J:Indian Journal of Pharmacology

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 5 0.52 12.7 7.73
2 INT194647 Binding of CD28 and CD80 15 2 0.40 4.9 3.22
3 INT289979 Binding of Helt and Negative_regulation of Maoa 1 4 0.00 0.17 3.14
4 INT186126 Binding of CD28 and CTLA4 9 1 0.52 4.13 3.12
5 INT175329 Binding of ICAM1 and ITGAL 14 4 0.18 10.06 2.81
6 INT279361 Binding of TNF and KLF1 4 1 0.00 3.72 2.19
7 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 2 0.22 1.27 0.57
8 INT170128 Binding of ITGAL and ITGB2 2 1 0.04 1.6 0.28
9 INT289954 Binding of APC and CD28 1 1 0.03 0.38 0.28
10 INT289959 Negative_regulation of Binding of CD28 and CD80 1 1 0.07 0.24 0.23
11 INT289953 Binding of CD80 and KLF1 1 1 0.00 0.21 0.23
12 INT289955 Binding of APCS and KLF1 1 1 0.00 0.21 0.23
13 INT289998 CNTF Negative_regulation of Casp3 1 1 0.04 0.99 0.22
14 INT289981 Cntf Negative_regulation of Casp3 1 1 0.02 1.01 0.22
15 INT289997 CNTF Negative_regulation of Binding of CNTF and Casp3 1 1 0.05 0.99 0.22
16 INT289999 Binding of CNTF and Casp3 1 1 0.04 0.99 0.22
17 INT315491 Hspg2 Negative_regulation of Gene_expression of Il4 1 1 0.04 0.22 0.17
18 INT315492 Hspg2 Negative_regulation of Gene_expression of Il2 1 1 0.06 0.14 0.14
19 INT289956 Binding of APC and ICAM1 1 1 0.04 0.5 0.13
20 INT289958 Binding of IL2 and IL2RB 1 1 0.02 0.59 0.12
21 INT315490 Hspg2 Negative_regulation of Il2 1 1 0.08 0 0.09
22 INT330855 Binding of Ins1 and Tgs1 1 1 0.02 0.86 0.09
23 INT289957 Binding of APCS and CD58 1 1 0.04 0.35 0.08
24 INT346695 Negative_regulation of SOD1 Positive_regulation of Negative_regulation of Hist3h2a 1 1 0.00 0.41 0.08
25 INT330875 PLDN Negative_regulation of Gene_expression of Ache 1 2 0.01 0.85 0.03
26 INT315499 Ctnnbl1 Positive_regulation of Ldha 1 1 0.29 0.26 0
27 INT339404 Binding of Ar and Tymp 1 5 0.10 0.06 0
28 INT339403 Negative_regulation of Binding of Ar and Tymp 1 4 0.12 0 0
29 INT339402 Binding of Dlat and Tymp 1 4 0.19 0 0
30 INT339405 Negative_regulation of Binding of Dlat and Tymp 1 4 0.22 0 0
31 INT330876 PLDN Negative_regulation of Ache 1 1 0.01 0.45 0
32 INT339407 Negative_regulation of Binding of AR and Tymp 1 4 0.04 0 0
33 INT330877 PLDN Positive_regulation of Gins4 1 1 0.00 0.08 0
34 INT339406 Binding of AR and Tymp 1 5 0.03 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 5 3152 0.78 2515.62 929.82
2 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
3 INT9238 Gene_expression of IL6 2 1575 0.78 1135.66 424.22
4 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
5 INT9158 Gene_expression of Tnf 2 722 0.78 522.01 277.68
6 INT49750 Negative_regulation of CPOX 1 735 0.58 360.06 274.19
7 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
8 INT10832 Gene_expression of IL8 3 1050 0.78 698.72 270
9 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
10 INT6481 Binding of TNF 4 624 0.48 510.2 214.82
11 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
