J:Frontiers in Aging Neuroscience

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT311525 Binding of Gria1 and Ltp 1 2 0.00 0.1 0.73
2 INT333544 CTSB Regulation of Protein_catabolism of APP 1 1 0.01 0.53 0.62
3 INT333543 CTSB Regulation of APP 1 1 0.01 0.53 0.62
4 INT311524 Gnrhr Positive_regulation of Transcription of Grin2a 1 1 0.02 0.54 0.55
5 INT311521 Gnrhr Positive_regulation of Gene_expression of Gria1 1 1 0.00 0.54 0.54
6 INT311522 Gnrhr Positive_regulation of Transcription of Gria1 1 1 0.00 0.54 0.54
7 INT311557 Binding of ROS1 and Ptpn2 1 2 0.02 2.32 0.46
8 INT316063 Ps Positive_regulation of IL8 1 2 0.09 1.33 0.41
9 INT316065 Eif1 Positive_regulation of IL8 1 2 0.01 1.34 0.41
10 INT323967 Il6 Positive_regulation of Gene_expression of App 1 1 0.10 0.86 0.38
11 INT311528 Binding of Grin2d and Ltp 1 1 0.00 0.37 0.28
12 INT311533 ROS1 Positive_regulation of Positive_regulation of RYR3 1 1 0.28 0.18 0.26
13 INT311532 ROS1 Regulation of RYR3 1 1 0.43 0.18 0.25
14 INT311531 IMMT Negative_regulation of Gene_expression of ROS1 1 1 0.11 1.09 0.24
15 INT311527 Binding of Grin2a and Gria1 1 1 0.01 0 0.21
16 INT316054 Eif1 Positive_regulation of Il6 1 1 0.00 0.78 0.21
17 INT316062 Ps Positive_regulation of Il6 1 1 0.04 0.77 0.21
18 INT316064 Binding of RBPJ and Csl 1 1 0.16 0.33 0.2
19 INT317322 Snca Regulation of Positive_regulation of Th 1 1 0.01 0.23 0.17
20 INT316052 Notch1 Regulation of Binding of Cd8a 1 1 0.01 0.86 0.15
21 INT316053 Notch1 Regulation of Binding of Cd4 1 1 0.02 0.86 0.15
22 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 1 0.01 0.86 0.15
23 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 1 0.02 0.86 0.15
24 INT311526 Gria1 Regulation of Gene_expression of Grin2a 1 1 0.01 0.32 0.15
25 INT316059 Ps Regulation of Binding of Cd4 1 1 0.06 0.86 0.13
26 INT316058 Ps Regulation of Binding of Cd8a 1 1 0.02 0.86 0.13
27 INT349274 Binding of CGF1 and NOS1 1 2 0.00 2.97 0.12
28 INT204996 Binding of Park7 and Pink1 2 1 0.34 1.09 0.11
29 INT215281 Mpz Positive_regulation of Gene_expression of Ros1 2 1 0.01 1.01 0.05
30 INT311535 ROS1 Negative_regulation of CA2 1 1 0.19 0.61 0.04
31 INT316057 Binding of Erbb4 and Nrg1 2 1 0.03 0.38 0.03
32 INT316060 Binding of Erbb4 and Ncor2 1 1 0.12 0.41 0.03
33 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 1 0.03 0.38 0.03
34 INT316056 Binding of Ncor2 and Tab2 1 1 0.12 0.41 0.03
35 INT317310 Binding of Large and Psmb10 1 1 0.00 0.94 0.03
36 INT316055 Binding of Erbb4 and Tab2 1 1 0.23 0.4 0.03
37 INT317301 Binding of Park2 and Park7 1 1 0.36 0.62 0
38 INT317318 Binding of Gfm1 and Trap1 1 1 0.01 0.83 0
39 INT317317 Binding of Psmb10 and Gfm1 1 1 0.00 0.73 0
40 INT311534 Binding of CISH and NFE2L2 1 1 0.02 0.64 0
41 INT317313 Atp13a2 Negative_regulation of Snca 1 1 0.13 0.59 0
42 INT317316 Park7 Positive_regulation of Protein_catabolism of Hmbs 1 1 0.11 0.68 0
43 INT317300 Binding of Park2 and Pink1 1 2 0.48 1.23 0
44 INT317302 Binding of Park2 and Mul1 1 1 0.01 0.62 0
45 INT317321 Mpz Positive_regulation of Gene_expression of Zfp263 1 1 0.02 0.58 0
46 INT317324 Park7 Positive_regulation of Protein_catabolism of SNCAIP 1 1 0.38 0.69 0
47 INT317307 Binding of Hsp90aa1 and Pink1 1 1 0.12 0.56 0
48 INT317315 Gene_expression of Snca Negative_regulation of Psmb10 1 1 0.00 0.52 0
