J:Environ Health

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT203758 Binding of IL6 and TNF 3 2 0.26 2.03 0.67
2 INT147575 Binding of Ahr and Cyp1a1 2 1 0.15 0.15 0.54
3 INT193480 Binding of ABCA1 and IRF6 1 1 0.00 1.08 0.46
4 INT193479 TLR2 Regulation of Binding of IRF6 1 1 0.04 0.75 0.28
5 INT251665 LRP5 Negative_regulation of Ache 1 2 0.31 0.39 0.19
6 INT203759 Binding of EDN1 and TNF 1 1 0.16 0.71 0.16
7 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 1 0.03 0.07 0.12
8 INT323392 SERPINH1 Negative_regulation of BCHE 1 3 0.02 0.52 0.04
9 INT197296 Ahr Regulation of Bhlha15 1 1 0.48 0.47 0.03
10 INT323395 Binding of BCHE and SERPINH1 1 2 0.02 0.74 0.03
11 INT243281 Binding of IGKV2D-38 and AIRN 1 1 0.20 0.1 0
12 INT197309 Ascl1 Regulation of Neurod1 1 1 0.01 0.13 0
13 INT197313 Atoh1 Regulation of Neurod1 1 1 0.01 0.13 0
14 INT323393 Positive_regulation of Binding of SERPINH1 and VRK1 1 1 0.01 0 0
15 INT197316 Hes1 Regulation of Atoh1 1 1 0.01 0.14 0
16 INT323394 Binding of SERPINH1 and VRK1 1 1 0.00 0 0
17 INT197304 Ahr Regulation of Hes1 1 1 0.06 0.17 0
18 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 1 0.20 0 0
19 INT197315 Hes5 Regulation of Atoh1 1 1 0.00 0.14 0
20 INT197306 Atoh1 Regulation of Neurod6 1 1 0.00 0.13 0
21 INT197314 Hes5 Regulation of Ascl1 1 1 0.00 0.14 0
22 INT197310 Hes1 Regulation of Ascl1 1 1 0.01 0.14 0
23 INT197307 Ascl1 Regulation of Neurod6 1 1 0.00 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
3 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
4 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
5 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
6 INT10194 Positive_regulation of IL6 3 702 0.70 600.62 183.38
7 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
8 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
9 INT17612 Gene_expression of CRP 2 676 0.78 580.61 119.03
10 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
11 INT69440 Gene_expression of ROS1 1 752 0.78 477.64 103.83
12 INT18009 Positive_regulation of CRP 3 518 0.70 553.03 103.74
13 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
14 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
15 INT1080 Negative_regulation of Ache 19 343 0.59 108.51 72.4
16 INT6849 Localization of IL1B 2 229 0.81 112.56 69.63
17 INT546 Binding of ALB 1 311 0.48 85.98 60.14
18 INT1759 Gene_expression of TIMP1 1 267 0.77 133.87 59.29
19 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
20 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
21 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
22 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
23 INT69437 Positive_regulation of ROS1 2 328 0.58 222.83 40.56
24 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
25 INT30817 Gene_expression of Th 5 142 0.76 33.56 38.12
26 INT52350 Gene_expression of CD14 2 184 0.75 71.37 33.13
27 INT8691 Localization of Insr 1 85 0.80 9.27 30.32
28 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
29 INT28361 Gene_expression of TP53 1 443 0.78 384.86 28.8
30 INT22045 Gene_expression of IRF6 4 158 0.75 58.07 27.81
31 INT64499 Positive_regulation of IRF6 1 123 0.49 52.73 27.51
32 INT2569 Gene_expression of Ache 2 120 0.78 26.29 26.89
33 INT100861 Binding of CRP 1 179 0.48 175.2 26.45
34 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