12 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
13 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
14 INT2085 Positive_regulation of LH 2 441 0.70 60.15 191.02
15 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
16 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
17 INT1114 Localization of Ins1 4 748 0.80 192.95 165.48
18 INT66280 Gene_expression of Nos2 1 534 0.78 330.78 157.07
19 INT49134 Gene_expression of Grin1 1 270 0.78 84.78 148.61
20 INT13353 Positive_regulation of Tnf 2 332 0.70 248.75 148.1
21 INT9852 Positive_regulation of Gpt 6 563 0.70 364.64 146.82
22 INT5116 Gene_expression of IL2 3 670 0.78 291.13 146.69
23 INT1047 Negative_regulation of LH 1 314 0.59 53.71 135.89
24 INT48953 Positive_regulation of Nos2 1 486 0.70 239.85 131.87
25 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
26 INT62124 Gene_expression of NOS1 1 444 0.78 218.08 114.85
27 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
28 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
29 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
30 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
31 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
32 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
33 INT77435 Positive_regulation of Nos2 3 343 0.70 208.49 91.43
34 INT10166 Localization of Tnf 3 237 0.81 153.95 88.64
35 INT1472 Positive_regulation of Ins1 4 349 0.69 146.2 86.36
36 INT3657 Gene_expression of Ins1 5 514 0.78 321.69 75.76
37 INT1080 Negative_regulation of Ache 5 343 0.59 108.51 72.4
38 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
39 INT58400 Negative_regulation of Tnf 2 182 0.59 129.97 71
40 INT10837 Positive_regulation of Gene_expression of IL8 1 294 0.70 190.08 70.34
41 INT1988 Positive_regulation of Localization of Ins1 4 254 0.69 59.25 68.37
42 INT11807 Gene_expression of Il2 1 266 0.78 112 64.97
43 INT17564 Gene_expression of Gpt 2 322 0.75 208.51 60.36
44 INT55344 Gene_expression of Ros1 1 396 0.54 217.64 59.98
45 INT49170 Negative_regulation of Nos1 2 116 0.59 60.66 58.87
46 INT1200 Negative_regulation of Ins1 2 274 0.58 155.17 56.14
47 INT69876 Negative_regulation of Nfkb1 2 147 0.58 89.81 55.5
48 INT78899 Gene_expression of CCL5 1 155 0.77 84.02 55.09
49 INT20375 Gene_expression of Hand1 1 213 0.60 148.51 54.53
50 INT2276 Regulation of Ins1 3 234 0.61 103.78 54.05
51 INT52264 Gene_expression of IK 2 180 0.77 90.87 51.87
52 INT20382 Gene_expression of Hand2 1 211 0.66 142.26 51.05
53 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
54 INT1977 Negative_regulation of Positive_regulation of Prl 1 98 0.59 17.06 47.88
55 INT374 Positive_regulation of Ldha 9 212 0.70 107.08 47.43
56 INT619 Positive_regulation of Positive_regulation of Prl 1 116 0.70 22.69 45.06
57 INT27493 Negative_regulation of Casp3 1 114 0.56 56.89 44.63
58 INT5307 Regulation of Tnf 3 87 0.62 78.71 43.4
