J:Int. J. Immunopharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT13238 POMC Regulation of Gene_expression of IL2 1 1 0.09 0.26 0.59
2 INT6280 Cpe Regulation of Gene_expression of Mc2r 1 1 0.09 0 0.46
3 INT6279 Cpe Regulation of Gene_expression of Pomc 1 1 0.27 0 0.46
4 INT10825 Binding of PDYN and Tyr 1 1 0.01 0 0.39

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
2 INT6483 Gene_expression of TNF 11 3152 0.78 2515.62 929.82
3 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
4 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
5 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
6 INT162 Regulation of Prl 3 794 0.62 165.01 322.24
7 INT4941 Positive_regulation of Oprd1 2 345 0.70 74.26 304.41
8 INT6852 Localization of TNF 7 883 0.81 705.95 270.84
9 INT1396 Binding of Penk 3 355 0.48 22.79 269.65
10 INT9659 Gene_expression of Il6 7 991 0.78 715.11 265.57
11 INT738 Regulation of POMC 3 459 0.62 111.19 243.74
12 INT6482 Positive_regulation of Gene_expression of TNF 3 659 0.70 569.88 210
13 INT528 Gene_expression of Prl 4 693 0.78 217.18 192.2
14 INT6488 Gene_expression of Tnf 2 484 0.78 339.61 191.58
15 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
16 INT2640 Gene_expression of Pomc 2 424 0.78 120.72 155.37
17 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
18 INT5116 Gene_expression of IL2 12 670 0.78 291.13 146.69
19 INT60694 Gene_expression of Il10 3 567 0.78 369.48 143.69
20 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
21 INT9235 Negative_regulation of Gene_expression of TNF 3 346 0.59 252.98 118.61
22 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
23 INT293 Protein_catabolism of Penk 4 161 1.00 11.71 98.45
24 INT203 Positive_regulation of Pomc 2 257 0.70 90.56 92.84
25 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
26 INT60691 Gene_expression of Il12a 1 331 0.78 208.03 75.96
27 INT15769 Gene_expression of Il1b 2 146 0.78 114.51 75.35
28 INT5056 Gene_expression of IFNG 7 216 0.78 137.52 74.57
29 INT48244 Gene_expression of Il4 2 172 0.76 132.38 73.42
30 INT9236 Regulation of Gene_expression of TNF 4 204 0.62 162.66 72.99
31 INT56298 Gene_expression of IL4 7 306 0.78 182.18 72.92
32 INT11380 Negative_regulation of IL1B 3 215 0.59 125.62 72.35
33 INT6849 Localization of IL1B 3 229 0.81 112.56 69.63
34 INT7534 Gene_expression of Ifng 6 193 0.78 111.02 68.6
35 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
36 INT3375 Gene_expression of IGHE 4 535 0.77 387.47 65.46
37 INT11807 Gene_expression of Il2 6 266 0.78 112 64.97
38 INT15514 Negative_regulation of Crp 1 275 0.59 194.6 64.86
39 INT9657 Positive_regulation of Gene_expression of Il6 1 237 0.70 180.45 63.6
40 INT1437 Negative_regulation of Pomc 3 132 0.59 35.22 60.97
41 INT1430 Regulation of PDYN 1 88 0.60 16.99 60.32
42 INT1510 Binding of PDYN 2 94 0.48 4.68 56.44
43 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
44 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
45 INT60695 Positive_regulation of Gene_expression of Il10 1 154 0.70 120.28 43.07
46 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
47 INT3971 Positive_regulation of Alb 1 175 0.70 98.46 36.45
48 INT62827 Positive_regulation of ICAM1 1 184 0.70 180.95 36.28
49 INT2296 Positive_regulation of Gene_expression of Prl 2 137 0.70 36.96 35.39
