J:International Journal of Clinical Practice

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT131249 Binding of Bdnf and Ntrk2 11 1 0.41 4 6.25
2 INT334928 Binding of pr and Aes 1 2 0.00 1.49 3.38
3 INT222335 Binding of Bdnf and Ngfr 3 2 0.05 2.66 1.48
4 INT222299 Binding of CYP19A1 and AIS 2 1 0.25 1.65 0.31
5 INT222301 Binding of ERBB2 and ESR1 5 1 0.36 5.07 0.29
6 INT71904 Binding of ESR1 and PGR 6 1 0.34 3.79 0.27
7 INT222300 Binding of ERBB2 and PGR 2 1 0.34 1.89 0.17
8 INT321465 Gip Regulation of DPP4 1 1 0.03 0.59 0.06
9 INT321466 Glp1r Regulation of DPP4 1 1 0.04 0.59 0.06
10 INT321467 Binding of DPP4 and Glp1r 1 1 0.03 0.42 0.05
11 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 1 0.11 1.27 0.03
12 INT246480 Binding of ALB and SHBG 2 1 0.14 1.45 0.03
13 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 1 0.01 0.53 0
14 INT334922 GNRHR Positive_regulation of Gene_expression of PLOD1 1 1 0.08 0.53 0
15 INT334919 GNRH1 Positive_regulation of Gene_expression of CGA 1 1 0.03 0.52 0
16 INT334917 GNRHR Positive_regulation of Gene_expression of FSHR 1 1 0.05 0.53 0
17 INT334920 GNRH1 Positive_regulation of Gene_expression of PLOD1 1 1 0.16 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 1 3083 0.78 894.43 1639.02
2 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
3 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
4 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
5 INT6056 Negative_regulation of Gene_expression of Fos 1 601 0.59 193.05 386.84
6 INT16260 Gene_expression of Bdnf 9 671 0.78 283.44 339.1
7 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
8 INT34869 Negative_regulation of PTGS2 3 778 0.59 366.76 319.85
9 INT16259 Positive_regulation of Bdnf 2 336 0.70 183.48 209.82
10 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
11 INT528 Gene_expression of Prl 1 693 0.78 217.18 192.2
12 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
13 INT812 Localization of INS 4 1026 0.81 515.6 145.31
14 INT17612 Gene_expression of CRP 2 676 0.78 580.61 119.03
15 INT7395 Localization of GNRH1 3 399 0.81 62.88 117.68
16 INT1793 Localization of CGA 2 379 0.81 67.38 114.69
17 INT16253 Positive_regulation of Gene_expression of Bdnf 5 196 0.70 92.67 113.01
18 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
19 INT3038 Gene_expression of INS 7 1583 0.78 1174.16 107.01
20 INT18009 Positive_regulation of CRP 2 518 0.70 553.03 103.74
21 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
22 INT920 Localization of PLOD1 3 223 0.81 42.25 78.7
23 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
24 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
25 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
26 INT47690 Regulation of Bdnf 2 118 0.62 53.02 64.5
27 INT822 Gene_expression of ESR1 3 529 0.78 302.16 63.64
28 INT546 Binding of ALB 3 311 0.48 85.98 60.14
29 INT16258 Gene_expression of Ntf3 1 121 0.78 53.93 59.03
30 INT251 Regulation of INS 2 398 0.62 232.47 55.04
31 INT50405 Negative_regulation of CYP3A4 3 238 0.59 53.65 51.51
32 INT1199 Positive_regulation of INS 5 579 0.70 399.64 50.43
33 INT17881 Gene_expression of LEP 2 278 0.78 221.61 48.31
34 INT47683 Negative_regulation of Bdnf 1 92 0.59 47.53 43.55
35 INT5130 Regulation of GNRH1 1 139 0.62 31.95 42.08
36 INT3933 Positive_regulation of PLOD1 2 128 0.70 30.76 42.03
