J:Int. Immunopharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 2 0.02 0.52 1.52
2 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 1 0.20 0.89 1.41
3 INT113242 TNF Regulation of Transcription of OPRM1 2 1 0.45 1.53 1.19
4 INT137144 ITIH4 Regulation of OPRM1 1 2 0.20 1.13 1.16
5 INT96008 Binding of KNG1 and EBP 1 1 0.01 0.15 0.88
6 INT96010 KNG1 Positive_regulation of Binding of MTG1 1 1 0.32 0.15 0.88
7 INT96009 KNG1 Positive_regulation of MTG1 1 1 0.32 0.15 0.88
8 INT135278 Gt(pU21)50Imeg Negative_regulation of Positive_regulation of Il6 1 1 0.02 0.26 0.8
9 INT135277 Gt(pU21)50Imeg Negative_regulation of Il6 1 1 0.02 0.23 0.78
10 INT110578 PENK Positive_regulation of Gene_expression of MME 1 1 0.35 0.1 0.76
11 INT98770 Binding of Dll1 and Gt(pU21)50Imeg 1 1 0.05 0 0.74
12 INT98771 Binding of Dll1 and Oprm1 1 1 0.29 0 0.74
13 INT137139 ITIH4 Positive_regulation of OPRM1 1 1 0.37 0.67 0.72
14 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 1 0.49 0.06 0.71
15 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 1 0.40 0.71 0.66
16 INT137140 HIVEP1 Regulation of Gene_expression of OPRM1 1 1 0.25 0.69 0.66
17 INT137145 HIVEP1 Regulation of OPRM1 1 1 0.10 0.7 0.64
18 INT154530 Positive_regulation of Ifng Negative_regulation of Il10 1 1 0.33 0.63 0.61
19 INT154533 Ifng Negative_regulation of Il4 1 1 0.11 0.62 0.6
20 INT154531 Ifng Negative_regulation of Il10 1 1 0.30 0.61 0.6
21 INT137138 ITIH4 Positive_regulation of Positive_regulation of OPRM1 1 1 0.42 0.55 0.59
22 INT137141 Binding of HIVEP1 and ITIH4 2 1 0.16 1.44 0.56
23 INT137143 HIVEP1 Positive_regulation of OPRM1 1 1 0.15 0.43 0.52
24 INT137137 Binding of HIVEP1 and ICAM1 1 1 0.01 0.68 0.51
25 INT70925 Binding of Ifng and Il4 2 1 0.14 0.9 0.5
26 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 1 0.11 0.51 0.32
27 INT121266 Mod2 Negative_regulation of Gene_expression of TNF 1 1 0.06 0.6 0.27
28 INT121265 Mod2 Negative_regulation of Gene_expression of IL1B 1 1 0.29 0.6 0.27

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
2 INT50058 Negative_regulation of Cpox 3 907 0.58 426.28 428.29
3 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
4 INT5895 Gene_expression of Oprm1 1 525 0.78 120.67 407.29
5 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
6 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
7 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
8 INT5540 Positive_regulation of Oprm1 1 344 0.70 76.77 319.71
9 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
10 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
11 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
12 INT9659 Gene_expression of Il6 3 991 0.78 715.11 265.57
13 INT5972 Gene_expression of IL1B 2 948 0.78 510.91 263.97
14 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
15 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
16 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