50 INT53577 Negative_regulation of Localization of TNF 6 110 0.59 59.28 35.23
51 INT2699 Binding of Cpe 1 40 0.48 7.07 33.64
52 INT10763 Localization of IL2 2 157 0.80 81.11 33.21
53 INT7133 Negative_regulation of MME 1 85 0.59 29.22 33.1
54 INT234 Binding of Alb 1 151 0.48 52.34 32.97
55 INT9658 Negative_regulation of Gene_expression of Il6 1 110 0.59 66.29 32.58
56 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
57 INT62830 Gene_expression of VCAM1 1 149 0.78 125.23 32.4
58 INT9655 Regulation of Il6 2 98 0.62 70.92 31.95
59 INT7538 Negative_regulation of IL2 1 95 0.57 47.31 31.7
60 INT35406 Localization of Tnf 1 94 0.81 64.63 31.65
61 INT6277 Positive_regulation of Gene_expression of Pomc 1 76 0.70 21.45 31.09
62 INT54302 Positive_regulation of Gene_expression of Il4 1 126 0.68 86.18 30.75
63 INT9993 Positive_regulation of Gene_expression of IL2 3 131 0.69 46.27 30.04
64 INT90792 Localization of Il10 1 144 0.80 87.88 30.03
65 INT5117 Negative_regulation of Gene_expression of IL2 4 118 0.59 52.33 29.96
66 INT10915 Gene_expression of ITGAM 1 164 0.78 92.42 29.78
67 INT724 Negative_regulation of Alb 3 151 0.59 93.57 29.65
68 INT10684 Negative_regulation of Protein_catabolism of Penk 2 41 0.59 2.33 28.63
69 INT57692 Positive_regulation of Gene_expression of Il1b 1 50 0.67 43.54 28.29
70 INT5298 Negative_regulation of MTHFS 2 70 0.57 27.07 28.11
71 INT48202 Gene_expression of Tgfb1 1 146 0.78 89.93 27.76
72 INT6174 Regulation of Gene_expression of POMC 1 49 0.61 9.75 27.69
73 INT5426 Negative_regulation of RTCA 2 58 0.51 12.34 25.74
74 INT15089 Regulation of SLC6A4 1 48 0.62 17.87 25.6
75 INT4877 Gene_expression of MME 1 184 0.78 122.82 24.78
76 INT5055 Positive_regulation of IFNG 1 89 0.69 64.03 23.05
77 INT49196 Gene_expression of SELE 1 105 0.78 107.29 22.92
78 INT11804 Positive_regulation of Gene_expression of Il2 3 70 0.70 33 21.63
79 INT7535 Negative_regulation of Tlr4 1 111 0.56 56.84 21.37
80 INT60690 Positive_regulation of Gene_expression of Il12a 1 69 0.63 41.41 20.85
81 INT63340 Positive_regulation of Gene_expression of ICAM1 1 109 0.70 90.82 20.61
82 INT62042 Positive_regulation of Gene_expression of IL4 1 67 0.56 42.05 20.39
83 INT35086 Positive_regulation of Gene_expression of Ifng 3 40 0.69 22.55 18.35
84 INT28642 Gene_expression of CXCR2 2 60 0.78 38.69 18.11
85 INT97984 Negative_regulation of SLC6A4 1 45 0.59 15.43 18.09
86 INT871 Negative_regulation of Gene_expression of Prl 1 53 0.58 18.89 17.79
87 INT62826 Negative_regulation of Gene_expression of ICAM1 1 75 0.58 46.39 17.72
88 INT9656 Regulation of Gene_expression of Il6 2 57 0.62 33.3 17.71
89 INT9780 Regulation of Penk 1 30 0.60 6.78 17.19
90 INT21532 Negative_regulation of Gene_expression of Il2 2 47 0.59 20.43 16.96
91 INT10918 Gene_expression of ITGB2 1 93 0.76 71.8 16.34
92 INT10000 Regulation of Gene_expression of IL2 5 56 0.45 15.33 16.2
93 INT9663 Protein_catabolism of PDYN 4 43 0.99 0.67 16.15
94 INT12087 Regulation of Localization of TNF 1 44 0.62 28.71 15.17
95 INT6278 Negative_regulation of Gene_expression of Pomc 1 35 0.59 11.07 14.8
96 INT16919 Gene_expression of IL36RN 1 48 0.48 32.78 13.83
97 INT19191 Negative_regulation of Localization of IL1B 2 35 0.58 15.19 13.63
98 INT7532 Negative_regulation of Gene_expression of Ifng 1 33 0.59 18.56 13.14
99 INT12156 Positive_regulation of MET 1 43 0.67 17.75 12.64
