J:Exp. Neurol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 6 1 0.76 8.19 6.66
2 INT102122 Binding of Calca and RT1-M4 7 2 0.29 5.83 4.94
3 INT85743 Pdyn Positive_regulation of Oprk1 3 1 0.32 2.12 3.52
4 INT41152 Binding of Penk and Slc3a1 3 1 0.12 0.11 2.91
5 INT103669 Hps4 Positive_regulation of Mors1 1 2 0.01 0 2.7
6 INT58678 Binding of Penk and Abat 2 1 0.40 1.39 1.97
7 INT139640 Jun Regulation of Gene_expression of Npy 1 2 0.21 1.98 1.75
8 INT93388 Rbm39 Positive_regulation of Positive_regulation of Pdyn 1 1 0.03 0.32 1.4
9 INT85742 Pdyn Positive_regulation of Rbm39 1 1 0.01 0.17 1.29
10 INT85744 Binding of Pdyn and Rbm39 1 1 0.01 0.16 1.12
11 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 1 0.02 0.97 1.1
12 INT134384 Trpa1 Negative_regulation of Gene_expression of Trpm8 1 1 0.47 1.21 1.02
13 INT139636 Jun Negative_regulation of Phosphorylation of Npy 1 1 0.33 1.07 1.01
14 INT139639 Jun Negative_regulation of Positive_regulation of Vip 1 1 0.53 1.07 1
15 INT139643 Jun Negative_regulation of Positive_regulation of Npy 1 1 0.33 1.07 1
16 INT139641 Positive_regulation of Jun Positive_regulation of Positive_regulation of Vip 1 1 0.37 0.95 0.99
17 INT139642 Positive_regulation of Jun Regulation of Gene_expression of Npy 1 1 0.21 1.07 0.97
18 INT139638 Positive_regulation of Jun Positive_regulation of Positive_regulation of Npy 1 1 0.36 1.18 0.96
19 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 1 0.28 0.63 0.75
20 INT127074 Gdnf Regulation of Gene_expression of Jun 1 1 0.10 0.28 0.43
21 INT127075 Bdnf Regulation of Gene_expression of Jun 1 1 0.11 0.28 0.43
22 INT127073 Bdnf Regulation of Gene_expression of Fos 1 1 0.42 0.28 0.43
23 INT127072 Gdnf Regulation of Gene_expression of Fos 1 1 0.38 0.28 0.43
24 INT127077 Gdnf Positive_regulation of Gene_expression of IER3 1 1 0.02 0.26 0.42
25 INT127079 Gene_expression of Gdnf Positive_regulation of Gene_expression of IER3 1 1 0.02 0.26 0.42
26 INT127078 Bdnf Positive_regulation of Gene_expression of IER3 1 1 0.02 0.26 0.42
27 INT127076 Gene_expression of Bdnf Positive_regulation of Gene_expression of IER3 1 1 0.03 0.26 0.42
28 INT53127 Binding of Ntrk2 and Ntf4 1 1 0.12 0 0.33
29 INT148995 Uts2 Positive_regulation of CDNF 1 1 0.00 0.41 0.2

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 3 2431 0.81 378.96 952.2
2 INT7114 Positive_regulation of Ltp 3 1192 0.62 290.76 755.77
3 INT3439 Localization of Abat 1 1017 0.78 112.39 727.06
4 INT292 Localization of Penk 5 876 0.81 88.44 669.14
5 INT728 Positive_regulation of Penk 5 1068 0.70 186.9 636.87
6 INT5228 Positive_regulation of Fos 4 934 0.70 209.8 503.87
7 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
8 INT1045 Localization of LH 2 1211 0.81 87.04 456.25
9 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
10 INT5895 Gene_expression of Oprm1 1 525 0.78 120.67 407.29
11 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
12 INT1395 Negative_regulation of Penk 4 537 0.59 87.33 389.81
13 INT6580 Negative_regulation of Ptgs1 2 929 0.59 381.53 376.26
14 INT287 Localization of Cck 1 518 0.81 86.84 364.04
15 INT439 Localization of Gnrh1 2 976 0.81 100.96 363.25
16 INT2649 Regulation of Calca 3 433 0.62 146.05 330.95
17 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
18 INT5979 Gene_expression of Oprd1 1 428 0.78 75.64 320.32
19 INT5540 Positive_regulation of Oprm1 4 344 0.70 76.77 319.71
20 INT4941 Positive_regulation of Oprd1 2 345 0.70 74.26 304.41
21 INT9131 Positive_regulation of Prkcg 1 431 0.70 130.8 302.41
22 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
23 INT1352 Localization of Acot1 4 728 0.80 73.01 296.01
24 INT5379 Gene_expression of Fos 4 656 0.78 255.5 292.54
