J:Eur J Pain

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT152501 Binding of Tnf and Tnfrsf1a 4 2 0.31 3 2.58
2 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 2 0.47 2.37 1.98
3 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 2 0.42 2.39 1.82
4 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 2 0.42 2.45 1.63
5 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 1 0.46 1.6 1.04
6 INT155259 RUNX1 Negative_regulation of Tnf 1 1 0.00 1.48 0.93
7 INT164783 Positive_regulation of Mapk14 Regulation of Gene_expression of Cx3cr1 1 1 0.19 0.81 0.68
8 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 1 0.20 1.17 0.67
9 INT155462 Tnfrsf1a Positive_regulation of Nfkb1 Regulation of Gene_expression of Il6 1 1 0.20 1.17 0.67
10 INT164782 Il6 Regulation of Gene_expression of Cx3cr1 1 1 0.27 0.79 0.67
11 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 1 0.22 1.11 0.63

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 25 3083 0.78 894.43 1639.02
2 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
3 INT7114 Positive_regulation of Ltp 5 1192 0.62 290.76 755.77
4 INT5202 Positive_regulation of Gene_expression of Fos 5 1163 0.70 319.28 684
5 INT292 Localization of Penk 3 876 0.81 88.44 669.14
6 INT58061 Gene_expression of Trpv1 1 1117 0.78 451.54 637.59
7 INT58061 Gene_expression of Trpv1 3 1117 0.78 451.54 637.59
8 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
9 INT5228 Positive_regulation of Fos 5 934 0.70 209.8 503.87
10 INT6056 Negative_regulation of Gene_expression of Fos 5 601 0.59 193.05 386.84
11 INT76660 Gene_expression of Trpv1 2 691 0.78 329.46 386.42
12 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
13 INT5979 Gene_expression of Oprd1 2 428 0.78 75.64 320.32
14 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
15 INT63932 Positive_regulation of Ephb1 1 537 0.70 259.67 296.14
16 INT9158 Gene_expression of Tnf 5 722 0.78 522.01 277.68
17 INT9381 Positive_regulation of TRPV1 5 523 0.70 187.4 276.05
18 INT5591 Regulation of Gene_expression of Fos 6 425 0.62 129.06 265.78
19 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
20 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
21 INT16868 Gene_expression of Il6 6 807 0.78 499.48 256.57
22 INT5501 Regulation of Oprd1 2 283 0.62 55.1 249.9
23 INT5597 Gene_expression of Pdyn 1 433 0.78 62.97 235.47
24 INT6665 Gene_expression of FOS 9 520 0.77 165.31 217.66
25 INT6293 Gene_expression of Oprm1 1 312 0.78 48.73 215.61
26 INT48955 Gene_expression of Nos2 6 753 0.78 403.87 208.08
27 INT11313 Positive_regulation of Il6 2 526 0.70 331.27 201.59
28 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
29 INT94952 Positive_regulation of Mapk14 6 305 0.70 197.83 186.61
30 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
31 INT49134 Gene_expression of Grin1 4 270 0.78 84.78 148.61
32 INT13353 Positive_regulation of Tnf 2 332 0.70 248.75 148.1
33 INT90910 Phosphorylation of Grin1 2 150 0.82 68.23 139.24
34 INT5595 Positive_regulation of Pdyn 2 223 0.70 48.37 130.14
35 INT65054 Positive_regulation of Nfkb1 5 285 0.70 149.33 126.73
36 INT64201 Negative_regulation of Trpv1 1 203 0.59 79.18 119.75
37 INT8243 Positive_regulation of Il6 1 451 0.70 358.24 119.28
38 INT1026 Binding of Lbp 2 207 0.48 150.96 119.16
39 INT7341 Positive_regulation of Grin1 3 169 0.70 65.86 118.38
40 INT48923 Gene_expression of Ephb1 1 211 0.77 106.23 109.9
41 INT7627 Negative_regulation of Positive_regulation of Ltp 3 162 0.50 41.2 106.27
