J:FEBS Lett.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT70757 Binding of Oprl1 and Pnoc 5 1 0.03 0.23 2.55
2 INT69666 Binding of OPRL1 and Pnoc 2 1 0.45 0.06 1.66
3 INT29599 Binding of Cyp21a1 and Adarb1 1 1 0.01 0 1.38
4 INT67383 Binding of OPRK1 and Pdyn 2 1 0.00 0 1.25
5 INT65203 OPRL1 Negative_regulation of ADCY1 1 1 0.19 0 1.19
6 INT65204 PNOC Negative_regulation of ADCY1 1 1 0.07 0 1.14
7 INT66767 Il1b Positive_regulation of Pla2g10 1 2 0.05 0.47 1.13
8 INT102690 IL1B Positive_regulation of ITGAL 1 2 0.05 0.87 0.99
9 INT57555 Binding of Oprm1 and Oprl1 2 1 0.06 0.05 0.97
10 INT129034 Nfkbia Positive_regulation of Nfkb1 1 2 0.02 0.67 0.89
11 INT43796 Binding of CDS1 and Adra2a 1 2 0.06 0 0.86
12 INT74829 Oprd1 Regulation of Slc1a2 1 1 0.17 0 0.76
13 INT57094 Oprl1 Positive_regulation of Negative_regulation of Rtcd1 1 1 0.01 0.1 0.71
14 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 1 0.04 0.62 0.65
15 INT99602 ZNF398 Negative_regulation of MMP2 1 2 0.14 0.85 0.63
16 INT66766 Casp1 Positive_regulation of Transcription of Pla2g10 1 1 0.06 0.19 0.6
17 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 1 0.05 0.22 0.6
18 INT17707 Binding of Calca and Iapp 1 2 0.42 0 0.54
19 INT66769 Negative_regulation of Il1b Positive_regulation of Pla2g10 1 1 0.04 0.25 0.53
20 INT33415 KNG1 Positive_regulation of GBP1 1 1 0.02 0.43 0.51
21 INT88215 Binding of PNOC and Pnoc 1 1 0.01 0.07 0.46
22 INT41039 Thop1 Positive_regulation of Mme 1 1 0.01 0 0.45
23 INT102691 RETNLB Positive_regulation of ITGAL 1 1 0.01 0.45 0.45
24 INT75728 PCDHB17 Positive_regulation of CCT6A 1 1 0.00 0.06 0.44
25 INT53802 SNORD50A Positive_regulation of Oprk1 1 1 0.12 0.16 0.37
26 INT91486 Negative_regulation of ZNF404 Positive_regulation of TRPV1 1 1 0.01 0 0.36
27 INT13548 Binding of PDYN and TALDO1 1 1 0.40 0 0.35
28 INT91485 ZNF404 Negative_regulation of AMT 1 1 0.01 0 0.35
29 INT99597 Negative_regulation of CPOX Regulation of Negative_regulation of ZNF398 1 1 0.02 0.44 0.33
30 INT57807 Binding of SST and SCG2 1 1 0.23 0 0.33
31 INT99603 ZNF398 Regulation of Transcription of MMP2 1 1 0.15 0.44 0.33
32 INT99598 ZNF398 Negative_regulation of Gene_expression of MMP2 1 1 0.10 0.44 0.33
33 INT116293 Gm9662 Negative_regulation of Pparg Negative_regulation of Positive_regulation of Pparg 1 1 0.00 0 0.33
34 INT116292 Gm9662 Negative_regulation of Pparg 1 1 0.00 0 0.33
35 INT116291 Gm9662 Negative_regulation of Positive_regulation of Pparg 1 1 0.00 0 0.32
36 INT99599 ZNF398 Negative_regulation of NR4A2 1 1 0.05 0.41 0.3
37 INT99601 ZNF398 Negative_regulation of Transcription of MMP2 1 1 0.10 0.41 0.3
38 INT99600 ZNF398 Negative_regulation of Transcription of NR4A2 1 1 0.10 0.41 0.3
39 INT116442 CD8B Negative_regulation of Positive_regulation of NFKB1 1 2 0.02 0 0.17
40 INT116443 LY9 Negative_regulation of Positive_regulation of NFKB1 1 2 0.12 0 0.17
41 INT116440 LY9 Negative_regulation of Gene_expression of CCL2 1 2 0.14 0.09 0.16
42 INT83271 Gda Negative_regulation of Napepld 1 1 0.05 0 0.1
43 INT83270 Snca Regulation of Napepld 1 1 0.14 0 0.09