35 INT62710 Gene_expression of HGF 1 160 0.78 88.27 26.14
36 INT72370 Gene_expression of Timp1 1 82 0.65 57.52 24.16
37 INT147792 Gene_expression of COPD 1 230 0.70 287.13 24.1
38 INT23257 Regulation of CRP 2 127 0.62 100.05 21.87
39 INT12951 Negative_regulation of Cat 2 126 0.57 64.39 20.61
40 INT24240 Positive_regulation of Th 1 60 0.70 9.92 20.18
41 INT8662 Positive_regulation of EDN1 1 144 0.70 125.34 19.59
42 INT70970 Binding of COPD 1 144 0.42 180.34 18.29
43 INT65856 Positive_regulation of TP53 1 138 0.67 112.65 16.71
44 INT1020 Negative_regulation of BCHE 10 109 0.59 44.86 16.4
45 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
46 INT2630 Positive_regulation of Shbg 1 134 0.70 65.26 15.19
47 INT54052 Gene_expression of App 1 33 0.78 25.08 14.7
48 INT2758 Binding of Dbp 1 36 0.44 8.3 14.47
49 INT22046 Negative_regulation of IRF6 1 52 0.43 25.69 14.13
50 INT99586 Binding of IRF6 10 60 0.36 27.87 13.2
51 INT711 Positive_regulation of PIK3C2A 4 83 0.70 76.87 13.18
52 INT10016 Negative_regulation of CD8A 1 81 0.42 56.68 13.15
53 INT15246 Regulation of FOS 1 32 0.60 15.34 12.94
54 INT31990 Positive_regulation of SOD1 1 124 0.69 67.79 12.52
55 INT3602 Negative_regulation of Shbg 1 148 0.53 69.05 11.65
56 INT94784 Binding of ROS1 2 113 0.40 71.57 10.26
57 INT1252 Binding of Ache 1 46 0.48 9.94 10.25
58 INT3366 Localization of PLEK 1 44 0.78 15.83 9.55
59 INT54588 Positive_regulation of CREB1 1 38 0.67 12.01 9.18
60 INT27551 Gene_expression of SERPINH1 3 45 0.62 42.87 9.04
61 INT17701 Gene_expression of PTHLH 3 103 0.78 64.23 8.85
62 INT44378 Gene_expression of GSTM1 2 69 0.76 34.61 8.81
63 INT28521 Gene_expression of HBG2 22 56 0.77 16.62 8.64
64 INT2597 Negative_regulation of ACHE 1 82 0.59 46.36 8.62
65 INT19185 Negative_regulation of Cd4 1 80 0.51 61.32 8.51
66 INT4046 Positive_regulation of HBG2 5 42 0.69 13.66 8.51
67 INT621 Positive_regulation of SERPINH1 6 19 0.57 21.52 8.44
68 INT8637 Negative_regulation of Dbp 2 112 0.50 33.28 8.4
69 INT109265 Transcription of Th 5 18 0.68 4.5 8.21
70 INT175526 Phosphorylation of Gopc 1 73 0.53 21.08 7.86
71 INT90603 Positive_regulation of Ahr 20 103 0.69 58.65 7.73
72 INT56031 Positive_regulation of App 5 25 0.69 13.46 7.37
73 INT86867 Regulation of CREB1 1 15 0.46 4.95 7.28
74 INT67822 Binding of SERPINH1 1 17 0.36 19.05 7.24
75 INT14903 Negative_regulation of SOD1 1 81 0.57 42.02 6.91
76 INT55091 Positive_regulation of Mgst1 1 35 0.69 10.77 6.88
77 INT170381 Transcription of Gopc 1 59 0.60 15.96 6.82
78 INT9951 Gene_expression of ANGPTL5 3 45 0.53 37.2 6.44
79 INT69561 Positive_regulation of GSTM1 2 23 0.50 5.69 6.36
80 INT150417 Negative_regulation of Gene_expression of IRF6 1 20 0.41 11.48 6.28
81 INT29561 Binding of GSTM1 2 35 0.48 25.86 6.24
82 INT6667 Gene_expression of CREB1 1 27 0.77 6.29 5.84
83 INT21103 Gene_expression of Dbp 1 48 0.61 22.6 5.59
84 INT185 Regulation of Cyp1a1 2 18 0.54 2.71 5.56
85 INT60585 Regulation of TP53 1 59 0.59 54.55 5.21
86 INT170470 Binding of CD14 2 27 0.35 14.89 5.16
87 INT186 Positive_regulation of Cyp1a1 2 30 0.70 5 5.02
88 INT113517 Binding of Fas 1 16 0.37 15.86 4.62
89 INT14502 Gene_expression of BCHE 8 40 0.67 18.52 4.6
90 INT3128 Negative_regulation of PON1 1 30 0.59 26.19 4.57
91 INT46121 Negative_regulation of SERPINH1 1 14 0.38 10.84 4.41