25 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
26 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
27 INT5591 Regulation of Gene_expression of Fos 2 425 0.62 129.06 265.78
28 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
29 INT11377 Positive_regulation of Ngf 8 331 0.70 206.5 238
30 INT5597 Gene_expression of Pdyn 4 433 0.78 62.97 235.47
31 INT1665 Positive_regulation of Pag1 4 270 0.68 186.63 229.87
32 INT11009 Phosphorylation of Creb1 4 458 0.82 111.34 221.97
33 INT626 Localization of CALCA 2 289 0.81 125.39 221.15
34 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
35 INT6293 Gene_expression of Oprm1 2 312 0.78 48.73 215.61
36 INT22548 Positive_regulation of Casp3 6 483 0.70 258.78 213.07
37 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
38 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
39 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
40 INT9132 Negative_regulation of Prkcg 1 279 0.59 88.05 203.47
41 INT798 Positive_regulation of Gene_expression of Penk 5 394 0.70 78.53 203.07
42 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
43 INT2211 Negative_regulation of Abat 1 267 0.59 66.51 200.98
44 INT2085 Positive_regulation of LH 1 441 0.70 60.15 191.02
45 INT63934 Phosphorylation of Ephb1 4 377 0.82 150.52 188.66
46 INT24326 Gene_expression of Ngf 4 346 0.78 218.67 184.71
47 INT4803 Transcription of Penk 5 435 0.72 59.09 182.4
48 INT3440 Negative_regulation of Localization of Abat 1 221 0.57 33.94 180.36
49 INT7506 Negative_regulation of Ltp 4 267 0.46 91.01 176.8
50 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
51 INT5930 Positive_regulation of Oprm1 2 221 0.70 31.19 172.93
52 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
53 INT739 Negative_regulation of POMC 3 358 0.59 102.28 166.77
54 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
55 INT4740 Gene_expression of Th 12 298 0.78 61.27 154.03
56 INT2910 Regulation of Abat 1 169 0.62 36.95 153.53
57 INT13353 Positive_regulation of Tnf 6 332 0.70 248.75 148.1
58 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
59 INT48895 Gene_expression of Il10 3 333 0.78 221.2 138.52
60 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
61 INT11012 Positive_regulation of Creb1 6 258 0.70 84.4 132
62 INT48953 Positive_regulation of Nos2 5 486 0.70 239.85 131.87
63 INT5380 Positive_regulation of Gene_expression of Fos 3 243 0.70 105.65 131.05
64 INT5931 Regulation of Oprm1 1 149 0.62 18.15 125.93
65 INT6822 Gene_expression of Pdyn 4 215 0.78 35.99 125.76
66 INT416 Regulation of LH 3 253 0.62 31.48 125.55
67 INT14151 Gene_expression of Casp3 2 311 0.78 140.26 120.68
68 INT2555 Positive_regulation of Localization of Penk 1 116 0.70 24.35 119.73
69 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
70 INT1438 Localization of Pomc 1 360 0.81 101.26 116.47
71 INT62124 Gene_expression of NOS1 4 444 0.78 218.08 114.85
72 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
73 INT118381 Gene_expression of Il17a 4 405 0.76 306.97 112.06
74 INT11011 Positive_regulation of Phosphorylation of Creb1 1 190 0.70 49.25 112.01
75 INT49651 Gene_expression of Creb1 4 276 0.78 114.77 111.96
76 INT7327 Regulation of Th 2 164 0.62 29.67 110.14
77 INT48923 Gene_expression of Ephb1 1 211 0.77 106.23 109.9
78 INT5283 Positive_regulation of Npy 5 191 0.70 66.77 109.2
79 INT4742 Gene_expression of Tac1 6 177 0.78 69.99 102.66
80 INT5587 Regulation of Fos 4 191 0.62 40.81 99.7
81 INT2159 Regulation of Localization of Gnrh1 1 200 0.62 13.28 99.07
82 INT7944 Positive_regulation of Fos 1 193 0.70 60.69 98.31
83 INT1004 Regulation of Sst 2 140 0.62 18.52 94.84
84 INT29971 Gene_expression of Oprk1 2 126 0.78 35.32 93.97
