J:Gastroenterology Research and Practice

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT215100 Binding of Hmgb1 and Tlr4 5 2 0.29 3.21 1.68
2 INT215096 Binding of Hmgb1 and Tlr2 9 2 0.38 11.61 1.61
3 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 1 0.03 1.8 0.73
4 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 1 0.40 5.85 0.6
5 INT253767 Binding of Hmgb1 and Tlr9 2 1 0.12 1.78 0.52
6 INT352521 Cnn1 Positive_regulation of Cp 1 1 0.00 1.45 0.5
7 INT348031 Binding of Irf3 and Tbk1 1 2 0.17 2.82 0.4
8 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 1 0.14 0.67 0.39
9 INT336339 Glp2r Positive_regulation of Timp1 1 2 0.16 1.82 0.36
10 INT336336 Il10 Regulation of Il13 1 1 0.04 0.67 0.34
11 INT348016 Binding of Mapk8 and Mapk8ip3 1 2 0.04 2.09 0.32
12 INT336335 Glp2r Regulation of Mmp13 1 1 0.06 0.68 0.28
13 INT331602 Binding of SSRP1 and Tlr4 1 1 0.03 0.9 0.21
14 INT348032 Fndc3b Positive_regulation of Tlr2 1 1 0.01 1.3 0.2
15 INT348027 Gramd3 Negative_regulation of Irf3 1 1 0.00 1.39 0.2
16 INT348014 Binding of Tbk1 and Gramd3 1 1 0.00 1.33 0.2
17 INT348041 Binding of IFNA1 and Irf3 1 1 0.02 1.41 0.2
18 INT348013 Negative_regulation of Binding of Irf3 and Tbk1 1 1 0.21 1.41 0.2
19 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 1 0.05 0.98 0.16
20 INT331600 Il18 Regulation of IFN1@ 1 1 0.00 1.05 0.16
21 INT331601 Il10 Regulation of IFN1@ 1 1 0.00 1.05 0.16
22 INT348044 Binding of Mapk8 and Mapk8ip3 Negative_regulation of Vps54 1 1 0.00 1.04 0.16
23 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 1 0.05 1.04 0.16
24 INT348043 Binding of Mapk8 and Mapk8ip3 Negative_regulation of Positive_regulation of Vps54 1 1 0.00 1.04 0.16
25 INT348012 Samsn1 Positive_regulation of Vps54 1 1 0.00 1.93 0.15
26 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 1 0.01 0.7 0.14
27 INT348040 TNF Positive_regulation of Gene_expression of Tlr2 1 1 0.02 0.98 0.14
28 INT182886 Ros1 Positive_regulation of Mapk8 3 1 0.09 2.3 0.12
29 INT348011 Binding of Samsn1 and Vps54 1 1 0.00 1.35 0.11
30 INT348042 Positive_regulation of Mapk8 Regulation of Gene_expression of VEGFA 1 1 0.03 0.85 0.1
31 INT334266 Binding of Irak1 and Myd88 2 2 0.35 0.16 0.09
32 INT348025 Mapk8 Regulation of Gene_expression of Proc 1 1 0.00 0.58 0.08
33 INT331576 IFN1@ Positive_regulation of TNFSF10 1 1 0.00 0.27 0.08
34 INT331575 Negative_regulation of IFN1@ Positive_regulation of TNFSF10 1 1 0.00 0.27 0.08
35 INT348029 Re Positive_regulation of Vps54 1 1 0.01 0.44 0.07
36 INT348021 Stat3 Regulation of Vps54 1 1 0.02 1.32 0.07
37 INT348030 Mapk8 Regulation of Re 1 1 0.17 0.95 0.06
38 INT334258 Binding of Myd88 and Irak4 2 2 0.26 0.24 0.05
39 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 1 0.14 0.24 0.05
40 INT348022 Binding of Jun and Trp53 1 1 0.07 0.46 0.04
41 INT348024 Binding of Chuk and Traf3 1 1 0.13 0.65 0.04
42 INT348033 Fndc3b Positive_regulation of Vps54 1 1 0.00 1.87 0.03
43 INT348038 Binding of Fos and Hltf 1 1 0.01 0.45 0.03
44 INT348017 Mapk8 Positive_regulation of Positive_regulation of Vps54 1 1 0.02 0.89 0.03
45 INT348028 Binding of Traf3 and Ticam1 1 1 0.01 0.56 0.03
46 INT239188 Proc Positive_regulation of Akt1 3 1 0.01 1.72 0
47 INT348045 Irak2 Positive_regulation of Binding of Traf6 and Irak2 1 1 0.11 0.05 0
