J:Eur. J. Clin. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT45279 Binding of CSF2 and GHR 1 1 0.05 0.07 0.93
2 INT104749 Ugt1a1 Regulation of Positive_regulation of G2e3 1 1 0.00 0.07 0.77
3 INT104748 Ugt1a1 Regulation of Positive_regulation of LOC100359830 1 1 0.01 0.07 0.77
4 INT52459 Binding of SUCLA2 and HEY2 1 1 0.01 0.09 0.21
5 INT88766 Binding of LIPC and CASZ1 1 1 0.03 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 4 2431 0.81 378.96 952.2
2 INT155 Positive_regulation of Prl 9 1233 0.70 317.93 457.82
3 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
4 INT157 Positive_regulation of Localization of Prl 2 790 0.70 104.54 374.78
5 INT439 Localization of Gnrh1 2 976 0.81 100.96 363.25
6 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
7 INT162 Regulation of Prl 3 794 0.62 165.01 322.24
8 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
9 INT49750 Negative_regulation of CPOX 1 735 0.58 360.06 274.19
10 INT1893 Localization of Gh 1 1041 0.79 340.23 256.58
11 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
12 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
13 INT156 Negative_regulation of Prl 2 542 0.59 131.97 192.24
14 INT528 Gene_expression of Prl 3 693 0.78 217.18 192.2
15 INT159 Negative_regulation of Localization of Prl 1 416 0.59 55.34 171.8
16 INT5127 Localization of Lhb 1 488 0.80 50.48 162.66
17 INT252 Localization of GH1 1 529 0.80 227.4 122.05
18 INT1530 Regulation of Gh 3 382 0.61 115.96 112.47
19 INT915 Positive_regulation of PRL 3 342 0.70 141.96 104.31
20 INT214 Localization of AVP 2 370 0.81 208.51 91.09
21 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
22 INT914 Positive_regulation of GH1 1 292 0.69 100.7 84.91
23 INT1498 Gene_expression of Gh 2 521 0.75 220.84 81.16
24 INT148 Positive_regulation of Gnrhr 2 182 0.70 47.44 79.64
25 INT920 Localization of PLOD1 1 223 0.81 42.25 78.7
26 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
27 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
28 INT15913 Negative_regulation of CYP2D6 6 174 0.59 22.45 70.91
29 INT253 Regulation of PRL 1 184 0.62 47.27 65.79
30 INT4960 Positive_regulation of CSF2 2 285 0.70 256.73 65.73
31 INT546 Binding of ALB 5 311 0.48 85.98 60.14
32 INT314 Positive_regulation of Ren 3 212 0.70 66.68 55.56
33 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
34 INT921 Regulation of GH1 2 172 0.60 52.88 51.04
35 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
36 INT654 Localization of REN 3 250 0.81 75.12 47.86
37 INT683 Positive_regulation of AVP 1 173 0.70 74.55 46.41
38 INT619 Positive_regulation of Positive_regulation of Prl 2 116 0.70 22.69 45.06
39 INT69992 Negative_regulation of Hmox2 2 93 0.50 49.01 44.07
40 INT1894 Negative_regulation of Localization of Gh 1 168 0.58 64.12 43.56
