J:Hum. Mol. Genet.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT127997 Binding of MC1R and RHCE 2 1 0.28 0.41 1.02
2 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 1 0.00 0.8 0.75
3 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 1 0.00 0.8 0.75
4 INT66020 Binding of Mc1r and RBM25 1 1 0.00 0.42 0.57
5 INT88252 Binding of RAP1A and Krit1 1 4 0.36 2.25 0.33
6 INT111909 Binding of HSPD1 and CCT4 1 1 0.29 0.48 0.25
7 INT111908 Binding of HSPD1 and AP4B1 1 1 0.03 0.48 0.25
8 INT91862 RPA1 Negative_regulation of Transcription of ATG9B 1 1 0.03 0.46 0.19
9 INT127995 Binding of RHCE and MINOS1 1 2 0.03 0.33 0.16
10 INT71329 Cacna1a Regulation of Ea2 1 1 0.01 0.71 0.15
11 INT71328 Cacna1a Regulation of Atxn2 1 1 0.00 0.71 0.15
12 INT127996 Binding of POMC and MINOS1 1 1 0.02 0.17 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT56130 Gene_expression of MC1R 7 259 0.78 62.7 97.55
2 INT6656 Gene_expression of YY1 1 135 0.75 24.73 72.16
3 INT21737 Binding of MC1R 2 129 0.48 45.45 56.54
4 INT62426 Gene_expression of Mc1r 1 127 0.78 42.99 48.01
5 INT122953 Gene_expression of COMT 1 65 0.77 25.84 40.49
6 INT47939 Gene_expression of Selp 2 171 0.76 87.54 39.03
7 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
8 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
9 INT6717 Negative_regulation of YY1 1 45 0.57 15.35 27.8
10 INT110638 Negative_regulation of COMT 1 43 0.59 21.03 21.05
11 INT84712 Regulation of MC1R 2 36 0.62 9.34 16.91
12 INT59365 Gene_expression of HTR1A 1 41 0.75 16.31 16.57
13 INT83201 Gene_expression of NOS3 1 93 0.78 47.16 12.48
14 INT57882 Negative_regulation of Kcnj5 1 33 0.35 13.06 12.27
15 INT59352 Positive_regulation of Fosb 1 16 0.58 1.89 10.09
16 INT59357 Gene_expression of Fosb 5 36 0.78 7.81 9.68
17 INT64451 Negative_regulation of MC1R 1 21 0.59 4.94 9.22
18 INT122952 Positive_regulation of COMT 1 13 0.50 8.1 8.89
19 INT67424 Positive_regulation of Gene_expression of Selp 1 36 0.68 17.08 7.95
20 INT30729 Binding of Ptger2 1 36 0.29 7.66 7.35
21 INT91609 Regulation of Gene_expression of MC1R 2 11 0.62 2.75 7.34
22 INT16631 Negative_regulation of APC 3 46 0.57 30.53 7.11
23 INT59351 Positive_regulation of Gene_expression of Fosb 3 20 0.70 3.53 6.74
24 INT71151 Regulation of NTRK1 1 10 0.62 6.65 6.21
25 INT10980 Gene_expression of GYPA 1 40 0.78 15.32 5.51
26 INT71152 Negative_regulation of NTRK1 1 15 0.59 10.28 5.5
27 INT4722 Gene_expression of Bloc1s2 1 3 0.78 3.35 4.39
28 INT32933 Gene_expression of GNAS 1 57 0.32 10.58 4.03
29 INT93110 Regulation of CDCP1 1 16 0.03 7.98 3.83
30 INT73802 Regulation of Selp 2 17 0.60 8.72 3.51
31 INT146300 Binding of RS1 1 31 0.22 29.55 3.04
32 INT93109 Phosphorylation of NTRK1 3 5 0.80 3.22 2.99
33 INT91869 Transcription of NOS3 4 13 0.67 6.81 2.86
34 INT61136 Localization of MC1R 1 8 0.75 2.8 2.85
35 INT143684 Negative_regulation of Fosb 1 4 0.43 2.37 2.72
36 INT91442 Binding of PTGDR2 1 6 0.46 1.5 2.2
37 INT56040 Negative_regulation of Binding of Ptger2 1 9 0.28 2 1.92