92 INT37863 Regulation of HBG2 14 11 0.61 3.95 4.34
93 INT3530 Regulation of BCHE 2 18 0.60 5.47 4.12
94 INT97799 Regulation of IRF6 1 23 0.26 6.54 3.75
95 INT33735 Binding of ANGPTL5 1 39 0.32 14.23 3.66
96 INT90823 Positive_regulation of Ptpn2 1 25 0.59 22.97 3.59
97 INT62360 Positive_regulation of PTHLH 1 31 0.70 28.23 3.46
98 INT25386 Positive_regulation of Cd3e 1 30 0.62 13.91 3.41
99 INT97138 Positive_regulation of Gene_expression of CD14 2 17 0.48 9.07 3.35
100 INT76098 Positive_regulation of Positive_regulation of IRF6 1 16 0.27 6.05 3.35
101 INT22431 Negative_regulation of HBG2 10 20 0.58 6.6 3.33
102 INT19211 Binding of Shbg 2 35 0.48 16.29 3.31
103 INT102901 Regulation of Gene_expression of Th 1 12 0.60 2.42 3.22
104 INT147572 Gene_expression of Ahr 41 73 0.75 38.99 3.15
105 INT42485 Binding of Pah 4 9 0.35 3.42 3.03
106 INT47207 Negative_regulation of Ahr 3 25 0.52 16.11 3.02
107 INT37363 Localization of PTHLH 1 14 0.68 13.23 2.92
108 INT44661 Regulation of Ahr 4 15 0.45 12.69 2.79
109 INT54054 Binding of App 18 4 0.48 10.89 2.78
110 INT2021 Binding of HBG2 2 13 0.36 4.2 2.65
111 INT163405 Positive_regulation of Binding of ROS1 1 15 0.27 9.39 2.58
112 INT175685 Positive_regulation of Gene_expression of Timp1 1 11 0.57 8.18 2.58
113 INT4435 Gene_expression of PIK3C2A 1 20 0.77 14.43 2.48
114 INT184914 Negative_regulation of Gene_expression of Th 2 15 0.43 9.17 2.46
115 INT56030 Regulation of App 1 8 0.62 4.06 2.32
116 INT89166 Transcription of Mgst1 1 6 0.72 2 2.27
117 INT161500 Gene_expression of PC 20 42 0.67 9.02 2.2
118 INT664 Positive_regulation of Fgg 1 14 0.46 8.75 2.11
119 INT33170 Binding of Chrm1 1 11 0.48 1.58 2.1
120 INT39008 Localization of App 2 13 0.77 9.07 2.05
121 INT57115 Negative_regulation of NT5E 1 8 0.57 4.35 2.03
122 INT14503 Binding of BCHE 1 13 0.48 3.95 1.85
123 INT135077 Binding of GSTP1 1 11 0.48 7.03 1.8
124 INT2847 Positive_regulation of Negative_regulation of Ache 1 8 0.49 1.09 1.65
125 INT29560 Negative_regulation of Binding of GSTM1 1 4 0.42 1.21 1.59
126 INT179686 Regulation of Gene_expression of COPD 1 10 0.34 14.1 1.52
127 INT116625 Phosphorylation of Nefh 3 13 0.79 5.94 1.4
128 INT186915 Binding of IGKV2D-38 1 15 0.23 7.14 1.32
129 INT70954 Negative_regulation of Cd3e 1 11 0.41 4.22 1.31
130 INT102200 Gene_expression of Nr4a2 3 9 0.72 3.69 1.28
131 INT103488 Positive_regulation of Localization of App 1 5 0.50 3.05 1.28
132 INT13674 Gene_expression of Cyp1a1 4 13 0.65 2.22 1.25
133 INT174987 Binding of AIRN 2 12 0.32 6.79 1.21
134 INT20950 Positive_regulation of PC 7 12 0.60 2.76 1.19
135 INT35148 Regulation of ANGPTL5 3 12 0.28 6.92 1.14
136 INT92654 Transcription of RETNLB 1 3 0.01 3.33 1.12
137 INT45079 Binding of Ahr 7 21 0.44 10.07 1
138 INT114741 Binding of PRB1 2 19 0.36 5.44 1
139 INT79017 Gene_expression of GSTT1 1 23 0.73 13.16 0.97
140 INT79605 Binding of NAT2 1 6 0.48 5.3 0.94
141 INT187155 Localization of SLEB1 1 3 0.05 2.83 0.9
142 INT72151 Phosphorylation of MYOT 1 2 0.01 1.49 0.88
143 INT50453 Regulation of Gene_expression of HBG2 2 6 0.45 1.6 0.86
144 INT72334 Negative_regulation of LRP5 2 7 0.35 1.71 0.81
145 INT144908 Gene_expression of SEA 1 15 0.52 3.81 0.79
146 INT40369 Gene_expression of LRP5 1 8 0.55 5.63 0.74
147 INT161501 Binding of PC 4 20 0.47 5.74 0.72