49 INT317320 Binding of Snca and Atp13a2 1 1 0.08 0.58 0
50 INT334718 Binding of NOS1 and Bax 1 1 0.02 0.87 0
51 INT317308 Binding of Park7 and Mul1 1 1 0.01 0.62 0
52 INT317319 Binding of Trap1 and Pink1 1 3 0.26 2.67 0
53 INT317306 Binding of Mul1 and Pink1 1 1 0.01 0.62 0
54 INT317314 Gfm1 Positive_regulation of Gene_expression of Ros1 1 1 0.00 0.61 0
55 INT317311 Binding of Cdc37 and Pink1 1 1 0.13 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT7114 Positive_regulation of Ltp 13 1192 0.62 290.76 755.77
2 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
3 INT5972 Gene_expression of IL1B 10 948 0.78 510.91 263.97
4 INT49441 Negative_regulation of Cpox 7 494 0.59 303.22 177.46
5 INT7506 Negative_regulation of Ltp 4 267 0.46 91.01 176.8
6 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
7 INT66280 Gene_expression of Nos2 2 534 0.78 330.78 157.07
8 INT7628 Gene_expression of Ltp 4 273 0.77 70.21 147.87
9 INT49439 Gene_expression of Cpox 8 508 0.73 326.97 130.17
10 INT115386 Gene_expression of Ppara 8 779 0.77 549.99 128.36
11 INT8243 Positive_regulation of Il6 2 451 0.70 358.24 119.28
12 INT62124 Gene_expression of NOS1 7 444 0.78 218.08 114.85
13 INT48593 Positive_regulation of NOS1 4 420 0.68 226.15 114.71
14 INT7627 Negative_regulation of Positive_regulation of Ltp 3 162 0.50 41.2 106.27
15 INT49171 Gene_expression of Nos1 4 241 0.78 140.7 104.76
16 INT69440 Gene_expression of ROS1 14 752 0.78 477.64 103.83
17 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
18 INT65500 Gene_expression of App 14 605 0.78 429.94 98.31
19 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
20 INT3537 Positive_regulation of Car2 2 413 0.56 103.51 94.35
21 INT71789 Positive_regulation of MAPK1 1 396 0.70 234.44 89.27
22 INT54571 Positive_regulation of NFKB1 1 263 0.70 138.99 87.32
23 INT21793 Positive_regulation of Ngf 1 154 0.70 94.78 85.27
24 INT82448 Gene_expression of S100a8 4 246 0.77 236.72 84.02
25 INT84546 Positive_regulation of Ppara 2 481 0.70 334.21 83.45
26 INT75999 Gene_expression of BDNF 2 344 0.78 114.19 83.12
27 INT68682 Positive_regulation of VEGFA 2 640 0.70 454.14 81.65
28 INT56291 Gene_expression of Ros1 5 503 0.63 274.12 81.5
29 INT3214 Localization of Ins1 1 527 0.80 196.9 79.26
30 INT13036 Positive_regulation of Positive_regulation of Ltp 1 105 0.51 23.71 77.66
31 INT29708 Gene_expression of Gria1 25 177 0.78 56.36 77.37
32 INT62374 Gene_expression of NGF 1 158 0.78 77.87 76.45
33 INT102546 Gene_expression of Ccl2 1 197 0.78 192.8 67.41
34 INT49170 Negative_regulation of Nos1 1 116 0.59 60.66 58.87
35 INT82055 Positive_regulation of Creb1 1 176 0.70 60.2 58.39
36 INT13277 Regulation of Positive_regulation of Ltp 1 83 0.52 19.68 55.78
37 INT52692 Gene_expression of Ptgs2 2 160 0.78 85.06 55.73
38 INT251 Regulation of INS 1 398 0.62 232.47 55.04
39 INT8071 Positive_regulation of Gria1 2 102 0.70 26.61 53.37
40 INT3213 Gene_expression of Ins1 4 511 0.76 357.59 53.32
41 INT52611 Negative_regulation of Ptgs2 1 142 0.59 66.31 52.71
42 INT122041 Binding of Ppara 4 308 0.48 189.17 51.48
43 INT6473 Positive_regulation of Gene_expression of IL1B 4 204 0.70 117.23 50.86
44 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
45 INT71786 Phosphorylation of MAPK1 1 256 0.82 110.09 46.17
46 INT6979 Positive_regulation of CA2 2 206 0.67 50.79 44.97
