J:Hypertension

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT38217 Penk Regulation of Localization of Avp 2 1 0.38 0.56 4.45
2 INT41591 Binding of PDYN and FAIM3 1 2 0.00 0 1.41
3 INT47342 Penk Regulation of Fabp6 1 1 0.01 0.39 0.95
4 INT80718 Trpv3 Negative_regulation of Chn1 1 1 0.01 0.7 0.92
5 INT33561 Crh Positive_regulation of POMC 3 1 0.45 1.19 0.64
6 INT17187 Binding of Adra2a and Fabp6 1 2 0.16 0.69 0.61
7 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 2 0.21 0.69 0.61
8 INT79809 Binding of Agtr1a and Adra1a 1 1 0.02 0.23 0.53
9 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 1 0.38 0.19 0.43
10 INT25430 Gtf3a Regulation of Nppa 1 1 0.24 0.57 0.43
11 INT36460 Binding of Agt and Avp 1 1 0.28 0.16 0.4
12 INT33560 Binding of POMC and Crh 1 1 0.24 0.22 0.2
13 INT33559 Binding of POMC and Avp 1 1 0.11 0.22 0.2
14 INT25431 Gtf3a Regulation of Sald1 1 1 0.03 0.2 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 4 1902 0.78 275.47 1057.59
2 INT292 Localization of Penk 3 876 0.81 88.44 669.14
3 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
5 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
6 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
7 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
8 INT6580 Negative_regulation of Ptgs1 5 929 0.59 381.53 376.26
9 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
10 INT477 Localization of Avp 13 813 0.81 131.58 300.4
11 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
12 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
13 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
14 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
15 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
16 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
17 INT1652 Regulation of Pomc 2 387 0.62 61.01 186.51
18 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
19 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
20 INT2451 Positive_regulation of Avp 6 355 0.70 102.66 147.69
21 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
22 INT4207 Regulation of Avp 1 267 0.62 63.72 115.33
23 INT1898 Regulation of Crh 1 220 0.62 61.33 102.64
24 INT5940 Negative_regulation of Avp 1 236 0.59 67.86 101.2
25 INT1472 Positive_regulation of Ins1 3 349 0.69 146.2 86.36
26 INT5617 Localization of Nppa 6 266 0.81 83.51 83.89
27 INT8650 Gene_expression of Gal 1 152 0.78 61.97 81.72
28 INT6107 Localization of Npy 3 180 0.81 26.76 81.67
29 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
30 INT4358 Positive_regulation of Localization of Avp 5 195 0.70 30.79 77.58
31 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
32 INT7886 Regulation of Localization of Avp 4 146 0.62 14.53 72.99
33 INT8357 Gene_expression of KNG1 2 153 0.75 77.26 68.66
34 INT5573 Negative_regulation of Gene_expression of Penk 2 113 0.59 21.83 64.66
35 INT480 Negative_regulation of Localization of Avp 3 151 0.59 27.64 63.72
36 INT46 Localization of Ren 4 233 0.81 46.15 62.44
37 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
38 INT1536 Negative_regulation of NA 2 244 0.55 52.67 59.79
39 INT5016 Negative_regulation of Crh 1 129 0.59 36.74 59.28
40 INT1463 Binding of Pomc 1 129 0.48 15.89 56.27
41 INT1200 Negative_regulation of Ins1 2 274 0.58 155.17 56.14
42 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