100 INT5057 Negative_regulation of Gene_expression of IFNG 3 23 0.58 8.33 12.3
101 INT1139 Gene_expression of IgG-2a 2 35 0.65 19.19 12
102 INT73829 Positive_regulation of Gene_expression of VCAM1 1 41 0.61 35.96 11.92
103 INT5464 Regulation of CALCRL 1 24 0.16 4.2 11.19
104 INT13240 Gene_expression of TF 2 94 0.76 57.81 10.99
105 INT17826 Positive_regulation of Pla2g1b 1 39 0.70 11.35 10.97
106 INT701 Localization of IGHE 3 87 0.80 40.5 10.62
107 INT25613 Gene_expression of Il1f5 2 32 0.77 13.29 10.44
108 INT15172 Positive_regulation of Itgam 1 45 0.67 23.54 10.3
109 INT3988 Positive_regulation of Gene_expression of IGHE 2 98 0.68 91.46 9.61
110 INT62829 Positive_regulation of VCAM1 1 39 0.70 38.42 9.15
111 INT15768 Gene_expression of Il1a 1 20 0.71 9.31 8.78
112 INT8903 Gene_expression of IFNA2 1 58 0.71 38.23 8.68
113 INT13435 Positive_regulation of RTCA 1 31 0.60 7.19 8.5
114 INT4880 Regulation of MME 1 17 0.61 7.78 8.2
115 INT61628 Negative_regulation of Gene_expression of IL4 2 31 0.55 20.96 8.18
116 INT1138 Positive_regulation of IgG-2a 1 16 0.68 5.59 8.11
117 INT15725 Positive_regulation of Fn1 1 17 0.67 14.93 8.03
118 INT2971 Regulation of IGHE 1 42 0.61 28.81 7.87
119 INT298 Negative_regulation of ADRB3 1 23 0.59 6.82 7.56
120 INT9397 Regulation of MET 1 17 0.60 8.36 7.04
121 INT5871 Binding of IFNA2 1 38 0.48 20.35 6.46
122 INT20389 Localization of LYZ 2 19 0.79 4.58 6.25
123 INT4422 Positive_regulation of Gene_expression of Alb 1 30 0.50 18.56 6.12
124 INT8157 Binding of Tyr 1 14 0.09 0.64 5.89
125 INT53684 Negative_regulation of Gene_expression of ITGAM 1 23 0.59 14.36 5.66
126 INT48201 Localization of Tgfb1 1 27 0.59 13.65 5.54
127 INT6276 Negative_regulation of Positive_regulation of Pomc 1 12 0.57 3.65 5.49
128 INT58145 Positive_regulation of Localization of Tnf 1 20 0.67 13.33 5.44
129 INT11062 Positive_regulation of MME 1 24 0.63 14.37 5.26
130 INT62525 Positive_regulation of SELE 1 38 0.70 46 5.25
131 INT67228 Regulation of Gene_expression of Il4 1 11 0.50 6.67 5.2
132 INT62832 Negative_regulation of Gene_expression of SELE 1 16 0.49 10.6 5.12
133 INT19187 Gene_expression of Lgals3 1 24 0.73 19.72 5.03
134 INT62822 Positive_regulation of Gene_expression of SELE 1 22 0.66 28.04 4.97
135 INT58459 Negative_regulation of Localization of IL2 2 13 0.41 6.46 4.88
136 INT19188 Binding of Igh-6 1 11 0.48 2.97 4.88
137 INT56032 Positive_regulation of NCAM1 1 38 0.49 26.01 4.68
138 INT62821 Negative_regulation of Gene_expression of VCAM1 1 21 0.54 12.24 4.41
139 INT48411 Gene_expression of Cd44 1 35 0.77 27.05 4.29
140 INT23035 Regulation of Il1a 1 6 0.60 5.69 4.25
141 INT25334 Negative_regulation of Pla2g2a 2 16 0.56 9.01 4.23
142 INT15462 Negative_regulation of Il1a 1 4 0.59 4.68 4.17
143 INT19190 Regulation of Localization of IL1B 1 14 0.50 8.71 4.12
144 INT20230 Negative_regulation of Positive_regulation of Alb 1 15 0.56 12.44 4.11
145 INT51654 Regulation of Bad 1 21 0.40 12.18 4.06
146 INT64473 Regulation of Gene_expression of IL4 3 17 0.58 6.61 3.96
147 INT15724 Negative_regulation of Fn1 1 15 0.53 5.61 3.87
148 INT17444 Gene_expression of MTHFS 1 14 0.66 5.17 3.85
149 INT19189 Localization of IL1A 1 14 0.78 9.02 3.78
150 INT34054 Regulation of Gene_expression of IFNG 1 8 0.42 3.69 3.76