47 INT25610 Positive_regulation of Gene_expression of Il1 1 136 0.67 104.43 43.86
48 INT25383 Gene_expression of Csf2 1 222 0.76 152.93 43.32
49 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
50 INT69437 Positive_regulation of ROS1 4 328 0.58 222.83 40.56
51 INT957 Positive_regulation of GHRH 1 136 0.70 36.84 40.52
52 INT97596 Localization of S100a8 3 94 0.78 90.69 40.41
53 INT3252 Negative_regulation of INS 3 428 0.59 271.65 39.52
54 INT92517 Gene_expression of Grin1 1 105 0.78 29.53 39.43
55 INT77434 Positive_regulation of Gene_expression of Nos2 2 151 0.69 96.76 38.94
56 INT92515 Gene_expression of Grin2a 17 84 0.76 26.68 38.37
57 INT77307 Gene_expression of Bcl2 3 399 0.77 319.77 38
58 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
59 INT8747 Positive_regulation of Ins1 1 221 0.69 154.28 35.15
60 INT74563 Positive_regulation of Gene_expression of ROS1 5 258 0.61 168.18 34.08
61 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
62 INT67039 Positive_regulation of Cpox 2 144 0.65 98.4 33.77
63 INT11325 Gene_expression of HLA-E 7 209 0.76 98.05 33.72
64 INT5489 Localization of CA2 2 172 0.80 39.46 33.56
65 INT9694 Positive_regulation of Csf2 1 102 0.68 70.09 33.07
66 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
67 INT96913 Positive_regulation of Mapk8 2 179 0.69 130.44 32.2
68 INT124860 Gene_expression of Bace1 4 330 0.78 157.11 31.65
69 INT114173 Phosphorylation of Gria1 1 27 0.82 33.73 31.24
70 INT49001 Regulation of Gria1 4 51 0.56 18.28 31.22
71 INT23435 Positive_regulation of NGF 1 54 0.70 32.41 30.11
72 INT64113 Positive_regulation of Gene_expression of NOS1 4 110 0.60 71.03 29.72
73 INT122039 Positive_regulation of Gene_expression of Ppara 2 144 0.68 113.55 28.55
74 INT66200 Gene_expression of Gfap 1 215 0.78 88.04 28.25
75 INT48853 Positive_regulation of BDNF 3 82 0.69 43.92 27.99
76 INT48202 Gene_expression of Tgfb1 1 146 0.78 89.93 27.76
77 INT133876 Positive_regulation of Gene_expression of Ros1 3 141 0.32 75.55 27.45
78 INT116861 Gene_expression of Apoe 16 182 0.78 100.41 27.26
79 INT145426 Positive_regulation of Ros1 1 185 0.56 106.76 27.21
80 INT32794 Gene_expression of Grin2d 36 81 0.68 20.87 26.99
81 INT16428 Positive_regulation of Gtf3a 1 135 0.20 106.44 26.67
82 INT111081 Gene_expression of CA1 10 19 0.75 51.09 26.64
83 INT9682 Positive_regulation of IGF1 2 238 0.70 120.03 26.36
84 INT56524 Gene_expression of Grip2 1 67 0.74 14.77 26.23
85 INT11014 Phosphorylation of CREB1 1 72 0.81 26.35 25.64
86 INT89662 Positive_regulation of Gene_expression of App 3 169 0.70 133.36 25.62
87 INT57192 Binding of Ltp 1 43 0.41 17.48 24.96
88 INT48766 Regulation of NOS1 1 73 0.61 37.01 24.59
89 INT44954 Gene_expression of APP 9 191 0.78 105.86 23.9
90 INT49172 Regulation of Nos1 1 43 0.52 27.53 23.66
91 INT66758 Binding of Nfkb1 1 97 0.48 50.65 23.65
92 INT55170 Gene_expression of NFKB1 1 97 0.77 52.75 23.04
93 INT71875 Localization of Nfkb1 1 92 0.78 48.13 22.94
94 INT17962 Regulation of Car2 1 124 0.41 33.98 22.71
95 INT18322 Negative_regulation of Ins1 1 132 0.58 88.49 22.59
96 INT49623 Negative_regulation of Gria1 4 39 0.59 12.4 21.59
97 INT11625 Localization of App 2 98 0.78 55.46 20.86
98 INT9237 Regulation of Gene_expression of IL1B 1 49 0.62 30.69 20.34
99 INT24240 Positive_regulation of Th 1 60 0.70 9.92 20.18