59 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
60 INT85943 Negative_regulation of Nos2 2 161 0.59 108.56 42.65
61 INT13556 Gene_expression of CD4 1 367 0.78 230.82 41.74
62 INT115 Negative_regulation of Maoa 8 65 0.59 16.27 38.66
63 INT3971 Positive_regulation of Alb 2 175 0.70 98.46 36.45
64 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
65 INT10763 Localization of IL2 1 157 0.80 81.11 33.21
66 INT92837 Negative_regulation of Gene_expression of Nos2 1 116 0.59 59.67 31.82
67 INT7538 Negative_regulation of IL2 2 95 0.57 47.31 31.7
68 INT35406 Localization of Tnf 1 94 0.81 64.63 31.65
69 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
70 INT77652 Negative_regulation of Gene_expression of IL8 1 99 0.59 67.57 30.21
71 INT5117 Negative_regulation of Gene_expression of IL2 4 118 0.59 52.33 29.96
72 INT724 Negative_regulation of Alb 2 151 0.59 93.57 29.65
73 INT11554 Negative_regulation of CSF2 1 129 0.59 108.55 29.44
74 INT3286 Positive_regulation of Gpt 1 90 0.69 45.08 28.34
75 INT87212 Negative_regulation of Positive_regulation of Nfkb1 1 74 0.57 38.21 28.31
76 INT5206 Gene_expression of AR 5 316 0.78 113.83 27.29
77 INT2569 Gene_expression of Ache 3 120 0.78 26.29 26.89
78 INT52801 Regulation of Gene_expression of Tnf 2 55 0.62 48.74 26.59
79 INT66758 Binding of Nfkb1 1 97 0.48 50.65 23.65
80 INT71875 Localization of Nfkb1 1 92 0.78 48.13 22.94
81 INT3330 Gene_expression of AGT 5 149 0.76 98.65 22.73
82 INT4369 Gene_expression of Ldha 6 157 0.76 88.12 22.45
83 INT8640 Positive_regulation of HSD11B1 2 332 0.67 377.84 22.36
84 INT35711 Positive_regulation of Sdcbp 1 110 0.60 50.45 22.11
85 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
86 INT614 Gene_expression of Cxcl2 2 29 0.76 25.53 20.8
87 INT12951 Negative_regulation of Cat 11 126 0.57 64.39 20.61
88 INT7336 Positive_regulation of VIP 1 60 0.70 24.2 19.62
89 INT1278 Negative_regulation of Ldha 9 93 0.59 37.66 19.36
90 INT66751 Negative_regulation of Localization of Tnf 2 48 0.59 26 19.36
91 INT76924 Positive_regulation of Slc17a5 4 71 0.70 41.21 19.31
92 INT9246 Positive_regulation of Cat 6 113 0.70 52.73 18.04
93 INT13244 Binding of Helt 2 30 0.31 4.56 18.01
94 INT2158 Negative_regulation of Positive_regulation of LH 1 41 0.58 4.52 17.75
95 INT107454 Positive_regulation of Stat3 1 43 0.68 19.63 17.69
96 INT3656 Positive_regulation of Gene_expression of Ins1 1 74 0.54 44.94 17.36
97 INT21532 Negative_regulation of Gene_expression of Il2 1 47 0.59 20.43 16.96
98 INT1533 Negative_regulation of AGT 4 105 0.42 46.54 16.92
99 INT10169 Positive_regulation of Localization of Tnf 1 44 0.70 27.71 16.75
100 INT22900 Positive_regulation of Cd4 1 126 0.67 82.77 16.43
101 INT6110 Negative_regulation of Gene_expression of Ins1 2 83 0.56 60.59 16.07
102 INT12950 Gene_expression of Cat 3 85 0.75 35.94 15.76
103 INT170754 Localization of IFN1@ 2 121 0.78 66.78 15.6
104 INT2630 Positive_regulation of Shbg 1 134 0.70 65.26 15.19