37 INT3252 Negative_regulation of INS 3 428 0.59 271.65 39.52
38 INT16323 Gene_expression of pr 5 62 0.66 36.14 38.26
39 INT9082 Positive_regulation of ESR1 3 238 0.69 148.51 36.69
40 INT2416 Negative_regulation of MAOA 1 92 0.59 42.24 36.5
41 INT84825 Gene_expression of CD36 1 121 0.78 43.73 33.23
42 INT7975 Regulation of PLOD1 1 97 0.62 20.9 30.51
43 INT7397 Negative_regulation of Localization of GNRH1 2 86 0.59 15.45 29.78
44 INT67620 Negative_regulation of Gene_expression of Bdnf 2 53 0.59 22.45 28.5
45 INT5135 Negative_regulation of GNRH1 2 106 0.58 36.63 27.71
46 INT20462 Binding of ESR1 3 210 0.44 102.7 26.34
47 INT130176 Positive_regulation of Gene_expression of CRP 2 125 0.66 137.06 25.9
48 INT11159 Gene_expression of EGFR 1 698 0.78 548.93 25.69
49 INT17625 Localization of GCG 1 210 0.80 55.69 24.97
50 INT2614 Gene_expression of CGA 1 187 0.78 105.89 24.77
51 INT48766 Regulation of NOS1 1 73 0.61 37.01 24.59
52 INT18400 Localization of Glp1r 3 97 0.80 11.96 24.32
53 INT96557 Binding of Bdnf 2 46 0.47 21.74 24.26
54 INT7113 Negative_regulation of Localization of CGA 1 71 0.51 17.7 23.42
55 INT47741 Negative_regulation of Flvcr2 1 43 0.51 5.72 23.37
56 INT8640 Positive_regulation of HSD11B1 1 332 0.67 377.84 22.36
57 INT71047 Gene_expression of CYP19A1 2 122 0.78 68.78 22.21
58 INT1644 Regulation of FSHR 1 77 0.55 15.62 21.49
59 INT5916 Positive_regulation of HTR1A 1 51 0.67 18.27 21.38
60 INT76336 Negative_regulation of PDE5A 5 192 0.59 112.02 20.09
61 INT106097 Localization of pr 7 20 0.62 12.01 19.46
62 INT68347 Negative_regulation of Cyp2d4 3 34 0.58 7.62 18.35
63 INT14724 Negative_regulation of CYP19A1 18 233 0.59 96.56 18.26
64 INT1642 Negative_regulation of Localization of PLOD1 2 40 0.58 10.67 17.95
65 INT84464 Gene_expression of DPP4 1 101 0.78 56.15 17.53
66 INT50579 Binding of CYP3A4 1 84 0.48 17.52 17.45
67 INT13510 Gene_expression of ERBB2 1 530 0.78 405.68 16.79
68 INT3400 Positive_regulation of pr 6 57 0.68 36.9 16.24
69 INT47742 Binding of Flvcr2 2 26 0.42 3.28 15.87
70 INT912 Localization of FSHR 1 91 0.79 23.61 15.58
71 INT7970 Gene_expression of PLOD1 3 120 0.71 44.42 15.54
72 INT26538 Positive_regulation of FSHR 2 103 0.69 30.95 15.33
73 INT16167 Negative_regulation of DMD 1 186 0.57 108.71 15.25
74 INT2630 Positive_regulation of Shbg 1 134 0.70 65.26 15.19
75 INT75908 Regulation of LEP 1 77 0.60 60.16 15.19
76 INT16166 Positive_regulation of DMD 1 348 0.67 133.22 15.06
77 INT90766 Gene_expression of PCS 1 93 0.77 40.48 14.51
78 INT18773 Localization of ALB 1 117 0.80 69.18 13.8
79 INT14572 Binding of INS 1 205 0.48 175.43 13.38
80 INT4145 Gene_expression of FSHR 3 124 0.77 44.98 13.04
81 INT8210 Positive_regulation of Gene_expression of INS 1 188 0.68 146.57 12.83
82 INT2415 Binding of MAOA 1 26 0.47 13.26 11.86
83 INT3602 Negative_regulation of Shbg 2 148 0.53 69.05 11.65
84 INT1734 Negative_regulation of HSD11B1 2 116 0.57 125.13 10.52
85 INT167964 Gene_expression of Aes 3 30 0.58 25.41 10.16
86 INT132036 Negative_regulation of DPP4 9 126 0.59 63.24 9.51
87 INT26492 Negative_regulation of Localization of GCG 1 73 0.58 22.2 9.48
88 INT25834 Positive_regulation of Dbp 1 59 0.68 24.34 9.32
89 INT38564 Binding of AIS 4 36 0.38 27.77 9.31
90 INT52924 Negative_regulation of GSR 2 49 0.58 28.08 9.28
91 INT35366 Binding of AR 1 87 0.47 30.52 8.9