100 INT102545 Gene_expression of Ccr2 1 42 0.78 61.43 19.81
101 INT46016 Gene_expression of Ngfr 1 69 0.77 41.22 19.8
102 INT16794 Binding of App 7 103 0.48 64.87 19.79
103 INT138696 Positive_regulation of Ccl2 2 57 0.67 59.57 19.58
104 INT65502 Regulation of App 1 77 0.62 52.05 19.44
105 INT23533 Gene_expression of CA2 2 110 0.75 30.81 19.4
106 INT91462 Positive_regulation of Phosphorylation of MAPK1 1 99 0.67 40.28 18.99
107 INT3060 Negative_regulation of Bche 1 94 0.59 46.75 18.51
108 INT65260 Positive_regulation of Col7a1 1 95 0.69 61.73 18.42
109 INT78990 Regulation of Cpox 2 72 0.57 35.22 18.16
110 INT7439 Positive_regulation of CFP 10 52 0.67 19.97 17.87
111 INT113602 Positive_regulation of Gene_expression of Ccl2 1 48 0.70 48.71 17.85
112 INT29709 Positive_regulation of Gene_expression of Gria1 2 36 0.69 9.43 17.83
113 INT80223 Positive_regulation of Hmox1 2 128 0.68 77.71 17.64
114 INT1767 Positive_regulation of PROC 3 83 0.67 54.14 17
115 INT24225 Gene_expression of Alms1 1 93 0.62 52.75 16.93
116 INT23657 Positive_regulation of APP 2 64 0.70 39.76 16.68
117 INT84924 Positive_regulation of Gene_expression of NGF 1 29 0.68 17.91 16.46
118 INT49263 Binding of Grip2 11 31 0.41 9.86 16.38
119 INT111073 Gene_expression of Psen1 17 167 0.76 78.65 15.83
120 INT139128 Positive_regulation of Negative_regulation of Ltp 1 12 0.42 4.94 15.52
121 INT16266 Gene_expression of Chat 1 80 0.67 16.14 15.01
122 INT61864 Regulation of Gene_expression of Gria1 3 24 0.62 13.27 14.3
123 INT34904 Negative_regulation of Gtf3a 1 48 0.15 38.88 13.73
124 INT69435 Negative_regulation of ROS1 3 74 0.51 50.38 13.71
125 INT71879 Negative_regulation of Localization of Nfkb1 1 30 0.57 21.8 13.48
126 INT49538 Binding of Gria1 1 22 0.47 2.66 13.35
127 INT123593 Gene_expression of Snca 8 58 0.78 35.76 12.87
128 INT107916 Protein_catabolism of App 5 114 1.00 66.71 12.38
129 INT69436 Negative_regulation of Gene_expression of ROS1 2 81 0.38 46.58 12.22
130 INT100799 Negative_regulation of Grin2a 3 27 0.57 7.33 12.2
131 INT110988 Gene_expression of Insr 2 58 0.42 42.12 12.18
132 INT112003 Localization of ROS1 6 94 0.73 66.32 12.16
133 INT194462 Localization of Ppara 2 94 0.78 68.33 12.09
134 INT146197 Positive_regulation of Rhoa 1 60 0.68 34.12 12.02
135 INT92686 Gene_expression of Ctgf 1 51 0.77 34.4 11.93
136 INT100821 Localization of Ros1 1 59 0.60 45.26 11.92
137 INT81640 Positive_regulation of Gene_expression of Bcl2 3 106 0.69 84.58 11.63
138 INT65501 Regulation of Gene_expression of App 2 56 0.62 32.51 11.48
139 INT56494 Localization of Ide 1 73 0.68 22.9 11.26
140 INT311552 Positive_regulation of Gene_expression of CA1 2 3 0.67 21.83 11.2
141 INT98789 Negative_regulation of Gene_expression of App 2 54 0.58 40.27 11.15
142 INT48203 Positive_regulation of Tgfb1 1 67 0.70 41.31 11.07
143 INT118390 Positive_regulation of Nfe2l2 1 82 0.70 20.41 10.61
144 INT86361 Positive_regulation of Positive_regulation of NOS1 2 39 0.53 18.93 10.42
145 INT101474 Positive_regulation of Gene_expression of Gfap 1 61 0.70 38.3 10.35
146 INT64193 Regulation of Grin2a 3 19 0.54 2.98 10.31
147 INT94784 Binding of ROS1 1 113 0.40 71.57 10.26
148 INT127123 Positive_regulation of Snca 1 35 0.70 14.76 10.1
149 INT169205 Gene_expression of Ps 13 23 0.58 15.88 9.99