44 INT116439 CD8B Negative_regulation of Gene_expression of CCL2 1 1 0.02 0 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 4 1902 0.78 275.47 1057.59
2 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
3 INT5895 Gene_expression of Oprm1 2 525 0.78 120.67 407.29
4 INT76660 Gene_expression of Trpv1 1 691 0.78 329.46 386.42
5 INT6580 Negative_regulation of Ptgs1 2 929 0.59 381.53 376.26
6 INT287 Localization of Cck 3 518 0.81 86.84 364.04
7 INT5660 Binding of Oprd1 2 477 0.48 71.86 342.06
8 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
9 INT5979 Gene_expression of Oprd1 2 428 0.78 75.64 320.32
10 INT4941 Positive_regulation of Oprd1 2 345 0.70 74.26 304.41
11 INT9131 Positive_regulation of Prkcg 2 431 0.70 130.8 302.41
12 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
13 INT11624 Gene_expression of OPRM1 5 445 0.78 72.36 294.36
14 INT9381 Positive_regulation of TRPV1 3 523 0.70 187.4 276.05
15 INT49750 Negative_regulation of CPOX 1 735 0.58 360.06 274.19
16 INT10832 Gene_expression of IL8 6 1050 0.78 698.72 270
17 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
18 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
19 INT5597 Gene_expression of Pdyn 2 433 0.78 62.97 235.47
20 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
21 INT1212 Binding of Oprl1 5 312 0.48 28.6 225.15
22 INT6293 Gene_expression of Oprm1 6 312 0.78 48.73 215.61
23 INT156 Negative_regulation of Prl 1 542 0.59 131.97 192.24
24 INT6488 Gene_expression of Tnf 6 484 0.78 339.61 191.58
25 INT24326 Gene_expression of Ngf 1 346 0.78 218.67 184.71
26 INT4803 Transcription of Penk 2 435 0.72 59.09 182.4
27 INT5930 Positive_regulation of Oprm1 3 221 0.70 31.19 172.93
28 INT4937 Negative_regulation of Oprd1 2 224 0.59 44.51 171.11
29 INT55879 Gene_expression of CCL2 12 421 0.78 240.74 166.02
30 INT4768 Positive_regulation of OPRM1 2 212 0.70 31.09 164.28
31 INT2366 Binding of Cck 1 192 0.48 30.64 163.46
32 INT768 Positive_regulation of Oprl1 6 179 0.70 40.05 156.93
33 INT6042 Binding of Oprm1 2 248 0.48 31.77 154.34
34 INT5061 Negative_regulation of Mme 2 306 0.59 51.97 136.9
35 INT4658 Binding of OPRM1 1 188 0.48 25.96 136.24
36 INT1614 Gene_expression of Oprl1 15 164 0.78 31.43 127.74
37 INT65054 Positive_regulation of Nfkb1 1 285 0.70 149.33 126.73
38 INT5931 Regulation of Oprm1 1 149 0.62 18.15 125.93
39 INT6822 Gene_expression of Pdyn 2 215 0.78 35.99 125.76
40 INT218 Positive_regulation of Th 1 245 0.70 40.5 120.1
41 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
42 INT27096 Positive_regulation of Nfkb1 6 325 0.70 195.11 109.06
43 INT10272 Gene_expression of Il1b 1 194 0.78 121.02 103.03
44 INT74826 Gene_expression of Slc1a2 1 131 0.78 61.83 100.84
45 INT293 Protein_catabolism of Penk 1 161 1.00 11.71 98.45
46 INT56130 Gene_expression of MC1R 6 259 0.78 62.7 97.55
47 INT29971 Gene_expression of Oprk1 1 126 0.78 35.32 93.97
48 INT1639 Negative_regulation of OPRM1 1 107 0.59 13.86 90.37
49 INT71789 Positive_regulation of MAPK1 4 396 0.70 234.44 89.27
50 INT54571 Positive_regulation of NFKB1 2 263 0.70 138.99 87.32
51 INT4798 Gene_expression of Nts 1 169 0.77 29.56 86.04
52 INT2289 Gene_expression of PENK 2 203 0.78 55.62 79.49