92 INT139613 Binding of pr 5 16 0.47 5.52 8.46
93 INT8637 Negative_regulation of Dbp 4 112 0.50 33.28 8.4
94 INT15529 Gene_expression of GCG 1 51 0.75 18.55 8.35
95 INT119904 Regulation of CYP19A1 1 25 0.62 9.36 8.34
96 INT150422 Positive_regulation of Aes 5 24 0.43 15.63 8
97 INT88868 Binding of MCS 1 45 0.40 37.43 7.98
98 INT6884 Negative_regulation of pr 3 20 0.42 13.18 7.97
99 INT30443 Positive_regulation of AIS 1 30 0.54 22.59 7.2
100 INT17041 Gene_expression of PER1 1 24 0.66 5.31 7.12
101 INT147583 Gene_expression of AIS 5 82 0.58 48.7 7.11
102 INT47942 Positive_regulation of Glp1r 2 38 0.70 15.94 6.47
103 INT9951 Gene_expression of ANGPTL5 1 45 0.53 37.2 6.44
104 INT72110 Gene_expression of Glp1r 7 48 0.78 22.46 6.17
105 INT17086 Binding of HSD11B1 1 84 0.47 122.28 6.16
106 INT15528 Positive_regulation of GCG 1 38 0.63 20.47 6.14
107 INT4144 Gene_expression of SHBG 2 64 0.68 39.94 6.08
108 INT17913 Regulation of HSD11B1 2 87 0.60 93.23 6.04
109 INT188844 Gene_expression of AES 1 44 0.58 33.94 5.85
110 INT77955 Negative_regulation of PCS 3 55 0.43 39.32 5.76
111 INT134346 Binding of PCS 1 51 0.37 22.27 5.67
112 INT21103 Gene_expression of Dbp 1 48 0.61 22.6 5.59
113 INT65356 Localization of LEP 1 46 0.79 41.17 5.43
114 INT23010 Positive_regulation of CYP19A1 1 28 0.58 24.18 5.37
115 INT23952 Gene_expression of Cyp2d4 1 18 0.78 4.76 5.31
116 INT156794 Gene_expression of CISH 1 41 0.58 23.09 5.03
117 INT8340 Negative_regulation of SHBG 1 49 0.57 35.96 4.73
118 INT4146 Binding of SHBG 5 49 0.47 31 4.71
119 INT133630 Negative_regulation of Gene_expression of ESR1 3 42 0.52 23.89 4.57
120 INT29231 Regulation of Dbp 1 44 0.53 10.08 4.47
121 INT39000 Regulation of pr 1 24 0.44 12.51 4.36
122 INT180338 Binding of Cyp2d4 2 12 0.47 6.87 4.09
123 INT28546 Regulation of SHBG 1 23 0.54 16.35 3.88
124 INT88867 Localization of MCS 1 19 0.62 28.31 3.88
125 INT119606 Regulation of Gene_expression of LEP 1 17 0.45 17.96 3.75
126 INT192951 Negative_regulation of AES 2 15 0.38 6.38 3.5
127 INT1646 Negative_regulation of Localization of FSHR 1 17 0.58 7.36 3.46
128 INT91070 Regulation of GSR 1 27 0.59 16.64 3.42
129 INT275878 Positive_regulation of Gene_expression of Aes 1 4 0.23 4.54 3.39
130 INT171998 Binding of DMD 3 58 0.47 38.13 3.35
131 INT87517 Gene_expression of LDLR 1 73 0.69 37.35 3.32
132 INT200443 Positive_regulation of AES 1 27 0.60 22.46 3.22
133 INT117348 Regulation of EGFR 1 75 0.61 47.73 3.09
134 INT133809 Negative_regulation of Gene_expression of CYP19A1 3 9 0.43 7.67 2.99
135 INT16616 Negative_regulation of SRD5A1 5 44 0.57 34.81 2.96
136 INT24149 Gene_expression of BPHL 19 58 0.59 93.54 2.91
137 INT123466 Binding of T2dm2 1 21 0.37 34.87 2.91
138 INT201952 Binding of DPP4 1 11 0.37 8.81 2.91
139 INT147582 Negative_regulation of AIS 2 13 0.37 13.26 2.46
140 INT334926 Positive_regulation of MEHMO 7 1 0.02 10.11 2.37
141 INT62511 Negative_regulation of MCS 2 20 0.50 6.77 2.35
142 INT70242 Localization of HCC 1 18 0.66 23.95 2.35
143 INT12033 Binding of PLOD1 1 15 0.48 8.04 2.3
144 INT15607 Localization of GNRHR 1 14 0.62 7.56 2.3
145 INT22984 Positive_regulation of FRTS 1 12 0.67 5.24 2.25
146 INT111113 Binding of CYP19A1 6 15 0.36 9.17 2.12
147 INT79140 Binding of HCC 1 36 0.31 46.96 1.87
148 INT3866 Positive_regulation of Positive_regulation of INS 1 30 0.59 21.58 1.86