43 INT5623 Positive_regulation of Nppa 8 174 0.70 69.96 52.33
44 INT5858 Positive_regulation of Drd1a 1 66 0.69 4.51 51.73
45 INT7059 Regulation of Adra2a 2 89 0.62 18.24 48.43
46 INT375 Positive_regulation of REN 11 293 0.70 152.46 47.55
47 INT5337 Negative_regulation of Npy 1 87 0.59 19.6 46.75
48 INT2275 Negative_regulation of Localization of Ins1 1 183 0.59 51.02 44.94
49 INT8465 Regulation of Ptgs1 4 100 0.57 36.03 44.41
50 INT5039 Positive_regulation of Gal 1 67 0.68 27.97 37.36
51 INT5620 Positive_regulation of Localization of Nppa 1 105 0.70 30.23 36.45
52 INT49 Negative_regulation of Ren 13 129 0.59 37.48 35.62
53 INT7608 Positive_regulation of Adra2a 1 66 0.70 17.81 35.15
54 INT8905 Gene_expression of EDN1 1 215 0.78 157.1 34.19
55 INT1116 Regulation of Ren 8 103 0.62 27.66 33.26
56 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
57 INT46833 Positive_regulation of SGSM3 2 56 0.67 24.49 30.31
58 INT6196 Regulation of Nppa 4 83 0.62 30.31 30.18
59 INT660 Negative_regulation of REN 11 194 0.59 82.06 29.46
60 INT18489 Binding of Man2a2 1 59 0.48 11.27 29.38
61 INT5514 Negative_regulation of Localization of Crh 1 64 0.58 8.12 29.29
62 INT1196 Positive_regulation of Positive_regulation of POMC 1 51 0.70 15.99 28.58
63 INT3167 Binding of KNG1 1 48 0.48 23.26 26.77
64 INT8205 Negative_regulation of Nppa 5 77 0.59 26.43 25.72
65 INT2140 Regulation of REN 3 104 0.62 28.24 24.49
66 INT9526 Negative_regulation of Localization of Pomc 1 41 0.58 6.93 23.3
67 INT825 Negative_regulation of ADRA1D 1 54 0.58 20.25 22.78
68 INT8640 Positive_regulation of HSD11B1 2 332 0.67 377.84 22.36
69 INT5040 Regulation of Gal 1 42 0.60 12.72 21.18
70 INT3593 Gene_expression of ADRA1D 1 70 0.75 29.48 20.87
71 INT3030 Gene_expression of Adra2a 2 37 0.68 5.58 19.76
72 INT5099 Localization of Gal 3 46 0.81 10.66 18.93
73 INT7680 Regulation of Drd1a 1 27 0.45 4.52 18.86
74 INT2660 Negative_regulation of Fabp6 6 58 0.49 33.74 18.27
75 INT48 Positive_regulation of Localization of Ren 2 69 0.70 12.47 18.03
76 INT67975 Gene_expression of Bdkrb2 2 38 0.68 21.69 17.94
77 INT5618 Regulation of Localization of Nppa 1 36 0.62 13.42 17.46
78 INT3656 Positive_regulation of Gene_expression of Ins1 1 74 0.54 44.94 17.36
79 INT18660 Binding of Gnrhr 1 45 0.41 10.6 16.85
80 INT3926 Regulation of Bdkrb1 1 22 0.61 16.72 16.1
81 INT7475 Positive_regulation of Hdl1 1 138 0.67 175.81 15.05
82 INT3962 Regulation of AGT 1 50 0.62 20.96 13.01
83 INT2578 Binding of Ins1 1 74 0.48 33.57 12.92
84 INT8086 Negative_regulation of Localization of Npy 2 24 0.59 3.31 12.76
85 INT4199 Binding of Agt 2 76 0.48 21.06 12.66
86 INT21979 Negative_regulation of EDN1 2 52 0.58 24.65 12.55
87 INT11141 Negative_regulation of Gene_expression of Avp 1 23 0.59 3.85 12.19
88 INT53038 Positive_regulation of Agtr1a 2 35 0.67 23.76 11.68
89 INT21632 Positive_regulation of Adh1 1 32 0.70 15.67 11.65
90 INT5011 Negative_regulation of Gal 1 30 0.57 9.88 11.49
91 INT661 Gene_expression of REN 3 100 0.78 48.21 11.36
92 INT14124 Negative_regulation of Adra1a 1 34 0.59 7.48 10.85
93 INT15262 Negative_regulation of Positive_regulation of Avp 1 22 0.58 3.28 10.81
94 INT1734 Negative_regulation of HSD11B1 1 116 0.57 125.13 10.52
95 INT1180 Gene_expression of Ren 2 63 0.77 27.33 10.51
96 INT10184 Regulation of EDN1 4 44 0.62 23.78 10.06
97 INT80717 Gene_expression of Trpv3 1 20 0.72 10.05 9.96