105 INT26729 Negative_regulation of Drd2 1 28 0.55 9.32 15.17
106 INT69952 Positive_regulation of IK 1 45 0.32 16.08 14.59
107 INT17565 Regulation of Gpt 1 85 0.60 43.64 13.68
108 INT71879 Negative_regulation of Localization of Nfkb1 1 30 0.57 21.8 13.48
109 INT2396 Regulation of Maoa 4 25 0.62 6.04 13.27
110 INT87235 Negative_regulation of Il4 2 54 0.48 31.51 13.15
111 INT132178 Binding of CD80 3 41 0.47 15.55 12.98
112 INT22213 Localization of Gpt 1 52 0.78 34.05 12.94
113 INT2578 Binding of Ins1 2 74 0.48 33.57 12.92
114 INT174838 Localization of INCENP 2 80 0.64 19.05 12.89
115 INT51014 Transcription of IL2 2 42 0.71 21.56 12.7
116 INT107875 Phosphorylation of Stat3 1 49 0.80 13.18 12.66
117 INT31990 Positive_regulation of SOD1 1 124 0.69 67.79 12.52
118 INT14510 Gene_expression of SOD1 1 208 0.76 88.56 12.4
119 INT94464 Negative_regulation of Hand1 2 44 0.41 31.5 12.39
120 INT9832 Gene_expression of Shbg 1 96 0.75 56.71 12.19
121 INT148207 Gene_expression of CTLA4 1 53 0.77 29.13 12.07
122 INT69158 Localization of IL4 1 48 0.71 31.3 11.98
123 INT36287 Binding of CD4 1 96 0.47 58.93 11.88
124 INT3602 Negative_regulation of Shbg 7 148 0.53 69.05 11.65
125 INT373 Regulation of Ldha 1 37 0.61 17.86 11.41
126 INT1734 Negative_regulation of HSD11B1 1 116 0.57 125.13 10.52
127 INT58904 Localization of TH1L 1 40 0.68 27.11 10.52
128 INT83292 Gene_expression of MIP 1 35 0.75 25.22 10.14
129 INT73504 Binding of CD28 4 35 0.45 15.99 10.04
130 INT80549 Binding of ICAM1 3 53 0.47 42.76 9.72
131 INT62166 Positive_regulation of Gene_expression of Gpt 1 64 0.50 39.13 9.69
132 INT63341 Negative_regulation of ICAM1 1 42 0.59 30.45 9.5
133 INT2976 Regulation of Bche 2 29 0.45 8.56 9.42
134 INT25834 Positive_regulation of Dbp 1 59 0.68 24.34 9.32
135 INT52924 Negative_regulation of GSR 2 49 0.58 28.08 9.28
136 INT97649 Gene_expression of Dlat 5 48 0.66 13.77 8.94
137 INT55597 Negative_regulation of Gpx1 2 59 0.55 28.3 8.83
138 INT22383 Binding of IL2 1 59 0.48 39.06 8.56
139 INT53573 Negative_regulation of Localization of Tnf 1 19 0.59 11.57 8.54
140 INT19185 Negative_regulation of Cd4 2 80 0.51 61.32 8.51
141 INT8637 Negative_regulation of Dbp 8 112 0.50 33.28 8.4
142 INT5194 Positive_regulation of Lpo 6 63 0.70 26.44 8.37
143 INT132278 Binding of CTLA4 4 32 0.39 18.69 8.17
144 INT65246 Negative_regulation of Nos3 1 36 0.50 25.65 7.62
145 INT5195 Negative_regulation of Lpo 2 32 0.59 14.45 7.3
146 INT70814 Negative_regulation of Il2 5 40 0.56 13.36 7.22
147 INT44920 Negative_regulation of IK 1 18 0.41 9.9 7.16
148 INT32709 Negative_regulation of Hbb 2 30 0.54 18.27 6.97
149 INT14903 Negative_regulation of SOD1 7 81 0.57 42.02 6.91
150 INT160562 Localization of Cd4 1 49 0.71 27.58 6.78
151 INT173639 Positive_regulation of INCENP 1 40 0.14 20.97 6.7
152 INT50387 Negative_regulation of AR 5 67 0.45 26.31 6.61
153 INT61258 Transcription of Nfkb1 1 24 0.67 10.89 6.32