149 INT236867 Gene_expression of AURKC 3 6 0.55 31.96 1.86
150 INT48792 Regulation of ERBB2 1 48 0.57 36.56 1.8
151 INT28954 Binding of GCG 1 7 0.36 3.14 1.68
152 INT86247 Gene_expression of Bcl2l10 1 14 0.34 12.21 1.61
153 INT24534 Positive_regulation of Slc35b3 1 3 0.25 0.6 1.58
154 INT7033 Binding of FSHR 1 19 0.37 6.66 1.52
155 INT236868 Negative_regulation of AURKC 2 3 0.48 12.2 1.46
156 INT8667 Localization of HSD11B1 1 22 0.73 22.74 1.25
157 INT177341 Negative_regulation of HMHB1 8 21 0.03 12.48 1.25
158 INT134663 Gene_expression of SOX9 3 40 0.75 9.07 1.2
159 INT105571 Gene_expression of SRGN 1 33 0.58 14.68 1.19
160 INT175652 Positive_regulation of BPHL 1 9 0.44 17.98 1.14
161 INT236872 Regulation of BPHL 3 6 0.16 6.52 1.14
162 INT121526 Localization of PCS 2 12 0.61 6.47 1.1
163 INT139852 Regulation of HCC 1 14 0.39 14.54 0.97
164 INT226478 Protein_catabolism of DPP4 2 11 0.85 5.52 0.95
165 INT147880 Regulation of SRGN 2 28 0.33 13.99 0.9
166 INT55422 Binding of Glp1r 1 7 0.48 3.35 0.9
167 INT222333 Positive_regulation of Positive_regulation of Slc35b3 1 1 0.02 0.54 0.89
168 INT168262 Positive_regulation of Gene_expression of BPHL 4 10 0.24 10.72 0.83
169 INT236871 Binding of AURKC 1 2 0.39 8.53 0.83
170 INT47943 Positive_regulation of Positive_regulation of Glp1r 1 5 0.70 1.38 0.59
171 INT236877 Negative_regulation of Gene_expression of BPHL 5 12 0.32 16.43 0.56
172 INT127291 Transcription of ALB 1 7 0.67 4.26 0.55
173 INT236865 Positive_regulation of AURKC 1 3 0.57 18.45 0.54
174 INT103942 Binding of BPHL 4 11 0.30 14.26 0.53
175 INT132326 Positive_regulation of Negative_regulation of MCS 1 3 0.28 1.83 0.51
176 INT60151 Positive_regulation of Positive_regulation of HSD11B1 1 4 0.45 3.54 0.49
177 INT133228 Protein_catabolism of Glp1r 2 8 0.88 2.65 0.48
178 INT252266 Localization of GPHA2 1 2 0.05 0.67 0.46
179 INT127890 Positive_regulation of Negative_regulation of CYP19A1 1 6 0.50 1.41 0.45
180 INT55367 Localization of Dbp 1 18 0.70 7.43 0.38
181 INT236870 Positive_regulation of Gene_expression of AURKC 2 3 0.41 10.18 0.35
182 INT102992 Regulation of Negative_regulation of SRD5A1 1 4 0.60 3.59 0.29
183 INT25047 Positive_regulation of Regulation of FSHR 1 3 0.31 0.92 0.29
184 INT121834 Gene_expression of IAPP 1 24 0.66 20.96 0.26
185 INT334924 Binding of MEHMO 7 1 0.01 9.69 0.26
186 INT265083 Regulation of OR5BS1P 1 1 0.02 1.05 0.13
187 INT236875 Localization of SRD5A1 1 2 0.73 0.8 0.11
188 INT334927 Negative_regulation of MEHMO 2 1 0.01 3.46 0.1
189 INT236864 Regulation of Gene_expression of BPHL 3 4 0.19 3.87 0.09
190 INT236878 Regulation of Gene_expression of AURKC 2 3 0.15 2.33 0.09
191 INT236874 Regulation of AURKC 2 3 0.37 2.83 0.09
192 INT227944 Binding of EDAR 1 5 0.25 2.88 0.07
193 INT236876 Negative_regulation of Localization of SRD5A1 1 1 0.41 0.81 0.06
194 INT265085 Binding of OR5BS1P 1 1 0.04 0.77 0.05
195 INT177342 Negative_regulation of SRGN 1 15 0.28 5.66 0.04
196 INT255034 Positive_regulation of Negative_regulation of DPP4 1 2 0.37 0.83 0.03
197 INT321462 Negative_regulation of Negative_regulation of Gip 1 1 0.05 0.69 0.03
198 INT321463 Negative_regulation of Gip 1 1 0.05 0.68 0.03
199 INT100664 Negative_regulation of MKI67 1 12 0.10 9.77 0
200 INT213288 Regulation of HMHB1 5 9 0.01 3.27 0
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