J:Frontiers in Neuroscience

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT356313 Crh Positive_regulation of Localization of Helt 1 4 0.02 0 2.11
2 INT356327 Crh Positive_regulation of Localization of Gabrg1 1 3 0.17 0 1.58
3 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 2 0.18 0.65 1.33
4 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 2 0.01 0.65 1.32
5 INT356316 Crh Positive_regulation of Localization of Cea 1 2 0.34 0 1.06
6 INT72917 Binding of Crh and Crhr1 4 1 0.32 0.73 0.91
7 INT356324 ORF61 Regulation of Localization of Gabrg1 1 2 0.00 0.19 0.76
8 INT356329 Crhr1 Regulation of Cea 1 1 0.09 0.31 0.64
9 INT356314 Binding of Crhr1 and ORF61 1 2 0.00 0 0.63
10 INT356328 Crh Positive_regulation of Cea 1 1 0.26 0.28 0.6
11 INT356315 Crh Regulation of Cea 1 1 0.16 0.08 0.58
12 INT356311 Crh Regulation of Gabrg1 1 1 0.08 0.08 0.57
13 INT356320 ORF61 Positive_regulation of Positive_regulation of Prkaca 1 1 0.01 0.05 0.57
14 INT356321 Positive_regulation of Crhr1 Positive_regulation of Cea 1 1 0.19 0.37 0.56
15 INT356322 Positive_regulation of Crhr1 Positive_regulation of ORF61 1 1 0.00 0 0.54
16 INT249717 Binding of NCL and MCF2L 1 1 0.23 0 0.54
17 INT205030 Crh Positive_regulation of Crhr1 2 1 0.54 1.33 0.51
18 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 1 0.01 0.22 0.48
19 INT321046 Anpep Regulation of Negative_regulation of Hps4 1 1 0.02 0.25 0.43
20 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 1 0.01 0.25 0.43
21 INT356330 ORF61 Regulation of ORF61 Regulation of Crh 1 1 0.00 0.1 0.38
22 INT356319 ORF61 Regulation of Crh 1 1 0.00 0.1 0.38
23 INT356323 Binding of ac and Crhr1 1 1 0.01 0 0.32
24 INT258574 Cysltr1 Positive_regulation of Positive_regulation of Cnr1 1 1 0.01 0.07 0.32
25 INT356312 Binding of ac and ORF61 1 1 0.00 0 0.32
26 INT336480 Binding of Pln and RLS 1 1 0.02 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT7114 Positive_regulation of Ltp 2 1192 0.62 290.76 755.77
2 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
3 INT5379 Gene_expression of Fos 1 656 0.78 255.5 292.54
4 INT11377 Positive_regulation of Ngf 1 331 0.70 206.5 238
5 INT11009 Phosphorylation of Creb1 2 458 0.82 111.34 221.97
6 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
7 INT6354 Localization of Gabrg1 14 321 0.74 41.41 186.74
8 INT7506 Negative_regulation of Ltp 1 267 0.46 91.01 176.8
9 INT14843 Gene_expression of Gabrg1 1 301 0.77 62.63 139.16
10 INT11012 Positive_regulation of Creb1 2 258 0.70 84.4 132
11 INT5380 Positive_regulation of Gene_expression of Fos 1 243 0.70 105.65 131.05
12 INT64161 Positive_regulation of Prkca 2 213 0.70 85.06 129.91
13 INT6323 Positive_regulation of Gabrg1 2 213 0.70 45.08 124.34
14 INT1438 Localization of Pomc 1 360 0.81 101.26 116.47
15 INT65731 Gene_expression of Cnr1 6 234 0.78 63.82 109.34
