J:Expert Opin Investig Drugs

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT91813 Binding of FAS and FASLG 4 1 0.23 9.89 0.99
2 INT80030 Binding of FAS and TNF 3 1 0.27 2.54 0.56
3 INT91814 Binding of TNF and TP53 1 2 0.14 2.2 0.32
4 INT93989 Rab8a Positive_regulation of Gene_expression of Il12a 1 1 0.10 0.48 0.3
5 INT93986 Rab8a Positive_regulation of Gene_expression of Il6 1 1 0.08 0.48 0.3
6 INT93988 Rab8a Regulation of Hand2 1 1 0.09 0.78 0.3
7 INT93990 Rab8a Positive_regulation of Gene_expression of Il1 1 1 0.05 0.48 0.3
8 INT93987 Positive_regulation of Rab8a Positive_regulation of Localization of Ifng 1 1 0.10 0.38 0.29
9 INT91812 Binding of FASLG and TP53 1 1 0.04 1.1 0.16
10 INT91811 Binding of FAS and TP53 1 1 0.21 1.1 0.16
11 INT91810 Binding of FASLG and TNF 1 1 0.05 0.92 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
2 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
3 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
4 INT477 Localization of Avp 2 813 0.81 131.58 300.4
5 INT49750 Negative_regulation of CPOX 3 735 0.58 360.06 274.19
6 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
7 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
8 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
9 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
10 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
11 INT5940 Negative_regulation of Avp 2 236 0.59 67.86 101.2
12 INT60691 Gene_expression of Il12a 2 331 0.78 208.03 75.96
13 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
14 INT11380 Negative_regulation of IL1B 1 215 0.59 125.62 72.35
15 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
16 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
17 INT17881 Gene_expression of LEP 1 278 0.78 221.61 48.31
18 INT48718 Positive_regulation of PRKCA 4 109 0.69 36.16 46.49
19 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
20 INT18992 Negative_regulation of Pdpk1 1 53 0.42 19.02 40.95
21 INT61925 Negative_regulation of Adk 2 53 0.59 22.46 40.38
22 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
23 INT52712 Negative_regulation of PRKCA 1 64 0.57 23.11 28.43
24 INT2040 Positive_regulation of CYP2B6 1 95 0.69 34.3 25.6
25 INT48235 Negative_regulation of NPEPPS 4 72 0.46 44.54 25.03
26 INT4465 Gene_expression of CEL 1 116 0.77 98.35 23.58
27 INT64175 Negative_regulation of Gene_expression of CPOX 1 66 0.38 39.64 23.07
28 INT60690 Positive_regulation of Gene_expression of Il12a 1 69 0.63 41.41 20.85
29 INT12243 Positive_regulation of PRSS1 1 91 0.70 52.87 19.48
30 INT19509 Localization of Ifng 2 55 0.78 28.25 18.67
31 INT3364 Binding of SGCG 1 87 0.47 31.93 17.24
32 INT20216 Localization of NGF 1 40 0.80 18.16 16.61
33 INT24684 Localization of PLAT 1 30 0.78 26.21 13.56
34 INT91817 Positive_regulation of RETNLB 1 22 0.34 21.4 13.12
35 INT20381 Localization of Il2 1 71 0.77 34.23 13.03
36 INT29745 Binding of APP 1 47 0.48 26.49 12.4
37 INT66718 Positive_regulation of BDKRB2 2 21 0.64 9.89 11.6
38 INT86291 Negative_regulation of Mmp2 1 33 0.57 20.38 10.76
39 INT12991 Negative_regulation of Gene_expression of PTGS1 1 28 0.41 13.39 8.9
40 INT2597 Negative_regulation of ACHE 1 82 0.59 46.36 8.62
41 INT12975 Regulation of PLEK 1 21 0.60 13.62 8.28
42 INT1925 Gene_expression of PLAT 1 47 0.75 34.76 7.88
43 INT35307 Regulation of Adk 1 11 0.35 3.21 7.79
44 INT75526 Positive_regulation of Positive_regulation of PRKCA 1 16 0.50 4.34 7.46
45 INT81586 Negative_regulation of Casp1 1 11 0.57 6.55 6.45
46 INT57562 Gene_expression of GLA 1 52 0.77 24.62 6.14
47 INT48270 Negative_regulation of RNF130 1 44 0.57 21.31 6.14
48 INT10888 Binding of Vwf 1 32 0.46 22.87 5.21
49 INT24889 Negative_regulation of CABIN1 2 36 0.48 16.76 4.73
50 INT35609 Negative_regulation of F10 1 37 0.57 17.15 4.41
51 INT4097 Localization of Pth 1 66 0.81 47.17 4.36
52 INT82871 Protein_catabolism of MMP1 1 13 0.96 10.71 4.09
53 INT51831 Negative_regulation of ITGA2B 3 20 0.57 10.59 3.91
54 INT100360 Negative_regulation of TF 1 19 0.42 10.43 2.68
55 INT92610 Positive_regulation of Ik 3 10 0.51 2.22 2.36
56 INT63780 Positive_regulation of Localization of Ado 2 3 0.32 2.79 2.29
57 INT59680 Binding of Lynx1 1 10 0.12 1.53 2.19
58 INT84060 Regulation of Apoe 1 4 0.62 3.33 2.05
59 INT8757 Binding of ACHE 1 10 0.48 5.84 1.72
60 INT93980 Gene_expression of Rab8a 4 1 0.74 2.72 1.21
61 INT76957 Negative_regulation of ITGB3 1 6 0.57 2.82 1.13
62 INT91815 Positive_regulation of Positive_regulation of PRSS1 1 6 0.49 3.79 0.75
63 INT93981 Positive_regulation of Rab8a 2 1 0.66 1.41 0.67
64 INT19395 Negative_regulation of Localization of Pth 1 11 0.58 10.16 0.55
65 INT117172 Regulation of Hpt 3 7 0.41 3.39 0.52
66 INT93985 Positive_regulation of Gene_expression of Rab8a 1 1 0.39 1.08 0.45
67 INT93983 Binding of Rab8a 1 1 0.31 1.05 0.44
68 INT93982 Negative_regulation of Rab8a 1 1 0.35 1.08 0.44
69 INT93979 Negative_regulation of Gene_expression of Rab8a 1 1 0.48 1.03 0.42
70 INT91820 Regulation of ITGA2B 2 3 0.44 2.03 0.32
71 INT93984 Positive_regulation of Positive_regulation of Rab8a 1 1 0.48 0.34 0.27
72 INT92609 Negative_regulation of Positive_regulation of Ik 2 3 0.35 0.36 0.22
73 INT57182 Negative_regulation of Dhfr 1 2 0.55 0.37 0.16
74 INT92611 Positive_regulation of Positive_regulation of Ik 1 1 0.41 0.17 0.05
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