J:Eur. J. Biochem.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 1 0.54 8.87 18.3
2 INT68852 MC1R Positive_regulation of Localization of POMC 1 1 0.31 0.47 0.19
3 INT68853 MC1R Regulation of Localization of POMC 1 1 0.30 0.47 0.19
4 INT67158 Binding of ITGA4 and Vcam1 1 2 0.00 0.2 0.17
5 INT67157 Negative_regulation of Binding of ITGA4 and Vcam1 1 1 0.00 0.1 0.09
6 INT66341 LIF Positive_regulation of Gene_expression of FOS 1 2 0.11 1.07 0
7 INT66339 LIF Positive_regulation of Phosphorylation of CLIP2 1 2 0.45 1.57 0
8 INT66344 ANTXR1 Positive_regulation of ART1 1 1 0.00 0.69 0
9 INT66342 LIF Positive_regulation of Phosphorylation of CLIP1 1 2 0.60 1.57 0
10 INT66353 LIF Regulation of Ctf2p 1 1 0.02 0.47 0
11 INT66340 LIF Positive_regulation of C1orf61 1 1 0.12 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 5 1020 0.81 284.52 443.17
2 INT64202 Positive_regulation of Trpv1 1 643 0.70 249.66 397.42
3 INT467 Gene_expression of POMC 4 1048 0.78 332.8 394.16
4 INT18357 Gene_expression of TRPV1 8 825 0.78 307.11 382.81
5 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
6 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
7 INT11624 Gene_expression of OPRM1 1 445 0.78 72.36 294.36
8 INT9381 Positive_regulation of TRPV1 3 523 0.70 187.4 276.05
9 INT6665 Gene_expression of FOS 2 520 0.77 165.31 217.66
10 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
11 INT1303 Negative_regulation of Npr1 3 278 0.55 35.1 156.78
12 INT5061 Negative_regulation of Mme 2 306 0.59 51.97 136.9
13 INT4658 Binding of OPRM1 1 188 0.48 25.96 136.24
14 INT695 Binding of POMC 1 304 0.48 56.66 126.85
15 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
16 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
17 INT56130 Gene_expression of MC1R 2 259 0.78 62.7 97.55
18 INT17459 Positive_regulation of Gene_expression of FOS 2 182 0.67 53.45 96.38
19 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
20 INT4798 Gene_expression of Nts 2 169 0.77 29.56 86.04
21 INT12476 Negative_regulation of TRPV1 1 124 0.59 47.95 77.98
22 INT9382 Regulation of TRPV1 2 149 0.62 53.99 77.46
23 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
24 INT49170 Negative_regulation of Nos1 3 116 0.59 60.66 58.87
25 INT21737 Binding of MC1R 3 129 0.48 45.45 56.54
26 INT49436 Binding of TRPV1 3 145 0.48 38.35 55.08
27 INT15091 Gene_expression of SLC6A4 1 101 0.78 29.91 53.64
28 INT48952 Negative_regulation of Nos2 2 204 0.59 101.73 53.15
29 INT7093 Negative_regulation of CYP2B6 1 146 0.58 37.3 48.39
30 INT1197 Negative_regulation of Localization of POMC 1 109 0.59 28.29 48.02
31 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
32 INT81251 Gene_expression of Trpv2 10 78 0.78 28.27 41.76
33 INT64558 Negative_regulation of Nos1 1 88 0.58 26.76 36.78
34 INT10796 Gene_expression of CYP2B6 7 131 0.77 30.14 35.27
35 INT10285 Binding of ADRA1D 1 102 0.47 25.82 31.11
36 INT12129 Gene_expression of CYP3A4 4 107 0.78 23.11 27.6
37 INT5232 Negative_regulation of Enpep 1 56 0.57 3.25 26.7
38 INT95481 Regulation of Gene_expression of TRPV1 3 48 0.62 29.3 26.28
39 INT16431 Localization of Lnpep 1 62 0.70 6.28 23.94
40 INT63419 Gene_expression of PTGES 1 109 0.77 40.83 23.67
