J:Gen. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT45502 TNS1 Positive_regulation of VIP 1 2 0.47 0.52 1.5
2 INT63594 Snai1 Negative_regulation of Binding of Ugt1a2 1 1 0.05 0.32 0.82
3 INT63596 Snai1 Negative_regulation of ITS 1 1 0.00 0.31 0.81
4 INT63588 Aap Positive_regulation of Positive_regulation of Got1 1 1 0.31 0.6 0.79
5 INT63589 Binding of Got1 and Gpt 1 1 0.36 0.56 0.74
6 INT33198 Binding of Sct and Vip 1 2 0.01 0 0.37
7 INT66257 Negative_regulation of Ptgs1 Positive_regulation of Gene_expression of Tnf 1 1 0.03 0.44 0.25
8 INT34949 Ins1 Positive_regulation of Negative_regulation of B3gat3 1 1 0.01 0.49 0.17
9 INT42608 Pomc Positive_regulation of Oprd1 1 1 0.27 0 0.17
10 INT34950 Ins1 Positive_regulation of B3gat3 1 1 0.01 0.49 0.17

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 12 2008 0.81 518.3 1408.65
2 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 4 2431 0.81 378.96 952.2
4 INT1912 Gene_expression of Calca 3 1152 0.78 453.25 739.84
5 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
6 INT4758 Positive_regulation of Localization of Calca 2 557 0.70 138.55 411.04
7 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
8 INT2540 Negative_regulation of Calca 2 538 0.59 172.11 384.38
9 INT6580 Negative_regulation of Ptgs1 5 929 0.59 381.53 376.26
10 INT157 Positive_regulation of Localization of Prl 2 790 0.70 104.54 374.78
11 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
12 INT9131 Positive_regulation of Prkcg 2 431 0.70 130.8 302.41
13 INT161 Regulation of Localization of Prl 3 615 0.62 65.37 298.66
14 INT1352 Localization of Acot1 5 728 0.80 73.01 296.01
15 INT11624 Gene_expression of OPRM1 1 445 0.78 72.36 294.36
16 INT9158 Gene_expression of Tnf 5 722 0.78 522.01 277.68
17 INT1396 Binding of Penk 5 355 0.48 22.79 269.65
18 INT2909 Positive_regulation of Abat 1 334 0.70 62.1 256.43
19 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
20 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
21 INT1665 Positive_regulation of Pag1 3 270 0.68 186.63 229.87
22 INT4759 Negative_regulation of Localization of Calca 1 294 0.59 82.62 226.45
23 INT156 Negative_regulation of Prl 1 542 0.59 131.97 192.24
24 INT1652 Regulation of Pomc 2 387 0.62 61.01 186.51
25 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
26 INT1114 Localization of Ins1 6 748 0.80 192.95 165.48
27 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
28 INT5050 Regulation of Localization of Calca 1 149 0.62 41.25 148.57
29 INT6108 Gene_expression of Npy 1 292 0.78 110.65 148.21
30 INT9852 Positive_regulation of Gpt 3 563 0.70 364.64 146.82
31 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
32 INT48895 Gene_expression of Il10 1 333 0.78 221.2 138.52
33 INT5061 Negative_regulation of Mme 3 306 0.59 51.97 136.9
34 INT4658 Binding of OPRM1 3 188 0.48 25.96 136.24
35 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
36 INT695 Binding of POMC 1 304 0.48 56.66 126.85
37 INT6323 Positive_regulation of Gabrg1 1 213 0.70 45.08 124.34
38 INT4259 Positive_regulation of Npr1 3 262 0.70 49.37 123.11
39 INT20374 Gene_expression of Il4 2 515 0.76 306.15 114.12
40 INT114 Binding of Oprl1 1 139 0.48 23 103.35