98 INT3954 Regulation of Fabp6 6 33 0.52 15.64 9.27
99 INT7104 Binding of Bdkrb1 1 6 0.37 6.54 9.02
100 INT10237 Binding of EDN1 1 40 0.48 16 8.48
101 INT12762 Negative_regulation of Positive_regulation of Ins1 1 24 0.59 8.51 8.28
102 INT13739 Positive_regulation of Positive_regulation of Avp 1 18 0.70 4.78 8.2
103 INT5401 Gene_expression of DBH 1 17 0.78 1.92 8.01
104 INT26551 Positive_regulation of Gene_expression of KNG1 2 19 0.67 11.05 7.98
105 INT6384 Regulation of Eef1a1 2 21 0.61 2.95 7.97
106 INT22491 Binding of Atrn 1 23 0.30 4.51 7.79
107 INT65246 Negative_regulation of Nos3 2 36 0.50 25.65 7.62
108 INT1771 Positive_regulation of Ace 2 31 0.68 10.47 7.46
109 INT3928 Localization of Bdkrb1 1 15 0.75 4.06 7.23
110 INT6210 Binding of Nppa 3 39 0.47 14.35 7.21
111 INT10863 Positive_regulation of Ldlr 1 45 0.68 31.06 7.05
112 INT15775 Positive_regulation of Ren1 2 50 0.69 22.38 6.19
113 INT21032 Gene_expression of Adh1 1 23 0.78 22.1 6.14
114 INT55034 Positive_regulation of Adm 6 27 0.61 14.1 6.13
115 INT17913 Regulation of HSD11B1 1 87 0.60 93.23 6.04
116 INT5762 Negative_regulation of Gene_expression of Agt 2 18 0.57 6.09 5.84
117 INT2613 Negative_regulation of Positive_regulation of Ren 2 16 0.59 8.2 5.62
118 INT18366 Negative_regulation of Positive_regulation of Drd1a 1 6 0.42 0.49 5.54
119 INT19993 Negative_regulation of Ren1 1 43 0.58 20.89 5.04
120 INT58766 Gene_expression of ANGPT2 2 41 0.67 21.65 4.82
121 INT69215 Gene_expression of Col1a1 1 38 0.68 17.39 4.77
122 INT1634 Gene_expression of Gcg 1 25 0.75 14.98 4.42
123 INT30522 Gene_expression of Acyp2-ps1 2 8 0.66 0.86 4.23
124 INT70756 Gene_expression of Adm 1 28 0.77 13.33 4.22
125 INT2453 Positive_regulation of Apoa2 1 20 0.54 3.49 4.08
126 INT109 Binding of ADRB3 1 17 0.47 3.02 3.84
127 INT54886 Negative_regulation of ANGPT2 1 25 0.42 9.33 3.79
128 INT15982 Positive_regulation of NLRP3 1 25 0.65 23.19 3.57
129 INT4479 Negative_regulation of Positive_regulation of REN 1 17 0.56 6.1 3.27
130 INT2837 Regulation of PAEP 3 17 0.53 7.84 3.17
131 INT67719 Positive_regulation of Col1a1 1 21 0.44 8.87 3.12
132 INT18365 Positive_regulation of Regulation of Drd1a 1 4 0.50 1.74 3.04
133 INT10556 Regulation of Apoa2 1 5 0.44 0.51 2.8
134 INT44730 Gene_expression of Hc3 2 3 0.64 1.66 2.75
135 INT8890 Transcription of Col1a1 1 10 0.63 4.02 2.48
136 INT73809 Regulation of Nos3 2 18 0.45 10.05 2.27
137 INT27989 Positive_regulation of Gene_expression of REN 1 18 0.55 12.69 2.11
138 INT47509 Gene_expression of Avpr1a 1 2 0.65 2.04 2.06
139 INT6530 Regulation of Abr 1 7 0.24 0.46 2.01
140 INT53500 Negative_regulation of Ppap2a 1 11 0.45 3.31 1.92
141 INT76532 Binding of Nos3 1 13 0.37 9.32 1.87
142 INT46832 Negative_regulation of Gene_expression of Fabp6 2 2 0.10 1.49 1.85
143 INT23622 Negative_regulation of Klk1c12 2 3 0.57 0.79 1.84
144 INT6130 Positive_regulation of Regulation of POMC 1 6 0.69 3.57 1.7
145 INT3084 Negative_regulation of Negative_regulation of REN 1 6 0.42 2.2 1.68
146 INT14842 Negative_regulation of Binding of EDN1 1 4 0.57 0.67 1.66
147 INT44731 Gene_expression of Slc5a7 1 4 0.76 0.83 1.58
148 INT43482 Regulation of Binding of ADRB3 1 4 0.60 1.06 1.54
149 INT23171 Negative_regulation of NLRP3 1 7 0.37 4.15 1.53
150 INT14239 Localization of Klk1c12 1 4 0.78 0.44 1.43