41 INT2290 Protein_catabolism of POMC 1 41 0.99 4.86 23.36
42 INT3030 Gene_expression of Adra2a 1 37 0.68 5.58 19.76
43 INT9490 Regulation of Mme 1 44 0.56 6.69 19.21
44 INT15166 Positive_regulation of Mme 1 40 0.70 13.01 16.24
45 INT12837 Binding of SIGMAR1 2 57 0.48 5.31 15.49
46 INT57734 Binding of SLC6A4 1 36 0.48 11.94 15.42
47 INT9904 Gene_expression of CYP2E1 5 64 0.78 13.11 14.65
48 INT8989 Binding of Npr1 2 25 0.36 5.52 14.58
49 INT103828 Negative_regulation of Gene_expression of TRPV1 1 23 0.59 13.63 13.81
50 INT12464 Binding of MET 1 38 0.47 10.3 13.15
51 INT81249 Positive_regulation of Trpv2 1 21 0.70 8.13 12.36
52 INT91413 Negative_regulation of PTGES 3 35 0.58 17.94 12.03
53 INT80251 Binding of Nos1 1 21 0.30 8.24 11.31
54 INT9385 Localization of LDHA 1 74 0.81 31.67 10.5
55 INT10627 Positive_regulation of Lnpep 2 24 0.69 3.36 7.85
56 INT91417 Positive_regulation of PTGES 3 36 0.68 18.45 7.64
57 INT8603 Binding of Mme 3 28 0.48 1.42 7.64
58 INT18759 Positive_regulation of Gene_expression of CYP2E1 1 22 0.70 5.02 6.84
59 INT12838 Gene_expression of SIGMAR1 1 30 0.78 3.52 6.81
60 INT2111 Gene_expression of LIF 4 34 0.77 16.82 6.76
61 INT18772 Positive_regulation of Gene_expression of CYP2B6 1 14 0.49 2.93 5.4
62 INT117422 Gene_expression of Pirt 1 13 0.33 2.17 5.23
63 INT114627 Positive_regulation of Gene_expression of Trpv2 2 9 0.70 6.41 5.18
64 INT8653 Protein_catabolism of Thop1 1 13 0.92 0.73 5.16
65 INT10504 Localization of Pla2g1b 1 18 0.65 8.19 5.05
66 INT11447 Positive_regulation of DECR1 1 9 0.67 3.12 4.94
67 INT24619 Regulation of Thop1 1 11 0.44 1.24 4.5
68 INT3332 Protein_catabolism of AGT 1 23 0.87 3.17 4.39
69 INT21817 Binding of Thop1 2 9 0.48 0.88 4.19
70 INT84700 Positive_regulation of HSP90B2P 1 34 0.67 30.22 4.07
71 INT3598 Regulation of Pla2g1b 1 12 0.44 3.45 3.9
72 INT12841 Gene_expression of Gnao1 1 6 0.60 1.34 3.7
73 INT35864 Regulation of PRSS1 1 19 0.61 8.14 3.63
74 INT39786 Transcription of Lnpep 1 3 0.69 0.52 3.61
75 INT66347 Gene_expression of MLL 1 29 0.65 14.82 3.18
76 INT12903 Gene_expression of Lnpep 3 14 0.71 1.3 2.78
77 INT12619 Positive_regulation of ANTXR1 1 7 0.49 3.17 2.61
78 INT9905 Gene_expression of DECR1 1 11 0.75 2.49 2.43
79 INT86625 Binding of Pla2g1b 1 8 0.24 2.52 2.43
80 INT8654 Protein_catabolism of Nts 3 10 0.61 0.77 2.41
81 INT20873 Negative_regulation of MTG1 1 6 0.42 1.23 2.34
82 INT12131 Gene_expression of POR 5 17 0.77 9.42 2.17
83 INT21819 Localization of Thop1 1 7 0.79 0.36 2.14
84 INT66794 Binding of Vcam1 2 14 0.48 7.84 1.87
85 INT81442 Binding of IFNA16 2 1 0.00 0 1.67
86 INT81441 Binding of IFNA21 2 1 0.01 0 1.66
87 INT96137 Gene_expression of LNPEP 1 8 0.68 5.27 1.43
88 INT38990 Negative_regulation of IDUA 2 12 0.59 5.04 1.33
89 INT104636 Regulation of TTN 2 2 0.33 0 1.29
90 INT38989 Gene_expression of IDUA 2 22 0.78 16.99 1.26
91 INT3046 Gene_expression of LGALS1 1 20 0.75 12.48 1.11
92 INT81440 Regulation of GTPBP4 1 3 0.02 0.09 1.1
93 INT41896 Regulation of Trhr 1 2 0.19 0.09 1.1
94 INT96138 Positive_regulation of LNPEP 1 6 0.45 3.81 1.07
95 INT67156 Binding of ITGA4 1 6 0.14 2.63 1.03