16 INT96917 Positive_regulation of Mapk14 1 261 0.70 173.29 88.79
17 INT64158 Negative_regulation of Prkca 1 121 0.59 29.8 88.66
18 INT15898 Positive_regulation of Prkaca 3 199 0.70 50.89 87.54
19 INT4798 Gene_expression of Nts 7 169 0.77 29.56 86.04
20 INT29708 Gene_expression of Gria1 2 177 0.78 56.36 77.37
21 INT7028 Localization of Pdyn 2 90 0.81 8.89 73.54
22 INT5993 Positive_regulation of Nts 1 122 0.70 26.82 70.45
23 INT8346 Gene_expression of Qrfp 1 136 0.70 19.49 70.21
24 INT5861 Gene_expression of Egr1 5 203 0.78 49.35 68.13
25 INT65733 Positive_regulation of Cnr1 3 125 0.70 40.27 67.33
26 INT8733 Localization of Oprm1 1 61 0.75 7.55 64.61
27 INT8363 Localization of Nts 1 135 0.81 14.29 61.71
28 INT2761 Regulation of Gabrg1 1 119 0.61 18.8 60.52
29 INT64159 Gene_expression of Prkca 1 90 0.78 34.65 55.97
30 INT17458 Negative_regulation of Gene_expression of FOS 1 98 0.57 36.77 55.69
31 INT8071 Positive_regulation of Gria1 1 102 0.70 26.61 53.37
32 INT52611 Negative_regulation of Ptgs2 1 142 0.59 66.31 52.71
33 INT16850 Negative_regulation of Localization of Gabrg1 1 73 0.51 8.28 47.89
34 INT671 Positive_regulation of Cea 2 221 0.69 164.5 47.79
35 INT60388 Gene_expression of Helt 8 90 0.07 19.18 41.72
36 INT6357 Positive_regulation of Localization of Gabrg1 12 53 0.41 7.03 39.21
37 INT1705 Gene_expression of pCA 1 126 0.65 88.65 34.81
38 INT66005 Regulation of Cnr1 2 47 0.61 19.21 34.52
39 INT1624 Gene_expression of Cea 8 212 0.76 180.44 34.21
40 INT5862 Positive_regulation of Egr1 4 82 0.70 30.4 33.96
41 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
42 INT67912 Gene_expression of GRIN1 2 75 0.77 28.99 29.28
43 INT11796 Positive_regulation of Helt 3 52 0.31 11.7 29.22
44 INT4459 Positive_regulation of Arc 6 74 0.69 33.61 28.29
45 INT48853 Positive_regulation of BDNF 1 82 0.69 43.92 27.99
46 INT73314 Gene_expression of Arc 12 133 0.78 67.78 27.44
47 INT93360 Gene_expression of Slc6a3 1 63 0.78 19.54 26.55
48 INT101120 Gene_expression of Comt 2 63 0.77 34.75 26.13
49 INT6054 Positive_regulation of Gene_expression of Egr1 1 67 0.70 18.45 25.93
50 INT11014 Phosphorylation of CREB1 2 72 0.81 26.35 25.64
51 INT12124 Gene_expression of MAPK1 2 141 0.75 82.4 25.58
52 INT1728 Negative_regulation of Cndp2 4 36 0.57 3.76 25.39
53 INT7584 Gene_expression of Crh 1 112 0.78 39.15 25.33
54 INT16851 Regulation of Localization of Gabrg1 3 34 0.39 4.34 22.29
55 INT8075 Localization of Crh 2 64 0.81 25.41 19.45
56 INT91916 Gene_expression of P2rx3 6 51 0.78 21.2 19.05
57 INT9230 Gene_expression of Htr3a 1 43 0.78 10.54 18.81
58 INT7439 Positive_regulation of CFP 1 52 0.67 19.97 17.87
59 INT30245 Binding of Pdyn 1 26 0.37 2.31 17
60 INT26972 Negative_regulation of Tenc1 2 57 0.57 56.71 16.87
61 INT87932 Positive_regulation of Gene_expression of Cnr1 1 28 0.69 8.86 16.38
62 INT30440 Gene_expression of Hps4 2 15 0.29 2.39 15.31