41 INT3933 Positive_regulation of PLOD1 1 128 0.70 30.76 42.03
42 INT957 Positive_regulation of GHRH 2 136 0.70 36.84 40.52
43 INT685 Regulation of AVP 1 124 0.62 34.9 39.91
44 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
45 INT1976 Regulation of Gene_expression of Prl 1 80 0.62 20.19 36
46 INT255 Regulation of Localization of GH1 1 89 0.62 18.71 35.3
47 INT10796 Gene_expression of CYP2B6 5 131 0.77 30.14 35.27
48 INT1116 Regulation of Ren 2 103 0.62 27.66 33.26
49 INT234 Binding of Alb 2 151 0.48 52.34 32.97
50 INT913 Regulation of Localization of PLOD1 1 71 0.62 8.64 32.72
51 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
52 INT10285 Binding of ADRA1D 1 102 0.47 25.82 31.11
53 INT7975 Regulation of PLOD1 1 97 0.62 20.9 30.51
54 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
55 INT11554 Negative_regulation of CSF2 1 129 0.59 108.55 29.44
56 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
57 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
58 INT5298 Negative_regulation of MTHFS 1 70 0.57 27.07 28.11
59 INT97 Negative_regulation of Adrb1 3 102 0.59 32.44 26.9
60 INT2140 Regulation of REN 5 104 0.62 28.24 24.49
61 INT250 Regulation of GHRH 2 65 0.61 17.46 23.19
62 INT956 Negative_regulation of PRL 1 94 0.59 42.72 23.01
63 INT9079 Gene_expression of PPBP 1 52 0.75 31.2 21.52
64 INT2978 Gene_expression of Tbxa2r 1 76 0.77 28.4 21.27
65 INT6127 Regulation of Localization of AVP 1 60 0.62 15.12 20.84
66 INT6699 Positive_regulation of ADRA1D 1 65 0.70 22.72 20.31
67 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
68 INT50403 Negative_regulation of CYP2C19 3 55 0.59 8.97 17.79
69 INT50579 Binding of CYP3A4 1 84 0.48 17.52 17.45
70 INT50404 Negative_regulation of CYP1A2 5 49 0.59 8.61 17.35
71 INT170 Negative_regulation of Adrb1 1 52 0.55 13.46 14.78
72 INT110 Regulation of Adrb3 1 33 0.60 8.09 13.84
73 INT18773 Localization of ALB 6 117 0.80 69.18 13.8
74 INT67855 Negative_regulation of PPIG 1 64 0.57 17.83 13.54
75 INT711 Positive_regulation of PIK3C2A 1 83 0.70 76.87 13.18
76 INT3040 Gene_expression of MIA3 1 81 0.24 53.61 12.62
77 INT48335 Negative_regulation of NOSTRIN 1 38 0.56 16.22 12.05
78 INT9954 Negative_regulation of Hrh1 1 16 0.52 13.04 11.76
79 INT3602 Negative_regulation of Shbg 1 148 0.53 69.05 11.65
80 INT1190 Positive_regulation of F2 1 53 0.70 46.41 11.64
81 INT58775 Binding of G2e3 1 10 0.33 0.19 11.52
82 INT70877 Gene_expression of PPIG 3 72 0.75 22.39 10.93
83 INT55418 Regulation of CYP2D6 3 29 0.61 1.83 10.21
84 INT1372 Regulation of Localization of REN 2 50 0.62 5.76 9.81
85 INT68372 Regulation of CYP2C9 2 28 0.62 5.64 9.53
86 INT25834 Positive_regulation of Dbp 1 59 0.68 24.34 9.32
87 INT14301 Binding of CSF2 1 82 0.48 67.95 8.98
88 INT860 Regulation of ALB 1 48 0.60 25.11 8.95
89 INT6019 Positive_regulation of NEUROD1 1 37 0.67 17.3 8.89