48 INT348018 Map3k7 Positive_regulation of Chuk 1 1 0.19 0.06 0
49 INT332825 GCSH Negative_regulation of G6PC 1 1 0.48 0.25 0
50 INT348015 Binding of Tlr4 and Tlr3 1 1 0.19 0 0
51 INT348039 Binding of Myd88 and Irak2 1 2 0.22 0 0
52 INT348020 Binding of Traf6 and Irak2 1 1 0.13 0.05 0
53 INT348037 Irak2 Positive_regulation of Binding of Traf6 1 1 0.18 0.05 0
54 INT348035 Map3k7 Positive_regulation of Binding of Chuk 1 1 0.20 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
2 INT18357 Gene_expression of TRPV1 1 825 0.78 307.11 382.81
3 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
4 INT9381 Positive_regulation of TRPV1 1 523 0.70 187.4 276.05
5 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
6 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
7 INT9852 Positive_regulation of Gpt 2 563 0.70 364.64 146.82
8 INT48895 Gene_expression of Il10 3 333 0.78 221.2 138.52
9 INT7533 Gene_expression of Tlr4 11 720 0.78 343.22 121.57
10 INT8243 Positive_regulation of Il6 1 451 0.70 358.24 119.28
11 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
12 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
13 INT56291 Gene_expression of Ros1 3 503 0.63 274.12 81.5
14 INT60691 Gene_expression of Il12a 2 331 0.78 208.03 75.96
15 INT170332 Gene_expression of IFN1@ 1 477 0.75 275.21 69.65
16 INT11937 Localization of Il6 1 228 0.81 139.83 64.39
17 INT1951 Positive_regulation of Tlr4 6 345 0.70 176.99 62.42
18 INT5058 Positive_regulation of IFNA1 2 356 0.70 245.75 60.52
19 INT14740 Gene_expression of TGFB1 1 272 0.78 168.48 60.18
20 INT63975 Positive_regulation of Il10 2 175 0.68 134.13 54.69
21 INT106525 Phosphorylation of Akt1 2 436 0.82 183.81 47.82
22 INT9383 Localization of TRPV1 1 98 0.81 33.23 46.24
23 INT89661 Gene_expression of Hrec 1 102 0.21 69.91 39.57
24 INT9094 Gene_expression of COL7A1 1 277 0.77 143.42 38.73
25 INT104551 Gene_expression of Il18 2 156 0.76 115.51 36.95
26 INT81289 Positive_regulation of Gene_expression of Tlr4 7 192 0.69 104.5 33.89
27 INT8915 Gene_expression of Igf1 4 199 0.78 78.58 32.51
28 INT96913 Positive_regulation of Mapk8 14 179 0.69 130.44 32.2
29 INT56809 Binding of Tlr4 6 184 0.48 106.02 31.18
30 INT2884 Positive_regulation of CCK 1 66 0.69 25.25 30.6
31 INT90792 Localization of Il10 2 144 0.80 87.88 30.03
32 INT6660 Positive_regulation of Jun 1 148 0.69 67.58 29.73
33 INT145426 Positive_regulation of Ros1 6 185 0.56 106.76 27.21
34 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
35 INT288 Positive_regulation of Sct 1 88 0.70 32.83 24.5
36 INT114362 Localization of Hmgb1 1 127 0.78 120.28 23.26
37 INT7383 Localization of VIP 4 53 0.81 17.7 22.65
38 INT142594 Gene_expression of Tlr2 2 165 0.78 139.73 22.26
39 INT8483 Positive_regulation of Positive_regulation of TNF 1 73 0.67 60.35 22.03
40 INT78057 Localization of Tlr4 1 140 0.77 67.75 21.72
41 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
42 INT60690 Positive_regulation of Gene_expression of Il12a 1 69 0.63 41.41 20.85
43 INT69877 Positive_regulation of Positive_regulation of Nfkb1 1 53 0.68 31.44 20.7
44 INT86751 Negative_regulation of Il10 2 62 0.59 40.1 20.51
45 INT88949 Positive_regulation of Il12a 1 79 0.60 47.68 19.98
46 INT51055 Positive_regulation of TIMP1 1 103 0.69 50.07 19.86