63 INT21177 Positive_regulation of Crh 4 39 0.70 17.5 15.28
64 INT18430 Positive_regulation of Hps4 2 14 0.24 0.81 14.82
65 INT11795 Negative_regulation of Helt 3 33 0.28 6.51 14.76
66 INT54924 Gene_expression of RLS 2 67 0.62 83.2 14.25
67 INT90942 Regulation of P2rx1 2 31 0.61 16.61 13.69
68 INT13572 Localization of Helt 2 31 0.36 5.85 13.41
69 INT76469 Positive_regulation of Gene_expression of Prkca 1 18 0.46 7.9 13.36
70 INT7585 Regulation of Crh 3 24 0.58 9.88 12.97
71 INT12369 Negative_regulation of Htr3a 1 28 0.59 8.78 12.62
72 INT7389 Positive_regulation of Localization of Pdyn 1 15 0.48 1.68 11.88
73 INT30236 Negative_regulation of Hps4 1 8 0.15 1.03 11.4
74 INT9586 Gene_expression of Eef1a2 4 29 0.65 6.79 11.12
75 INT104039 Positive_regulation of Crhr1 7 15 0.70 8.34 10.99
76 INT2491 Regulation of Cea 3 38 0.61 26.18 10.95
77 INT79556 Gene_expression of GRIN3B 2 16 0.77 7.71 10.75
78 INT102865 Positive_regulation of Positive_regulation of Prkca 2 25 0.69 8.34 9.9
79 INT95342 Gene_expression of GRIN2B 2 21 0.75 4.99 9.32
80 INT40609 Binding of Prkaca 1 23 0.36 3.42 9.19
81 INT2139 Negative_regulation of Cea 1 55 0.43 43.59 9.14
82 INT34474 Negative_regulation of Positive_regulation of Gabrg1 1 10 0.57 1.28 9
83 INT4159 Gene_expression of Hp 4 33 0.72 12.49 8.39
84 INT13840 Negative_regulation of CPQ 1 19 0.57 1.25 8.36
85 INT18185 Gene_expression of Tyr 3 32 0.76 12.52 8.17
86 INT18736 Gene_expression of Ptpn6 7 19 0.59 4.44 8.06
87 INT119940 Positive_regulation of Gene_expression of Arc 3 36 0.70 18.87 7.85
88 INT4457 Regulation of Arc 1 27 0.60 14.96 7.83
89 INT95172 Localization of P2rx1 1 14 0.78 6.77 7.81
90 INT6055 Transcription of Egr1 3 47 0.69 3.61 7.68
91 INT11441 Negative_regulation of Anpep 6 18 0.59 3.73 7.51
92 INT9491 Positive_regulation of Ptpn6 6 11 0.51 2.33 7.32
93 INT102080 Positive_regulation of P2rx3 1 20 0.67 6.91 7.3
94 INT10478 Protein_catabolism of Alms1 2 25 0.47 12.95 7.19
95 INT6057 Negative_regulation of Gene_expression of Egr1 1 17 0.57 4.17 7.17
96 INT18428 Protein_catabolism of Pdyn 1 9 0.92 1.2 6.87
97 INT28424 Regulation of Cysltr1 1 17 0.41 7.33 6.34
98 INT85655 Gene_expression of Crhr1 4 17 0.68 9.34 6.31
99 INT163052 Regulation of Msn 1 11 0.38 1.21 6.31
100 INT2137 Localization of Cea 3 27 0.70 19.22 6.14
101 INT6667 Gene_expression of CREB1 2 27 0.77 6.29 5.84
102 INT3905 Positive_regulation of Positive_regulation of Rtcd1 1 10 0.27 1.76 5.82
103 INT50975 Localization of Ptpn6 4 8 0.65 2.64 5.7
104 INT80344 Regulation of Camk2a 1 9 0.56 0.99 5.66
105 INT3768 Negative_regulation of ANPEP 1 16 0.59 4.96 5.52
106 INT187133 Protein_catabolism of TIMP1 1 19 0.73 11.3 5.51
107 INT177584 Gene_expression of MR1 1 80 0.58 46.48 5.48
108 INT12726 Gene_expression of Rtcd1 2 17 0.32 2.55 4.76
109 INT51944 Positive_regulation of Transcription of Egr1 2 12 0.49 1.96 4.72