90 INT8637 Negative_regulation of Dbp 3 112 0.50 33.28 8.4
91 INT12975 Regulation of PLEK 1 21 0.60 13.62 8.28
92 INT7743 Binding of Hrh2 1 19 0.47 7.75 7.11
93 INT7464 Regulation of Mbp 2 25 0.62 6.62 6.43
94 INT6097 Negative_regulation of NEUROD1 1 30 0.57 9.71 6.24
95 INT12054 Negative_regulation of MIA3 1 32 0.45 23.2 6.18
96 INT17913 Regulation of HSD11B1 1 87 0.60 93.23 6.04
97 INT48004 Positive_regulation of Negative_regulation of PTGS1 1 12 0.49 4.07 5.87
98 INT12042 Regulation of MIA3 1 28 0.23 17.33 5.79
99 INT68899 Binding of CYP1A2 1 19 0.48 2.33 5.73
100 INT9895 Binding of GHR 1 18 0.36 4.8 5.65
101 INT60475 Gene_expression of Ugt1a1 1 17 0.77 4.26 5.62
102 INT10980 Gene_expression of GYPA 1 40 0.78 15.32 5.51
103 INT18772 Positive_regulation of Gene_expression of CYP2B6 1 14 0.49 2.93 5.4
104 INT38160 Binding of Caf 1 6 0.37 3 5.1
105 INT18345 Positive_regulation of Positive_regulation of Gnrhr 1 16 0.42 4.99 4.91
106 INT15920 Regulation of Serpine1 3 34 0.42 17.36 4.89
107 INT65514 Gene_expression of Cyp1a2 1 25 0.77 6.12 4.6
108 INT37168 Positive_regulation of APCS 1 22 0.67 9.61 4.59
109 INT65881 Gene_expression of CYP2C19 1 21 0.76 1.19 4.57
110 INT29231 Regulation of Dbp 3 44 0.53 10.08 4.47
111 INT9080 Regulation of PPBP 2 17 0.44 5.75 4.3
112 INT19104 Regulation of Gene_expression of Gh 1 24 0.40 8.42 3.88
113 INT9748 Negative_regulation of Sysbp1 1 28 0.35 8.93 3.87
114 INT17444 Gene_expression of MTHFS 1 14 0.66 5.17 3.85
115 INT9077 Regulation of Tbxa2r 1 13 0.45 5.49 3.75
116 INT27964 Negative_regulation of CBR1 1 12 0.58 5.48 3.74
117 INT50022 Positive_regulation of G2e3 2 10 0.42 0.47 3.72
118 INT39199 Positive_regulation of Ugt1a1 1 9 0.45 1.78 3.69
119 INT10650 Regulation of Ugt2b7 2 7 0.60 1.12 3.67
120 INT16263 Regulation of Serpine1 1 13 0.45 5.24 3.6
121 INT58005 Gene_expression of M1 1 27 0.78 12.43 3.52
122 INT88549 Regulation of SLC35A2 1 8 0.60 0.7 3.52
123 INT45132 Positive_regulation of Dap 1 14 0.69 0.62 3.5
124 INT28802 Binding of F2 1 15 0.47 8.8 3.47
125 INT5345 Positive_regulation of BRD2 1 14 0.67 6.72 3.43
126 INT27864 Regulation of Sysbp1 1 9 0.22 3.76 3.42
127 INT100562 Binding of LOC100359830 1 3 0.05 0.07 3.33
128 INT63025 Gene_expression of BHLHE22 1 10 0.75 3.79 3.3
129 INT65120 Regulation of Ugt1a1 1 3 0.45 1.07 3.29
130 INT11245 Negative_regulation of Dap 1 15 0.59 1.95 3.18
131 INT32394 Regulation of Pf4 1 12 0.23 6.07 2.85
132 INT72053 Localization of GSTA2 6 15 0.78 6.12 2.78
133 INT11282 Negative_regulation of Rrsv 1 9 0.18 1.88 2.76
134 INT44424 Regulation of BRD2 1 5 0.58 1.7 2.75
135 INT44426 Localization of BRD2 1 6 0.78 4.02 2.59
136 INT9374 Regulation of Plat 4 19 0.61 6.04 2.55
137 INT17063 Localization of Esyt1 1 3 0.45 0.5 2.55
138 INT2695 Regulation of DBH 1 5 0.45 1.09 2.48