47 INT69304 Negative_regulation of Il10 2 47 0.59 36.88 19.79
48 INT12243 Positive_regulation of PRSS1 2 91 0.70 52.87 19.48
49 INT101188 Gene_expression of Rela 2 81 0.56 23.43 19.15
50 INT65260 Positive_regulation of Col7a1 1 95 0.69 61.73 18.42
51 INT11938 Positive_regulation of Localization of Il6 1 61 0.70 35.72 18.25
52 INT109316 Negative_regulation of Mapk8 5 72 0.59 50.59 17.24
53 INT2432 Positive_regulation of Cp 3 41 0.67 31.1 16.68
54 INT2243 Localization of GAST 2 67 0.81 34.54 16.19
55 INT170754 Localization of IFN1@ 1 121 0.78 66.78 15.6
56 INT43906 Regulation of Tlr4 1 71 0.53 35.18 15.49
57 INT36554 Gene_expression of PRSS1 2 70 0.78 50.25 15.33
58 INT129584 Positive_regulation of Stat3 1 97 0.68 87.07 14.86
59 INT67641 Negative_regulation of Gene_expression of Tlr4 2 90 0.58 46 14.6
60 INT36262 Positive_regulation of Tbce 1 35 0.49 28.79 14.33
61 INT55740 Gene_expression of Timp1 1 53 0.75 28.63 13.85
62 INT142593 Positive_regulation of Tlr2 7 85 0.70 75.9 13.62
63 INT141014 Positive_regulation of Gene_expression of Il18 1 46 0.68 47.63 13.3
64 INT174838 Localization of INCENP 1 80 0.64 19.05 12.89
65 INT158124 Gene_expression of COL5A2 4 136 0.69 72.3 12.44
66 INT39553 Gene_expression of Hmgb1 1 50 0.75 51.18 12.21
67 INT100821 Localization of Ros1 2 59 0.60 45.26 11.92
68 INT28872 Positive_regulation of CSRP1 1 49 0.70 47.23 11.7
69 INT109315 Gene_expression of Mapk8 5 70 0.78 45.46 11.65
70 INT96915 Phosphorylation of Mapk8 4 73 0.81 40.69 11.44
71 INT135022 Gene_expression of Cd14 1 79 0.76 36.37 10.63
72 INT145695 Regulation of Mapk8 3 26 0.62 14.67 9.83
73 INT170333 Binding of IFN1@ 1 68 0.47 49.01 9.72
74 INT107307 Transcription of IFNA1 1 30 0.52 18.16 9.61
75 INT54834 Gene_expression of Col2a1 2 48 0.72 13.5 9.41
76 INT56292 Negative_regulation of Gene_expression of Ros1 1 70 0.38 36.14 9.17
77 INT26795 Gene_expression of Mtpn 1 44 0.62 27.66 8.62
78 INT97331 Positive_regulation of Timp1 2 20 0.45 13.32 8.57
79 INT109005 Gene_expression of Proc 5 61 0.75 37.86 8.49
80 INT87650 Positive_regulation of EPHB2 1 49 0.67 22.77 8.25
81 INT114363 Positive_regulation of Hmgb1 1 50 0.67 48.92 8.15
82 INT233645 Transcription of Tsc22d3 1 11 0.71 5.83 7.97
83 INT15161 Positive_regulation of Localization of VIP 2 12 0.50 3.3 7.87
84 INT12010 Gene_expression of Cp 1 38 0.65 20.55 7.84
85 INT212758 Binding of Hmgb1 2 40 0.44 35.6 7.41
86 INT1952 Negative_regulation of Positive_regulation of Tlr4 1 33 0.51 15.8 7.41
87 INT22782 Localization of PRSS1 3 25 0.81 14.44 7.34
88 INT125143 Gene_expression of EPHB2 1 40 0.71 13.27 6.97
89 INT73479 Positive_regulation of Hrec 1 21 0.04 16.16 6.87
90 INT207892 Binding of Tlr9 5 35 0.46 26.66 6.61
91 INT24946 Binding of PRSS1 1 23 0.47 16.75 6.41
92 INT28042 Gene_expression of Tsc22d3 2 14 0.77 6.54 6.4
93 INT155780 Gene_expression of Mmp8 1 19 0.77 15.85 6.33
94 INT9494 Positive_regulation of Gene_expression of Igf1 4 34 0.67 17.77 6.26
95 INT33612 Binding of NTS 1 16 0.46 4.65 6
96 INT103760 Regulation of Gene_expression of Tlr4 1 35 0.59 16.26 5.95
97 INT188844 Gene_expression of AES 1 44 0.58 33.94 5.85
98 INT113700 Positive_regulation of Chuk 5 30 0.41 21.17 5.69
99 INT190520 Negative_regulation of Hmgb1 1 24 0.53 20.08 5.6
100 INT141146 Gene_expression of Mmp13 2 18 0.38 8.61 5.54