110 INT55114 Gene_expression of CRS 1 42 0.58 26.86 4.69
111 INT13590 Negative_regulation of Localization of Nts 1 8 0.42 1.36 4.59
112 INT91917 Negative_regulation of P2rx3 1 11 0.59 6.56 4.51
113 INT102187 Gene_expression of SH2B2 1 23 0.59 26.54 4.39
114 INT19777 Binding of Crh 2 16 0.40 6.65 4.36
115 INT63840 Positive_regulation of Positive_regulation of Gabrg1 1 9 0.49 0.9 4.11
116 INT85677 Positive_regulation of Gpbar1 2 24 0.68 8.41 4.09
117 INT173910 Gene_expression of LRP2 1 24 0.75 19.99 4.09
118 INT172197 Positive_regulation of Gene_expression of Comt 1 12 0.69 7.61 4.06
119 INT41878 Positive_regulation of EP300 1 13 0.61 5.24 3.95
120 INT151684 Gene_expression of MCF2L 1 7 0.54 6.25 3.76
121 INT106095 Localization of Arc 1 17 0.80 7.61 3.74
122 INT192129 Gene_expression of P2rx2 5 24 0.67 7.62 3.68
123 INT206598 Regulation of Gene_expression of Comt 1 9 0.60 6 3.56
124 INT22270 Regulation of IGKV1-5 1 13 0.39 3.56 3.54
125 INT6339 Negative_regulation of Ptpn6 2 6 0.14 0.71 3.44
126 INT195964 Transcription of Comt 1 8 0.71 4.72 3.4
127 INT4799 Negative_regulation of Gene_expression of Nts 1 7 0.40 2.03 3.35
128 INT1727 Gene_expression of Cndp2 1 22 0.74 4.28 3.34
129 INT12388 Negative_regulation of Crhr1 1 17 0.59 9.47 3.33
130 INT117117 Positive_regulation of REM1 3 12 0.40 10.1 3.33
131 INT175262 Binding of SH2B2 1 18 0.36 22.85 3.18
132 INT45199 Protein_catabolism of Cndp2 1 7 0.86 0.31 3.15
133 INT8043 Binding of Ntsr2 2 3 0.31 0.11 3.12
134 INT61791 Positive_regulation of SH2B2 1 9 0.50 8.36 2.99
135 INT103049 Regulation of P2rx3 2 9 0.60 6 2.92
136 INT178457 Positive_regulation of LIFR 2 12 0.56 3.98 2.9
137 INT15288 Regulation of Hp 2 11 0.60 3.68 2.89
138 INT30228 Protein_catabolism of Anpep 4 3 0.42 0.82 2.87
139 INT91918 Localization of P2rx3 2 10 0.72 3.16 2.82
140 INT162957 Positive_regulation of STON1 1 5 0.35 4.83 2.77
141 INT167311 Gene_expression of Aqp5 2 8 0.61 1.77 2.75
142 INT321018 Protein_catabolism of Ptpn6 4 1 0.14 0.52 2.73
143 INT44998 Regulation of Eef1a2 1 6 0.42 2.37 2.65
144 INT176892 Binding of MR1 3 36 0.32 15.55 2.58
145 INT82284 Negative_regulation of Gene_expression of Arc 1 10 0.41 4.26 2.58
146 INT84599 Gene_expression of Aqp2 2 31 0.77 22.58 2.54
147 INT167096 Positive_regulation of Gene_expression of Helt 2 10 0.05 0.89 2.49
148 INT178458 Negative_regulation of LIFR 1 13 0.47 8.75 2.48
149 INT9455 Negative_regulation of Rnpep 1 5 0.31 0.52 2.47
150 INT44880 Gene_expression of REM1 7 21 0.30 5.3 2.43
151 INT249718 Binding of MCF2L 1 6 0.16 3.52 2.36
152 INT85630 Positive_regulation of Tyr 2 11 0.56 3.07 2.31
153 INT37347 Positive_regulation of Itpr3 1 6 0.34 1.3 2.31
154 INT321023 Positive_regulation of Localization of Ptpn6 3 1 0.07 0.27 2.15
155 INT26123 Regulation of Ep300 1 6 0.23 1.22 2.03