17 INT11313 Positive_regulation of Il6 3 526 0.70 331.27 201.59
18 INT26472 Regulation of Oprm1 1 191 0.62 35.84 173.1
19 INT4768 Positive_regulation of OPRM1 2 212 0.70 31.09 164.28
20 INT51921 Gene_expression of Cpox 4 501 0.73 229.81 157.81
21 INT66280 Gene_expression of Nos2 4 534 0.78 330.78 157.07
22 INT13353 Positive_regulation of Tnf 5 332 0.70 248.75 148.1
23 INT9852 Positive_regulation of Gpt 1 563 0.70 364.64 146.82
24 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
25 INT48895 Gene_expression of Il10 7 333 0.78 221.2 138.52
26 INT8243 Positive_regulation of Il6 3 451 0.70 358.24 119.28
27 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
28 INT29971 Gene_expression of Oprk1 1 126 0.78 35.32 93.97
29 INT77435 Positive_regulation of Nos2 6 343 0.70 208.49 91.43
30 INT10166 Localization of Tnf 1 237 0.81 153.95 88.64
31 INT15898 Positive_regulation of Prkaca 3 199 0.70 50.89 87.54
32 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
33 INT55944 Positive_regulation of Cpox 2 214 0.57 105.14 81.4
34 INT10359 Gene_expression of Ifng 3 159 0.78 79.6 72.14
35 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
36 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
37 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
38 INT53964 Negative_regulation of Prkaca 1 131 0.58 38.76 69.52
39 INT8357 Gene_expression of KNG1 3 153 0.75 77.26 68.66
40 INT7534 Gene_expression of Ifng 3 193 0.78 111.02 68.6
41 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
42 INT1425 Gene_expression of Rbm39 4 143 0.58 51.32 65.44
43 INT9657 Positive_regulation of Gene_expression of Il6 2 237 0.70 180.45 63.6
44 INT3950 Gene_expression of Ptger2 1 293 0.77 122.28 62.42
45 INT10706 Regulation of Il6 2 150 0.62 93.23 62.34
46 INT55344 Gene_expression of Ros1 1 396 0.54 217.64 59.98
47 INT20964 Gene_expression of OPRK1 2 96 0.78 23.54 58.18
48 INT68813 Transcription of Oprm1 1 93 0.71 20.11 57.65
49 INT20266 Positive_regulation of Bdkrb1 1 60 0.69 63.64 56.59
50 INT52692 Gene_expression of Ptgs2 3 160 0.78 85.06 55.73
51 INT69876 Negative_regulation of Nfkb1 3 147 0.58 89.81 55.5
52 INT5770 Binding of Rbm39 1 88 0.41 13.23 55.5
53 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
54 INT117223 Gene_expression of TLR4 1 348 0.78 206.18 54.42
55 INT49993 Positive_regulation of Gene_expression of Il6 1 149 0.70 88.07 53.78
56 INT69484 Positive_regulation of Gene_expression of OPRM1 1 75 0.70 12.86 52.27
57 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
58 INT52264 Gene_expression of IK 2 180 0.77 90.87 51.87
59 INT71786 Phosphorylation of MAPK1 3 256 0.82 110.09 46.17
60 INT8713 Regulation of Tac1 2 56 0.60 25.29 45.94
61 INT29105 Positive_regulation of OPRK1 1 68 0.70 7.06 44.69
62 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
63 INT50957 Negative_regulation of Il6 1 134 0.59 79.08 42.67
64 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
65 INT11939 Negative_regulation of Il6 2 138 0.59 87.46 41.24
