J:Eur. J. Biochem.

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT69872	Binding of MC1R and POMC	52	1	0.54	8.87	18.3
2	INT68852	MC1R Positive_regulation of Localization of POMC	1	1	0.31	0.47	0.19
3	INT68853	MC1R Regulation of Localization of POMC	1	1	0.30	0.47	0.19
4	INT67158	Binding of ITGA4 and Vcam1	1	2	0.00	0.2	0.17
5	INT67157	Negative_regulation of Binding of ITGA4 and Vcam1	1	1	0.00	0.1	0.09
6	INT66341	LIF Positive_regulation of Gene_expression of FOS	1	2	0.11	1.07	0
7	INT66339	LIF Positive_regulation of Phosphorylation of CLIP2	1	2	0.45	1.57	0
8	INT66344	ANTXR1 Positive_regulation of ART1	1	1	0.00	0.69	0
9	INT66342	LIF Positive_regulation of Phosphorylation of CLIP1	1	2	0.60	1.57	0
10	INT66353	LIF Regulation of Ctf2p	1	1	0.02	0.47	0
11	INT66340	LIF Positive_regulation of C1orf61	1	1	0.12	0.52	0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT443	Localization of POMC	5	1020	0.81	284.52	443.17
2	INT64202	Positive_regulation of Trpv1	1	643	0.70	249.66	397.42
3	INT467	Gene_expression of POMC	4	1048	0.78	332.8	394.16
4	INT18357	Gene_expression of TRPV1	8	825	0.78	307.11	382.81
5	INT6580	Negative_regulation of Ptgs1	1	929	0.59	381.53	376.26
6	INT720	Positive_regulation of POMC	1	807	0.70	237.37	353.83
7	INT11624	Gene_expression of OPRM1	1	445	0.78	72.36	294.36
8	INT9381	Positive_regulation of TRPV1	3	523	0.70	187.4	276.05
9	INT6665	Gene_expression of FOS	2	520	0.77	165.31	217.66
10	INT739	Negative_regulation of POMC	1	358	0.59	102.28	166.77
11	INT1303	Negative_regulation of Npr1	3	278	0.55	35.1	156.78
12	INT5061	Negative_regulation of Mme	2	306	0.59	51.97	136.9
13	INT4658	Binding of OPRM1	1	188	0.48	25.96	136.24
14	INT695	Binding of POMC	1	304	0.48	56.66	126.85
15	INT6128	Positive_regulation of Localization of POMC	2	256	0.70	68.77	121.64
16	INT50674	Gene_expression of PTGS2	1	459	0.78	253.33	118.51
17	INT56130	Gene_expression of MC1R	2	259	0.78	62.7	97.55
18	INT17459	Positive_regulation of Gene_expression of FOS	2	182	0.67	53.45	96.38
19	INT48767	Negative_regulation of NOS1	1	312	0.59	154.25	90.32
20	INT4798	Gene_expression of Nts	2	169	0.77	29.56	86.04
21	INT12476	Negative_regulation of TRPV1	1	124	0.59	47.95	77.98
22	INT9382	Regulation of TRPV1	2	149	0.62	53.99	77.46
23	INT1603	Negative_regulation of Rtcd1	1	131	0.51	29.99	66.66
24	INT49170	Negative_regulation of Nos1	3	116	0.59	60.66	58.87
25	INT21737	Binding of MC1R	3	129	0.48	45.45	56.54
26	INT49436	Binding of TRPV1	3	145	0.48	38.35	55.08
27	INT15091	Gene_expression of SLC6A4	1	101	0.78	29.91	53.64
28	INT48952	Negative_regulation of Nos2	2	204	0.59	101.73	53.15
29	INT7093	Negative_regulation of CYP2B6	1	146	0.58	37.3	48.39
30	INT1197	Negative_regulation of Localization of POMC	1	109	0.59	28.29	48.02
31	INT8465	Regulation of Ptgs1	1	100	0.57	36.03	44.41
32	INT81251	Gene_expression of Trpv2	10	78	0.78	28.27	41.76
33	INT64558	Negative_regulation of Nos1	1	88	0.58	26.76	36.78
34	INT10796	Gene_expression of CYP2B6	7	131	0.77	30.14	35.27
35	INT10285	Binding of ADRA1D	1	102	0.47	25.82	31.11
36	INT12129	Gene_expression of CYP3A4	4	107	0.78	23.11	27.6
37	INT5232	Negative_regulation of Enpep	1	56	0.57	3.25	26.7
38	INT95481	Regulation of Gene_expression of TRPV1	3	48	0.62	29.3	26.28