156 INT156064 Gene_expression of LMNA 4 50 0.65 13.38 2.01
157 INT22269 Gene_expression of IGKV1-5 6 32 0.50 1.71 1.95
158 INT26124 Negative_regulation of Ep300 2 5 0.37 1.25 1.94
159 INT348096 Regulation of Gene_expression of GJD2 7 1 0.43 3.3 1.83
160 INT43143 Binding of Bad 1 8 0.21 5.12 1.81
161 INT68196 Protein_catabolism of Rnpep 1 2 0.07 0 1.76
162 INT348094 Regulation of GJD2 7 1 0.59 2.94 1.76
163 INT294504 Gene_expression of Safb 2 9 0.41 0.97 1.72
164 INT172622 Localization of EP300 1 8 0.65 2.56 1.72
165 INT216977 Gene_expression of Lpar4 1 7 0.35 3.93 1.66
166 INT300417 Localization of Tyr 3 5 0.11 0.26 1.65
167 INT267806 Negative_regulation of Pln 1 8 0.40 4.01 1.63
168 INT54366 Gene_expression of Anpep 1 6 0.77 1.38 1.52
169 INT72329 Transcription of Arc 3 20 0.67 12.52 1.51
170 INT172752 Protein_catabolism of Hps4 4 2 0.16 0.22 1.51
171 INT93792 Binding of Crhr1 2 4 0.48 1.32 1.49
172 INT53003 Positive_regulation of Positive_regulation of Egr1 1 6 0.64 2.36 1.44
173 INT9454 Gene_expression of Rnpep 1 5 0.65 0.58 1.43
174 INT73553 Gene_expression of Aqp1 3 23 0.67 4.65 1.34
175 INT356309 Gene_expression of Adcy7 3 1 0.52 0.13 1.31
176 INT213723 Regulation of Gene_expression of Eef1a2 1 1 0.03 0.57 1.28
177 INT37602 Gene_expression of behavior 3 5 0.11 0.93 1.27
178 INT162467 Gene_expression of ERN1 1 10 0.56 5.11 1.26
179 INT55113 Positive_regulation of Gene_expression of CRS 1 5 0.29 4.92 1.25
180 INT118682 Positive_regulation of KRIT1 1 4 0.67 1.25 1.24
181 INT243771 Negative_regulation of Safb 2 7 0.26 0.77 1.23
182 INT296914 Regulation of Pln 2 2 0.19 3.08 1.23
183 INT135483 Protein_catabolism of Em 2 3 0.56 0.14 1.21
184 INT314388 Positive_regulation of Gene_expression of Ptpn6 1 3 0.11 0.05 1.15
185 INT321016 Regulation of Positive_regulation of Ptpn6 1 1 0.05 0.05 1.15
186 INT321020 Regulation of Protein_catabolism of Ptpn6 1 1 0.06 0.05 1.12
187 INT118054 Regulation of ARMC9 1 23 0.34 11.32 1.06
188 INT251515 Positive_regulation of Gene_expression of REM1 4 5 0.18 0.99 1.06
189 INT197721 Positive_regulation of ARMC9 1 36 0.35 20.08 1.03
190 INT85963 Gene_expression of LIFR 4 23 0.75 9 0.98
191 INT321025 Gene_expression of Cbln1 1 1 0.01 0.19 0.97
192 INT192124 Positive_regulation of P2rx2 1 5 0.60 1.36 0.96
193 INT115069 Positive_regulation of Localization of Cea 1 5 0.34 3.31 0.95
194 INT251516 Regulation of Gene_expression of REM1 1 4 0.20 1.81 0.95
195 INT224865 Positive_regulation of TBCB 1 2 0.01 0.71 0.92
196 INT159668 Positive_regulation of Bad 1 8 0.45 6.32 0.89
197 INT321014 Regulation of Protein_catabolism of Rnpep 1 1 0.02 0 0.89
198 INT307250 Negative_regulation of Gene_expression of P2rx3 1 3 0.40 0.71 0.87
199 INT178455 Localization of LIFR 1 6 0.61 2.24 0.83
200 INT224863 Regulation of TBCB 1 2 0.01 0.65 0.82
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