41 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
42 INT203 Positive_regulation of Pomc 2 257 0.70 90.56 92.84
43 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
44 INT9516 Negative_regulation of Gabrg1 3 149 0.53 27.83 91.02
45 INT1635 Gene_expression of Vip 1 245 0.78 53.36 88.13
46 INT3766 Positive_regulation of Localization of Acot1 3 192 0.69 21.8 85.35
47 INT2520 Negative_regulation of Ca2 1 271 0.57 72.13 83.71
48 INT339 Regulation of Trh 5 156 0.62 39.27 83.55
49 INT403 Localization of Trh 2 241 0.81 28.55 81.45
50 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
51 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
52 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
53 INT1376 Binding of Trh 7 121 0.48 20 69.86
54 INT53964 Negative_regulation of Prkaca 5 131 0.58 38.76 69.52
55 INT1988 Positive_regulation of Localization of Ins1 3 254 0.69 59.25 68.37
56 INT8388 Positive_regulation of Vip 5 142 0.70 39.72 67.61
57 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
58 INT13286 Gene_expression of Ca2 1 317 0.67 71.58 65.01
59 INT1437 Negative_regulation of Pomc 3 132 0.59 35.22 60.97
60 INT2761 Regulation of Gabrg1 2 119 0.61 18.8 60.52
61 INT1536 Negative_regulation of NA 2 244 0.55 52.67 59.79
62 INT5017 Negative_regulation of Tacr1 1 76 0.58 17 57.07
63 INT2148 Negative_regulation of Oxt 1 105 0.59 11.42 57
64 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
65 INT1316 Positive_regulation of Acot1 1 129 0.60 18.86 56.13
66 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
67 INT4241 Regulation of CALCA 1 87 0.62 28.19 55.29
68 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
69 INT4957 Negative_regulation of Grin1 1 87 0.59 24.51 53.21
70 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
71 INT5337 Negative_regulation of Npy 2 87 0.59 19.6 46.75
72 INT4776 Localization of TAC1 1 82 0.78 16.89 45.21
73 INT8824 Regulation of Vip 1 95 0.62 15.7 43.63
74 INT66383 Phosphorylation of Prkaca 1 143 0.80 30.85 43.38
75 INT1474 Regulation of Localization of Ins1 4 132 0.61 25.96 43.07
76 INT2364 Localization of Sct 1 134 0.80 26.21 41.47
77 INT7824 Regulation of Cck 1 39 0.62 5.31 39.28
78 INT3188 Regulation of Localization of Acot1 1 84 0.59 8.94 38.56
79 INT48959 Positive_regulation of Positive_regulation of Prkcg 1 52 0.70 16.47 36.49
80 INT6943 Positive_regulation of Gabrd 1 71 0.70 17.36 35.25
81 INT7675 Gene_expression of ENG 2 146 0.77 45.35 34.6
82 INT1457 Negative_regulation of Binding of Penk 4 40 0.57 0.25 34.24
83 INT7833 Positive_regulation of Cck 2 33 0.70 8.54 34.21
84 INT2732 Gene_expression of VIP 2 74 0.78 24.57 33.72
85 INT11764 Positive_regulation of ENG 2 78 0.61 27.65 33.69
86 INT2699 Binding of Cpe 1 40 0.48 7.07 33.64
87 INT7538 Negative_regulation of IL2 1 95 0.57 47.31 31.7
88 INT1159 Negative_regulation of Agt 1 133 0.59 40.14 31.67
89 INT5069 Negative_regulation of Mthfs 1 69 0.57 22.54 31.36
90 INT1179 Negative_regulation of Ace 2 157 0.59 67.03 30.46
91 INT23222 Binding of Phax 7 52 0.31 7.61 30.4
92 INT11650 Negative_regulation of Gpt 2 122 0.59 69.15 30.36
93 INT5117 Negative_regulation of Gene_expression of IL2 1 118 0.59 52.33 29.96