151 INT8845 Negative_regulation of Localization of Gal 1 5 0.42 1.05 1.33
152 INT44311 Positive_regulation of Klk1c12 3 4 0.67 0 1.29
153 INT48037 Regulation of Adm 1 8 0.44 3.96 1.24
154 INT47507 Negative_regulation of Gene_expression of Adh1 1 1 0.11 0.42 1.17
155 INT47508 Negative_regulation of Gene_expression of Avpr1a 1 1 0.06 0.42 1.17
156 INT67974 Positive_regulation of Gene_expression of Bdkrb2 1 3 0.37 1.13 1.12
157 INT20687 Positive_regulation of Regulation of Adra2a 1 1 0.35 1.07 0.95
158 INT29759 Negative_regulation of Negative_regulation of Nppa 2 3 0.58 1.5 0.9
159 INT14976 Negative_regulation of Adrb2 1 3 0.24 0.75 0.86
160 INT19824 Negative_regulation of Abr 1 3 0.59 0.88 0.84
161 INT57433 Positive_regulation of Binding of EDN1 1 3 0.49 0.62 0.82
162 INT40053 Positive_regulation of Positive_regulation of Ren1 1 4 0.54 4.41 0.81
163 INT21488 Negative_regulation of Positive_regulation of Fabp6 1 3 0.20 0.89 0.79
164 INT43481 Positive_regulation of ADRB1 1 3 0.19 1.36 0.68
165 INT44305 Regulation of Klk1c12 2 1 0.44 0 0.66
166 INT44306 Regulation of Positive_regulation of Klk1c12 2 1 0.44 0 0.61
167 INT28931 Negative_regulation of LRPAP1 1 6 0.57 1.42 0.57
168 INT32618 Regulation of Positive_regulation of Agt 1 2 0.43 0.42 0.52
169 INT73301 Positive_regulation of ACTA1 1 2 0.01 0.58 0.51
170 INT40089 Positive_regulation of Chga 1 2 0.67 0.63 0.45
171 INT27723 Regulation of Negative_regulation of Ren 2 4 0.45 1.14 0.44
172 INT57434 Regulation of Regulation of EDN1 2 1 0.40 0.47 0.44
173 INT57643 Negative_regulation of Binding of Ins1 1 6 0.43 3.51 0.43
174 INT71561 Positive_regulation of Gene_expression of Adm 1 4 0.61 2.67 0.43
175 INT73302 Transcription of ACTA1 1 2 0.02 0.55 0.43
176 INT44307 Negative_regulation of Kng1l1 1 1 0.08 0 0.42
177 INT44309 Regulation of Localization of Klk1c12 1 1 0.44 0 0.38
178 INT84555 Negative_regulation of Spi1 1 6 0.42 0.71 0.34
179 INT40347 Regulation of Regulation of Eef1a1 1 1 0.13 0.77 0.3
180 INT44308 Regulation of Localization of Bdkrb1 1 1 0.02 0 0.29
181 INT44304 Regulation of Gene_expression of Klk1c12 1 1 0.44 0 0.28
182 INT73296 Positive_regulation of Myh7 2 3 0.67 1.05 0.27
183 INT44310 Gene_expression of Klk1c12 1 1 0.65 0 0.27
184 INT73299 Negative_regulation of Positive_regulation of Myh7 2 1 0.42 0.59 0.27
185 INT40346 Positive_regulation of Regulation of Eef1a1 1 1 0.14 0.7 0.24
186 INT84554 Regulation of Regulation of Nppa 1 1 0.27 0.39 0.18
187 INT85977 Localization of Tead4 1 1 0.04 0.7 0.17
188 INT73297 Positive_regulation of Transcription of Col1a1 1 2 0.32 3.12 0.14
189 INT73303 Positive_regulation of Transcription of ACTA1 1 1 0.01 0.29 0.14
190 INT73300 Positive_regulation of Transcription of Myh7 1 1 0.49 0.29 0.14
191 INT73298 Transcription of Myh7 1 1 0.70 0.29 0.13
192 INT3329 Protein_catabolism of REN 2 5 1.00 0.95 0.11
193 INT37403 Negative_regulation of Regulation of REN 1 1 0.43 0.35 0.11
194 INT27838 Gene_expression of Avpr1b 1 1 0.33 0.48 0.08
195 INT25428 Negative_regulation of Amhr2 1 1 0.17 0.13 0.07
196 INT35232 Regulation of Positive_regulation of Apoa2 1 1 0.48 0.18 0.05
197 INT27724 Regulation of Negative_regulation of Agt 1 2 0.35 0.32 0
198 INT71562 Regulation of Regulation of Fabp6 1 2 0.04 0.4 0
199 INT71560 Regulation of Positive_regulation of Fabp6 1 1 0.07 0.29 0
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