101 INT2132 Localization of SCT 1 29 0.81 8.39 5.43
102 INT197491 Gene_expression of Myd88 3 32 0.74 14.59 5.29
103 INT174688 Binding of Tlr2 2 45 0.42 36.65 5.25
104 INT135291 Positive_regulation of Positive_regulation of Mapk8 4 24 0.64 19.37 5.16
105 INT157622 Positive_regulation of Localization of Tlr4 1 34 0.48 22.63 5.09
106 INT36030 Gene_expression of Il1r1 1 16 0.68 11.42 4.87
107 INT106524 Phosphorylation of Jun 1 23 0.80 15.35 4.78
108 INT69215 Gene_expression of Col1a1 2 38 0.68 17.39 4.77
109 INT26069 Positive_regulation of Positive_regulation of IFNA1 2 26 0.50 16.61 4.76
110 INT104549 Localization of Il18 1 16 0.78 13.01 4.64
111 INT149093 Positive_regulation of TNFSF10 1 31 0.49 34.61 4.56
112 INT183681 Positive_regulation of Tlr3 3 20 0.62 16.25 4.54
113 INT188672 Positive_regulation of Tlr9 1 15 0.67 13.1 4.48
114 INT142752 Positive_regulation of Myd88 3 26 0.66 12.07 4.4
115 INT22973 Gene_expression of Col3a1 1 22 0.42 15.85 4.32
116 INT215085 Positive_regulation of Gene_expression of Hmgb1 1 17 0.63 16.81 4.13
117 INT183560 Binding of GABRB3 1 12 0.23 2.59 3.77
118 INT62784 Gene_expression of NT5E 1 46 0.65 15.95 3.72
119 INT158596 Binding of Tlr3 2 24 0.47 11.66 3.69
120 INT192951 Negative_regulation of AES 1 15 0.38 6.38 3.5
121 INT67719 Positive_regulation of Col1a1 1 21 0.44 8.87 3.12
122 INT158630 Positive_regulation of Positive_regulation of Stat3 1 16 0.49 14.75 3.08
123 INT55739 Transcription of Timp1 1 7 0.67 4.72 3
124 INT11775 Gene_expression of Ema 1 39 0.65 38.12 2.99
125 INT110755 Negative_regulation of Positive_regulation of Mapk8 1 15 0.46 9.91 2.98
126 INT174958 Negative_regulation of Chuk 2 21 0.25 8.73 2.96
127 INT260424 Negative_regulation of Tlr9 1 8 0.41 8.19 2.92
128 INT114181 Negative_regulation of Positive_regulation of Il12a 1 7 0.34 3.65 2.82
129 INT22237 Localization of NTS 1 14 0.75 5.5 2.77
130 INT184257 Positive_regulation of Gene_expression of Mmp8 1 7 0.49 6.32 2.74
131 INT195531 Gene_expression of Rel 2 9 0.75 5.02 2.72
132 INT222845 Gene_expression of Chuk 16 27 0.52 25.15 2.67
133 INT15752 Positive_regulation of Ema 1 15 0.40 14.57 2.34
134 INT204775 Regulation of Tlr2 1 21 0.41 13.6 2.18
135 INT112868 Gene_expression of Pcna 1 21 0.75 8.6 2.15
136 INT38154 Negative_regulation of Vps54 2 7 0.37 7.99 1.99
137 INT3179 Positive_regulation of SCT 1 15 0.50 4.79 1.98
138 INT109313 Binding of Mapk8 1 6 0.48 1.78 1.98
139 INT190480 Positive_regulation of Localization of Ros1 1 11 0.34 8.29 1.81
140 INT135029 Positive_regulation of Gene_expression of Cd14 1 11 0.66 6.4 1.75
141 INT170605 Gene_expression of RELB 1 12 0.65 8 1.7
142 INT98469 Positive_regulation of Transcription of Timp1 1 4 0.45 3.2 1.68
143 INT233975 Positive_regulation of Gene_expression of Myd88 1 7 0.66 4.17 1.65
144 INT190519 Positive_regulation of Positive_regulation of Ros1 2 14 0.32 9.99 1.52
145 INT650 Gene_expression of Afp 1 13 0.78 7.44 1.47
146 INT172953 Binding of Trp53 1 33 0.37 20.76 1.41
147 INT224501 Positive_regulation of Gene_expression of EPHB2 1 9 0.49 4.29 1.39
148 INT96420 Positive_regulation of NT5E 1 9 0.49 3.7 1.38
149 INT159784 Gene_expression of Mapk9 4 8 0.61 6.28 1.37
150 INT199183 Regulation of Positive_regulation of Ros1 1 4 0.21 1.52 1.37