139 INT9764 Gene_expression of Adrb3 1 10 0.62 4.14 2.33
140 INT18853 Negative_regulation of APCS 2 13 0.57 4.51 2.3
141 INT63505 Negative_regulation of F2 2 18 0.57 7.4 2.2
142 INT69314 Binding of CYP3A 1 16 0.48 1.78 2.19
143 INT45176 Negative_regulation of LPL 1 34 0.59 22.22 2.01
144 INT35109 Binding of SUCLA2 1 6 0.32 5.79 2.01
145 INT45838 Positive_regulation of LPL 2 15 0.69 11.33 2
146 INT65880 Gene_expression of CYP2C8 1 25 0.77 9.49 1.92
147 INT9076 Regulation of Gene_expression of Tbxa2r 1 7 0.61 1.16 1.92
148 INT104745 Positive_regulation of Binding of G2e3 1 1 0.05 0.07 1.77
149 INT22836 Regulation of F2 3 9 0.59 2.3 1.49
150 INT51635 Negative_regulation of LRTOMT 1 5 0.41 1.17 1.49
151 INT44288 Binding of Ugt1a1 1 7 0.45 0.54 1.48
152 INT2824 Positive_regulation of HTN1 1 10 0.40 10.41 1.4
153 INT8339 Negative_regulation of GC 1 12 0.57 4.9 1.37
154 INT91176 Regulation of Localization of GSTA2 2 2 0.33 1.04 1.31
155 INT45133 Regulation of Binding of Alb 1 4 0.45 0.55 1.07
156 INT79928 Positive_regulation of Localization of ALB 1 10 0.60 8.96 1.05
157 INT97994 Binding of Hmox2 1 4 0.32 1.98 1.04
158 INT4609 Gene_expression of Klkb1 1 5 0.47 0.81 1.03
159 INT12072 Negative_regulation of MOXD1 1 1 0.01 0.15 1.03
160 INT52460 Localization of SUCLA2 1 5 0.67 2.5 0.86
161 INT11949 Negative_regulation of Apob 1 11 0.09 8.13 0.85
162 INT44425 Regulation of Localization of BRD2 1 1 0.37 0 0.82
163 INT829 Binding of B3GAT2 1 4 0.36 0.42 0.8
164 INT104746 Positive_regulation of LOC100359830 1 1 0.01 0.07 0.77
165 INT13826 Positive_regulation of Negative_regulation of Dbp 1 5 0.42 2.19 0.74
166 INT45839 Regulation of LPL 1 10 0.55 7.64 0.55
167 INT87741 Localization of Msr1 1 5 0.60 4.77 0.5
168 INT19592 Localization of AQP1 1 4 0.81 1.09 0.44
169 INT91175 Regulation of Localization of ALB 4 4 0.28 0.1 0.41
170 INT16177 Positive_regulation of UGT1A3 1 3 0.57 0.98 0.41
171 INT67586 Positive_regulation of Lipo1 2 1 0.07 0.49 0.37
172 INT24861 Regulation of Positive_regulation of NEUROD1 1 2 0.44 0.39 0.33
173 INT88771 Negative_regulation of CASZ1 1 2 0.28 0.63 0.33
174 INT88769 Negative_regulation of SULT1A2 1 1 0.27 0.19 0.29
175 INT88770 Negative_regulation of LIPC 3 1 0.37 0.17 0.28
176 INT88996 Negative_regulation of GSTA2 1 2 0.23 0 0.25
177 INT828 Positive_regulation of B3GAT2 1 2 0.61 0.27 0.17
178 INT19590 Localization of cod 1 2 0.17 0.27 0.09
179 INT146283 Regulation of ERLIN1 1 2 0.22 0.06 0
180 INT104744 Negative_regulation of Gene_expression of Ugt1a1 1 2 0.53 0.85 0
181 INT80131 Negative_regulation of Regulation of F2 1 1 0.05 0 0
182 INT104747 Positive_regulation of Binding of Ugt1a1 1 1 0.45 0 0
183 INT91177 Negative_regulation of Localization of GSTA2 1 1 0.23 0 0
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