85 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
86 INT1160 Positive_regulation of Rbm39 1 122 0.57 28.19 90.28
87 INT18032 Positive_regulation of Oprk1 1 108 0.70 30.78 89.7
88 INT67682 Localization of Bdnf 7 204 0.81 72.36 88.92
89 INT1635 Gene_expression of Vip 8 245 0.78 53.36 88.13
90 INT5594 Regulation of Pdyn 1 137 0.62 27.04 86.63
91 INT5610 Positive_regulation of Insr 3 140 0.69 37.26 86.24
92 INT4798 Gene_expression of Nts 1 169 0.77 29.56 86.04
93 INT21793 Positive_regulation of Ngf 1 154 0.70 94.78 85.27
94 INT4857 Regulation of Tacr1 1 115 0.62 39.01 84.52
95 INT4631 Positive_regulation of Sst 1 127 0.70 17.37 83.29
96 INT75999 Gene_expression of BDNF 1 344 0.78 114.19 83.12
97 INT16254 Positive_regulation of Gene_expression of Ngf 1 144 0.70 80.61 82.08
98 INT8650 Gene_expression of Gal 4 152 0.78 61.97 81.72
99 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
100 INT55944 Positive_regulation of Cpox 2 214 0.57 105.14 81.4
101 INT2155 Negative_regulation of Sst 1 111 0.59 16.58 77.74
102 INT24958 Gene_expression of Nkx1-1 1 106 0.74 51.29 76.88
103 INT62374 Gene_expression of NGF 2 158 0.78 77.87 76.45
104 INT60691 Gene_expression of Il12a 2 331 0.78 208.03 75.96
105 INT1353 Negative_regulation of Localization of Acot1 1 153 0.53 15.05 75.17
106 INT1724 Negative_regulation of ACE 3 437 0.59 315.64 74.48
107 INT5593 Positive_regulation of Gene_expression of Pdyn 1 114 0.70 29.1 74.46
108 INT10274 Positive_regulation of Il1b 2 123 0.70 79.76 73.56
109 INT48244 Gene_expression of Il4 1 172 0.76 132.38 73.42
110 INT79506 Gene_expression of Grin2b 1 122 0.78 43.71 73.42
111 INT63936 Positive_regulation of Phosphorylation of Ephb1 1 131 0.70 49.38 73.16
112 INT3034 Localization of Ngf 2 126 0.81 50.81 72.84
113 INT1080 Negative_regulation of Ache 4 343 0.59 108.51 72.4
114 INT10359 Gene_expression of Ifng 1 159 0.78 79.6 72.14
115 INT31774 Positive_regulation of Vta1 1 67 0.44 14.52 71.79
116 INT49111 Negative_regulation of Prkaca 1 102 0.59 27.44 71.77
117 INT8962 Gene_expression of Cpe 3 110 0.71 39.67 71.67
118 INT2055 Regulation of Gnrh1 1 185 0.62 23.65 71.26
119 INT5852 Gene_expression of Penk 6 167 0.78 44.44 71.13
120 INT5993 Positive_regulation of Nts 2 122 0.70 26.82 70.45
121 INT7534 Gene_expression of Ifng 1 193 0.78 111.02 68.6
122 INT9484 Gene_expression of Jun 2 175 0.78 34.89 68.54
123 INT5861 Gene_expression of Egr1 3 203 0.78 49.35 68.13
124 INT8388 Positive_regulation of Vip 5 142 0.70 39.72 67.61
125 INT1046 Gene_expression of LH 1 180 0.77 29.75 66.87
126 INT1425 Gene_expression of Rbm39 7 143 0.58 51.32 65.44
127 INT6926 Regulation of Pag1 1 72 0.39 55.79 65.09
128 INT9304 Negative_regulation of Pag1 1 70 0.39 51.97 64.23
129 INT2212 Binding of Abat 1 89 0.48 18.36 63.99
130 INT217 Negative_regulation of Th 2 134 0.59 26.83 62.63
131 INT3950 Gene_expression of Ptger2 1 293 0.77 122.28 62.42
132 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
133 INT4760 Negative_regulation of Gene_expression of Calca 1 93 0.59 34.19 60.3
134 INT109431 Gene_expression of Trpa1 4 123 0.78 51.84 59.98
135 INT7032 Positive_regulation of Pdyn 3 94 0.66 26.51 58.83
136 INT8732 Positive_regulation of Gene_expression of Oprm1 1 76 0.70 22.59 58.83
137 INT7340 Regulation of Grin1 3 87 0.62 30.37 57.93
138 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
139 INT4509 Gene_expression of IGG 1 426 0.76 293.69 56.64
140 INT13277 Regulation of Positive_regulation of Ltp 1 83 0.52 19.68 55.78
141 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
142 INT5598 Negative_regulation of Pdyn 1 95 0.59 14.4 55.43
143 INT82650 Gene_expression of Bcl2 3 312 0.78 211.71 55.03