66 INT49643 Gene_expression of Bdkrb1 1 39 0.78 46.49 40.21
67 INT77434 Positive_regulation of Gene_expression of Nos2 2 151 0.69 96.76 38.94
68 INT133028 Gene_expression of TLR2 3 209 0.73 131.92 36.17
69 INT11292 Gene_expression of Mme 1 77 0.78 20.98 35.85
70 INT77407 Regulation of Gene_expression of OPRM1 1 51 0.62 12.58 35.75
71 INT48896 Positive_regulation of Gene_expression of Il10 1 73 0.70 43.14 35.5
72 INT59466 Gene_expression of ISYNA1 3 204 0.77 112.57 35.48
73 INT72651 Gene_expression of TH1L 1 114 0.75 80.15 35.15
74 INT7133 Negative_regulation of MME 2 85 0.59 29.22 33.1
75 INT9658 Negative_regulation of Gene_expression of Il6 3 110 0.59 66.29 32.58
76 INT92837 Negative_regulation of Gene_expression of Nos2 2 116 0.59 59.67 31.82
77 INT7538 Negative_regulation of IL2 1 95 0.57 47.31 31.7
78 INT13186 Positive_regulation of Il4 2 113 0.68 71.22 31.4
79 INT66381 Regulation of Prkaca 1 40 0.62 13.38 27.96
80 INT64499 Positive_regulation of IRF6 1 123 0.49 52.73 27.51
81 INT59449 Negative_regulation of Timp1 3 76 0.42 54.86 26.99
82 INT29107 Regulation of Oprk1 1 31 0.45 6.16 26.61
83 INT53949 Positive_regulation of Gene_expression of Cpox 1 82 0.65 38.12 25.93
84 INT15089 Regulation of SLC6A4 1 48 0.62 17.87 25.6
85 INT12124 Gene_expression of MAPK1 3 141 0.75 82.4 25.58
86 INT56224 Negative_regulation of Gene_expression of Ifng 2 40 0.58 23.34 25.08
87 INT4877 Gene_expression of MME 3 184 0.78 122.82 24.78
88 INT43486 Positive_regulation of Ifng 6 52 0.69 32.71 24.77
89 INT71781 Phosphorylation of MAPK3 1 62 0.80 27.73 23.73
90 INT2290 Protein_catabolism of POMC 1 41 0.99 4.86 23.36
91 INT5905 Negative_regulation of ELANE 1 113 0.59 47.43 22.09
92 INT11893 Positive_regulation of Ptger2 1 96 0.69 31.49 21.92
93 INT52693 Positive_regulation of Gene_expression of Ptgs2 1 57 0.70 25.51 21.18
94 INT28001 Gene_expression of Gpm6a 1 23 0.66 16.66 21.09
95 INT20379 Localization of Il4 2 85 0.73 51.22 20.55
96 INT13108 Binding of MTG1 1 35 0.47 6.36 20.5
97 INT69304 Negative_regulation of Il10 1 47 0.59 36.88 19.79
98 INT48006 Negative_regulation of Oprk1 2 27 0.58 10.14 19.11
99 INT19509 Localization of Ifng 2 55 0.78 28.25 18.67
100 INT89594 Gene_expression of Ccl5 2 44 0.54 24.08 18.62
101 INT10833 Regulation of Gene_expression of IL8 1 68 0.62 38.74 18.46
102 INT55335 Binding of Cpox 1 49 0.34 15.48 18.46
103 INT22900 Positive_regulation of Cd4 1 126 0.67 82.77 16.43
104 INT9663 Protein_catabolism of PDYN 1 43 0.99 0.67 16.15
105 INT3926 Regulation of Bdkrb1 2 22 0.61 16.72 16.1
106 INT4977 Binding of ITIH4 2 60 0.46 42.48 15.65
107 INT61301 Positive_regulation of Gene_expression of Bdkrb1 1 7 0.68 16.95 15.44
108 INT10360 Positive_regulation of Ifng 2 33 0.68 21.73 15.19
109 INT69952 Positive_regulation of IK 1 45 0.32 16.08 14.59
110 INT37803 Positive_regulation of Bdkrb2 1 18 0.68 14.21 13.99
111 INT24684 Localization of PLAT 1 30 0.78 26.21 13.56
