde4d 4 5 0.73 2.07 0.64
165 INT95135 Negative_regulation of Gene_expression of FASLG 1 4 0.20 2.99 0.64
166 INT211489 Gene_expression of ARHGAP4 1 6 0.65 2.88 0.61
167 INT235079 Negative_regulation of Phosphorylation of TNF 1 2 0.41 1.16 0.6
168 INT231014 Negative_regulation of MC4R 1 4 0.43 5.52 0.58
169 INT333277 Positive_regulation of Pet1 1 1 0.27 0 0.57
170 INT333289 Positive_regulation of Binding of Adcy1 2 1 0.28 0 0.52
171 INT219573 Positive_regulation of Localization of Pde4d 1 2 0.49 1.39 0.5
172 INT81645 Positive_regulation of Gene_expression of Ctnnb1 1 6 0.63 3.78 0.47
173 INT333283 Positive_regulation of Gene_expression of Ephb1 2 3 0.32 1.17 0.47
174 INT155236 Negative_regulation of TXN 3 5 0.53 0.66 0.46
175 INT219592 Positive_regulation of Positive_regulation of Zglp1 2 3 0.31 0.1 0.46
176 INT90764 Positive_regulation of Furin 1 4 0.32 1.7 0.44
177 INT210194 Positive_regulation of Gene_expression of TXN 8 1 0.46 1.17 0.43
178 INT235064 Regulation of Positive_regulation of Gsk3b 1 3 0.41 1.5 0.42
179 INT100287 Regulation of TXN 1 2 0.41 0.62 0.42
180 INT95872 Localization of Ctnnb1 2 7 0.74 2.75 0.4
181 INT333284 Positive_regulation of Gene_expression of Maoa 1 1 0.08 0.07 0.4
182 INT83212 Positive_regulation of Gene_expression of Mki67 1 21 0.55 17.53 0.39
183 INT204012 Regulation of Negative_regulation of Gsk3b 1 4 0.42 4.51 0.39
184 INT219565 Regulation of Pde4d 2 3 0.44 0.5 0.39
185 INT326554 Regulation of Zic2 2 3 0.39 2.02 0.39
186 INT212246 Binding of Slc6a12 1 2 0.47 0 0.39
187 INT235063 Positive_regulation of Gene_expression of Gla 1 2 0.04 0.81 0.39
188 INT210206 Positive_regulation of Gene_expression of TNFRSF8 4 1 0.64 2.13 0.38
189 INT174476 Regulation of CD28 1 3 0.34 0.67 0.37
190 INT225223 Localization of Cdkn2b 1 2 0.62 1.29 0.37
191 INT333281 Localization of Zic2 1 1 0.75 0 0.37
192 INT140336 Negative_regulation of Csf1 1 3 0.43 3.64 0.36
193 INT333278 Negative_regulation of Transcription of Slc6a4 1 2 0.37 0.56 0.36
194 INT185882 Binding of TNFSF8 10 2 0.12 3.24 0.35
195 INT312672 Regulation of DSE 1 1 0.41 0.16 0.35
196 INT219588 Negative_regulation of Gene_expression of Pde3a 3 1 0.25 0 0.32
197 INT219563 Gene_expression of Pde3a 3 1 0.39 0 0.32
198 INT202106 Positive_regulation of Gene_expression of TNFRSF1A 1 3 0.22 1.17 0.31
199 INT312681 Negative_regulation of Gene_expression of MC4R 1 1 0.35 0.15 0.31
200 INT204021 Transcription of Gsk3b 1 8 0.57 2.75 0.23
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