42 INT10272 Gene_expression of Il1b 4 194 0.78 121.02 103.03
43 INT82878 Gene_expression of Ccl2 1 201 0.78 164.95 101.35
44 INT97701 Phosphorylation of Mapk14 3 191 0.82 115.33 100.46
45 INT1351 Gene_expression of Pag1 2 131 0.57 89.48 98.76
46 INT17459 Positive_regulation of Gene_expression of FOS 2 182 0.67 53.45 96.38
47 INT940 Negative_regulation of Ptgs1 2 219 0.59 104.34 95.97
48 INT74058 Gene_expression of Nos1 1 260 0.78 80.04 95.71
49 INT29971 Gene_expression of Oprk1 1 126 0.78 35.32 93.97
50 INT10166 Localization of Tnf 2 237 0.81 153.95 88.64
51 INT15898 Positive_regulation of Prkaca 1 199 0.70 50.89 87.54
52 INT75999 Gene_expression of BDNF 2 344 0.78 114.19 83.12
53 INT8650 Gene_expression of Gal 6 152 0.78 61.97 81.72
54 INT92518 Gene_expression of Grin2b 1 131 0.78 65.52 80.91
55 INT99070 Gene_expression of Mapk14 2 147 0.78 103.99 79.59
56 INT64636 Positive_regulation of Gene_expression of Nos2 3 242 0.70 147.52 79.53
57 INT9382 Regulation of TRPV1 1 149 0.62 53.99 77.46
58 INT62374 Gene_expression of NGF 1 158 0.78 77.87 76.45
59 INT12001 Regulation of Ngf 1 97 0.62 54.64 76.25
60 INT15769 Gene_expression of Il1b 2 146 0.78 114.51 75.35
61 INT98621 Regulation of Trpv1 1 121 0.62 79.24 75.23
62 INT11380 Negative_regulation of IL1B 1 215 0.59 125.62 72.35
63 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
64 INT13276 Regulation of Ltp 1 107 0.53 30.78 69.13
65 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
66 INT6486 Positive_regulation of Tnf 2 168 0.70 123.47 66.05
67 INT9304 Negative_regulation of Pag1 1 70 0.39 51.97 64.23
68 INT96622 Localization of Trpv1 2 110 0.81 59.82 63.25
69 INT3950 Gene_expression of Ptger2 4 293 0.77 122.28 62.42
70 INT90911 Positive_regulation of Phosphorylation of Grin1 1 62 0.70 27.45 59.26
71 INT7340 Regulation of Grin1 2 87 0.62 30.37 57.93
72 INT5819 Regulation of Localization of Penk 2 64 0.62 6.69 57.68
73 INT74389 Gene_expression of Gdnf 4 131 0.78 58.52 57.06
74 INT6669 Negative_regulation of Positive_regulation of Fos 1 98 0.59 23.5 56.82
75 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
76 INT13277 Regulation of Positive_regulation of Ltp 1 83 0.52 19.68 55.78
77 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
78 INT17458 Negative_regulation of Gene_expression of FOS 1 98 0.57 36.77 55.69
79 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
80 INT49436 Binding of TRPV1 1 145 0.48 38.35 55.08
81 INT84495 Positive_regulation of Positive_regulation of Ephb1 1 85 0.70 46.12 54.11
82 INT6073 Negative_regulation of Localization of Penk 1 63 0.59 8.67 53.95
83 INT49993 Positive_regulation of Gene_expression of Il6 4 149 0.70 88.07 53.78
84 INT49747 Transcription of Oprm1 2 68 0.72 9.01 53.78
85 INT929 Positive_regulation of Oprl1 1 64 0.70 14.67 52.84
86 INT10668 Positive_regulation of Gene_expression of Oprd1 1 61 0.69 15.21 52.12
87 INT66040 Positive_regulation of Bdnf 1 114 0.69 67.67 51.81
88 INT83199 Gene_expression of Nos3 1 193 0.78 100.72 51.57
89 INT57021 Positive_regulation of Gene_expression of Grin1 4 62 0.70 24.77 47.31
90 INT1028 Positive_regulation of Lbp 1 102 0.69 67.86 46.05
91 INT5307 Regulation of Tnf 2 87 0.62 78.71 43.4
92 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
93 INT48075 Positive_regulation of Il1b 4 71 0.67 48.63 40.48
94 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
95 INT5039 Positive_regulation of Gal 1 67 0.68 27.97 37.36