151 INT10824 Negative_regulation of Cyp19a1 3 38 0.57 25.18 3.56
152 INT9999 Regulation of Gene_expression of IGHE 1 32 0.60 15.75 3.53
153 INT53683 Negative_regulation of Gene_expression of ITGB2 1 10 0.57 9.11 3.2
154 INT28640 Positive_regulation of Gene_expression of CXCR2 1 8 0.69 5.51 2.91
155 INT48106 Positive_regulation of LBR 3 11 0.49 5.14 2.86
156 INT51377 Localization of Hexb 1 10 0.80 3.02 2.8
157 INT11139 Gene_expression of LBR 1 20 0.75 5.13 2.78
158 INT59245 Localization of Pla2g1b 1 10 0.75 4.72 2.76
159 INT24880 Positive_regulation of HRH2 1 7 0.69 1.34 2.74
160 INT90791 Regulation of Localization of Il10 1 6 0.44 2.94 2.5
161 INT4879 Positive_regulation of Gene_expression of MME 1 17 0.69 12.48 2.46
162 INT6282 Negative_regulation of Del(7)Tyr<c-1DThWb>-p 6 10 0.57 6.74 2.38
163 INT9995 Localization of C6orf25 1 13 0.69 6.48 2.29
164 INT30372 Regulation of ADRB3 1 8 0.60 0.57 2.24
165 INT35380 Binding of Fn1 1 8 0.35 4.84 2.23
166 INT21013 Regulation of Gene_expression of IL36RN 1 4 0.11 1.71 2.11
167 INT51658 Regulation of GZMA 2 1 0.00 1.48 2.03
168 INT30917 Gene_expression of Hexb 1 5 0.52 1.68 2.01
169 INT9662 Positive_regulation of Protein_catabolism of PDYN 1 5 0.57 0 1.9
170 INT59244 Regulation of Pla2g2a 1 5 0.57 3.02 1.82
171 INT59248 Positive_regulation of Localization of Pla2g1b 1 4 0.47 2.27 1.81
172 INT9996 Positive_regulation of Localization of IGHE 1 8 0.49 1.95 1.8
173 INT48412 Gene_expression of Apcs 1 26 0.54 7.16 1.53
174 INT22075 Positive_regulation of Gene_expression of IFNA2 1 7 0.64 4.7 1.45
175 INT6273 Gene_expression of Mc2r 1 7 0.18 1.04 1.38
176 INT35271 Negative_regulation of Apcs 1 12 0.59 8.05 1.36
177 INT25389 Localization of Pbk 3 2 0.51 0.17 1.22
178 INT25336 Localization of Pla2g2a 1 5 0.72 4.97 1.17
179 INT28790 Regulation of Localization of LYZ 1 4 0.50 0.74 1.16
180 INT28643 Positive_regulation of Gene_expression of LBR 1 3 0.11 2.43 1.16
181 INT49486 Gene_expression of Cma1 1 6 0.52 4.17 1.13
182 INT10686 Regulation of Binding of PDYN 1 3 0.43 0.61 1.1
183 INT51657 Negative_regulation of Regulation of GZMA 1 1 0.00 0.72 1.07
184 INT17443 Gene_expression of IGKV2D-26 2 4 0.75 0.41 1.01
185 INT13241 Negative_regulation of Gene_expression of TF 1 7 0.57 3.03 0.93
186 INT26295 Positive_regulation of mea 1 4 0.49 1.08 0.91
187 INT28641 Regulation of Gene_expression of CXCR2 1 1 0.45 1.9 0.91
188 INT19186 Negative_regulation of Gene_expression of IgG-2a 1 1 0.04 0.27 0.85
189 INT51656 Positive_regulation of Hivan1 1 5 0.06 7.66 0.76
190 INT28644 Negative_regulation of Gene_expression of Il1f5 2 3 0.55 1.01 0.76
191 INT90790 Regulation of Localization of Tgfb1 1 2 0.29 0.46 0.75
192 INT53576 Regulation of Gene_expression of Il1a 1 2 0.41 0.6 0.73
193 INT62831 Negative_regulation of Positive_regulation of SELE 1 3 0.36 1.63 0.69
194 INT31457 Regulation of Localization of Pbk 2 1 0.19 0 0.68
195 INT48592 Positive_regulation of Regulation of MME 1 1 0.40 0.32 0.66
196 INT26294 Regulation of Gem 1 2 0.18 1.73 0.6
197 INT78495 Negative_regulation of Art2a-ps 1 2 0.23 1.03 0.59
198 INT78494 Negative_regulation of Oas1b 1 2 0.22 1.02 0.59
199 INT28876 Positive_regulation of Localization of LYZ 1 3 0.68 0.46 0.58
200 INT25391 Negative_regulation of Localization of Pbk 1 1 0.31 0.17 0.54
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