150 INT75768 Transcription of Cpox 1 37 0.27 19.41 9.79
151 INT23535 Positive_regulation of Localization of CA2 1 41 0.41 13.52 9.43
152 INT140224 Localization of Ccl2 2 32 0.72 26.91 9.39
153 INT20371 Gene_expression of Cd8a 1 125 0.60 67.59 8.97
154 INT64815 Binding of Jun 2 49 0.48 21.47 8.59
155 INT109005 Gene_expression of Proc 1 61 0.75 37.86 8.49
156 INT91772 Gene_expression of PSEN1 4 115 0.75 38.12 8.48
157 INT28671 Positive_regulation of Gene_expression of HLA-E 2 43 0.67 22.85 8.39
158 INT193832 Localization of Ps 2 19 0.13 6.96 8.04
159 INT87271 Positive_regulation of Phosphorylation of CREB1 1 27 0.66 12.87 7.91
160 INT80220 Positive_regulation of Bcl2 1 71 0.58 57.73 7.86
161 INT181817 Negative_regulation of Gene_expression of Ppara 1 58 0.58 43.24 7.67
162 INT189230 Gene_expression of GSN 1 12 0.75 25.04 7.6
163 INT36405 Positive_regulation of Insr 1 26 0.66 24.5 7.24
164 INT4228 Gene_expression of CAT 1 50 0.75 20.62 7.18
165 INT57023 Negative_regulation of Gene_expression of Gria1 6 20 0.58 6.92 7.17
166 INT63373 Negative_regulation of Gene_expression of NGF 1 14 0.57 8.9 7.1
167 INT197493 Localization of Apoe 4 61 0.79 27.48 7.06
168 INT76120 Gene_expression of Ptprc 1 102 0.59 30.42 7.02
169 INT61120 Positive_regulation of Gene_expression of Tgfb1 2 34 0.70 21.15 6.93
170 INT138799 Regulation of Gene_expression of Ppara 1 40 0.60 29.42 6.89
171 INT69441 Regulation of Gene_expression of ROS1 1 38 0.50 26.78 6.78
172 INT50255 Regulation of Cd4 1 39 0.49 29.73 6.77
173 INT182351 Positive_regulation of Gene_expression of Apoe 3 38 0.50 19.78 6.72
174 INT195145 Positive_regulation of Gene_expression of CA2 1 25 0.37 7.2 6.59
175 INT98837 Positive_regulation of Bax 1 72 0.61 63.14 6.41
176 INT96164 Positive_regulation of CA1 3 8 0.67 10.99 6.23
177 INT46721 Regulation of Csf2 1 26 0.45 20.4 6.18
178 INT84965 Gene_expression of MAOA 1 15 0.75 6.9 6.06
179 INT143357 Binding of Ros1 1 48 0.36 27.76 6
180 INT99438 Positive_regulation of Atf6b 1 12 0.49 4.28 5.97
181 INT63822 Gene_expression of Mmp23 1 23 0.43 14.15 5.96
182 INT94927 Transcription of Gria1 2 12 0.69 3.14 5.94
183 INT63042 Binding of Apoe 5 59 0.48 31.23 5.88
184 INT111069 Regulation of Psen1 1 19 0.44 7.78 5.87
185 INT112530 Localization of Ptgs2 1 13 0.70 7.77 5.86
186 INT53196 Binding of Cd4 1 44 0.47 27.28 5.85
187 INT60724 Gene_expression of Psen2 4 30 0.72 27 5.79
188 INT5490 Binding of CA2 1 52 0.36 9.73 5.53
189 INT116229 Gene_expression of C1qa 1 28 0.77 18.53 5.35
190 INT107173 Phosphorylation of App 2 20 0.82 12.64 5.3
191 INT64767 Negative_regulation of Gene_expression of HLA-E 1 18 0.57 12.64 5.23
192 INT115816 Protein_catabolism of APP 2 35 0.99 20.14 5.06
193 INT67597 Negative_regulation of Das 1 17 0.37 9.95 5.05
194 INT135474 Negative_regulation of Gene_expression of Grin2a 5 7 0.39 6.94 4.89
195 INT104391 Gene_expression of Tnpo1 1 12 0.65 9.61 4.87
196 INT111947 Positive_regulation of Gene_expression of Grin2a 2 7 0.68 1.75 4.84
197 INT204971 Gene_expression of Pink1 1 42 0.77 23.95 4.75
198 INT127122 Positive_regulation of Gene_expression of Snca 2 11 0.69 15.36 4.56
199 INT259520 Negative_regulation of Gene_expression of Ps 5 6 0.08 4.8 4.52
200 INT72703 Gene_expression of Ide 1 79 0.70 45.04 4.47
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