112 INT73594 Positive_regulation of Gene_expression of ISYNA1 2 61 0.55 31.35 13.45
113 INT7532 Negative_regulation of Gene_expression of Ifng 1 33 0.59 18.56 13.14
114 INT86950 Negative_regulation of Gene_expression of Il10 2 26 0.42 18.92 12.73
115 INT63104 Negative_regulation of CALCRL 1 29 0.37 13.62 12.42
116 INT70050 Negative_regulation of IL10 1 56 0.58 37.45 12.39
117 INT59080 Negative_regulation of Gene_expression of PTGS2 1 55 0.58 22.92 12.39
118 INT9160 Negative_regulation of Ifng 1 31 0.58 16.37 11.84
119 INT14867 Gene_expression of Igh-6 1 47 0.67 30.05 11.75
120 INT97381 Negative_regulation of Positive_regulation of Nos2 1 34 0.59 16.66 11.6
121 INT88223 Gene_expression of Bdkrb2 1 17 0.69 13.94 11.44
122 INT67401 Gene_expression of Il12a 1 25 0.55 20.04 11.12
123 INT19944 Negative_regulation of IFNG 1 39 0.58 22.35 10.91
124 INT133030 Positive_regulation of Gene_expression of TLR2 2 53 0.65 38.15 10.65
125 INT29802 Localization of Rbm39 1 18 0.64 4.04 9.84
126 INT59465 Negative_regulation of ISYNA1 1 41 0.49 21.9 9.46
127 INT55342 Negative_regulation of Gene_expression of Ros1 1 49 0.37 31.62 8.93
128 INT71478 Positive_regulation of Positive_regulation of Prkaca 1 21 0.37 5.14 8.85
129 INT98835 Positive_regulation of Transcription of Oprm1 1 15 0.65 2.47 8.67
130 INT117553 Regulation of MIF 2 10 0.56 12.76 8.67
131 INT9573 Regulation of Bdkrb2 1 9 0.43 6.04 8.41
132 INT113987 Localization of IK 1 29 0.23 16.73 8.25
133 INT71785 Gene_expression of MAPK3 1 22 0.75 11.35 8.21
134 INT94122 Negative_regulation of Mmp23 1 21 0.37 15.81 8.03
135 INT94082 Regulation of Gene_expression of IK 1 19 0.23 10.03 7.93
136 INT50191 Positive_regulation of Gene_expression of OPRK1 2 9 0.67 3.44 7.91
137 INT87139 Negative_regulation of Positive_regulation of Il6 2 18 0.59 10.65 7.76
138 INT6652 Negative_regulation of FPR1 1 11 0.42 5.29 7.41
139 INT89589 Negative_regulation of Ccl5 1 9 0.40 4.62 7.39
140 INT39417 Gene_expression of Fcer2a 1 65 0.76 32.1 7.37
141 INT5326 Regulation of Ifng 2 12 0.55 4.56 7.19
142 INT42832 Negative_regulation of Positive_regulation of OPRM1 1 6 0.36 0.96 6.35
143 INT11814 Positive_regulation of Alb 1 43 0.63 31.71 6.28
144 INT9695 Negative_regulation of Csf2 1 41 0.57 31.65 6.28
145 INT22128 Positive_regulation of HIVEP1 1 61 0.43 70.52 6.07
146 INT15143 Protein_catabolism of MME 2 16 1.00 4.56 5.54
147 INT19271 Binding of Aap 1 6 0.30 0.88 5.27
148 INT51950 Positive_regulation of Binding of MTG1 1 6 0.67 1.05 5.15
149 INT60252 Binding of HIVEP1 1 59 0.32 65.12 5.06
150 INT48277 Regulation of BDKRB2 1 9 0.59 2.69 5.05
151 INT51839 Positive_regulation of Localization of PLAT 1 5 0.49 7.09 4.92
152 INT19188 Binding of Igh-6 1 11 0.48 2.97 4.88
153 INT85413 Negative_regulation of IL9 2 5 0.47 4.42 4.77
154 INT89590 Negative_regulation of Gene_expression of Ccl5 1 8 0.36 3.97 4.67
155 INT26218 Gene_expression of Gt(pU21)50Imeg 1 3 0.02 0.26 4.63