39	INT16431	Localization of Lnpep	1	62	0.70	6.28	23.94
40	INT63419	Gene_expression of PTGES	1	109	0.77	40.83	23.67
41	INT2290	Protein_catabolism of POMC	1	41	0.99	4.86	23.36
42	INT3030	Gene_expression of Adra2a	1	37	0.68	5.58	19.76
43	INT9490	Regulation of Mme	1	44	0.56	6.69	19.21
44	INT15166	Positive_regulation of Mme	1	40	0.70	13.01	16.24
45	INT12837	Binding of SIGMAR1	2	57	0.48	5.31	15.49
46	INT57734	Binding of SLC6A4	1	36	0.48	11.94	15.42
47	INT9904	Gene_expression of CYP2E1	5	64	0.78	13.11	14.65
48	INT8989	Binding of Npr1	2	25	0.36	5.52	14.58
49	INT103828	Negative_regulation of Gene_expression of TRPV1	1	23	0.59	13.63	13.81
50	INT12464	Binding of MET	1	38	0.47	10.3	13.15
51	INT81249	Positive_regulation of Trpv2	1	21	0.70	8.13	12.36
52	INT91413	Negative_regulation of PTGES	3	35	0.58	17.94	12.03
53	INT80251	Binding of Nos1	1	21	0.30	8.24	11.31
54	INT9385	Localization of LDHA	1	74	0.81	31.67	10.5
55	INT10627	Positive_regulation of Lnpep	2	24	0.69	3.36	7.85
56	INT91417	Positive_regulation of PTGES	3	36	0.68	18.45	7.64
57	INT8603	Binding of Mme	3	28	0.48	1.42	7.64
58	INT18759	Positive_regulation of Gene_expression of CYP2E1	1	22	0.70	5.02	6.84
59	INT12838	Gene_expression of SIGMAR1	1	30	0.78	3.52	6.81
60	INT2111	Gene_expression of LIF	4	34	0.77	16.82	6.76
61	INT18772	Positive_regulation of Gene_expression of CYP2B6	1	14	0.49	2.93	5.4
62	INT117422	Gene_expression of Pirt	1	13	0.33	2.17	5.23
63	INT114627	Positive_regulation of Gene_expression of Trpv2	2	9	0.70	6.41	5.18
64	INT8653	Protein_catabolism of Thop1	1	13	0.92	0.73	5.16
65	INT10504	Localization of Pla2g1b	1	18	0.65	8.19	5.05
66	INT11447	Positive_regulation of DECR1	1	9	0.67	3.12	4.94
67	INT24619	Regulation of Thop1	1	11	0.44	1.24	4.5
68	INT3332	Protein_catabolism of AGT	1	23	0.87	3.17	4.39
69	INT21817	Binding of Thop1	2	9	0.48	0.88	4.19
70	INT84700	Positive_regulation of HSP90B2P	1	34	0.67	30.22	4.07
71	INT3598	Regulation of Pla2g1b	1	12	0.44	3.45	3.9
72	INT12841	Gene_expression of Gnao1	1	6	0.60	1.34	3.7
73	INT35864	Regulation of PRSS1	1	19	0.61	8.14	3.63
74	INT39786	Transcription of Lnpep	1	3	0.69	0.52	3.61
75	INT66347	Gene_expression of MLL	1	29	0.65	14.82	3.18
76	INT12903	Gene_expression of Lnpep	3	14	0.71	1.3	2.78
77	INT12619	Positive_regulation of ANTXR1	1	7	0.49	3.17	2.61
78	INT9905	Gene_expression of DECR1	1	11	0.75	2.49	2.43
79	INT86625	Binding of Pla2g1b	1	8	0.24	2.52	2.43
80	INT8654	Protein_catabolism of Nts	3	10	0.61	0.77	2.41
81	INT20873	Negative_regulation of MTG1	1	6	0.42	1.23	2.34
82	INT12131	Gene_expression of POR	5	17	0.77	9.42	2.17
83	INT21819	Localization of Thop1	1	7	0.79	0.36	2.14
84	INT66794	Binding of Vcam1	2	14	0.48	7.84	1.87
85	INT81442	Binding of IFNA16	2	1	0.00	0	1.67
86	INT81441	Binding of IFNA21	2	1	0.01	0	1.66
87	INT96137	Gene_expression of LNPEP	1	8	0.68	5.27	1.43
88	INT38990	Negative_regulation of IDUA	2	12	0.59	5.04	1.33
89	INT104636	Regulation of TTN	2	2	0.33	0	1.29
90	INT38989	Gene_expression of IDUA	2	22	0.78	16.99	1.26
91	INT3046	Gene_expression of LGALS1	1	20	0.75	12.48	1.11
92	INT81440	Regulation of GTPBP4	1	3	0.02	0.09	1.1
93	INT41896	Regulation of Trhr	1	2	0.19	0.09	1.1
94	INT96138	Positive_regulation of LNPEP	1	6	0.45	3.81	1.07