96 INT59466 Gene_expression of ISYNA1 1 204 0.77 112.57 35.48
97 INT63933 Negative_regulation of Positive_regulation of Ephb1 1 53 0.58 22.83 33.43
98 INT65536 Negative_regulation of Positive_regulation of Nfkb1 2 77 0.59 38.86 33.33
99 INT63935 Positive_regulation of Gene_expression of Ephb1 1 52 0.61 24.3 33.05
100 INT48925 Gene_expression of Mapk1 1 95 0.74 42.21 32.91
101 INT57024 Regulation of Gene_expression of Grin1 2 32 0.62 9.77 32.6
102 INT35406 Localization of Tnf 5 94 0.81 64.63 31.65
103 INT5069 Negative_regulation of Mthfs 1 69 0.57 22.54 31.36
104 INT56290 Negative_regulation of Gene_expression of Il6 2 79 0.59 47.98 31.07
105 INT6058 Localization of Fos 2 73 0.81 16.7 30.84
106 INT23435 Positive_regulation of NGF 1 54 0.70 32.41 30.11
107 INT15000 Transcription of Oprd1 1 32 0.72 5.7 29.22
108 INT106540 Negative_regulation of Phosphorylation of Grin1 1 15 0.58 9.32 29.13
109 INT57692 Positive_regulation of Gene_expression of Il1b 1 50 0.67 43.54 28.29
110 INT82882 Localization of Ccl2 1 61 0.80 41.96 28
111 INT56053 Negative_regulation of Bdnf 2 77 0.58 64.4 26.83
112 INT78251 Positive_regulation of LBP 1 38 0.69 39.98 26.73
113 INT29107 Regulation of Oprk1 2 31 0.45 6.16 26.61
114 INT10273 Positive_regulation of Gene_expression of Il1b 2 47 0.68 31.15 26.21
115 INT48979 Regulation of Gene_expression of FOS 3 52 0.61 14.4 25.95
116 INT76095 Positive_regulation of ISYNA1 2 117 0.55 79.73 25.86
117 INT61953 Transcription of Nos2 1 101 0.72 46.64 25.49
118 INT48248 Gene_expression of Scn10a 3 38 0.78 19.3 25.05
119 INT124144 Negative_regulation of Mors1 1 21 0.41 2.87 24.71
120 INT5596 Negative_regulation of Gene_expression of Pdyn 1 41 0.59 5.34 24.36
121 INT70503 Regulation of Gene_expression of Nos2 1 71 0.62 44 24.01
122 INT58301 Positive_regulation of Mpo 1 87 0.70 80.19 23.99
123 INT1704 Positive_regulation of PCa 1 68 0.59 34.92 23.36
124 INT48081 Localization of Il1b 3 46 0.80 21.59 22.4
125 INT60779 Negative_regulation of CYP3A 2 63 0.59 8.38 21.27
126 INT1703 Regulation of pCA 2 52 0.52 23.65 20.6
127 INT51474 Binding of Il6 1 55 0.48 44.99 20.52
128 INT87794 Positive_regulation of Mors1 1 19 0.38 4.74 20.23
129 INT28151 Positive_regulation of CTs 2 55 0.61 35.09 20.14
130 INT3030 Gene_expression of Adra2a 1 37 0.68 5.58 19.76
131 INT5099 Localization of Gal 3 46 0.81 10.66 18.93
132 INT19763 Gene_expression of CTs 1 69 0.78 32.92 18.87
133 INT9230 Gene_expression of Htr3a 1 43 0.78 10.54 18.81
134 INT103469 Positive_regulation of Gene_expression of BDNF 1 59 0.67 24.39 18.36
135 INT11275 Regulation of Fos 1 37 0.60 5.79 18.18
136 INT67975 Gene_expression of Bdkrb2 2 38 0.68 21.69 17.94
137 INT151747 Positive_regulation of PSMD2 5 26 0.68 17.48 17.89
138 INT63928 Negative_regulation of Grin1 1 51 0.56 11.81 17.57
139 INT150934 Gene_expression of GCH1 1 17 0.78 14.54 17.53
140 INT52358 Gene_expression of Cx3cr1 7 25 0.78 18.48 16.65
141 INT20216 Localization of NGF 1 40 0.80 18.16 16.61
142 INT88356 Negative_regulation of Positive_regulation of Grin1 1 16 0.58 4.72 16.58
143 INT78827 Gene_expression of Bdkrb1 1 34 0.78 18.48 15.81
144 INT4977 Binding of ITIH4 1 60 0.46 42.48 15.65
145 INT11335 Regulation of Ptger2 3 46 0.51 22.3 15.42
146 INT73916 Gene_expression of Esr1 2 58 0.77 26.59 15.15
147 INT104674 Positive_regulation of F2rl1 5 35 0.65 27.76 14.16
148 INT8986 Positive_regulation of Gene_expression of Gal 4 24 0.67 10.96 14.09