148 INT145514 Localization of Nefh 2 5 0.32 2.23 0.72
149 INT226631 Phosphorylation of Cd4 1 5 0.61 1.89 0.7
150 INT231558 Regulation of LRP5 1 2 0.24 1.02 0.68
151 INT94548 Localization of Fas 1 9 0.77 5.15 0.65
152 INT174986 Gene_expression of AIRN 3 20 0.57 6.13 0.64
153 INT121985 Positive_regulation of SLEB1 5 10 0.29 10.52 0.64
154 INT194048 Binding of PM20D2 1 11 0.04 4.1 0.62
155 INT142827 Regulation of Gene_expression of CREB1 1 3 0.61 0.39 0.61
156 INT180107 Regulation of Cdc42 1 3 0.16 0.18 0.6
157 INT215301 Binding of PQBP1 8 9 0.27 10.36 0.59
158 INT117683 Positive_regulation of Gene_expression of GSTM1 1 4 0.50 1.31 0.58
159 INT191905 Binding of EXOSC10 2 19 0.04 11.24 0.57
160 INT191904 Positive_regulation of EXOSC10 1 11 0.06 5.43 0.57
161 INT203763 Localization of EGFL7 1 4 0.08 3 0.56
162 INT203764 Binding of EGFL7 1 6 0.05 2.84 0.53
163 INT115826 Transcription of Cyp1a1 1 4 0.52 1.15 0.53
164 INT28238 Positive_regulation of Hrct1 1 5 0.38 3.66 0.5
165 INT45111 Gene_expression of PRB1 1 15 0.58 4.16 0.47
166 INT251661 Phosphorylation of NT5E 1 2 0.21 1.59 0.46
167 INT323400 Localization of BCHE 3 1 0.66 1.87 0.46
168 INT99454 Gene_expression of NAT2 1 4 0.67 1.76 0.43
169 INT153702 Positive_regulation of CLDN7 1 4 0.29 0.97 0.41
170 INT110258 Negative_regulation of PTHLH 1 6 0.56 5.42 0.39
171 INT187902 Negative_regulation of PC 6 4 0.48 1.22 0.39
172 INT161504 Positive_regulation of Gene_expression of PC 3 4 0.44 1.75 0.39
173 INT197286 Positive_regulation of Gene_expression of Ahr 9 10 0.67 9.78 0.36
174 INT251659 Positive_regulation of Prdx6 1 2 0.11 2.07 0.36
175 INT87406 Gene_expression of GSTP1 1 16 0.77 11.37 0.35
176 INT54056 Negative_regulation of Binding of App 1 2 0.37 0.99 0.32
177 INT215302 Gene_expression of PQBP1 3 15 0.53 3.93 0.31
178 INT186895 Localization of PC 2 5 0.65 1.16 0.3
179 INT253647 Phosphorylation of CD8A 1 3 0.25 0.7 0.29
180 INT99628 Positive_regulation of Gene_expression of Cyp1a1 1 4 0.25 1.3 0.27
181 INT63043 Positive_regulation of Gene_expression of HBG2 4 6 0.48 1.75 0.26
182 INT148898 Negative_regulation of Gene_expression of Nr4a2 1 3 0.54 1.13 0.26
183 INT203765 Regulation of Gene_expression of ANGPTL5 1 1 0.04 0.91 0.26
184 INT313869 Gene_expression of Pah 9 4 0.63 3.1 0.23
185 INT71670 Regulation of Junb 1 2 0.27 0.17 0.23
186 INT173655 Binding of LRP5 3 10 0.39 3.06 0.22
187 INT197292 Positive_regulation of Ahrr 1 2 0.39 0.57 0.21
188 INT238020 Gene_expression of Tspan31 1 3 0.65 0.66 0.2
189 INT203766 Regulation of Transcription of RETNLB 1 1 0.00 0.99 0.19
190 INT251660 Positive_regulation of Positive_regulation of Prdx6 1 1 0.04 0.09 0.17
191 INT186919 Regulation of IGKV2D-38 1 8 0.25 0.36 0.16
192 INT197290 Gene_expression of Cdc42 6 9 0.35 2.52 0.15
193 INT183658 Regulation of PRB1 1 5 0.34 0.69 0.15
194 INT124296 Positive_regulation of Cd19 1 4 0.65 3.89 0.15
195 INT187905 Negative_regulation of Gene_expression of PC 3 2 0.37 0.11 0.13
196 INT192311 Binding of GSTT1 1 7 0.48 10.62 0.12
197 INT197289 Transcription of Nr4a2 1 1 0.06 0.06 0.12
198 INT187997 Regulation of AIRN 2 5 0.38 0.13 0.11
199 INT197287 Regulation of Gene_expression of Ahr 3 5 0.45 1 0.11
200 INT323396 Positive_regulation of VRK1 2 1 0.12 0.77 0.09
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