96 INT31314 Positive_regulation of Negative_regulation of Enpep 1 3 0.35 0.18 1.02
97 INT59575 Gene_expression of MGST1 1 2 0.52 3.47 0.98
98 INT69134 Positive_regulation of MPEG1 1 9 0.26 5.95 0.97
99 INT40293 Regulation of CTRC 1 3 0.04 1.35 0.96
100 INT43648 Positive_regulation of Binding of Mme 2 3 0.50 0.24 0.94
101 INT43021 Binding of MPDU1 1 2 0.07 0 0.88
102 INT91416 Negative_regulation of Positive_regulation of PTGES 1 3 0.40 1.88 0.82
103 INT42356 Negative_regulation of Binding of Npr1 1 1 0.32 0.37 0.82
104 INT114625 Gene_expression of KPNB1 2 5 0.42 0.87 0.72
105 INT84250 Positive_regulation of IDUA 1 8 0.56 15.89 0.62
106 INT86624 Binding of Efnb1 1 4 0.27 1.09 0.6
107 INT59576 Positive_regulation of Gene_expression of MGST1 1 2 0.34 2.07 0.54
108 INT9903 Gene_expression of CYB5A 6 9 0.37 2.78 0.53
109 INT30783 Positive_regulation of Gene_expression of Lnpep 1 3 0.64 0.66 0.53
110 INT57943 Protein_catabolism of Lnpep 1 2 0.89 0.09 0.5
111 INT38433 Gene_expression of GRHPR 1 3 0.06 0.42 0.48
112 INT123338 Regulation of HSP90B2P 1 4 0.26 1.52 0.47
113 INT570 Negative_regulation of C6 1 2 0.06 0.31 0.46
114 INT86627 Negative_regulation of Binding of Efnb1 1 1 0.00 0.07 0.4
115 INT86626 Negative_regulation of Efnb1 1 1 0.00 0.07 0.4
116 INT65292 Binding of ABL2 1 2 0.36 0 0.39
117 INT43249 Binding of TDP1 2 1 0.32 0 0.38
118 INT118489 Negative_regulation of Binding of TRPV1 1 4 0.57 0 0.37
119 INT40289 Regulation of Oplah 1 1 0.09 0 0.36
120 INT59862 Phosphorylation of CEL 1 2 0.70 0.53 0.3
121 INT12132 Positive_regulation of Gene_expression of POR 4 5 0.31 1.96 0.27
122 INT118490 Regulation of CNOT4 1 2 0.02 1.18 0.27
123 INT84244 Positive_regulation of Gene_expression of IDUA 1 5 0.70 3.75 0.19
124 INT28255 Gene_expression of Gnl3 1 2 0.16 1.2 0.19
125 INT91414 Regulation of Positive_regulation of PTGES 1 1 0.14 0.28 0.19
126 INT67151 Negative_regulation of Binding of Vcam1 2 1 0.19 0.2 0.17
127 INT68855 Gene_expression of PTPRJ 1 9 0.65 2.99 0.16
128 INT84247 Regulation of Gene_expression of IDUA 1 2 0.45 0.54 0.15
129 INT20863 Negative_regulation of Gnao1 2 1 0.03 1.36 0.15
130 INT43649 Positive_regulation of Binding of Thop1 1 1 0.15 0 0.12
131 INT59572 Localization of MGST1 1 1 0.19 0.16 0.1
132 INT12130 Positive_regulation of Gene_expression of CYB5A 1 1 0.10 0.35 0.09
133 INT67155 Negative_regulation of Binding of ITGA4 1 1 0.01 0.1 0.08
134 INT103266 Positive_regulation of Positive_regulation of MPEG1 1 1 0.03 0.2 0.07
135 INT103267 Positive_regulation of Positive_regulation of IDUA 1 1 0.44 0.2 0.07
136 INT66352 Phosphorylation of CLIP1 1 2 0.63 0.88 0.05
137 INT59574 Positive_regulation of Gene_expression of DECR1 1 1 0.49 0.16 0.05
138 INT59573 Positive_regulation of Gene_expression of GRHPR 1 1 0.02 0.17 0.05
139 INT100487 Negative_regulation of Binding of Nos1 1 1 0.28 0 0.04
140 INT66346 Binding of LIF 1 7 0.47 0.9 0
141 INT66345 Gene_expression of TOX 1 2 0.65 0.57 0
142 INT66351 Phosphorylation of CLIP2 1 1 0.65 0.78 0
143 INT66349 Positive_regulation of Phosphorylation of CLIP1 1 1 0.36 0.78 0
144 INT66348 Positive_regulation of C1orf61 1 1 0.11 0.52 0
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