154 INT61417 Gene_expression of ITGAL 2 36 0.75 29.62 6.15
155 INT4422 Positive_regulation of Gene_expression of Alb 1 30 0.50 18.56 6.12
156 INT46886 Positive_regulation of Maoa 1 12 0.69 5.29 5.9
157 INT21103 Gene_expression of Dbp 1 48 0.61 22.6 5.59
158 INT38366 Regulation of Cat 3 45 0.62 23.45 5.34
159 INT39900 Positive_regulation of Gene_expression of Ldha 4 36 0.50 20.35 5.22
160 INT65276 Gene_expression of Fst 1 12 0.65 4.99 5.05
161 INT15131 Gene_expression of CD2 4 20 0.75 9.47 5.01
162 INT86219 Negative_regulation of GSTK1 2 25 0.41 8.99 4.97
163 INT59320 Transcription of Il2 1 32 0.69 6.39 4.95
164 INT114311 Negative_regulation of Gene_expression of Gpt 2 33 0.38 17.83 4.94
165 INT66757 Negative_regulation of Binding of Nfkb1 1 17 0.57 8.14 4.94
166 INT11064 Positive_regulation of NPR1 1 24 0.49 14.63 4.78
167 INT87322 Binding of ITGAL 3 23 0.47 15.73 4.68
168 INT84727 Negative_regulation of Gene_expression of AR 1 38 0.58 12.46 4.63
169 INT115927 Negative_regulation of Hspg2 1 27 0.57 4.16 4.53
170 INT98251 Binding of IL12A 1 20 0.37 16.03 4.51
171 INT16887 Binding of Maoa 1 10 0.41 2.32 4.49
172 INT94466 Regulation of Gene_expression of Hand2 1 14 0.28 7.97 4.46
173 INT64653 Binding of CD2 1 17 0.44 6.74 4.45
174 INT91158 Regulation of Ros1 1 26 0.25 17 4.23
175 INT48518 Gene_expression of ANPEP 1 51 0.78 22.88 4.18
176 INT42317 Negative_regulation of Dlat 12 21 0.43 3.13 4.11
177 INT97392 Gene_expression of Stat3 1 27 0.65 14.21 4.06
178 INT52980 Positive_regulation of Dlat 1 20 0.37 5.14 4.06
179 INT181642 Negative_regulation of Narf 30 2 0.01 28.07 4.01
180 INT101506 Regulation of Tst 1 13 0.48 7.34 3.94
181 INT54701 Localization of Ptafr 1 19 0.49 18.68 3.82
182 INT63121 Binding of APC 1 29 0.41 23.02 3.8
183 INT94406 Regulation of Slc17a5 1 10 0.44 3.71 3.77
184 INT40034 Localization of Maoa 1 7 0.80 2.17 3.69
185 INT140337 Negative_regulation of Cd8a 1 42 0.50 25.4 3.66
186 INT5204 Positive_regulation of Gene_expression of AR 1 60 0.67 23.54 3.53
187 INT64310 Negative_regulation of GRIN2A 2 7 0.42 2.16 3.49
188 INT53584 Regulation of Gpx1 2 19 0.62 14.38 3.48
189 INT37110 Positive_regulation of Ptgfr 1 10 0.69 2.38 3.44
190 INT91070 Regulation of GSR 2 27 0.59 16.64 3.42
191 INT151421 Negative_regulation of Positive_regulation of Sdcbp 1 11 0.30 6.61 3.32
192 INT60541 Regulation of GSTK1 2 12 0.61 6.76 3.31
193 INT17511 Negative_regulation of PRTN3 1 19 0.41 12 3.3
194 INT174232 Gene_expression of PNP 2 36 0.30 8.74 3.17
195 INT23044 Gene_expression of Hbb 1 13 0.43 5.77 3.1
196 INT24873 Binding of KLF1 1 12 0.07 6.73 3.1
197 INT209033 Positive_regulation of Localization of IFN1@ 1 27 0.67 12.55 2.84
198 INT94463 Regulation of Gene_expression of Hand1 1 10 0.36 5.17 2.72
199 INT4647 Regulation of Hbb 1 10 0.60 5.28 2.66
200 INT93207 Negative_regulation of Cyp4a3 1 11 0.36 4.32 2.63
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