151 INT92383 Gene_expression of KRAS 1 38 0.65 32.94 1.32
152 INT217438 Binding of Chuk 3 24 0.25 7.29 1.29
153 INT139144 Positive_regulation of Glp2r 3 5 0.69 2.03 1.26
154 INT141467 Gene_expression of Glp2r 7 5 0.77 4.21 1.25
155 INT222843 Positive_regulation of Map3k7 1 4 0.24 3.04 1.24
156 INT154048 Negative_regulation of Gene_expression of Mapk8 1 5 0.43 4.43 1.22
157 INT202548 Positive_regulation of Re 1 4 0.20 2.27 1.2
158 INT233620 Positive_regulation of Gene_expression of Tsc22d3 1 3 0.69 1.46 1.17
159 INT245844 Gene_expression of Tir1 15 16 0.58 24.82 1.11
160 INT135806 Regulation of Bcl2l1 1 10 0.44 7.21 1.05
161 INT169431 Gene_expression of Vps54 3 17 0.21 21.76 0.96
162 INT100888 Gene_expression of GCSH 1 3 0.53 1.8 0.93
163 INT2131 Positive_regulation of Localization of SCT 1 6 0.47 2.01 0.88
164 INT8888 Regulation of Col1a1 1 4 0.13 1.97 0.86
165 INT139147 Localization of Glp2r 2 3 0.80 0.96 0.85
166 INT68447 Positive_regulation of PDP1 3 11 0.64 5.69 0.83
167 INT181129 Positive_regulation of Araf 1 8 0.21 4.3 0.79
168 INT165105 Localization of Mapk8 1 7 0.69 4.45 0.76
169 INT139146 Positive_regulation of Localization of Glp2r 1 2 0.67 0.37 0.76
170 INT190611 Gene_expression of Cnn1 1 13 0.56 5.87 0.75
171 INT106523 Positive_regulation of Phosphorylation of Jun 1 7 0.45 3.1 0.74
172 INT92382 Positive_regulation of Gene_expression of KRAS 2 7 0.49 4.82 0.71
173 INT331594 Localization of Tlr9 1 1 0.41 1.66 0.71
174 INT331595 Positive_regulation of Localization of Tlr9 1 1 0.28 1.66 0.71
175 INT132528 Gene_expression of TAPBP 1 17 0.65 5.93 0.69
176 INT314571 Binding of Tbk1 2 3 0.24 2.88 0.69
177 INT277347 Localization of Vps54 1 3 0.09 3.14 0.63
178 INT155035 Binding of NT5E 2 3 0.36 1.78 0.61
179 INT38153 Binding of Vps54 2 6 0.31 7.31 0.57
180 INT95550 Negative_regulation of Positive_regulation of ALB 1 4 0.42 1.16 0.57
181 INT334219 Phosphorylation of Irak1 1 6 0.73 1.21 0.55
182 INT347974 Negative_regulation of Gene_expression of Ema 1 1 0.15 1.27 0.55
183 INT138429 Negative_regulation of Gene_expression of Col3a1 1 3 0.17 2.51 0.54
184 INT169432 Positive_regulation of Vps54 4 10 0.16 13.96 0.53
185 INT166833 Phosphorylation of Proc 1 5 0.80 3.56 0.51
186 INT213533 Positive_regulation of Gene_expression of Proc 1 6 0.01 5.55 0.49
187 INT147606 Positive_regulation of TLR1 1 5 0.67 4.35 0.47
188 INT100731 Negative_regulation of Localization of PRSS1 2 2 0.14 2.17 0.47
189 INT222850 Positive_regulation of Gene_expression of Chuk 3 7 0.34 4.91 0.44
190 INT94381 Negative_regulation of Col4a2 1 2 0.31 0.57 0.43
191 INT125708 Negative_regulation of Col3a1 1 2 0.16 1.37 0.42
192 INT222840 Gene_expression of Ikbkg 2 2 0.52 3.15 0.42
193 INT96419 Positive_regulation of Gene_expression of NT5E 1 3 0.49 1.46 0.41
194 INT141466 Regulation of Glp2r 1 2 0.45 0.28 0.4
195 INT336333 Binding of Glp2r 4 1 0.36 1.5 0.4
196 INT217464 Binding of Traf6 1 5 0.29 1.28 0.35
197 INT309176 Negative_regulation of Gene_expression of Proc 1 4 0.01 3.12 0.35
198 INT260316 Regulation of Localization of Ros1 1 3 0.08 1.58 0.35
199 INT336330 Regulation of Transcription of Apoc3 1 1 0.00 0.68 0.35
200 INT336332 Negative_regulation of Transcription of Apoc3 1 1 0.01 0.68 0.35
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