95	INT67156	Binding of ITGA4	1	6	0.14	2.63	1.03
96	INT31314	Positive_regulation of Negative_regulation of Enpep	1	3	0.35	0.18	1.02
97	INT59575	Gene_expression of MGST1	1	2	0.52	3.47	0.98
98	INT69134	Positive_regulation of MPEG1	1	9	0.26	5.95	0.97
99	INT40293	Regulation of CTRC	1	3	0.04	1.35	0.96
100	INT43648	Positive_regulation of Binding of Mme	2	3	0.50	0.24	0.94
101	INT43021	Binding of MPDU1	1	2	0.07	0	0.88
102	INT91416	Negative_regulation of Positive_regulation of PTGES	1	3	0.40	1.88	0.82
103	INT42356	Negative_regulation of Binding of Npr1	1	1	0.32	0.37	0.82
104	INT114625	Gene_expression of KPNB1	2	5	0.42	0.87	0.72
105	INT84250	Positive_regulation of IDUA	1	8	0.56	15.89	0.62
106	INT86624	Binding of Efnb1	1	4	0.27	1.09	0.6
107	INT59576	Positive_regulation of Gene_expression of MGST1	1	2	0.34	2.07	0.54
108	INT9903	Gene_expression of CYB5A	6	9	0.37	2.78	0.53
109	INT30783	Positive_regulation of Gene_expression of Lnpep	1	3	0.64	0.66	0.53
110	INT57943	Protein_catabolism of Lnpep	1	2	0.89	0.09	0.5
111	INT38433	Gene_expression of GRHPR	1	3	0.06	0.42	0.48
112	INT123338	Regulation of HSP90B2P	1	4	0.26	1.52	0.47
113	INT570	Negative_regulation of C6	1	2	0.06	0.31	0.46
114	INT86627	Negative_regulation of Binding of Efnb1	1	1	0.00	0.07	0.4
115	INT86626	Negative_regulation of Efnb1	1	1	0.00	0.07	0.4
116	INT65292	Binding of ABL2	1	2	0.36	0	0.39
117	INT43249	Binding of TDP1	2	1	0.32	0	0.38
118	INT118489	Negative_regulation of Binding of TRPV1	1	4	0.57	0	0.37
119	INT40289	Regulation of Oplah	1	1	0.09	0	0.36
120	INT59862	Phosphorylation of CEL	1	2	0.70	0.53	0.3
121	INT12132	Positive_regulation of Gene_expression of POR	4	5	0.31	1.96	0.27
122	INT118490	Regulation of CNOT4	1	2	0.02	1.18	0.27
123	INT84244	Positive_regulation of Gene_expression of IDUA	1	5	0.70	3.75	0.19
124	INT28255	Gene_expression of Gnl3	1	2	0.16	1.2	0.19
125	INT91414	Regulation of Positive_regulation of PTGES	1	1	0.14	0.28	0.19
126	INT67151	Negative_regulation of Binding of Vcam1	2	1	0.19	0.2	0.17
127	INT68855	Gene_expression of PTPRJ	1	9	0.65	2.99	0.16
128	INT84247	Regulation of Gene_expression of IDUA	1	2	0.45	0.54	0.15
129	INT20863	Negative_regulation of Gnao1	2	1	0.03	1.36	0.15
130	INT43649	Positive_regulation of Binding of Thop1	1	1	0.15	0	0.12
131	INT59572	Localization of MGST1	1	1	0.19	0.16	0.1
132	INT12130	Positive_regulation of Gene_expression of CYB5A	1	1	0.10	0.35	0.09
133	INT67155	Negative_regulation of Binding of ITGA4	1	1	0.01	0.1	0.08
134	INT103266	Positive_regulation of Positive_regulation of MPEG1	1	1	0.03	0.2	0.07
135	INT103267	Positive_regulation of Positive_regulation of IDUA	1	1	0.44	0.2	0.07
136	INT66352	Phosphorylation of CLIP1	1	2	0.63	0.88	0.05
137	INT59574	Positive_regulation of Gene_expression of DECR1	1	1	0.49	0.16	0.05
138	INT59573	Positive_regulation of Gene_expression of GRHPR	1	1	0.02	0.17	0.05
139	INT100487	Negative_regulation of Binding of Nos1	1	1	0.28	0	0.04
140	INT66346	Binding of LIF	1	7	0.47	0.9	0
141	INT66345	Gene_expression of TOX	1	2	0.65	0.57	0
142	INT66351	Phosphorylation of CLIP2	1	1	0.65	0.78	0
143	INT66349	Positive_regulation of Phosphorylation of CLIP1	1	1	0.36	0.78	0
144	INT66348	Positive_regulation of C1orf61	1	1	0.11	0.52	0