53 INT1335 Negative_regulation of Oprl1 6 123 0.59 18.02 77.13
54 INT25363 Negative_regulation of Trpv1 2 144 0.59 64.78 75.7
55 INT6656 Gene_expression of YY1 2 135 0.75 24.73 72.16
56 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
57 INT6490 Negative_regulation of ADCY1 3 145 0.58 26.25 70.96
58 INT5993 Positive_regulation of Nts 1 122 0.70 26.82 70.45
59 INT10837 Positive_regulation of Gene_expression of IL8 8 294 0.70 190.08 70.34
60 INT6489 Positive_regulation of Gene_expression of Tnf 2 140 0.70 92.31 67.85
61 INT4637 Binding of Adarb1 2 132 0.41 14.48 67.76
62 INT1603 Negative_regulation of Rtcd1 2 131 0.51 29.99 66.66
63 INT11937 Localization of Il6 2 228 0.81 139.83 64.39
64 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
65 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
66 INT50672 Positive_regulation of CPOX 1 205 0.44 125.93 60.06
67 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
68 INT6623 Gene_expression of NA 4 231 0.78 45.78 59.36
69 INT1510 Binding of PDYN 1 94 0.48 4.68 56.44
70 INT83602 Positive_regulation of Gene_expression of TRPV1 3 114 0.70 51.19 56.35
71 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
72 INT69876 Negative_regulation of Nfkb1 2 147 0.58 89.81 55.5
73 INT72182 Gene_expression of Mcpt1 2 167 0.75 123.7 52.15
74 INT27954 Positive_regulation of Gene_expression of Ngf 1 87 0.70 57.91 51.96
75 INT74827 Positive_regulation of Gene_expression of Slc1a2 1 52 0.70 26.54 50.63
76 INT7287 Positive_regulation of Transcription of Penk 1 103 0.70 19.81 50.37
77 INT76620 Gene_expression of Cnr2 1 93 0.78 34.7 50.14
78 INT10304 Binding of OPRK1 1 89 0.48 9.28 49.42
79 INT62521 Phosphorylation of Oprm1 5 44 0.82 2.66 47.45
80 INT6544 Negative_regulation of Localization of Cck 2 67 0.59 8.05 47.23
81 INT26500 Gene_expression of MMP2 4 201 0.78 110.57 46.9
82 INT2406 Gene_expression of CCK 11 85 0.78 28.04 46.67
83 INT55670 Negative_regulation of Gene_expression of Tnf 5 83 0.59 57.16 46.33
84 INT81498 Positive_regulation of Gene_expression of CCL2 7 107 0.70 53.89 45.22
85 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
86 INT52531 Gene_expression of Nfkb1 1 153 0.75 82.84 42.9
87 INT7828 Positive_regulation of Oprd1 1 55 0.69 14.11 42.86
88 INT88322 Gene_expression of CCR5 1 111 0.78 77.36 39.84
89 INT55135 Positive_regulation of Gene_expression of PTGS2 1 137 0.70 80.32 38.46
90 INT116321 Regulation of Nav1 2 38 0.62 26.62 37.97
91 INT927 Gene_expression of Oxt 1 184 0.78 44.71 35.79
92 INT67613 Positive_regulation of PPARG 2 94 0.70 69.15 34.38
93 INT34465 Regulation of Oprd1 1 34 0.45 7.14 34.29
94 INT2732 Gene_expression of VIP 2 74 0.78 24.57 33.72
95 INT48907 Positive_regulation of Gene_expression of Oprm1 2 53 0.69 8.55 33.52
96 INT64171 Regulation of CPOX 1 109 0.36 55.36 32.96
97 INT99610 Localization of MMP9 1 126 0.79 48.46 32.67
98 INT9658 Negative_regulation of Gene_expression of Il6 2 110 0.59 66.29 32.58
99 INT1495 Positive_regulation of Rtcd1 2 91 0.54 22.93 32.43
100 INT14497 Gene_expression of GRP 4 82 0.78 17.67 32.27
101 INT12397 Gene_expression of Oprd1 3 53 0.78 9.1 31.31