38 INT71327 Localization of Cacna1a 1 3 0.60 2.51 1.7
39 INT91868 Transcription of B4GALNT1 1 5 0.10 1.5 1.66
40 INT146302 Gene_expression of NRXN3 3 3 0.78 1.32 1.54
41 INT128003 Negative_regulation of Gene_expression of MC1R 1 4 0.59 1.56 1.41
42 INT91441 Binding of MINOS1 2 3 0.03 0.31 1.35
43 INT91863 Negative_regulation of Gene_expression of NOS3 1 13 0.51 9.43 1.34
44 INT128004 Negative_regulation of Gene_expression of MINOS1 3 4 0.04 0.51 1.31
45 INT128001 Gene_expression of MINOS1 2 3 0.07 0.36 1.24
46 INT13063 Binding of RHCE 2 16 0.38 6.54 1.22
47 INT128000 Gene_expression of RHCE 1 9 0.75 1.39 1.18
48 INT91872 Gene_expression of RPA1 3 9 0.77 5.28 1.12
49 INT112830 Binding of Tg(EGFR)5Jlj 2 3 0.03 2.39 1.07
50 INT116655 Binding of NAA50 1 3 0.36 1.93 0.78
51 INT43489 Gene_expression of Mtnr1a 1 5 0.20 0.97 0.73
52 INT93111 Phosphorylation of NGF 1 1 0.49 0.61 0.73
53 INT145142 Gene_expression of RPL5 1 3 0.12 1.54 0.62
54 INT56135 Negative_regulation of Grik4 1 2 0.36 0.69 0.59
55 INT66019 Binding of RBM25 1 1 0.00 0.42 0.57
56 INT139713 Binding of Ttc12 1 1 0.09 0.77 0.57
57 INT146301 Binding of NRXN3 1 1 0.48 0.34 0.49
58 INT91864 Negative_regulation of Transcription of NOS3 3 4 0.54 1.41 0.48
59 INT146299 Regulation of NRXN3 1 1 0.45 0.34 0.48
60 INT146297 Positive_regulation of Gene_expression of NRXN3 1 1 0.50 0.34 0.48
61 INT146298 Regulation of Gene_expression of NRXN3 1 1 0.62 0.34 0.48
62 INT89729 Gene_expression of Sim2 2 3 0.78 2.85 0.45
63 INT145143 Gene_expression of OR7E84P 1 1 0.01 0.09 0.41
64 INT112391 Negative_regulation of Scn2b 1 1 0.09 0.69 0.35
65 INT122401 Binding of Stat1 1 1 0.07 0.81 0.28
66 INT138715 Gene_expression of POLG 1 12 0.66 6.97 0.23
67 INT91865 Negative_regulation of Transcription of B4GALNT1 1 2 0.02 0.52 0.22
68 INT111910 Negative_regulation of Positive_regulation of CCT4 1 1 0.31 0.41 0.22
69 INT111913 Negative_regulation of CCT4 1 1 0.31 0.41 0.22
70 INT111911 Positive_regulation of CCT4 1 1 0.36 0.41 0.22
71 INT111912 Negative_regulation of TAP1 1 1 0.04 0.41 0.22
72 INT91867 Transcription of ATG9B 1 1 0.03 0.46 0.19
73 INT60209 Transcription of RYR1 1 3 0.69 3.06 0.16
74 INT91870 Negative_regulation of Gene_expression of RPA1 1 1 0.58 0.4 0.16
75 INT91871 Transcription of RPA1 1 1 0.69 0.38 0.15
76 INT91866 Positive_regulation of Gene_expression of RPA1 1 1 0.69 0.38 0.15
77 INT122404 Localization of Bloc1s2 1 1 0.00 0.93 0.14
78 INT91436 Localization of MCOLN1 1 1 0.27 0.36 0.13
79 INT89728 Binding of Sim2 2 1 0.37 1.93 0.11
80 INT89727 Positive_regulation of Gene_expression of Sim2 1 1 0.70 0.98 0.1
81 INT88251 Binding of RAP1A 1 1 0.03 0.57 0.09
82 INT122405 Localization of Mtnr1a 1 2 0.05 0.9 0.08
83 INT127998 Negative_regulation of GTPBP4 1 1 0.03 0.17 0.08
84 INT127999 Localization of MINOS1 1 1 0.07 0.16 0.07
85 INT138714 Positive_regulation of Polg 1 3 0.18 0.39 0
86 INT94006 Negative_regulation of Srd5a3 1 1 0.06 1.17 0
87 INT138716 Positive_regulation of PAPOLG 1 1 0.12 0.23 0
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