94 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
95 INT67 Negative_regulation of Ddc 1 66 0.59 15.34 28.96
96 INT3286 Positive_regulation of Gpt 3 90 0.69 45.08 28.34
97 INT22499 Regulation of Calca 1 42 0.62 17.32 28.02
98 INT66381 Regulation of Prkaca 1 40 0.62 13.38 27.96
99 INT6717 Negative_regulation of YY1 1 45 0.57 15.35 27.8
100 INT2650 Positive_regulation of Slc3a1 1 50 0.57 2.95 27.52
101 INT5232 Negative_regulation of Enpep 2 56 0.57 3.25 26.7
102 INT605 Regulation of Acot1 1 61 0.62 10.7 26.34
103 INT13415 Positive_regulation of Hpse 1 58 0.70 24.9 25.53
104 INT6179 Binding of Oprk1 1 37 0.48 9.24 24.83
105 INT5690 Negative_regulation of Binding of Oprd1 1 36 0.59 8.29 24.52
106 INT12441 Positive_regulation of Gpr156 2 29 0.67 5.7 24.44
107 INT12424 Binding of Npy 1 48 0.48 8.23 24.26
108 INT825 Negative_regulation of ADRA1D 1 54 0.58 20.25 22.78
109 INT7383 Localization of VIP 2 53 0.81 17.7 22.65
110 INT9988 Regulation of Hrh1 1 22 0.46 12.87 22.13
111 INT7017 Regulation of Npr1 1 45 0.52 3.38 20.05
112 INT7336 Positive_regulation of VIP 13 60 0.70 24.2 19.62
113 INT9490 Regulation of Mme 1 44 0.56 6.69 19.21
114 INT6807 Regulation of Gabrd 1 39 0.62 9.22 18.74
115 INT16110 Positive_regulation of ZC3H12D 2 30 0.46 6.27 18.72
116 INT7000 Positive_regulation of Htr2a 3 42 0.67 9.48 18.7
117 INT3060 Negative_regulation of Bche 1 94 0.59 46.75 18.51
118 INT13790 Binding of HTR1A 1 52 0.47 18.83 17.59
119 INT3206 Positive_regulation of Got1 5 39 0.69 19.36 17.02
120 INT9663 Protein_catabolism of PDYN 1 43 0.99 0.67 16.15
121 INT2480 Negative_regulation of Got1 2 43 0.51 14.47 16.09
122 INT4616 Regulation of Maoa 1 40 0.62 6.09 15.94
123 INT7531 Positive_regulation of Eef1a1 1 29 0.62 8.16 15.41
124 INT75434 Gene_expression of Il13 1 27 0.52 26.19 15.4
125 INT7040 Binding of Vip 4 43 0.48 4.57 15.05
126 INT7674 Regulation of ENG 1 42 0.30 11.41 14.44
127 INT6947 Negative_regulation of Gene_expression of POMC 1 37 0.59 10.32 14.14
128 INT5806 Regulation of Edn1 1 63 0.62 23.46 13.88
129 INT23344 Gene_expression of Alox5 1 60 0.75 28.2 13.82
130 INT4757 Localization of Nrtim1 3 27 0.49 1.83 13.58
131 INT12281 Negative_regulation of Gene_expression of Npy 1 23 0.59 7.45 13.41
132 INT2490 Regulation of Sct 2 44 0.62 9.45 13.11
133 INT22213 Localization of Gpt 4 52 0.78 34.05 12.94
134 INT3770 Negative_regulation of Nrm 2 13 0.43 3.55 12.83
135 INT26217 Binding of Calca 1 22 0.48 5.22 12.57
136 INT6148 Gene_expression of Nrtim1 1 34 0.42 10.17 12.27
137 INT8725 Gene_expression of Mln 1 32 0.77 14.9 12.22
138 INT28770 Negative_regulation of Gene_expression of PDYN 1 16 0.57 4.95 12.06
139 INT20450 Regulation of Binding of Penk 1 11 0.60 0.47 11.92
140 INT5045 Regulation of VIP 2 26 0.62 7.15 11.61
141 INT787 Localization of Ptgs1 1 31 0.80 12.36 11.55
142 INT23825 Negative_regulation of Binding of Trh 2 17 0.59 1.62 11.24
143 INT27258 Regulation of Htr2a 1 18 0.60 6.37 11.06
144 INT3851 Gene_expression of Got1 3 58 0.65 29.15 10.52
145 INT66382 Positive_regulation of Phosphorylation of Prkaca 1 33 0.49 7.05 9.69
146 INT6125 Localization of Ahsp 1 35 0.78 9.17 9.42
147 INT18941 Regulation of Enpep 2 17 0.55 2.56 9.38