156 INT103037 Transcription of Bdkrb1 1 8 0.70 4.76 4.33
157 INT14026 Positive_regulation of Igh-6 1 24 0.68 10.84 4.32
158 INT5870 Negative_regulation of IFNA2 1 20 0.49 12 4.3
159 INT91158 Regulation of Ros1 1 26 0.25 17 4.23
160 INT56594 Positive_regulation of Localization of Il4 2 17 0.48 10.17 4.15
161 INT76227 Binding of NPC1 1 30 0.41 32.31 4.05
162 INT124815 Binding of Col2a1 1 9 0.37 10.27 3.93
163 INT92200 Negative_regulation of Localization of Il4 2 10 0.51 5.66 3.65
164 INT99348 Negative_regulation of PARP1 1 38 0.58 30.96 3.36
165 INT28852 Negative_regulation of OFC1 1 11 0.42 4.23 3.24
166 INT88220 Transcription of Bdkrb2 1 6 0.65 3.08 3.21
167 INT85750 Regulation of Positive_regulation of Nos2 1 10 0.54 7.78 2.83
168 INT11291 Positive_regulation of Gene_expression of Mme 1 6 0.61 5.93 2.81
169 INT133029 Regulation of TLR2 1 18 0.56 11.31 2.62
170 INT111145 Negative_regulation of Positive_regulation of Ifng 2 7 0.41 2.21 2.61
171 INT88222 Positive_regulation of Transcription of Bdkrb2 1 3 0.47 1.32 2.51
172 INT40748 Negative_regulation of Mif 1 6 0.56 8.33 2.46
173 INT95808 Negative_regulation of Negative_regulation of Nfkb1 1 8 0.41 2.84 2.44
174 INT35027 Positive_regulation of Gene_expression of Igh-6 1 6 0.02 4.26 2.24
175 INT94060 Transcription of ISYNA1 1 18 0.43 6.7 2.18
176 INT19823 Negative_regulation of Pbrgcsf1 1 12 0.36 7.37 2.13
177 INT140818 Positive_regulation of Positive_regulation of Ifng 1 2 0.47 4.2 2.06
178 INT13605 Localization of Me1 1 5 0.68 0.31 2.03
179 INT2116 Negative_regulation of VSX1 2 29 0.36 10.67 1.89
180 INT141002 Negative_regulation of Fcer2a 1 15 0.12 7.17 1.88
181 INT148917 Positive_regulation of Transcription of Bdkrb1 1 4 0.50 0.88 1.83
182 INT110579 Negative_regulation of Gene_expression of MME 1 15 0.58 12.8 1.81
183 INT102825 Regulation of Timp1 1 10 0.38 5.49 1.79
184 INT98154 Positive_regulation of Igk 1 2 0.67 0.18 1.75
185 INT135275 Regulation of Negative_regulation of Il6 2 4 0.45 0.89 1.67
186 INT105248 Negative_regulation of Vegfa 1 8 0.47 6.19 1.61
187 INT124817 Regulation of CAMP 1 2 0.44 1.62 1.44
188 INT45155 Negative_regulation of Polymerase 1 18 0.51 15.18 1.38
189 INT124816 Negative_regulation of PDCD2 1 2 0.42 1.35 1.25
190 INT70224 Binding of oh 1 2 0.27 0.21 1.24
191 INT118606 Protein_catabolism of CXCL10 1 2 0.86 0.98 1.22
192 INT69821 Negative_regulation of Hrh3 1 4 0.43 3.59 1.15
193 INT103699 Negative_regulation of IL15 1 5 0.24 2.42 1.12
194 INT102827 Protein_catabolism of Mif 3 1 0.33 0 1.06
195 INT96012 Gene_expression of EBP 1 3 0.67 0.8 0.85
196 INT16003 Gene_expression of Phex 1 3 0.65 4.68 0.77
197 INT152550 Regulation of Hrh3 1 2 0.45 1.17 0.75
198 INT95860 Regulation of Phex 1 1 0.00 0 0.69
199 INT95855 Positive_regulation of Regulation of Oprk1 1 1 0.37 0.19 0.65
200 INT137146 Positive_regulation of Binding of ITIH4 1 1 0.41 0.7 0.64
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