102 INT29477 Transcription of Oprl1 8 52 0.72 5.05 30.52
103 INT7845 Regulation of OPRK1 1 44 0.62 4.54 30.49
104 INT49431 Phosphorylation of OPRM1 1 31 0.82 2.2 29.09
105 INT87212 Negative_regulation of Positive_regulation of Nfkb1 2 74 0.57 38.21 28.31
106 INT56072 Negative_regulation of NFKB1 1 94 0.59 53.16 28.19
107 INT83708 Negative_regulation of MAPK1 1 156 0.57 84.93 27.85
108 INT62169 Positive_regulation of MC1R 1 72 0.69 14.56 27.52
109 INT5206 Gene_expression of AR 1 316 0.78 113.83 27.29
110 INT32794 Gene_expression of Grin2d 1 81 0.68 20.87 26.99
111 INT2408 Regulation of CCK 1 37 0.61 10.01 26.66
112 INT67610 Positive_regulation of Pparg 7 53 0.70 31.91 25.2
113 INT81496 Gene_expression of CNR2 2 68 0.75 30.04 24.92
114 INT66758 Binding of Nfkb1 1 97 0.48 50.65 23.65
115 INT34487 Localization of MMP2 1 56 0.81 31.41 23.61
116 INT15458 Gene_expression of NPY 2 50 0.76 22.67 23.03
117 INT34488 Negative_regulation of MMP2 1 85 0.59 41.98 21.72
118 INT1876 Positive_regulation of HLA-B 2 82 0.69 52.16 21.08
119 INT79349 Gene_expression of Sert1 1 58 0.77 12.7 20.65
120 INT1512 Binding of Prl 2 73 0.48 26.22 20.63
121 INT53575 Regulation of Gene_expression of Tnf 1 46 0.62 34.35 20.63
122 INT47876 Binding of Pnoc 1 20 0.47 4.99 20.01
123 INT7336 Positive_regulation of VIP 2 60 0.70 24.2 19.62
124 INT89396 Phosphorylation of AKT1 1 225 0.82 111.66 19.61
125 INT67608 Gene_expression of Pparg 2 41 0.78 25.09 19.53
126 INT12725 Positive_regulation of Racgap1 1 66 0.68 32.74 19.29
127 INT21105 Phosphorylation of Oprm1 3 32 0.82 0.83 19.29
128 INT68970 Positive_regulation of Pnoc 1 33 0.67 9.29 19.08
129 INT11803 Positive_regulation of Il2 1 62 0.70 31.44 18.93
130 INT40811 Binding of OPRL1 1 26 0.48 2.76 18.68
131 INT14114 Binding of Adra2a 1 30 0.48 4.24 18.53
132 INT90937 Negative_regulation of Gene_expression of Trpv1 1 34 0.59 22.74 18.12
133 INT55880 Negative_regulation of Gene_expression of CCL2 3 49 0.59 22.37 18.09
134 INT97984 Negative_regulation of SLC6A4 2 45 0.59 15.43 18.09
135 INT55878 Regulation of Gene_expression of CCL2 2 34 0.62 15.71 17.97
136 INT6782 Gene_expression of SCN5A 1 156 0.78 33.13 17.88
137 INT22068 Binding of CALCRL 2 53 0.41 6.14 17.32
138 INT36054 Transcription of IL1B 1 53 0.72 32.64 17.31
139 INT3364 Binding of SGCG 1 87 0.47 31.93 17.24
140 INT23784 Gene_expression of FAIM3 1 25 0.55 2.89 17.14
141 INT48055 Gene_expression of Grm1 1 27 0.78 14.29 17.01
142 INT13989 Negative_regulation of Slc3a1 1 27 0.24 5.34 16.76
143 INT110767 Localization of Mcpt1 2 43 0.68 24.3 16.74
144 INT15237 Protein_catabolism of Mme 1 31 0.96 10.26 16.69
145 INT78749 Gene_expression of SCN10A 3 25 0.75 9.23 16.5
146 INT48238 Regulation of Gene_expression of Ngf 1 25 0.62 11.48 16.42
147 INT52107 Transcription of IL8 1 63 0.72 41.66 16.06
148 INT19948 Gene_expression of Sds 1 34 0.63 14.69 15.44
149 INT5674 Gene_expression of Adra2a 2 34 0.77 6.14 15.13
150 INT89293 Positive_regulation of Gene_expression of CCR5 1 29 0.70 22.14 15
151 INT49376 Negative_regulation of Localization of Il6 2 37 0.59 12.66 14.99
152 INT29086 Negative_regulation of Sert1 1 37 0.58 7.49 14.98