148 INT18830 Localization of TBXA2R 2 25 0.81 7.14 9.28
149 INT285 Positive_regulation of Salpa1 1 73 0.68 61.47 9.19
150 INT7697 Positive_regulation of Adra1a 1 22 0.68 2.3 9.16
151 INT49866 Negative_regulation of Parp1 3 53 0.58 35.37 8.84
152 INT57057 Gene_expression of APC 1 131 0.78 122.24 8.7
153 INT7673 Negative_regulation of ENG 1 31 0.42 7.9 8.61
154 INT3287 Gene_expression of Gpt 2 50 0.75 23.69 8.57
155 INT12463 Binding of FPR1 1 21 0.48 3.16 7.98
156 INT18025 Binding of Pah 2 32 0.45 30.72 7.93
157 INT22214 Positive_regulation of Localization of Gpt 3 14 0.62 8.42 7.89
158 INT15161 Positive_regulation of Localization of VIP 1 12 0.50 3.3 7.87
159 INT10821 Positive_regulation of Abo 1 32 0.67 9.43 7.65
160 INT17028 Positive_regulation of Scn7a 1 35 0.41 9.83 7.44
161 INT22919 Negative_regulation of Gpt 4 18 0.55 6.84 7.4
162 INT51741 Regulation of Gene_expression of Il4 1 23 0.36 12.7 7.39
163 INT10104 Negative_regulation of Edn1 1 43 0.59 15.63 7.2
164 INT25772 Regulation of HTR1B 1 15 0.60 3.8 7.17
165 INT17029 Regulation of Scn7a 1 23 0.45 3.89 7.02
166 INT12359 Negative_regulation of Tac1 1 26 0.58 8.16 6.89
167 INT10505 Gene_expression of Ptafr 1 18 0.62 10.7 6.83
168 INT19146 Negative_regulation of Apoa2 1 19 0.36 5.34 6.73
169 INT612 Positive_regulation of Orm1 1 15 0.68 5.24 6.73
170 INT4208 Regulation of Got1 1 23 0.44 6.72 6.62
171 INT19366 Negative_regulation of Localization of Ca2 1 33 0.50 6.51 6.61
172 INT1280 Negative_regulation of Pebp1 1 7 0.28 2.12 6.45
173 INT13137 Binding of Kcnk4 9 10 0.48 0 6.38
174 INT6097 Negative_regulation of NEUROD1 1 30 0.57 9.71 6.24
175 INT17779 Negative_regulation of Got1 2 12 0.40 3.5 6.08
176 INT12440 Regulation of Gpr156 1 11 0.45 3.2 6.07
177 INT52749 Gene_expression of alp 1 24 0.44 12.84 5.97
178 INT20673 Binding of CDS1 1 18 0.31 1.96 5.72
179 INT3395 Negative_regulation of VIP 1 15 0.59 4.23 5.62
180 INT31648 Binding of Trh 3 11 0.48 2.09 5.48
181 INT32889 Positive_regulation of Pde4dl1 1 6 0.49 1.69 4.6
182 INT62813 Negative_regulation of ZNF398 1 12 0.09 6.2 4.49
183 INT16349 Positive_regulation of alp 1 25 0.60 16.74 4.34
184 INT25468 Regulation of Htr3a 1 7 0.60 0.61 4.3
185 INT311 Positive_regulation of Tat 4 9 0.67 0.83 4.17
186 INT6126 Gene_expression of Ahsp 1 16 0.67 7.72 4.08
187 INT38249 Positive_regulation of VIPR1 2 9 0.40 2.58 3.96
188 INT28062 Regulation of Negative_regulation of Gabrg1 1 3 0.47 0 3.87
189 INT13134 Binding of ADRA2C 1 11 0.46 0.73 3.86
190 INT12707 Negative_regulation of Binding of FPR1 1 9 0.59 1.45 3.72
191 INT69904 Binding of Hc 1 11 0.35 7.79 3.69
192 INT42243 Positive_regulation of Negative_regulation of Maoa 1 5 0.50 2.15 3.59
193 INT26773 Protein_catabolism of CPQ 2 8 0.86 0.17 3.49
194 INT21572 Gene_expression of Pebp1 1 9 0.71 2.52 3.3
195 INT22949 Gene_expression of CCBE1 1 8 0.19 4.27 3.25
196 INT10170 Negative_regulation of Ns5atp9 1 14 0.55 3.99 3.18
197 INT743 Negative_regulation of Salpa1 1 16 0.57 8.75 3.1
198 INT2135 Regulation of Gpt 1 13 0.44 2.17 3.03
199 INT47011 Positive_regulation of Gusb 1 14 0.44 8.93 2.87
200 INT31875 Regulation of CCBE1 1 8 0.04 4.18 2.64
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