144 INT6826 Transcription of Pdyn 6 130 0.71 22.19 54.88
145 INT5034 Negative_regulation of Insr 4 100 0.55 28.08 54.5
146 INT84495 Positive_regulation of Positive_regulation of Ephb1 2 85 0.70 46.12 54.11
147 INT1486 Negative_regulation of Cpe 1 85 0.59 28.78 54.08
148 INT6116 Regulation of Gene_expression of Oprd1 1 69 0.62 16.43 54
149 INT7898 Gene_expression of Homer1 2 123 0.78 31.52 53.67
150 INT48952 Negative_regulation of Nos2 2 204 0.59 101.73 53.15
151 INT929 Positive_regulation of Oprl1 1 64 0.70 14.67 52.84
152 INT27954 Positive_regulation of Gene_expression of Ngf 1 87 0.70 57.91 51.96
153 INT22546 Positive_regulation of Gene_expression of Casp3 1 97 0.70 47.89 51.92
154 INT52264 Gene_expression of IK 1 180 0.77 90.87 51.87
155 INT5704 Binding of Slc3a1 3 78 0.43 8.52 51.78
156 INT7287 Positive_regulation of Transcription of Penk 2 103 0.70 19.81 50.37
157 INT6796 Positive_regulation of Jun 3 165 0.70 37.18 49.64
158 INT40777 Positive_regulation of Akt1 5 163 0.69 59.41 49.43
159 INT109430 Positive_regulation of Trpa1 2 119 0.70 44 49.14
160 INT1715 Positive_regulation of Nrm 1 51 0.70 24 47.53
161 INT6864 Positive_regulation of Gene_expression of Gfap 1 110 0.70 59.01 47.07
162 INT20345 Gene_expression of Dbi 4 136 0.78 56.41 46.2
163 INT6823 Negative_regulation of Pdyn 3 68 0.58 13.95 46.12
164 INT8713 Regulation of Tac1 1 56 0.60 25.29 45.94
165 INT42980 Gene_expression of GAD1 2 139 0.69 94.77 45.11
166 INT14853 Negative_regulation of Tac1 2 80 0.59 30.87 45.06
167 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
168 INT49552 Negative_regulation of Positive_regulation of Casp3 4 76 0.55 36.04 44.78
169 INT27493 Negative_regulation of Casp3 4 114 0.56 56.89 44.63
170 INT5214 Localization of Cpe 1 49 0.73 13.3 44.36
171 INT88617 Positive_regulation of Gene_expression of Creb1 2 90 0.69 51.69 44.29
172 INT47683 Negative_regulation of Bdnf 1 92 0.59 47.53 43.55
173 INT5307 Regulation of Tnf 4 87 0.62 78.71 43.4
174 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
175 INT27798 Gene_expression of Ntrk2 2 111 0.78 56.08 42.68
176 INT13354 Transcription of TNF 2 108 0.72 85.81 42.32
177 INT48929 Regulation of Ephb1 1 71 0.62 24.42 42.11
178 INT28265 Positive_regulation of Calca 1 62 0.70 29.1 41.17
179 INT4887 Gene_expression of Tac4 4 70 0.77 11.66 40.97
180 INT16261 Transcription of Bdnf 1 101 0.72 49.41 40.64
181 INT7029 Regulation of Pdyn 3 51 0.61 12.89 40.34
182 INT107576 Gene_expression of Atf3 1 114 0.78 72.42 38.64
183 INT68975 Gene_expression of Mmp9 2 111 0.78 79.57 38.55
184 INT30817 Gene_expression of Th 3 142 0.76 33.56 38.12
185 INT5039 Positive_regulation of Gal 1 67 0.68 27.97 37.36
186 INT82054 Positive_regulation of Grin2b 3 56 0.70 17.45 37.14
187 INT6067 Positive_regulation of Positive_regulation of Oprd1 1 37 0.69 6.56 36.58
188 INT3971 Positive_regulation of Alb 2 175 0.70 98.46 36.45
189 INT12029 Gene_expression of Car1 5 143 0.67 29.69 36.39
190 INT14137 Localization of Oprm1 2 56 0.81 2.88 36.09
191 INT84260 Positive_regulation of Mapk8 2 124 0.69 72.84 35.98
192 INT48896 Positive_regulation of Gene_expression of Il10 1 73 0.70 43.14 35.5
193 INT316 Regulation of Cebpz 3 105 0.00 27.21 35.41
194 INT7326 Transcription of Th 2 83 0.72 13.5 35.33
195 INT21527 Gene_expression of FosB 1 47 0.78 11.2 34.39
196 INT67613 Positive_regulation of PPARG 3 94 0.70 69.15 34.38
197 INT1457 Negative_regulation of Binding of Penk 1 40 0.57 0.25 34.24
198 INT11325 Gene_expression of HLA-E 1 209 0.76 98.05 33.72
199 INT7286 Regulation of Transcription of Penk 2 81 0.62 9.25 33.45
200 INT7133 Negative_regulation of MME 5 85 0.59 29.22 33.1
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