153 INT14453 Localization of Mme 1 44 0.80 2.46 14.75
154 INT14264 Binding of Gal 1 39 0.47 5.7 14.48
155 INT26975 Gene_expression of Adipoq 2 113 0.75 106.71 14.46
156 INT81495 Positive_regulation of CNR2 1 28 0.67 14.62 14.27
157 INT80688 Positive_regulation of Positive_regulation of MAPK1 1 72 0.69 39.35 14.11
158 INT29170 Negative_regulation of Gene_expression of Il1b 1 25 0.59 16.36 13.68
159 INT1491 Regulation of Rtcd1 1 33 0.53 5.17 13.4
160 INT62523 Positive_regulation of Phosphorylation of Oprm1 1 11 0.53 0.75 12.51
161 INT85214 Gene_expression of SCN11A 2 24 0.78 4.05 12.5
162 INT1612 Regulation of Binding of Oprl1 1 19 0.62 2.34 12.45
163 INT113490 Gene_expression of SCN9A 2 22 0.77 5.45 12.27
164 INT21987 Positive_regulation of Rorb 1 30 0.33 12.7 12.24
165 INT72804 Negative_regulation of OPRL1 1 16 0.43 1.79 12.14
166 INT93715 Negative_regulation of MMP9 1 69 0.55 36.05 11.73
167 INT5045 Regulation of VIP 1 26 0.62 7.15 11.61
168 INT2260 Gene_expression of Tyr 3 30 0.49 7.05 11.31
169 INT75525 Negative_regulation of Positive_regulation of MAPK1 1 40 0.59 25.15 11.15
170 INT141 Binding of Th 1 21 0.48 3.53 11.04
171 INT6870 Positive_regulation of Oprk1 2 14 0.70 4 10.91
172 INT93129 Negative_regulation of KCNH2 2 42 0.54 9.63 10.85
173 INT34485 Negative_regulation of Localization of MMP2 1 17 0.50 9.96 10.49
174 INT74828 Regulation of Slc1a2 2 12 0.61 3.92 10.3
175 INT2294 Protein_catabolism of PENK 3 19 1.00 0.64 10.22
176 INT67048 Gene_expression of ITGA4 1 58 0.75 28.93 10.16
177 INT98130 Positive_regulation of CASP8 4 79 0.67 65.29 10.08
178 INT113603 Negative_regulation of Gene_expression of Mcpt1 2 26 0.41 22.82 9.91
179 INT10041 Protein_catabolism of Cck 1 18 0.96 2.71 9.81
180 INT55014 Positive_regulation of Ednrb 1 31 0.70 16.61 9.68
181 INT3431 Negative_regulation of Positive_regulation of Oprl1 3 14 0.46 2.55 9.65
182 INT62997 Gene_expression of Kcnj6 3 17 0.77 2.16 9.44
183 INT26502 Negative_regulation of Gene_expression of MMP2 4 39 0.58 21.45 9.42
184 INT67612 Binding of PPARG 1 38 0.48 22.67 8.94
185 INT6573 Regulation of Negative_regulation of Ptgs1 1 19 0.45 6.16 8.71
186 INT80872 Protein_catabolism of Nfkbia 1 28 0.92 10.56 8.62
187 INT89292 Positive_regulation of CCR5 3 27 0.70 15.12 8.59
188 INT53798 Gene_expression of Oprk1 2 14 0.73 1.82 8.24
189 INT62996 Gene_expression of Kcnj3 1 9 0.73 1.87 8.03
190 INT2093 Gene_expression of GAST 2 50 0.78 32.32 7.98
191 INT22491 Binding of Atrn 1 23 0.30 4.51 7.79
192 INT31060 Negative_regulation of Binding of OPRM1 1 12 0.37 2.65 7.75
193 INT26643 Negative_regulation of Positive_regulation of Th 1 12 0.59 1.26 7.74
194 INT165 Regulation of HRH1 1 12 0.45 1.76 7.57
195 INT105381 Binding of NPFF 1 4 0.48 1.07 7.48
196 INT17028 Positive_regulation of Scn7a 1 35 0.41 9.83 7.44
197 INT65206 Regulation of PNOC 1 8 0.38 1.61 7.43
198 INT103399 Positive_regulation of Positive_regulation of Pparg 3 11 0.66 7 7.36
199 INT6596 Positive_regulation of HLA-DRB1 1 33 0.61 27.01 7.26
200 INT11042 Localization of Tbxa2r 1 26 0.76 10.15 7.24
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