149 INT64048 Positive_regulation of Positive_regulation of Tnf 2 32 0.70 21.24 13.74
150 INT55874 Binding of GPM6A 1 20 0.34 4.2 13.63
151 INT3174 Negative_regulation of Ptger2 1 43 0.38 20.95 13.43
152 INT100655 Regulation of BDNF 4 51 0.60 21.49 13.14
153 INT85510 Positive_regulation of Bdkrb2 1 23 0.70 12.08 12.68
154 INT51028 Regulation of Il1b 1 28 0.60 21.15 12.47
155 INT28770 Negative_regulation of Gene_expression of PDYN 1 16 0.57 4.95 12.06
156 INT150851 Positive_regulation of Cxcl1 1 45 0.57 20.83 11.88
157 INT49509 Negative_regulation of Ptger2 1 53 0.42 24.87 11.66
158 INT11894 Negative_regulation of Gene_expression of Ptger2 2 47 0.55 16.95 11.59
159 INT150285 Positive_regulation of Efnb1 5 6 0.29 10.22 11.44
160 INT23122 Gene_expression of Ptger3 1 31 0.72 11.94 11.37
161 INT91932 Positive_regulation of Scn10a 2 18 0.67 10.39 10.9
162 INT79981 Positive_regulation of Gene_expression of Gdnf 2 27 0.70 12.49 10.77
163 INT72579 Localization of BDNF 3 56 0.80 14.84 10.65
164 INT60434 Negative_regulation of Positive_regulation of Tnf 1 20 0.46 10.01 10.64
165 INT50196 Transcription of Il1b 1 25 0.69 19.08 10.43
166 INT10120 Negative_regulation of Positive_regulation of Pdyn 2 14 0.58 6.05 10.19
167 INT139443 Positive_regulation of GCH1 3 9 0.69 8.2 10.14
168 INT70850 Positive_regulation of Transcription of Nos2 1 30 0.70 18.95 9.68
169 INT48078 Regulation of Gene_expression of Il1b 1 15 0.62 14.78 9.53
170 INT59465 Negative_regulation of ISYNA1 3 41 0.49 21.9 9.46
171 INT36354 Localization of CTs 1 26 0.64 20.84 9.31
172 INT26795 Gene_expression of Mtpn 1 44 0.62 27.66 8.62
173 INT53573 Negative_regulation of Localization of Tnf 1 19 0.59 11.57 8.54
174 INT53798 Gene_expression of Oprk1 1 14 0.73 1.82 8.24
175 INT117212 Gene_expression of Hcn2 1 13 0.78 5.83 8.19
176 INT108690 Gene_expression of Hcn1 1 19 0.76 7.2 8
177 INT113038 Positive_regulation of Gene_expression of Bdkrb1 1 12 0.69 7.11 7.93
178 INT92003 Positive_regulation of Transcription of Gdnf 1 10 0.66 5.54 7.84
179 INT9032 Regulation of Htr2c 1 11 0.60 2.77 7.81
180 INT121977 Phosphorylation of Nfkb1 4 15 0.51 9.83 7.77
181 INT87546 Transcription of Gdnf 1 15 0.71 7.49 7.76
182 INT48077 Positive_regulation of Localization of Il1b 4 17 0.69 8.8 7.68
183 INT130272 Gene_expression of Kcna4 3 12 0.75 9.25 7.61
184 INT13507 Gene_expression of Erbb2 1 17 0.77 34.23 7.58
185 INT105185 Negative_regulation of Gene_expression of Oprk1 1 9 0.42 3.53 7.53
186 INT64280 Positive_regulation of Ptger1 2 22 0.67 14.9 7.49
187 INT150287 Positive_regulation of Ephb2 4 5 0.33 5.54 6.9
188 INT99088 Gene_expression of HPT 1 5 0.59 9.1 6.72
189 INT154773 Regulation of Accn3 1 7 0.62 7.09 6.63
190 INT48076 Negative_regulation of Localization of Il1b 1 10 0.59 3.46 6.58
191 INT84716 Negative_regulation of Positive_regulation of Il1b 1 9 0.57 5.34 6.27
192 INT50712 Gene_expression of Comt 1 13 0.68 6.33 6.23
193 INT145188 Gene_expression of Efnb1 3 4 0.32 6.07 5.74
194 INT150853 Negative_regulation of Cxcl1 1 22 0.49 12.61 5.72
195 INT14388 Regulation of TACR1 2 12 0.45 3.1 5.58
196 INT126177 Positive_regulation of Atf3 1 14 0.70 14.34 5.56
197 INT3838 Regulation of FCGR3B 1 16 0.60 6.67 5.53
198 INT114180 Negative_regulation of Il1rn 1 22 0.57 11.06 5.44
199 INT58145 Positive_regulation of Localization of Tnf 4 20 0.67 13.33 5.44
200 INT139933 Negative_regulation of Slc17a6 1 3 0.59 10.25 5.43
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